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10. The grey mouse lemur: A non-human primate model for ageing studies

Author

Languille, S., Blanc, S., Blin, O., Canale, C.I., Dal-Pan, A., Devau, G., Dhenain, M., Dorieux, O., Epelbaum, J., Gomez, D., Hardy, I., Henry, P.-Y., Irving, E.A., Marchal, J., Mestre-Francés, N., Perret, M., Picq, J.-L., Pifferi, F., Rahman, A., Schenker, E., Terrien, J., Théry, M., Verdier, J.-M., and Aujard, F.

Published
2012
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12. Clinical and biomarker profiling of prodromal Alzheimerʼs disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a ‘European ADNI study’

Author

Galluzzi, S., Marizzoni, M., Babiloni, C., Albani, D., Antelmi, L., Bagnoli, C., Bartres-Faz, D., Cordone, S., Didic, M., Farotti, L., Fiedler, U., Forloni, G., Girtler, N., Hensch, T., Jovicich, J., Leeuwis, A., Marra, C., Molinuevo, J. L., Nobili, F., Pariente, J., Parnetti, L., Payoux, P., Del Percio, C., Ranjeva, J.-P., Rolandi, E., Rossini, P. M., Schönknecht, P., Soricelli, A., Tsolaki, M., Visser, P. J., Wiltfang, J., Richardson, J. C., Bordet, R., Blin, O., and Frisoni, G. B.

Published
2016
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15. Cross-sectional clinical, neuropsychological, neuroimaging, and neurophysiological characterization of mild cognitive impairment patients in WP5 PharmaCog/E-ADNI study: EP1105

Author

Galluzzi, S., Marizzoni, M., Babiloni, C., Bartres-Faz, D., Blin, O., Bordet, R., Bosch, B., De Anna, F., Didic, M., Farotti, L., Forloni, G., Jovicich, J., Marra, C., Marzano, N., Molinuevo, J. L., Nobili, F., Pariente, J., Parnetti, L., Payoux, P., Picco, A., Quaranta, D., Ranjeva, J.-P., Roccatagliata, L., Rossini, P. M., Salvadori, N., Schonknecht, P., Soricelli, A., Tsolaki, M., Vecchio, F., Visser, P. J., Wiltfang, J., and Frisoni, G. B.

Published
2014

17. How to Anticipate the Assessment of the Public Health Benefit of New Medicines?

Author

Alperovitch, A., Bamberger, M., Begaud, B., Blin, O., Blin, P., Breart, G., Brun Strang, C., Buyse, M., Castot, A., Chauvenet, M., Chicoye, A., David, N., De Bels, F., De Sahb Berkovitch, R., Dohin, E., Fagnani, F., Falissard, B., Gastaldi-Menager, C., Giri, I., Haim, M., Joubert, J.M., Lapeyre-Mestre, M., Lassale, C., Marchant Ramirez, I., Meyer, F., Micallef, J., Mollimard, M., Moreau-Defarges, T., Pazart, L., Perret, L., Pigeon, M., Rumeau Pichon, C., Tcheng, Ph., Woler, M., Zanetti, L., Zylberman, M., Massol, Jacques, Puech, Alain, and Boissel, Jean-Pierre

Published
2007
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23. Abstracts of posters

Author

Suffisseau L., Taugourdeau M. C., Goldstein F. W., Mainardi J. L., Larrouturou Ph., Romero, M., Cervino, A. R., Albertone, G., Di Pasquale, R., Venturini, F., Congedo, R., Benettolo, F., Pistolesi, C., Olivato, R., Casasin T., Agusti C., Gurrera M. T., Fabregas X., Rizo A., Badia J. M., Santa-Olalla M., Marini, P., Rampazzo, R., Scroccaro, G., Dell'Aera, M., Luzzi, R., Ciccarone, G., Martinet, N., Beney, J., Marty, S., Reymond, J. -Ph., Cairns, Chris, Morgutti M., Posco M., Moltempi M., Lonqhini P., Rossignoli A., Rihet, P., Carles, G., Braguer, D., Azulay, J. P., Pouget, J., Pelletier, J., Crevat, A., Past.o, L., Barroso, E., Pujol, R., Ferrer, I., Ibars, M., Llop, J. M., Frankfort, Ellen, van Dongen, Robert T. M., Hekster, Yechiel A., Kart, T., Rasmussen, M., Horn, A., Wested, L., Gagyi, O., Markó, E., Regazzi M. B., Martinelli L., Goggi C., Bellotti E., Molinaro M., Rinaldi M., Gavazzi A., Buggia I., Daneri A., Guarnone E., Bascapē V., Viganô M., Lazzaro, A., Palozzo, A., Banfi R., Borselli G., Fabbiani P., Marinai C., Delorme, J., Tubiana, N., Buck, M., Chinot, O., De Wever, C., Robays, H., Montoro J. B., Flores G., Juárez J. C., Juste C., Jardí R., Altisent C., Tusell J. M., Arpinelli, F., De Carli, G., Olivieri, A., Recchia, G., Rossignoli A., Longhini P., La Guidara C., Russo B., Moltempi M., Tamés, M. J., Cajaraville, G., Ponz, L., Echaniz, E., Garcia, B., van Mil, J. W. Foppe, Leufkens, Hubert G., v. Haelst, Ingrid M. M., Parel, Piet C. M., Scholten, Wim K., Sessink, F. G. M., Raschatt, R., Traversa, G., Donini, G., Arpino, C., Da Cas, R., Pasquin, P., Bernadotte af Wisborg G., Claesson C., Lundberg O., Thorslund M., Ferraro L., Marrazzo E., Ostino G., Tognoni G., Heerdink, Eibert R., Koppedraaijer, Corrie, Bakker, Albert, Bidoli E., Battistin M., Troncon M. G., Franceschi S., Serraino D., Marino, M., Matera, M. G., Berrino, L., Contaldi, C., Piucci, B., Rossi, F., Rolle C., Marrazzo E. 0., Murgia, V., Bussi, R., Schievano, P., Pedrini, A., Baraghini, M., Benini, A., Cataldo, M. M., Galletti, P., Magnani, M., Manzoli, M., Novi, M. V., Pezzi, O., Font M., Salmaso A. B., Mezzalira L., Braybrook, Saran, Walker, Roger, van Mil, J. W. F., Tromp, F. T. J., de Jong-v.d. Berg, L. T. W., Bakker, A., Paes, A. H. P., Soe-Agnie, C., Llopis, P., Tortajada, J. J., Font, I., Climente, M., Real, J. V., Almenar, D., Molins, C., Jiménez, N. V., Bellés Medall MD, Casterá Melchor DE, Marco Sena MA, Cantarinz Marti I., Abad Gimeno FJ, Török, J., Thurzó, L., Juárez J. C., Oliveras M., Hidalgo E., Cabañas M. J., Barroso C., Moraga F. A., Sánchez de Toledo J., Kollöffel, W. J., Driessen, F. G. W. H. M., Goldhoorn, P. B., Moral, M. A., Roglan, A., Mangues, M. A., Bonal, J., Clopés, A., Badell, I., Fraga, G., Deinum, J. T., van Lingen, R. A., Quak, J. M. E., Kuizenga, A. J., van Dam, J. G., Villani P., Maserati R., Viale P., Alberici F., Iacona I., Wasieczko, A., Szymura-Oleksiak, J., Wyska, E., Magulova, L., Sirotiakova, J., Letkovicova, M., Branger, E., Besse, D., Blin, O., Bille, F., Serratrice, G., Desnuelle, C., Grassin, J., Reben, I., Meunier, Ph., Antier, D., Berthet, M., Søndergaard B., Herborg H., Frøkjær B., Hepler C., Steckner, H., Bergold, A., Drings, P., Märkel, A., Manegold, C., Venning, Mary, Pazzagli, Luciana, Semmola, Maria Vittoria, Mannoni, Alessandro, Tersen I., Huchet J., Sevilla, E., Ferrari, J. M., Herreros de Tejada, A., Congedo, R., Font, M., Fraccaro, A., Osti, M., Pappagallo, G., Spolaor, A., Terrazzani, G., Vezzani, M., Edouard B., Laine G., Geeraerts D., Robays H., Carrera-Hueso, F. J., Font, B., Marquina, C., Idoate, A., Giráldez, J., Fernández, E., Lacasa, C., Guzzo, D., Martini, N., Boya, P. Giner, González, M. M. Negredo, Agulló, J. Muñoz, Mansilla, L. Lorente, Nahata, Milap C., Troncon, M. G., Cattaruzzi, C., Bilbao G., Galende I., Atañé C., Bermudez de Castro A., Delgado O., Escribano B., Frías J., Gabriel R., Gómez J. A., Gracia D., Gutiérrez E., Hellín T., Izquierdo J. L., Moreno A., Requena T., Sainz-Terreros M., Tejedor J. C., Torralba A., Vigil D., Scuffi, C., Trallori, G., Messori, A., Bardazzi, G., Bonanomi, A., Silvano, R., D'Albasio, G., Bardelli, F., Verona, Firenzee, Bardelli, F., Corrado, A., Ferriols R., Aleixander M. J., Garcia J., Faus M., Ibañez E., Alós M., Rinaldi, M., Pharmacy & Therapeutic Committee (Ps&TC), Collaborative Group, SIFO-Veneto Working Group on Clinical Trials, Working Group on the Elaboration of an Approval Conditions Document to certify the Clinical Trials Ethics Committees in the Autonomous Community of Madrid, and Area SIFO di Metanalisi

Published
1994
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34. Mox sensors for transdermal alcohol measurement: clinical trials and SnO2 sensors studies

Author

Lawson, B., Laithier, V., Fiorido, T., Annanouch, F., Burtey, Stéphane, Cassé-Perrot, C., Audebert, Ch., Bendahan, Marc, Bouchakour, R., Blin, O., Aguir, Khalifa, Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), and Bibliométrie, IM2NP

Subjects
[SPI.NANO] Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

36. External evaluation of population pharmacokinetic models for continuous administration of meropenem in critically ill adult patients.

Author

Wang, YL., Guilhaumou, R., Blin, O., Velly, L., and Marsot, Amélie

Subjects
BIOLOGICAL models, CRITICALLY ill, HOSPITALS, INTENSIVE care units, MEDLINE, ONLINE information services, PATIENTS, SYSTEMATIC reviews, DATA analysis software, MEROPENEM, ADULTS
Abstract

Purpose: Beta-lactams (BL), the most commonly prescribed class of antibiotics, are recommended as the first-line therapy for multiple indications in infectious disease guidelines. Meropenem (MERO) is frequently used in intensive care units (ICU) to treat bacterial infections with or without sepsis. The pharmacokinetics of MERO display a large variability in patients admitted to ICUs due to altered pathophysiology. The aim of this study was to perform an external evaluation of published population pharmacokinetic models of MERO in order to test their predictive performance in a cohort of ICU adult patients. Methods: A literature search in PubMed/Medline database was made following the PRISMA statement. External evaluation was performed using NONMEM software, and the bias and inaccuracy values were calculated. Results: An external validation dataset from the Timone Hospital in Marseille, France, included 84 concentration samples from 27 patients. Four models of MERO were identified according to the inclusion criteria of the study. None of the models presented acceptable values of bias and inaccuracy. Conclusion: While performing external evaluations on some populations may confirm a model's suitability to diverse groups of patients, there is still some variability that cannot be explained nor solved by the procedure. This brings to light the difficulty to develop only one model for ICU patients and the need to develop one specific model to each population of critically ill patients. [ABSTRACT FROM AUTHOR]

Published
2020
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39. Cross-sectional clinical, neuropsychological, neuroimaging, and neurophysiological characterization of mild cognitive impairment patients in WP5 PharmaCog/E-ADNI study

Author

Galluzzi, S., Marizzoni, M., Babiloni, C., Bartres-Faz, D., Blin, O., Bordet, R., Bosch, B., Anna, F., Didic, M., Farotti, L., Forloni, G., Jovicich, J., Marra, C., Marzano, N., Molinuevo, J. L., Nobili, F., Pariente, J., Parnetti, L., Payoux, P., Picco, A., Quaranta, D., Ranjeva, J. P., Roccatagliata, L., Rossini, P. M., Salvadori, N., Schonknecht, P., Andrea Soricelli, Tsolaki, M., Vecchio, F., Visser, P. J., Wiltfang, J., Frisoni, G. B., and Pharmacog, Consortium

Subjects
Medizin, ComputingMethodologies_GENERAL
Abstract

Poster Abstract

Published
2014

40. Vancomycin in Pediatric Patients with Solid or Hematological Malignant Disease: Predictive Performance of a Population Pharmacokinetic Model and New Optimized Dosing Regimens.

Author

Marsot, Amélie, Gallais, F., Galambrun, C., Coze, C., Blin, O., Andre, N., and Guilhaumou, R.

Subjects
CHILDHOOD cancer, VANCOMYCIN, CHILD patients, PHARMACOKINETICS, CYCLOSPORINE, CANCER treatment
Abstract

Background: The application of population pharmacokinetic models and Bayesian methods offers the potential to develop individualized therapeutic approaches.Objectives: The current study presents an external evaluation of a vancomycin pharmacokinetic model in a pediatric cancer population and proposes an easy-to-use chart for clinicians for a priori vancomycin schedule adaptation to achieve target concentration.Methods: External evaluation of a population pharmacokinetic model of vancomycin administered via continuous infusion was realized in a new retrospective dataset of pediatric patients with cancer. The published population pharmacokinetic model was implemented in NONMEM 7.3 with the structural and variance parameter values set equal to estimates previously reported. Predictive performance was assessed by quantifying bias and accuracy of model prediction. Normalized prediction distribution errors were also evaluated. Dosage simulations were performed according to the target concentration.Results: A total of 77 patients were included in this study, representing 146 vancomycin courses and 289 concentrations. The model adequately predicted vancomycin concentrations (median prediction error % of − 9.4%, median |PE|% of 24.1%). Based on simulation results, vancomycin dosage (mg/kg) should be adapted for each child on the basis of body weight and cyclosporine coadministration.Conclusion: The model previously proposed by Guilhaumou et al. in pediatric patients with solid or hematological malignant disease was externally validated. Simulations have enabled the description of new dosage schedules and creation of a chart to help clinicians adapt vancomycin dosage. [ABSTRACT FROM AUTHOR]

Published
2018
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41. Effects of Dietary Resveratrol on the Sleep-Wake Cycle in the Non-Human Primate Gray Mouse Lemur ( Microcebus murinus )

Author

Languille, S., Blanc, S., Blin, O., Canale, C.I., Dal-Pan, A., Devau, G., Dhenain, M., Dorieux, O., Epelbaum, J., Gomez, D., Hardy, I., Henry, P.-Y., Irving, E.A., Marchal, J., Mestre-Francès, N., Perret, M., Picq, J.-L., Pifferi, F., Rahman, A., Schenker, E., Terrien, J., Théry, M., Verdier, J.-M., Aujard, F., Mécanismes adaptatifs : des organismes aux communautés (MECADEV), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Centre investigation clinique - Unité de pharmacologie clinique et d'évaluations thérapeutiques (CIC-UPCET), Assistance Publique - Hôpitaux de Marseille (APHM), UCB BioPharma [Braine l’Alleud, Belgium], Institute for Integrated Micro and Nano Systems, University of Edinburgh, Neurobiologie de l'apprentissage, de la mémoire et de la communication (NAMC), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Mécanismes adaptatifs : des organismes aux communautés (MAOAC), Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Muséum national d'Histoire naturelle (MNHN), Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université Montpellier 2 - Sciences et Techniques (UM2)-École pratique des hautes études (EPHE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratoire des Maladies Neurodégénératives - UMR 9199 (LMN), Service MIRCEN (MIRCEN), Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Jean Le Rond d'Alembert (DALEMBERT), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Microbiologie et Pathologie Cellulaire Infectieuse, Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM), NOAA Center for Earth System Sciences and Remote Sensing Technologies (CREST), National Oceanic and Atmospheric Administration (NOAA), Institut de Recherche Servier, Reykjavik University, University of Reykjavik [Islande], Mécanismes adaptatifs : des organismes aux communautés, Muséum national d'Histoire naturelle (MNHN)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Institut de Biologie François JACOB (JACOB), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, medicine.medical_specialty, Microcebus murinus, Physiology, media_common.quotation_subject, Photoperiod, [SDV]Life Sciences [q-bio], Lemur, Neuropathology, Resveratrol, resveratrol, Body Temperature, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Physiology (medical), Internal medicine, biology.animal, Stilbenes, medicine, Animals, Primate, Circadian rhythm, sleep, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, media_common, 0303 health sciences, biology, Mouse lemur, microcebus murinus, Longevity, biology.organism_classification, 3. Good health, Circadian Rhythm, Endocrinology, chemistry, circadian rhythms, electroencephalography, metabolism, Dietary Supplements, Sleep Stages, Cheirogaleidae, 030217 neurology & neurosurgery
Abstract

International audience; Converging evidence shows that the non-human primate gray mouse lemur (Microcebus murinus) is ideal for the study of the aging process and for testing the effects of new therapies and dietary interventions on age-associated pathologies. One such dietary supplement is resveratrol (RSV), a dietary polyphenolic compound with several positive effects on metabolic functions and longevity. However, little is known about the effect of RSV on the lemur sleep-wake cycle, which reflects mammalian brain function and health. In the present study, the authors investigated this effect by comparing sleep-wake cycles in adult lemurs based on electroencephalographic (EEG) rhythms. The effect of short-term RSV supplementation on the sleep-wake cycle of mouse lemurs was evaluated in entrained conditions (long-day photoperiods, light:dark 14:10). After 3 wks of RSV supplementation, the animals exhibited a significantly increased proportion of active-wake time, occurring mainly during the resting phase of the sleep-wake cycle (+163%). The increase in active-wake time with RSV supplementation was accompanied by a significant reduction of both paradoxical sleep (-95%) and slow-wave sleep (-38%). These changes mainly occurred during the resting phase of the sleep-wake cycle (RSV supplementation induced negligible changes in active-wake time during the active phase of the sleep-wake cycle). The present data suggest that RSV may be a potent regulator of sleep-wake rhythms and could be of major interest in the study of sleep perturbations associated with aging and neuropathology.

Published
2012
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42. «Validation of the Retardation Rating Scale for detecting depression in geriatric inpatients.»

Author

S Sautel L Demattei C Jouve E Blin O., Bonin-Guillaume, Institut de neurosciences cognitives de la méditerranée - UMR 6193 (INCM), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), and Iherti, Taarabte

Subjects
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Published
2007

43. Validation of a screening tool for depression in geriatric inpatients: the Retardation Rating Scale

Author

S Sautel L Demattei C Blin O, Bonin-Guillaume, Iherti, Taarabte, Institut de neurosciences cognitives de la méditerranée - UMR 6193 (INCM), and Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Published
2007

45. Effect of topiramate in a human model of schizophrenia

Author

Gavaudan, G, Micalllef-Roll, J, Hasbroucq, T, Masson, G., Lancon, C, Blin, O, Laboratoire de Neurosciences Cognitives [Marseille] (LNC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
[SCCO]Cognitive science, [SCCO.NEUR]Cognitive science/Neuroscience
Abstract

24th CINP Congress, Paris, FRANCE, JUN 20-24, 2004; International audience; no abstract

Published
2004

46. ID 284 – Abnormal delta cortical sources of resting state eyes closed EEG rhythms correlate with cerebrospinal fluid (CSF) ® amyloid (A®) level in amnesic MCI subjects

Author

Noce, G., Del Percio, C., Marzano, N., Cordone, S., Bagnoli, C., Rossini, P.M., Soricelli, A., Nobili, F.M., Bartres Faz, D., Blin, O., Payoux, P., Bordet, R., Müller, B.W., Tsolaki, M., Parnetti, L., Hegerl, U., Hensch, T., Dukar, J., Bertolino, A., Forloni, G., Richardson, J.C., Frisoni, G., and Babiloni, C.

Published
2016
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47. ID 286 – Auditory oddball event-related potentials cortical sources are related to cerebrospinal fluid (CSF)® amyloid (A®) level in amnesic MCI subjects

Author

Cordone, S., Del Percio, C., Marzano, N., Noce, G., Bagnoli, C., Rossini, P.M., Soricelli, A., Famá, F., Bartres Faz, D., Blin, O., Payoux, P., Bordet, R., Müller, B.W., Tsolaki, M., Parnetti, L., Hegerl, U., Hensch, T., Dukart, J., Bertolino, A., Forloni, G., Richardson, J.C., Frisoni, G., and Babiloni, C.

Published
2016
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48. Cortical generation of on-going “Delta” and “Alpha” EEG rhythms in mouse models of Alzheimer’s disease and Alzheimer’s disease patients at prodromic stages

Author

Babiloni, C., Del Percio, C., Marzano, N., Cordone, S., Noce, G., Bagnoli, C., Rossini, P. Maria, Soricelli, A., Nobili, F. Mariano, Faz, D. Bartres, Blin, O., Payoux, P., Bordet, R., Mueller, B., Tsolaki, M., Parnetti, L., Hegerl, U., Hensch, T., Dukart, J., Bertolino, A., Forloni, G., Frasca, A., Richardson, J., Bastlund, J. Frank, Clausen, B., Bentivoglio, M., Fabene, P.F., Bertini, G., Dix, S., Kelley, J., Drinkenburg, W., and Frisoni, G.

Published
2016
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50. EVALUATION OF SACCADIC EYE-MOVEMENTS AS AN OBJECTIVE TEST OF RECOVERY FROM ANESTHESIA

Author

Paut, O., Vercher, Jl, Blin, O., Lacarelle, B., Daniel Mestre, Durand, A., Gauthier, Gm, Camboulives, J., Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Vercher, Jean-Louis, and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
genetic structures, SACCADIC EYE MOVEMENTS, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, PSYCHOMOTOR TESTS, MIDAZOLAM, RECOVERY
Abstract

International audience; Saccadic eye movements have been previously used to assess residual effect of anaesthetics, but this test is seldom compared to other psychomotor tests. The aim of the present study was to validate saccades as a recovery index in relation to frequently referred subjective and psychometric tests. Eight healthy subjects were tested before and after intra-muscular injection of either placebo or 0.15 mg . kg(-1) of midazolam. Each session consisted of a saccadic rest (recorded by electro-oculography), a choice-reaction-time test (CRT), a subjective state-of-alertness test (11 visual analogic scales) and blood sampling (to monitor midazolam plasma concentration), before and 30 (t30), 60 (t60), 120 (t120), 180 (t180), 240 (t240) minutes after drug administration In the placebo group, there was no change in subjective assessment, saccade characteristics (latency, peak velocity and duration) or CRT results. In the midazolam group, 6 subjective items changed with different time-courses, when compared to baseline: from t30 to t120 (drowsy, in shape, tired, clumsy strong) and at t120 (woolly). Saccade latency and duration were significantly different from 130 to t120 and until t180 for peak velocity. CRT performance was significantly altered From t30 to t120. Midazolam plasma concentration decreased From 177+/-33 ng . ml(-1) at t30 to 47+/-12 ng . ml(-1) at t240. At this latter time, sensorimotor functions returned to the baseline. All subjects fulfilled the clinical conditions for home discharge 4 hours after administration. These results suggest that a saccadic eye movement test is a sensitive and reliable tool for the assessment of residual effect of anaesthetics. This test was found to be more sensitive than CRT test since peak saccadic velocity was the last psychometric parameter to be returned to baseline after midazolam injection. This study also confirms the poor reliability of subjective assessment, as subjects tended to underestimate the alteration of their performance immediately following drug injection.

Published
1995

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