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4. Direct comparison of sterile neutrino constraints from cosmological data, νe disappearance data and νμ→νe appearance data in a 3+1 model

Author

Adams, M., Bezrukov, F., Elvin-Poole, J., Evans, J.J., Guzowski, P., Fearraigh, B.Ó., Söldner-Rembold, S., and IoP (FNWI)

Abstract

We present a quantitative, direct comparison of constraints on sterile neutrinos derived from neutrino oscillation experiments and from Planck data, interpreted assuming standard cosmological evolution. We extend a 1+1 model, which is used to compare exclusion contours at the 95% Cl derived from Planck data to those from νe-disappearance measurements, to a 3+1 model. This allows us to compare the Planck constraints with those obtained through νμ→νe appearance searches, which are sensitive to more than one active-sterile mixing angle. We find that the cosmological data fully exclude the allowed regions published by the LSND, MiniBooNE and Neutrino-4 collaborations, and those from the gallium and rector anomalies, at the 95% Cl. Compared to the exclusion region from the Daya Bay νe-disappearance search, the Planck data are more strongly excluding above |Δm241|≈0.1eV2 and msterileeff≈0.2eV, with the Daya Bay exclusion being stronger below these values. Compared to the combined Daya Bay/Bugey/MINOS exclusion region on νμ→νe appearance, the Planck data is more strongly excluding above Δm241≈5×10−2eV2, with the exclusion strengths of the Planck data and the Daya Bay/Bugey/MINOS combination becoming comparable below this value.

Published
2020
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9. A White Paper on keV Sterile Neutrino Dark Matter

Author

Adhikari, R., Agostini, M., Ky, N. Anh, Araki, T., Archidiacono, M., Bahr, M., Behrens, J., Bezrukov, F., Bhupal Dev, P. S., Borah, D., Boyarsky, A., Gouvea, A., Pires, C. A. S., Vega, H. J., Dias, A. G., Di Bari, P., Djurcic, Z., Dolde, K., Dorrer, H., Durero, M., Dragoun, O., Drewes, M., Düllmann, Ch E., Eberhardt, K., Eliseev, S., Enss, C., Evans, N. W., Faessler, A., Filianin, P., Fischer, V., Fleischmann, A., Formaggio, J. A., Franse, J., Fraenkle, F. M., Frenk, C. S., Fuller, G., Gastaldo, L., Garzilli, A., Giunti, C., Glück, F., Goodman, M. C., Gonzalez-Garcia, M. C., Gorbunov, D., Hamann, J., Hannestad, S., Heeck, J., Hannen, V., Hansen, S. H., Hassel, C., Florian Hofmann, Houdy, T., Huber, A., Iakubovskyi, D., Ianni, A., Ibarra, A., Jacobsson, R., Jeltema, T., Kempf, S., Kieck, T., Korzeczek, M., Kornoukhov, V., Lachenmaier, T., Laine, M., Langacker, P., Lasserre, T., Lesgourgues, J., Lhuillier, D., Li, Y. F., Liao, W., Long, A. W., Maltoni, M., Mangano, G., Mavromatos, N. E., Menci, N., Merle, A., Mertens, S., Mirizzi, A., Monreal, B., Nozik, A., Neronov, A., Niro, V., Novikov, Y., Oberauer, L., Otten, E., Palanque-Delabrouille, N., Pallavicini, M., Pantuev, V. S., Papastergis, E., Parke, S., Pastor, S., Patwardhan, A., Pilaftsis, A., Radford, D. C., Ranitzsch, P. C. -O, Rest, O., Robinson, D. J., Rodrigues Da Silva, P. S., Ruchayskiy, O., Sanchez, N. G., Sasaki, M., Saviano, N., Schneider, A., Schneider, F., Schwetz, T., Schönert, S., Shankar, F., Steinbrink, N., Strigari, L., Suekane, F., Suerfu, B., Takahashi, R., Van, N. Thi Hong, Tkachev, I., Totzauer, M., Tsai, Y., Tully, C. G., Valerius, K., Valle, J., Venos, D., Viel, M., Wang, M. Y., Weinheimer, C., Wendt, K., Winslow, L., Wolf, J., Wurm, M., Xing, Z., Zhou, S., and Zuber, K.

Subjects
High Energy Physics - Phenomenology, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment
Abstract

We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved - cosmology, astrophysics, nuclear, and particle physics - in each case viewed from both theoretical and experimental/observational perspectives. After reviewing the role of active neutrinos in particle physics, astrophysics, and cosmology, we focus on sterile neutrinos in the context of the Dark Matter puzzle. Here, we first review the physics motivation for sterile neutrino Dark Matter, based on challenges and tensions in purely cold Dark Matter scenarios. We then round out the discussion by critically summarizing all known constraints on sterile neutrino Dark Matter arising from astrophysical observations, laboratory experiments, and theoretical considerations. In this context, we provide a balanced discourse on the possibly positive signal from X-ray observations. Another focus of the paper concerns the construction of particle physics models, aiming to explain how sterile neutrinos of keV-scale masses could arise in concrete settings beyond the Standard Model of elementary particle physics. The paper ends with an extensive review of current and future astrophysical and laboratory searches, highlighting new ideas and their experimental challenges, as well as future perspectives for the discovery of sterile neutrinos.

Published
2016

10. Helmholtz Aliance Linear Collider Forum

Author

Moortgat-Pick, Gudrid, Fleck, I., Riemann, S., Simon, F., Adeyemi, O.S., Alexander, G., Amjad, M.S., Andreev, V.V., Arana-Catania, M., Avetisyan, E., Baer, H., Beneke, M., Berge, S., Bernreuther, W., Bezrukov, F., Bharucha, A., Boronat, M., Brau, J., Buesser, K., Calancha, C., Englert, C., Fiorini, L., Frisson, T., Fujii, K., Gai, W., Garcia, I., Godbole, R., Grefe, C., Grober, R., Groote, S., Gunion, J., Hartin, A., Heinemeyer, S., Heisig, J., Herrero, M.J., Jantzen, B., Korner, J.G., Kalinowski, J., Kalmykov, M.Y., Katayama, R., Kawada, S., Kawagoe, K., Kittel, O., Kniehl, B., Kovalenko, V., Kraml, S., Lastovicka, T., Le Diberder, F., List, B., List, J., Liu, W., Lopex-Val, D., Muhlleitner, M., Malysheva, L.I., Martin, V., Matsumoto, S., Melic, B., Mordechai, I.B., Mori, T., Ohl, T., OLeary, B., Ono, H., Osland, P., Poschl, R., Pahlen, F.V.D., Pankov, A.A., Paver, N., Penaranda, S., Porod, W., Prelovsek, S., Price, T., Rauch, M., Reuter, J., Richard, F., Rodriguez-Sanchez, A., Rolbiecki, K., Ros, E., Rosca, A., Rouene, J., Ruiz-Femenia, P., Rzehak, H., Salimkhani, K., Schade, P., Schappacher, C., Seidel, K., Shaposhnikov, M., Sola, J., Speckner, C., Spiesberger, H., Stockinger, D., Staub, F., Staufenbiel, F., Strube, J., Suchara, T., Takahashi, T., Tanabe, T., Tattersall, J., Terwort, M., Tesar, M., Thomson, M., Tian, J., Trenado, J., Tsytrinov, A.V., Ushakov, A., Vos, M., Walker, N.J., Watson, N., Weerts, H., Weiglein, G., Wells, J., Yamamoto, H., and Yamashita, S.

Subjects
Physics
Abstract

The Linear Collider Forum is an initiative born within the Helmholtz-Alliance ”Physics at the Terascale”, a network of German Universities and Research Centers working in high-energy particle physics. Yearly dedicated meetings focus on the physics case and the technologies at a future linear collider, covering both the ILC and CLIC concepts. In February 2012 an extended meeting with significant international participation was dedicated to the discussion of physics scenarios to strengthen and update the case for a linear e+e- collider in light of new developments and the latest LHC results. Contributions to LC Forum sessions were collected on the DESY LC-note server with a dedicated mark ‘LC-REPyear- number’. These Proceedings comprise all contributions that have been submitted with the dedicated mark in 2012 and 2013. Therefore also contributions are included that actually have not been presented on a LC Forum meeting but are strongly related to the subject.

Published
2013
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11. Light Sterile Neutrinos: A White Paper

Author

Abazajian, K. N., Acero, M. A., Agarwalla, S. K., Aguilar-Arevalo, A. A., Albright, C. H., Antusch, S., Arguelles, C. A., Balantekin, A. B., Barenboim, G., Barger, V., Bernardini, P., Bezrukov, F., Bjaelde, O. E., Bogacz, S. A., Bowden, N. S., Boyarsky, A., Bravar, A., Bravo Berguno, D., Brice, S. J., Bross, A. D., Caccianiga, B., Cavanna, F., Chun, E. J., Cleveland, B. T., Collin, A. P., Coloma, P., Conrad, J. M., Cribier, M., Cucoanes, A. S., D Olivo, J. C., Das, Subinoy, Gouvea, A., Derbin, A. V., Dharmapalan, R., Diaz, J. S., Ding, X. J., Djurcic, Z., Donini, A., Duchesneau, D., Ejiri, H., Elliott, S. R., Ernst, D. J., Esmaili, A., Evans, J. J., Fernandez-Martinez, E., Figueroa-Feliciano, E., Fleming, B. T., Formaggio, J. A., Franco, D., Gaffiot, J., Gandhi, R., Gao, Y., Garvey, G. T., Gavrin, V. N., Ghoshal, P., Gibin, D., Giunti, C., Gninenko, S. N., Gorbachev, V. V., Gorbunov, D. S., Guenette, R., Guglielmi, A., Halzen, F., Hamann, J., Hannestad, S., Haxton, W., Heeger, K. M., Henning, R., Hernandez, P., Huber, P., Huelsnitz, W., Ianni, A., Ibragimova, T. V., Karadzhov, Y., Karagiorgi, G., Keefer, G., Kim, Y. D., Kopp, J., Kornoukhov, V. N., Kusenko, A., Kyberd, P., Paul Langacker, Lasserre, Th, Laveder, M., Letourneau, A., Lhuillier, D., Li, Y. F., Lindner, M., Link, J. M., Littlejohn, B. L., Lombardi, P., Long, K., Lopez-Pavon, J., Louis, W. C., Ludhova, L., Lykken, J. D., Machado, P. A. N., Maltoni, M., Mann, W. A., Marfatia, D., Mariani, C., Matveev, V. A., Mavromatos, N. E., Melchiorri, A., Meloni, D., Mena, O., Mention, G., Merle, A., Meroni, E., Mezzetto, M., Mills, G. B., Minic, D., Miramonti, L., Mohapatra, D., Mohapatra, R. N., Montanari, C., Mori, Y., Mueller, Th A., Mumm, H. P., Muratova, V., Nelson, A. E., Nico, J. S., Noah, E., Nowak, J., Smirnov, O. Yu, Obolensky, M., Pakvasa, S., Palamara, O., Pallavicini, M., Pascoli, S., Patrizii, L., Pavlovic, Z., Peres, O. L. G., Pessard, H., Pietropaolo, F., Pitt, M. L., Popovic, M., Pradler, J., Ranucci, G., Ray, H., Razzaque, S., Rebel, B., Robertson, R. G. H., Rodejohann, W., Rountree, S. D., Rubbia, C., Ruchayskiy, O., Sala, P. R., Scholberg, K., Schwetz, T., Shaevitz, M. H., Shaposhnikov, M., Shrock, R., Simone, S., Skorokhvatov, M., Sorel, M., Sousa, A., Spergel, D. N., Spitz, J., Stanco, L., Stancu, I., Suzuki, A., Takeuchi, T., Tamborra, I., Tang, J., Testera, G., Tian, X. C., Tonazzo, A., Tunnell, C. D., Water, R. G., Verde, L., Veretenkin, E. P., Vignoli, C., Vivier, M., Vogelaar, R. B., Wascko, M. O., Wilkerson, J. F., Winter, W., Wong, Y. Y. Y., Yanagida, T. T., Yasuda, O., Yeh, M., Yermia, F., Yokley, Z. W., Zeller, G. P., Zhan, L., Zhang, H., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), APC - Neutrinos, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Théorique - UMR CNRS 3681 (IPHT), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Center for Neutrino Physics, Physics, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO), Nuclear Theory, nucl-th, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], hep-ex, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, FOS: Physical sciences, hep-ph, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], nucl-ex, High Energy Physics - Experiment, Nuclear Theory (nucl-th), High Energy Physics - Phenomenology, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], astro-ph.CO, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Particle Physics - Phenomenology
Abstract

This white paper addresses the hypothesis of light sterile neutrinos based on recent anomalies observed in neutrino experiments and the latest astrophysical data. This white paper addresses the hypothesis of light sterile neutrinos based on recent anomalies observed in neutrino experiments and the latest astrophysical data.

Published
2012

13. Non-minimal coupling in inflation and inflating with the Higgs boson

Author

Bezrukov, F. L.

Subjects
General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics
Abstract

We analyse the effect of the non-minimal coupling of the form $\xi\phi^2R/2$ on the single field inflation. If the non-minimal coupling is large, it relaxes the constraint on the field self coupling, making it possible to use the Standard Model Higgs field as the inflaton. At the same time, even small non-minimal coupling constant, $\xi\gtrsim10^{-3}$, brings the usual inflaton with quartic potential in agreement with the WMAP5 observations., Comment: 5 pages, prepared for proceedings of the 15th International Seminar on High Energy Physics QUARKS-2008, Sergiev Posad, Russia, 23-29 May, 2008

Published
2008

14. Theta--instantons in SU(2) Higgs theory

Author

Bezrukov, F. and Levkov, D.

Subjects
High Energy Physics - Theory, High Energy Physics - Theory (hep-th), High Energy Physics::Phenomenology, FOS: Physical sciences
Abstract

We consider topology changing processes in SU(2)--Higgs theory. In the Standard Model of particle physics they are accompanied by baryon--and lepton--number non--conservation. At fixed energy and multiplicity of initial state, these processes are described by classical Theta--instanton solutions. We describe these solutions and calculate the suppression exponents for the probabilities of the topology changing transitions at relatively low energies., 12 pages, 5 figures

Published
2003

15. Pinning down the kaon form factors in K^+ -> mu^+ nu_mu gamma decay

Author

Bezrukov, F. L., Gorbunov, D. S., and Kudenko, Yu. G.

Subjects
High Energy Physics - Phenomenology, High Energy Physics::Experiment, High Energy Physics - Experiment
Abstract

We find that the normal muon polarization in the decay K->mu nu_mu gamma is very sensitive to the values of the kaon vector F_V and axial-vector F_A form factors. It is shown that the ongoing KEK-E246 experiment can definitely determine the signs of the sum of the form factors if their difference is fixed from other considerations. This method can also verify the form factor values and signs obtained from the K^+ -> l^+ nu_l e^+ e^- decays. A new experiment with sensitivity to the normal and transverse muon polarizations of about 10^-4 will provide a unique possibility to determine the F_V and F_A values with a few percent accuracy., Comment: revtex, 5 pages, 2 figures. Minor corrections made for the journal version of the paper

Published
2003

16. T-odd Correlations in pi->e nu_e gamma Decay

Author

Bezrukov, F. and Gorbunov, D.

Subjects
High Energy Physics - Phenomenology, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

The transverse lepton polarization asymmetry in pi_e2gamma decay may probe T-violating interactions beyond the Standard Model. Dalitz plot distributions of the expected effects are presented and compared to the contribution from the Standard Model final state interactions. We give an example of a phenomenologically viable model, where a considerable contribution to the transverse lepton polarization asymmetry arises., Comment: 3 pages; Talk given at the XXXVIIth Rencontres de Moriond, Electroweak Interactions and Unified Theories, Les Arcs, March 9-16 2002

Published
2002

17. T-Odd Correlations in pi->e nu_e gamma and pi->mu nu_mu gamma Decays

Author

Bezrukov, F. and Gorbunov, D.

Subjects
High Energy Physics - Phenomenology, High Energy Physics::Phenomenology, High Energy Physics::Experiment, High Energy Physics - Experiment
Abstract

The transverse lepton polarization asymmetry in pi_l2gamma decays may probe T-violating interactions beyond the Standard Model. Dalitz plot distributions of the expected effects are presented and compared to the contribution from the Standard Model final state interactions. We give an example of a phenomenologically viable model, where a considerable contribution to the transverse lepton polarization asymmetry arises., Comment: 19 pages, 5 figures. To be published in Phys.Rev.D. Fixed sign in FSI contribution figure, fixed formulas in K-bar{K} mixing analysis, added some minor comments

Published
2002

18. Instanton-Like Processes in Particle Collisions: a Numerical Study of the SU(2)-Higgs Theory below the Sphaleron Energy

Author

Bezrukov, F., Rebbi, C., Rubakov, V., and Tinyakov, P.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), FOS: Physical sciences
Abstract

We use semiclassical methods to calculate the probability of inducing a change of topology via a high-energy collision in the SU(2)-Higgs theory. This probability is determined by a complex solution to a classical boundary value problem on a contour in the complex time plane. In the case of small particle number it is the probability of instanton-like processes in particle collisions. We obtain numerically configurations with the correct topological features and expected properties in the complex time plane. Our work demonstrates the feasibility of the numerical approach to the calculation of instanton-like processes in gauge theories. We present our preliminary results for the suppression factor of topology changing processes, which cover a wide range of incoming particle numbers and energies below the sphaleron energy., 19 pages, 5 figures. To be published in proceedings of XI-th International School "Particles and Cosmology", Baksan, Russia 2001

Published
2001

19. Inflation in the Standard Model and νMSM with non-minimal coupling to gravity.

Author

Bezrukov, F.

Subjects
*HIGGS bosons, *GRAVITY, *ASTRONOMICAL perturbation, *PHYSICS experiments, *METAPHYSICAL cosmology
Abstract

The possibility of inflation in the Standard Model is described. The only addition is the non-minimal coupling of the Higgs boson to gravity. The Higgs boson itself then plays the role if the inflaton field at high field values. The spectral index is predicted by the model, well in agreement with the current experimental data. Amplitude of the tensor perturbations (primordial gravity waves) is expected to be very small. The reheating temperature in the model is naturally high. The quantum corrections predict a window for allowed Higgs boson masses and provide a possible connection between the particle physics experiments and cosmology. [ABSTRACT FROM AUTHOR]

Published
2010
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20. Leptogenesis in models with keV sterile neutrino dark matter.

Author

Bezrukov, F., Kartavtsev, A., and Lindner, M.

Subjects
*NEUTRINOS, *DARK matter, *BARYONS, *NUCLEAR reactions, UNIVERSE
Abstract

We analyze leptogenesis in gauge extensions of the Standard Model with keV sterile neutrino dark matter. We find that both the observed dark matter abundance and the correct baryon asymmetry of the Universe can simultaneously emerge in these models. Both the dark matter abundance and the leptogenesis are controlled by the out-of-equilibrium decays of the same heavy right-handed neutrino. [ABSTRACT FROM AUTHOR]

Published
2013
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22. Suppression of baryon number violation in electroweak collisions: numerical results

Author

Bezrukov, F., Levkov, D., Rebbi, C., Rubakov, V., and Tinyakov, P.

Subjects
*BARYON number, *ELECTROWEAK interactions, *COLLISIONS (Nuclear physics)
Abstract

We present a semiclassical study of the suppression of topology changing, baryon number violating transitions induced by particle collisions in the electroweak theory. We find that below the sphaleron energy the suppression exponent is remarkably close to the analytic estimates based on a low energy expansion about the instanton. Above the sphaleron energy, the relevant semiclassical solutions have qualitatively different properties from those below the sphaleron: they correspond to jumps on top of the barrier. Yet these processes remain exponentially suppressed, and, furthermore, the tunneling exponent flattens out in energy. We also derive lower bounds on the tunneling exponent which show that baryon number violation remains exponentially suppressed up to very high energies of at least 30 sphaleron masses (250 TeV). [Copyright &y& Elsevier]

Published
2003
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23. Transverse muon polarization in ... : scanning over the Dalitz plot.

Author

Bezrukov, F. L., Gorbunov, D. S., and Kudenko, Yu G.

Subjects
ELECTROMAGNETISM, KAONS, SYMMETRY (Physics), NEUTRONS, LEPTONS (Nuclear physics), NUCLEAR physics
Abstract

We study the potential of the measurement of the transverse muon polarization PT in the K → μvμγ decay with a sensitivity of δPT ≈ 10-4. It is shown that the forthcoming experiment can measure the contribution of the electromagnetic final state interactions to PT that gives a possibility to unambiguously determine the signs of the sum of the kaon form factors FV and FA even without fixing their difference. We also estimate the sensitivity of this experiment to the new physics, which could give rise to T-violation: multi-Higgs doublet models, supersymmetric extensions of the Standard Model, left-right symmetric model and leptoquark models. [ABSTRACT FROM AUTHOR]

Published
2003
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24. Scalar induced resonant sterile neutrino production in the early Universe.

Author

Bezrukov, F., Chudaykin, A., and Gorbunov, D.

Subjects
*STERILE neutrinos, *PARTICLE physics, *NEUTRINOS, *SCALAR field theory, *DARK matter, *SOLAR neutrinos, UNIVERSE
Abstract

It has been recently suggested [F. Bezrukov et al. J. Cosmol. Astropart. Phys. 06 (2017) 051; F. Bezrukov et al. Phys. Rev. D 99, 083507 (2019)] that a cosmic scalar field can completely change the keV-scale sterile neutrino production in the early Universe. Its effect may, for various parameter choices, either suppress sterile neutrino production and make moderate active-sterile mixing cosmologically acceptable, or increase the production and generate a considerable dark matter component out of sterile neutrino with otherwise negligible mixing with SM. In this paper, we provide analytic estimates complementing and improving of the numerical calculations performed by F. Bezrukov et al. [Phys. Rev. D 99, 083507 (2019) in the case of the resonant amplification of the sterile neutrino production by the scalar field. We found the substantially cooler velocity distribution of sterile neutrinos as compared to most production mechanisms, opening a new window for warm dark matter, which is otherwise forbidden by structure formation considerations. We also discuss phenomenological and theoretical issues related to the successful implementation of this idea in fully realistic extensions of the Standard Model of particle physics. [ABSTRACT FROM AUTHOR]

Published
2020
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25. Human genome meeting 2016

Author

Srivastava, A. K., Wang, Y., Huang, R., Skinner, C., Thompson, T., Pollard, L., Wood, T., Luo, F., Stevenson, R., Polimanti, R., Gelernter, J., Lin, X., Lim, I. Y., Wu, Y., Teh, A. L., Chen, L., Aris, I. M., Soh, S. E., Tint, M. T., MacIsaac, J. L., Yap, F., Kwek, K., Saw, S. M., Kobor, M. S., Meaney, M. J., Godfrey, K. M., Chong, Y. S., Holbrook, J. D., Lee, Y. S., Gluckman, P. D., Karnani, N., Kapoor, A., Lee, D., Chakravarti, A., Maercker, C., Graf, F., Boutros, M., Stamoulis, G., Santoni, F., Makrythanasis, P., Letourneau, A., Guipponi, M., Panousis, N., Garieri, M., Ribaux, P., Falconnet, E., Borel, C., Antonarakis, S. E., Kumar, S., Curran, J., Blangero, J., Chatterjee, S., Akiyama, J., Auer, D., Berrios, C., Pennacchio, L., Donti, T. R., Cappuccio, G., Miller, M., Atwal, P., Kennedy, A., Cardon, A., Bacino, C., Emrick, L., Hertecant, J., Baumer, F., Porter, B., Bainbridge, M., Bonnen, P., Graham, B., Sutton, R., Sun, Q., Elsea, S., Hu, Z., Wang, P., Zhu, Y., Zhao, J., Xiong, M., Bennett, David A., Hidalgo-Miranda, A., Romero-Cordoba, S., Rodriguez-Cuevas, S., Rebollar-Vega, R., Tagliabue, E., Iorio, M., D’Ippolito, E., Baroni, S., Kaczkowski, B., Tanaka, Y., Kawaji, H., Sandelin, A., Andersson, R., Itoh, M., Lassmann, T., Hayashizaki, Y., Carninci, P., Forrest, A. R. R., Semple, C. A., Rosenthal, E. A., Shirts, B., Amendola, L., Gallego, C., Horike-Pyne, M., Burt, A., Robertson, P., Beyers, P., Nefcy, C., Veenstra, D., Hisama, F., Bennett, R., Dorschner, M., Nickerson, D., Smith, J., Patterson, K., Crosslin, D., Nassir, R., Zubair, N., Harrison, T., Peters, U., Jarvik, G., Menghi, F., Inaki, K., Woo, X., Kumar, P., Grzeda, K., Malhotra, A., Kim, H., Ucar, D., Shreckengast, P., Karuturi, K., Keck, J., Chuang, J., Liu, E. T., Ji, B., Tyler, A., Ananda, G., Carter, G., Nikbakht, H., Montagne, M., Zeinieh, M., Harutyunyan, A., Mcconechy, M., Jabado, N., Lavigne, P., Majewski, J., Goldstein, J. B., Overman, M., Varadhachary, G., Shroff, R., Wolff, R., Javle, M., Futreal, A., Fogelman, D., Bravo, L., Fajardo, W., Gomez, H., Castaneda, C., Rolfo, C., Pinto, J. A., Akdemir, K. C., Chin, L., Patterson, S., Statz, C., Mockus, S., Nikolaev, S. N., Bonilla, X. I., Parmentier, L., King, B., Bezrukov, F., Kaya, G., Zoete, V., Seplyarskiy, V., Sharpe, H., McKee, T., Popadin, K., Basset-Seguin, N., Chaabene, R. Ben, Andrianova, M., Verdan, C., Grosdemange, K., Sumara, O., Eilers, M., Aifantis, I., Michielin, O., de Sauvage, F., Antonarakis, S., Likhitrattanapisal, S., Lincoln, S., Kurian, A., Desmond, A., Yang, S., Kobayashi, Y., Ford, J., Ellisen, L., Peters, T. L., Alvarez, K. R., Hollingsworth, E. F., Lopez-Terrada, D. H., Hastie, A., Dzakula, Z., Pang, A. W., Lam, E. T., Anantharaman, T., Saghbini, M., Cao, H., Gonzaga-Jauregui, C., Ma, L., King, A., Rosenzweig, E. Berman, Krishnan, U., Reid, J. G., Overton, J. D., Dewey, F., Chung, W. K., Small, K., DeLuca, A., Cremers, F., Lewis, R. A., Puech, V., Bakall, B., Silva-Garcia, R., Rohrschneider, K., Leys, M., Shaya, F. S., Stone, E., Sobreira, N. L., Schiettecatte, F., Ling, H., Pugh, E., Witmer, D., Hetrick, K., Zhang, P., Doheny, K., Valle, D., Hamosh, A., Jhangiani, S. N., Akdemir, Z. Coban, Bainbridge, M. N., Charng, W., Wiszniewski, W., Gambin, T., Karaca, E., Bayram, Y., Eldomery, M. K., Posey, J., Doddapaneni, H., Hu, J., Sutton, V. R., Muzny, D. M., Boerwinkle, E. A., Lupski, J. R., Gibbs, R. A., Shekar, S., Salerno, W., English, A., Mangubat, A., Bruestle, J., Thorogood, A., Knoppers, B. M., Takahashi, H., Nitta, K. R., Kozhuharova, A., Suzuki, A. M., Sharma, H., Cotella, D., Santoro, C., Zucchelli, S., Gustincich, S., Mulvihill, J. J., Baynam, G., Gahl, W., Groft, S. C., Kosaki, K., Lasko, P., Melegh, B., Taruscio, D., Ghosh, R., Plon, S., Scherer, S., Qin, X., Sanghvi, R., Walker, K., Chiang, T., Muzny, D., Wang, L., Black, J., Boerwinkle, E., Weinshilboum, R., Gibbs, R., Karpinets, T., Calderone, T., Wani, K., Yu, X., Creasy, C., Haymaker, C., Forget, M., Nanda, V., Roszik, J., Wargo, J., Haydu, L., Song, X., Lazar, A., Gershenwald, J., Davies, M., Bernatchez, C., Zhang, J., Woodman, S., Chesler, E. J., Reynolds, T., Bubier, J. A., Phillips, C., Langston, M. A., Baker, E. J., Lin, N., Amos, C., Calhoun, V., Dobretsberger, O., Egger, M., Leimgruber, F., Sadedin, S., Oshlack, A., Antonio, V. A. A., Ono, N., Ahmed, Z., Bolisetty, M., Zeeshan, S., Anguiano, E., Sarkar, A., Nandineni, M. R., Zeng, C., Shao, J., Liang, T., Pham, K., Chee-Wei, Y., Dongsheng, L., Lai-Ping, W., Lian, D., Hee, R. O. Twee, Yunus, Y., Aghakhanian, F., Mokhtar, S. S., Lok-Yung, C. V., Bhak, J., Phipps, M., Shuhua, X., Yik-Ying, T., Kumar, V., Boon-Peng, H., Campbell, I., Young, M. -A., James, P., Rain, M., Mohammad, G., Kukreti, R., Pasha, Q., Akilzhanova, A. R., Guelly, C., Abilova, Z., Rakhimova, S., Akhmetova, A., Kairov, U., Trajanoski, S., Zhumadilov, Z., Bekbossynova, M., Schumacher, C., Sandhu, S., Harkins, T., Makarov, V., Glenn, R., Momin, Z., Dilrukshi, B., Chao, H., Meng, Q., Gudenkauf, B., Kshitij, R., Jayaseelan, J., Nessner, C., Lee, S., Blankenberg, K., Lewis, L., Han, Y., Dinh, H., Jireh, S., Buhay, C., Liu, X., Wang, Q., Ding, Y., Veeraraghavan, N., Yang, Y., Beaudet, A. L., Eng, C. M., Worley, K. C. C., Liu, Y., Hughes, D. S. T., Murali, S. C., Harris, R. A., English, A. C., Hampton, O. A., Larsen, P., Beck, C., Wang, M., Kovar, C. L., Salerno, W. J., Yoder, A., Richards, S., Rogers, J., Raveenedran, M., Xue, C., Dahdouli, M., Cox, L., Fan, G., Ferguson, B., Hovarth, J., Johnson, Z., Kanthaswamy, S., Kubisch, M., Platt, M., Smith, D., Vallender, E., Wiseman, R., Below, J., Yu, F., Lin, J., Zhang, Y., Ouyang, Z., Moore, A., Wang, Z., Hofmann, J., Purdue, M., Stolzenberg-Solomon, R., Weinstein, S., Albanes, D., Liu, C. S., Cheng, W. L., Lin, T. T., Lan, Q., Rothman, N., Berndt, S., Chen, E. S., Bahrami, H., Khoshzaban, A., Keshal, S. Heidari, Alharbi, K. K. R., Zhalbinova, M., Akilzhanova, A., Bekbosynova, M., Myrzakhmetova, S., Matar, M., Mili, N., Molinari, R., Ma, Y., Guerrier, S., Elhawary, N., Tayeb, M., Bogari, N., Qotb, N., McClymont, S. A., Hook, P. W., Goff, L. A., McCallion, A., Kong, Y., Charette, J. R., Hicks, W. L., Naggert, J. K., Zhao, L., Nishina, P. M., Edrees, B. M., Athar, M., Al-Allaf, F. A., Taher, M. M., Khan, W., Bouazzaoui, A., Harbi, N. A., Safar, R., Al-Edressi, H., Anazi, A., Altayeb, N., Ahmed, M. A., Alansary, K., Abduljaleel, Z., Kratz, A., Beguin, P., Poulain, S., Kaneko, M., Takahiko, C., Matsunaga, A., Kato, S., Bertin, N., Vigot, R., Plessy, C., Launey, T., Graur, D., Friis-Nielsen, J., Izarzugaza, J. M., Brunak, S., Chakraborty, A., Basak, J., Mukhopadhyay, A., Soibam, B. S., Das, D., Biswas, N., Das, S., Sarkar, S., Maitra, A., Panda, C., Majumder, P., Morsy, H., Gaballah, A., Samir, M., Shamseya, M., Mahrous, H., Ghazal, A., Arafat, W., Hashish, M., Gruber, J. J., Jaeger, N., Snyder, M., Patel, K., Bowman, S., Davis, T., Kraushaar, D., Emerman, A., Russello, S., Henig, N., Hendrickson, C., Zhang, K., Rodriguez-Dorantes, M., Cruz-Hernandez, C. D., Garcia-Tobilla, C. D. P., Solorzano-Rosales, S., Jäger, N., Chen, J., Haile, R., Hitchins, M., Brooks, J. D., Jiménez-Morales, S., Ramírez, M., Nuñez, J., Bekker, V., Leal, Y., Jiménez, E., Medina, A., Hidalgo, A., Mejía, J., Halytskiy, V., Naggert, J., Collin, G. B., DeMauro, K., Hanusek, R., Belhassa, K., Belhassan, K., Bouguenouch, L., Samri, I., Sayel, H., moufid, FZ., El Bouchikhi, I., Trhanint, S., Hamdaoui, H., Elotmani, I., Khtiri, I., Kettani, O., Quibibo, L., Ahagoud, M., Abbassi, M., Ouldim, K., Marusin, A. V., Kornetov, A. N., Swarovskaya, M., Vagaiceva, K., Stepanov, V., De La Paz, E. M. Cutiongco, Sy, R., Nevado, J., Reganit, P., Santos, L., Magno, J. D., Punzalan, F. E., Ona, D., Llanes, E., Santos-Cortes, R. L., Tiongco, R., Aherrera, J., Abrahan, L., Pagauitan-Alan, P., Morelli, K. H., Domire, J. S., Pyne, N., Harper, S., Burgess, R., Gari, M. A., Dallol, A., Alsehli, H., Gari, A., Gari, M., Abuzenadah, A., Thomas, M., Sukhai, M., Garg, S., Misyura, M., Zhang, T., Schuh, A., Stockley, T., Kamel-Reid, S., Sherry, S., Xiao, C., Slotta, D., Rodarmer, K., Feolo, M., Kimelman, M., Godynskiy, G., O’Sullivan, C., Yaschenko, E., Rangel-Escareño, C., Rueda-Zarate, H., Tayubi, I. A., Mohammed, R., Ahmed, I., Ahmed, T., Seth, S., Amin, S., Mao, X., Sun, H., Verhaak, R. G., Whiite, S. J., Farek, J., Kahn, Z., Kasukawa, T., Lizio, M., Harshbarger, J., Hisashi, S., Severin, J., Imad, A., Sahin, S., Freeman, T. C., Baillie, K., Shekar, S. N., Salem, A. H., Ali, M., Ibrahim, A., Ibrahim, M., Barrera, H. A., Garza, L., Torres, J. A., Barajas, V., Ulloa-Aguirre, A., Kershenobich, D., Mortaji, Shahroj, Guizar, Pedro, Loera, Eliezer, Moreno, Karen, De León, Adriana, Monsiváis, Daniela, Gómez, Jackeline, Cardiel, Raquel, Fernandez-Lopez, J. C., Bonifaz-Peña, V., Contreras, A. V., Polfus, L., Wang, X., Philip, V., Abuzenadah, A. A., Turki, R., Uyar, A., Kaygun, A., Zaman, S., Marquez, E., George, J., Hendrickson, C. L., Starr, D. B., Baird, M., Kirkpatrick, B., Sheets, K., Nitsche, R., Prieto-Lafuente, L., Landrum, M., Lee, J., Rubinstein, W., Maglott, D., Thavanati, P. K. R., de Dios, A. Escoto, Hernandez, R. E. Navarro, Aldrate, M. E. Aguilar, Mejia, M. R. Ruiz, Kanala, K. R. R., Shahzad, N., Huber, E., Dan, A., Herr, W., Sprotte, G., Köstler, J., Hiergeist, A., Gessner, A., Andreesen, R., Holler, E., Al-Allaf, F., Alashwal, A., Taher, M., Abalkhail, H., Al-Allaf, A., Bamardadh, R., Filiptsova, O., Kobets, M., Kobets, Y., Burlaka, I., Timoshyna, I., Kobets, M. N., Al-allaf, F. A., Mohiuddin, M. T., Zainularifeen, A., Mohammed, A., and Owaidah, T.

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26. A White Paper on keV sterile neutrino Dark Matter

Author

Hassel, C., Wendt, K., Mavromatos, N.E., Drexlin, G., Xing, Z., Lasserre, T., Wolf, J., Adhikari, R., Papastergis, E., Saviano, N., Merle, A., Baur, J., Tsai, Y., Hannen, V., Kieck, T., De Gouvea, A., Sanchez, N.G., Valle, J.W.F., Schneider, A., Tully, C.G., Goodman, M.C., Durero, M., Schwetz, T., Agostini, M., Zhou, S., Fischer, V., Ruchayskiy, O., Gorbunov, D., Winslow, L., Tkachev, I., Enss, C., Lachenmaier, T., Dolde, K., Otten, E., Suerfu, B., Radford, D.C., Takahashi, R., Steinbrink, N., Maltoni, M., Hamann, J., Araki, T., Faessler, A., Bahr, M., Niro, V., Hannestad, S., Nozik, A., Düllmann, Ch.E., Pilaftsis, A., Hansen, S.H., Glück, F., Menci, N., Shrock, R., Huber, A., Ky, N. Anh, Rest, O., Filianin, P., Pires, C.A. De S., Fleischmann, A., Liao, W., Evans, N.W., Pastor, S., Schönert, S., Jacobsson, R., Scholl, S., Zuber, K., Long, A.W., Fraenkle, F.M., Totzauer, M., Mangano, G., Parke, S., Heeck, J., Lesgourgues, J., Houdy, T., Laine, Mikko Sakari, Monreal, B., Fuller, G., Borah, D., Iakubovskyi, D., Wurm, M., Jeltema, T., Neronov, A., Gonzalez-Garcia, M.C., De Vega, H.J., Ranitzsch, P.C.-O., Strigari, L., Frenk, C.S., Mertens, S., Bari, P. Di, Bezrukov, F., Kornoukhov, V., Drewes, M., Oberauer, L., Dorrer, H., Suekane, F., Palanque-Delabrouille, N., Van, N. Thi Hong, Wang, M.Y., Sasaki, M., Pantuev, V.S., Dev, P.S. Bhupal, Ibarra, A., Hofmann, F., Djurcic, Z., Patwardhan, A., Archidiacono, M., Schneider, F., Novikov, Y., Boyarsky, A., Weinheimer, C., Dragoun, O., Robinson, D.J., Kempf, S., Shankar, F., Formaggio, J.A., Eliseev, S., Eberhardt, K., Gastaldo, L., Pallavicini, M., Langacker, P., Venos, D., Mirizzi, A., Behrens, J., Garzilli, A., Valerius, K., Li, Y.F., Franse, J., Dias, A.G., Lhuillier, D., Vivier, M., Ianni, A., Jochum, J., Viel, M., Korzeczek, M., Pascoli, S., Silva, P.S. Rodrigues Da, and Giunti, C.

Subjects
13. Climate action, 530 Physics, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved—cosmology, astrophysics, nuclear, and particle physics—in each case viewed from both theoretical and experimental/observational perspectives. After reviewing the role of active neutrinos in particle physics, astrophysics, and cosmology, we focus on sterile neutrinos in the context of the Dark Matter puzzle. Here, we first review the physics motivation for sterile neutrino Dark Matter, based on challenges and tensions in purely cold Dark Matter scenarios. We then round out the discussion by critically summarizing all known constraints on sterile neutrino Dark Matter arising from astrophysical observations, laboratory experiments, and theoretical considerations. In this context, we provide a balanced discourse on the possibly positive signal from X-ray observations. Another focus of the paper concerns the construction of particle physics models, aiming to explain how sterile neutrinos of keV-scale masses could arise in concrete settings beyond the Standard Model of elementary particle physics. The paper ends with an extensive review of current and future astrophysical and laboratory searches, highlighting new ideas and their experimental challenges, as well as future perspectives for the discovery of sterile neutrinos.

27. Higgs boson mass and new physics

Author

Bezrukov, F., Kalmykov, M. Y., Kniehl, B. A., and Shaposhnikov, M.

Subjects
13. Climate action, 7. Clean energy, 3. Good health
Abstract

Journal of high energy physics 2012, 140(2012). doi:10.1007/JHEP10(2012)140, Published by Springer, Berlin

28. Induced resonance makes light sterile neutrino dark matter cool.

Author

Bezrukov, F., Chudaykin, A., and Gorbunov, D.

Subjects
*STERILE neutrinos, *DARK matter, *NEUTRINOS, *SCALAR field theory, *RESONANCE, *PLASMA oscillations
Abstract

We describe two new generation mechanisms for dark matter (DM) composed of sterile neutrinos with O(1) keV mass. The model contains a light scalar field that coherently oscillates in the early Universe and modulates the Majorana mass of the sterile neutrino. In a region of model parameter space, the oscillations between active and sterile neutrinos are resonantly enhanced. This mechanism allows us to produce sterile neutrino DM with a small mixing angle with active neutrinos, thus evading the x-ray constraints. At the same time, the spectrum of produced DM is much cooler than in the case of ordinary oscillations in plasma, opening a window of lower mass DM, which is otherwise forbidden by structure formation considerations. In other regions of the model parameter space, where the resonance does not appear, another mechanism can operate: a large field suppresses the active-sterile oscillations, but instead sterile neutrinos are produced by the oscillating scalar field when the effective fermion mass crosses zero. In this case, the DM component is cold, and even the 1 keV neutrino is consistent with the cosmic structure formation. [ABSTRACT FROM AUTHOR]

Published
2019
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30. A White Paper on keV sterile neutrino Dark Matter.

Author

Adhikari, R., Agostini, M., Ky, N. Anh, Araki, T., Archidiacono, M., Bahr, M., Baur, J., Behrens, J., Bezrukov, F., Dev, P. S. Bhupal, Borah, D., Boyarsky, A., de Gouvea, A., Pires, C. A. de S., de Vega, H. J., Dias, A. G., Bari, P. Di, Djurcic, Z., Dolde, K., and Dorrer, H.

Published
2017
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33. Enlightening the primordial dark ages

Author

Iarygina, O., Achúcarro, A., Sfakianakis, E.I., Copeland, E.J., Vilchinskiy, S.I., Bezrukov, F., Maleknejad, A., Aarts, J., Schalm, K.E., and Leiden University

Subjects
General Relativity and Quantum Cosmology, Primordial gravitational waves, Reheating, Effective field theory, Primordial power spectrum, Cosmic inflation, Astrophysics::Cosmology and Extragalactic Astrophysics, Theoretical high energy physics, Multi-field inflation, Physics of the early universe, Cosmological perturbation theory, Cosmology
Abstract

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”. The energy that drives inflation must be transferred to elementary particles and radiation. This process is called reheating. The unknown expansion history of the universe during the reheating era connects the cosmic microwave background (CMB) observations to inflationary physics. CMB is a relic radiation that provides us a snapshot of the primordial universe. Both the inflationary and reheating eras generate signatures to be seen via upcoming gravitational waves and CMB polarization experiments. In this thesis we show analytically a scaling behaviour that allows for an easy estimate of the reheating efficiency for one broad family of multi-field models of inflation that is called α-attractors. We show the influence of the asymmetry around the minimum of potential on the reheating efficiency. Moreover, we study the predictions for chiral gravitational waves production by a spectator gauge field sector in scalar single-field inflation. Finally, we present a new class of inflationary models that is called “shift-symmetric orbital inflation”.

Published
2021

37. A White Paper on keV sterile neutrino Dark Matter

Author

Marco Drewes, P. Di Bari, Michele Maltoni, N. Anh Ky, B. Suerfu, H. Dorrer, Benjamin Monreal, Ernst W. Otten, Klaus Eberhardt, S. Scholl, P. S. Bhupal Dev, Aldo Ianni, Gianpiero Mangano, F. Hofmann, Joseph A. Formaggio, Volker Hannen, Ch. E. Düllmann, Z. Xing, N. Steinbrink, L. Oberauer, Debasish Borah, Klaus Wendt, Jeroen Franse, V. N. Kornoukhov, O. Dragoun, C. Hassel, Sebastian Kempf, Nick Evans, Sergio Pastor, P. S. Rodrigues da Silva, S. Schönert, L. Gastaldo, M. C. Gonzalez-Garcia, Tobias Lachenmaier, Tesla E. Jeltema, A. Faessler, Nick E. Mavromatos, Kai Zuber, George M. Fuller, José W. F. Valle, A.W. Long, F. Schneider, C. A. de S. Pires, N. Thi Hong Van, Manami Sasaki, Apostolos Pilaftsis, Sergey Eliseev, T. Schwetz, Matteo Agostini, Rathin Adhikari, Maria Archidiacono, F. Suekane, Shun Zhou, A. A. Nozik, M. Bahr, Francesco Shankar, V. Niro, J. Baur, Silvia Pascoli, P. C.-O. Ranitzsch, Dmytro Iakubovskyi, Alexander Merle, Christopher George Tully, Ch. Weinheimer, V. S. Pantuev, Ninetta Saviano, Marco Pallavicini, Carlos S. Frenk, D. Vénos, Alejandro Ibarra, H. J. de Vega, Louis E. Strigari, Robert Shrock, Josef Jochum, Andrii Neronov, Lindley Winslow, Nathalie Palanque-Delabrouille, D. Lhuillier, T. Houdy, T. Araki, Aurel Schneider, T. Kieck, Antonella Garzilli, Yu. N. Novikov, W. Liao, Mei-Yu Wang, Carlo Giunti, Yufeng Li, Ferenc Glück, Steen Hannestad, Alexey Boyarsky, V. Fischer, Fedor Bezrukov, F.M. Fraenkle, Andreas Fleischmann, Maury Goodman, Emmanouil Papastergis, Y. Tsai, M. Durero, Kai Dolde, D. C. Radford, O. Rest, Alex G. Dias, Kathrin Valerius, A. Huber, Igor Tkachev, Julian Heeck, A. de Gouvea, Richard Jacobsson, M. Korzeczek, J. Lesgourgues, Susanne Mertens, Matteo Viel, Norma G. Sanchez, Amol V. Patwardhan, Dean J. Robinson, Mikko Laine, Christian Enss, Stephen J. Parke, Alessandro Mirizzi, Pavel Filianin, Paul Langacker, Jan Hamann, J. Behrens, R. Takahashi, Maximilian Totzauer, Dmitry Gorbunov, M. Vivier, Michael Wurm, Z. Djurcic, Steen Honoré Hansen, Thierry Lasserre, Guido Drexlin, Oleg Ruchayskiy, Nicola Menci, Joachim Wolf, Laboratoire de Physique Théorique et Hautes Energies (LPTHE), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres (LERMA), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Astronomy, Adhikari, R., Agostini, M., Ky, N. Anh, Araki, T., Archidiacono, M., Bahr, M., Baur, J., Behrens, J., Bezrukov, F., Dev, P. S. Bhupal, Borah, D., Boyarsky, A., de Gouvea, A., Pires, C. A. de S., de Vega, H. J., Dias, A. G., Bari, P. Di, Djurcic, Z., Dolde, K., Dorrer, H., Durero, M., Dragoun, O., Drewes, M., Drexlin, G., Düllmann, C.h. E., Eberhardt, K., Eliseev, S., Enss, C., Evans, N. W., Faessler, A., Filianin, P., Fischer, V., Fleischmann, A., Formaggio, J. A., Franse, J., Fraenkle, F. M., Frenk, C. S., Fuller, G., Gastaldo, L., Garzilli, A., Giunti, C., Glück, F., Goodman, M. C., Gonzalez Garcia, M. C., Gorbunov, D., Hamann, J., Hannen, V., Hannestad, S., Hansen, S. H., Hassel, C., Heeck, J., Hofmann, F., Houdy, T., Huber, A., Iakubovskyi, D., Ianni, A., Ibarra, A., Jacobsson, R., Jeltema, T., Jochum, J., Kempf, S., Kieck, T., Korzeczek, M., Kornoukhov, V., Lachenmaier, T., Laine, M., Langacker, P., Lasserre, T., Lesgourgues, J., Lhuillier, D., Li, Y. F., Liao, W., Long, A. W., Maltoni, M., Mangano, G., Mavromatos, N. E., Menci, N., Merle, A., Mertens, S., Mirizzi, A., Monreal, B., Nozik, A., Neronov, A., Niro, V., Novikov, Y., Oberauer, L., Otten, E., Palanque Delabrouille, N., Pallavicini, M., Pantuev, V. S., Papastergis, E., Parke, S., Pascoli, Silvia, Pastor, S., Patwardhan, A., Pilaftsis, A., Radford, D. C., Ranitzsch, P. C. O., Rest, O., Robinson, D. J., Silva, P. S. Rodrigues da, Ruchayskiy, O., Sanchez, N. G., Sasaki, M., Saviano, N., Schneider, A., Schneider, F., Schwetz, Thoma, Schönert, S., Scholl, S., Shankar, F., Shrock, R., Steinbrink, N., Strigari, L., Suekane, F., Suerfu, B., Takahashi, R., Van, N. Thi Hong, Tkachev, I., Totzauer, M., Tsai, Y., Tully, C. G., Valerius, K., Valle, J. W. F., Venos, D., Viel, Matteo, Vivier, M., Wang, M. Y., Weinheimer, C., Wendt, K., Winslow, L., Wolf, J., Wurm, M., Xing, Z., Zhou, Shuangyong, Zuber, K., Massachusetts Institute of Technology. Department of Physics, Laboratoire de Physique Théorique et Hautes Energies ( LPTHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique ( LERMA ), École normale supérieure - Paris ( ENS Paris ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université de Cergy Pontoise ( UCP ), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique ( CNRS ), USA, GBR, FRA, DEU, Anh Ky, N., Bhupal Dev, P. S., De Gouvea, A., Pires, C. A. D. S., De Vega, H. J., Di Bari, P., Dullmann, Ch. E., Gluck, F., Gonzalez-Garcia, M. C., Palanque-Delabrouille, N., Pascoli, S., Ranitzsch, P. C. -O., Rodrigues Da Silva, P. S., Schwetz, T., Schonert, S., Thi Hong Van, N., Viel, M., Zhou, S., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)

Subjects
Astrofísica, Sterile neutrino, cosmological model, Cold dark matter, cosmological neutrinos, Physics beyond the Standard Model, [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Dark matter theory, 01 natural sciences, Cosmology, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), White paper, High Energy Physics - Phenomenology (hep-ph), X-RAY-EMISSION, METALLIC MAGNETIC CALORIMETERS, QUANTUM-FIELD THEORY, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], neutrino: dark matter, Cosmological neutrinos, Dark matter experiments, Particle physics - cosmology connection, 010303 astronomy & astrophysics, Physics, dark matter theory, new physics, DOUBLE-BETA-DECAY, hep-ph, neutrino: sterile, Astronomy and Astrophysics, Nuclear & Particles Physics, High Energy Physics - Phenomenology, neutrino: detector, particle physics - cosmology connection, astro-ph.CO, MILKY-WAY SATELLITES, 3.5 KEV LINE, Neutrino, Particle Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, Particle physics, Astrophysics and Astronomy, Cosmology and Nongalactic Astrophysics (astro-ph.CO), astro-ph.GA, Dark matter, LY-ALPHA FOREST, review, FOS: Physical sciences, Context (language use), neutrino: production, X-ray, Settore FIS/05 - Astronomia e Astrofisica, [ PHYS.HEXP ] Physics [physics]/High Energy Physics - Experiment [hep-ex], RIGHT-HANDED NEUTRINOS, 0103 physical sciences, Astronomical And Space Sciences, numerical calculations, Dark matter experiment, XMM-NEWTON OBSERVATIONS, neutrino: model, Particle Physics - Phenomenology, DWARF SPHEROIDAL GALAXY, Cosmologia, 010308 nuclear & particles physics, hep-ex, dark matter experiments, High Energy Physics::Phenomenology, Atomic, Molecular, Nuclear, Particle And Plasma Physics, Cosmological neutrino, Astrophysics - Astrophysics of Galaxies, 13. Climate action, Astrophysics of Galaxies (astro-ph.GA), [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], [ PHYS.HPHE ] Physics [physics]/High Energy Physics - Phenomenology [hep-ph], High Energy Physics::Experiment, neutrino: oscillation, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved - cosmology, astrophysics, nuclear, and particle physics - in each case viewed from both theoretical and experimental/observational perspectives. After reviewing the role of active neutrinos in particle physics, astrophysics, and cosmology, we focus on sterile neutrinos in the context of the Dark Matter puzzle. Here, we first review the physics motivation for sterile neutrino Dark Matter, based on challenges and tensions in purely cold Dark Matter scenarios. We then round out the discussion by critically summarizing all known constraints on sterile neutrino Dark Matter arising from astrophysical observations, laboratory experiments, and theoretical considerations. In this context, we provide a balanced discourse on the possibly positive signal from X-ray observations. Another focus of the paper concerns the construction of particle physics models, aiming to explain how sterile neutrinos of keV-scale masses could arise in concrete settings beyond the Standard Model of elementary particle physics. The paper ends with an extensive review of current and future astrophysical and laboratory searches, highlighting new ideas and their experimental challenges, as well as future perspectives for the discovery of sterile neutrinos., v2: 257 pages, 57 figures, content matches published version [JCAP01(2017)025]; over 100 authors from several different communities

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38. MazF toxin causes alterations in Staphylococcus aureus transcriptome, translatome and proteome that underlie bacterial dormancy.

Author

Bezrukov F, Prados J, Renzoni A, and Panasenko OO

Subjects
Bacterial Toxins biosynthesis, Cell Division genetics, Cell Wall genetics, Cell Wall metabolism, Endoribonucleases biosynthesis, Endoribonucleases metabolism, Protein Biosynthesis, Proteome, Staphylococcus aureus enzymology, Transcriptome, Bacterial Toxins metabolism, Endoribonucleases physiology, Staphylococcus aureus genetics, Staphylococcus aureus metabolism
Abstract

Antibiotic resistance is a serious problem which may be caused by bacterial dormancy. It has been suggested that bacterial toxin-antitoxin systems induce dormancy. We analyzed the genome-wide role of Staphylococcus aureus endoribonuclease toxin MazF using RNA-Seq, Ribo-Seq and quantitative proteomics. We characterized changes in transcriptome, translatome and proteome caused by MazF, and proposed that MazF decreases translation directly by cleaving mRNAs, and indirectly, by decreasing translation factors and by promoting ribosome hibernation. Important pathways affected during the early stage of MazF induction were identified: MazF increases cell wall thickness and decreases cell division; MazF activates SsrA-system which rescues stalled ribosomes, appearing as a result of MazF mRNA cleavage. These pathways may be promising targets for new antibacterial drugs that prevent bacteria dormancy. Finally, we described the overall impact of MazF on S. aureus cell physiology, and propose one of the mechanisms by which MazF might regulate cellular changes leading to dormancy., (© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.)

Published
2021
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39. FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth.

Author

Ramadori G, Ioris RM, Villanyi Z, Firnkes R, Panasenko OO, Allen G, Konstantinidou G, Aras E, Brenachot X, Biscotti T, Charollais A, Luchetti M, Bezrukov F, Santinelli A, Samad M, Baldi P, Collart MA, and Coppari R

Subjects
Animals, Carcinogenesis pathology, Cell Line, Tumor, Cell Proliferation, Down-Regulation, Mice, Inbred NOD, Mice, SCID, Neoplastic Stem Cells metabolism, Neoplastic Stem Cells pathology, Peptidylprolyl Isomerase metabolism, Proto-Oncogene Proteins p21(ras) metabolism, Ribosomes metabolism, Lung Neoplasms metabolism, Lung Neoplasms pathology, Protein Biosynthesis, Tacrolimus Binding Proteins metabolism
Abstract

Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are selectively expressed by, and relevant for, cancer cells is of paramount medical importance. Here, we show that peptidyl-prolyl-cis-trans-isomerase (PPIase) FK506-binding protein 10 (FKBP10)-positive cells are present in cancer lesions but absent in the healthy parenchyma of human lung. FKBP10 expression negatively correlates with survival of lung cancer patients, and its downregulation causes a dramatic diminution of lung tumor burden in mice. Mechanistically, our results from gain- and loss-of-function assays show that FKBP10 boosts cancer growth and stemness via its PPIase activity. Also, FKBP10 interacts with ribosomes, and its downregulation leads to reduction of translation elongation at the beginning of open reading frames (ORFs), particularly upon insertion of proline residues. Thus, our data unveil FKBP10 as a cancer-selective molecule with a key role in translational reprogramming, stem-like traits, and growth of lung cancer., Competing Interests: Declaration of Interests The authors declare no competing interests., (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2020
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40. YjbH Solubility Controls Spx in Staphylococcus aureus : Implication for MazEF Toxin-Antitoxin System Regulation.

Author

Panasenko OO, Bezrukov F, Komarynets O, and Renzoni A

Abstract

Bacterial cells respond to environmental stresses by modulating their gene expression and adjusting their proteome. In Staphylococcus aureus , selective degradation by ClpP protease eliminates damaged proteins and regulates the abundance of functional proteins such as many important stress-induced transcriptional regulators. Degradation by ClpP requires the unfolding activity of partner Clp ATPases, such as ClpX and ClpC, and assistance of substrate-specific adaptor proteins such as YjbH and TrfA. Herein, we demonstrated that YjbH is aggregated in response to growth stress stimuli, such as oxidative and antibiotic stresses. In consequence, its function as an adaptor protein is compromised. YjbH controls the degradation of the stress-induced transcriptional regulator, Spx. Aggregated YjbH cannot assist Spx degradation, which results in Spx accumulation. We discovered that depending on the stress stimulus, Spx can be soluble or insoluble, and, consequently, transcriptionally active or inactive. Therefore, Spx accumulation and solubility are key components governing activation of Spx-dependent genes. Spx positively regulates expression of a ClpCP adaptor protein TrfA. TrfA in turn is required for degradation of MazE antitoxin, the unstable component of the MazEF toxin-antitoxin system, that neutralizes the endoribonuclease activity of MazF toxin. Bacterial toxin-antitoxin systems are associated with dormancy and tolerance to antibiotics that are related to chronic and relapsing infections, and it is at present a key unresolved problem in medicine. MazF activity was linked to growth stasis, yet the precise environmental signals that trigger MazE degradation and MazF activation are poorly understood. Here we propose a model where YjbH serves as a sensor of environmental stresses for downstream regulation of MazEF activity. YjbH aggregation, soluble Spx, and TrfA, coordinately control MazE antitoxin levels and consequently MazF toxin activity. This model implies that certain stress conditions culminate in modulation of MazF activity resulting in growth stasis during in vivo infections., (Copyright © 2020 Panasenko, Bezrukov, Komarynets and Renzoni.)

Published
2020
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41. Multi-omic measurements of heterogeneity in HeLa cells across laboratories.

Author

Liu Y, Mi Y, Mueller T, Kreibich S, Williams EG, Van Drogen A, Borel C, Frank M, Germain PL, Bludau I, Mehnert M, Seifert M, Emmenlauer M, Sorg I, Bezrukov F, Bena FS, Zhou H, Dehio C, Testa G, Saez-Rodriguez J, Antonarakis SE, Hardt WD, and Aebersold R

Subjects
Genomics standards, Humans, Proteome genetics, Reproducibility of Results, DNA Copy Number Variations genetics, Genome, Human genetics, HeLa Cells, Transcriptome genetics
Abstract

Reproducibility in research can be compromised by both biological and technical variation, but most of the focus is on removing the latter. Here we investigate the effects of biological variation in HeLa cell lines using a systems-wide approach. We determine the degree of molecular and phenotypic variability across 14 stock HeLa samples from 13 international laboratories. We cultured cells in uniform conditions and profiled genome-wide copy numbers, mRNAs, proteins and protein turnover rates in each cell line. We discovered substantial heterogeneity between HeLa variants, especially between lines of the CCL2 and Kyoto varieties, and observed progressive divergence within a specific cell line over 50 successive passages. Genomic variability has a complex, nonlinear effect on transcriptome, proteome and protein turnover profiles, and proteotype patterns explain the varying phenotypic response of different cell lines to Salmonella infection. These findings have implications for the interpretation and reproducibility of research results obtained from human cultured cells.

Published
2019
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42. Co-translational assembly of proteasome subunits in NOT1-containing assemblysomes.

Author

Panasenko OO, Somasekharan SP, Villanyi Z, Zagatti M, Bezrukov F, Rashpa R, Cornut J, Iqbal J, Longis M, Carl SH, Peña C, Panse VG, and Collart MA

Subjects
Adenosine Triphosphatases genetics, Adenosine Triphosphatases metabolism, Algorithms, Cell Cycle Proteins genetics, Cell Cycle Proteins metabolism, Cell Line, Tumor, Genome, Fungal genetics, Humans, In Situ Hybridization, Male, Oligonucleotides genetics, Oligonucleotides metabolism, Proteasome Endopeptidase Complex genetics, Protein Binding, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae metabolism, Saccharomyces cerevisiae Proteins genetics, Saccharomyces cerevisiae Proteins metabolism, Transcription Factors genetics, Transcription Factors metabolism, Proteasome Endopeptidase Complex metabolism
Abstract

The assembly of large multimeric complexes in the crowded cytoplasm is challenging. Here we reveal a mechanism that ensures accurate production of the yeast proteasome, involving ribosome pausing and co-translational assembly of Rpt1 and Rpt2. Interaction of nascent Rpt1 and Rpt2 then lifts ribosome pausing. We show that the N-terminal disordered domain of Rpt1 is required to ensure efficient ribosome pausing and association of nascent Rpt1 protein complexes into heavy particles, wherein the nascent protein complexes escape ribosome quality control. Immunofluorescence and in situ hybridization studies indicate that Rpt1- and Rpt2-encoding messenger RNAs co-localize in these particles that contain, and are dependent on, Not1, the scaffold of the Ccr4-Not complex. We refer to these particles as Not1-containing assemblysomes, as they are smaller than and distinct from other RNA granules such as stress granules and GW- or P-bodies. Synthesis of Rpt1 with ribosome pausing and Not1-containing assemblysome induction is conserved from yeast to human cells.

Published
2019
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43. A facility to search for hidden particles at the CERN SPS: the SHiP physics case.

Author

Alekhin S, Altmannshofer W, Asaka T, Batell B, Bezrukov F, Bondarenko K, Boyarsky A, Choi KY, Corral C, Craig N, Curtin D, Davidson S, de Gouvêa A, Dell'Oro S, deNiverville P, Bhupal Dev PS, Dreiner H, Drewes M, Eijima S, Essig R, Fradette A, Garbrecht B, Gavela B, Giudice GF, Goodsell MD, Gorbunov D, Gori S, Grojean C, Guffanti A, Hambye T, Hansen SH, Helo JC, Hernandez P, Ibarra A, Ivashko A, Izaguirre E, Jaeckel J, Jeong YS, Kahlhoefer F, Kahn Y, Katz A, Kim CS, Kovalenko S, Krnjaic G, Lyubovitskij VE, Marcocci S, Mccullough M, McKeen D, Mitselmakher G, Moch SO, Mohapatra RN, Morrissey DE, Ovchynnikov M, Paschos E, Pilaftsis A, Pospelov M, Reno MH, Ringwald A, Ritz A, Roszkowski L, Rubakov V, Ruchayskiy O, Schienbein I, Schmeier D, Schmidt-Hoberg K, Schwaller P, Senjanovic G, Seto O, Shaposhnikov M, Shchutska L, Shelton J, Shrock R, Shuve B, Spannowsky M, Spray A, Staub F, Stolarski D, Strassler M, Tello V, Tramontano F, Tripathi A, Tulin S, Vissani F, Winkler MW, and Zurek KM

Abstract

This paper describes the physics case for a new fixed target facility at CERN SPS. The SHiP (search for hidden particles) experiment is intended to hunt for new physics in the largely unexplored domain of very weakly interacting particles with masses below the Fermi scale, inaccessible to the LHC experiments, and to study tau neutrino physics. The same proton beam setup can be used later to look for decays of tau-leptons with lepton flavour number non-conservation, [Formula: see text] and to search for weakly-interacting sub-GeV dark matter candidates. We discuss the evidence for physics beyond the standard model and describe interactions between new particles and four different portals-scalars, vectors, fermions or axion-like particles. We discuss motivations for different models, manifesting themselves via these interactions, and how they can be probed with the SHiP experiment and present several case studies. The prospects to search for relatively light SUSY and composite particles at SHiP are also discussed. We demonstrate that the SHiP experiment has a unique potential to discover new physics and can directly probe a number of solutions of beyond the standard model puzzles, such as neutrino masses, baryon asymmetry of the Universe, dark matter, and inflation.

Published
2016
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44. Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.

Author

Bonilla X, Parmentier L, King B, Bezrukov F, Kaya G, Zoete V, Seplyarskiy VB, Sharpe HJ, McKee T, Letourneau A, Ribaux PG, Popadin K, Basset-Seguin N, Ben Chaabene R, Santoni FA, Andrianova MA, Guipponi M, Garieri M, Verdan C, Grosdemange K, Sumara O, Eilers M, Aifantis I, Michielin O, de Sauvage FJ, Antonarakis SE, and Nikolaev SI

Subjects
Anilides therapeutic use, Antineoplastic Agents therapeutic use, Carcinogenesis genetics, Carcinoma, Basal Cell drug therapy, Carcinoma, Basal Cell pathology, DNA Mutational Analysis, Disease Progression, Exome, Genetic Association Studies, Genetic Predisposition to Disease, HEK293 Cells, Humans, Mutation, Pyridines therapeutic use, Skin Neoplasms drug therapy, Skin Neoplasms pathology, Transcriptome, Carcinoma, Basal Cell genetics, Signal Transduction radiation effects, Skin Neoplasms genetics
Abstract

Basal cell carcinoma (BCC) of the skin is the most common malignant neoplasm in humans. BCC is primarily driven by the Sonic Hedgehog (Hh) pathway. However, its phenotypic variation remains unexplained. Our genetic profiling of 293 BCCs found the highest mutation rate in cancer (65 mutations/Mb). Eighty-five percent of the BCCs harbored mutations in Hh pathway genes (PTCH1, 73% or SMO, 20% (P = 6.6 × 10(-8)) and SUFU, 8%) and in TP53 (61%). However, 85% of the BCCs also harbored additional driver mutations in other cancer-related genes. We observed recurrent mutations in MYCN (30%), PPP6C (15%), STK19 (10%), LATS1 (8%), ERBB2 (4%), PIK3CA (2%), and NRAS, KRAS or HRAS (2%), and loss-of-function and deleterious missense mutations were present in PTPN14 (23%), RB1 (8%) and FBXW7 (5%). Consistent with the mutational profiles, N-Myc and Hippo-YAP pathway target genes were upregulated. Functional analysis of the mutations in MYCN, PTPN14 and LATS1 suggested their potential relevance in BCC tumorigenesis.

Published
2016
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