33 results on '"Borges, Lysandro Pinto"'
Search Results
2. Exacerbation of oral pemphigus vulgaris after COVID‐19 vaccine: Coincidence or potential adverse effect?
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da Mota Santana, Lucas Alves, Borges, Lysandro Pinto, dos Santos Barreto, Marina, Santos, Ronaldy Santana, Silva, Deise Maria Rego Rodrigues, Silva, Eloia Emanuelly Dias, Barbosa, Breno Ferreira, Floresta, Lara Góis, Melo, Lucas Morais Rodrigues, Repeke, Carlos Eduardo Palanch, Ribeiro, Maria Amália Gonzaga, and Trento, Cleverson Luciano
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PEMPHIGUS vulgaris ,COVID-19 vaccines ,PEMPHIGUS ,MEDICAL personnel ,VACCINE effectiveness ,COINCIDENCE - Abstract
This article discusses a rare case of a patient who experienced an exacerbation of oral pemphigus vulgaris, an autoimmune disorder, after receiving the Pfizer BioNTech COVID-19 vaccine. The patient presented with painful lesions in the oral cavity, which appeared one month after vaccination. A diagnosis of pemphigus vulgaris was made based on histological analysis. The article also explores the potential mechanisms underlying vaccine-induced autoimmune disorders and highlights the importance of understanding these clinical implications for improving vaccine efficacy and public adherence. [Extracted from the article]
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- 2024
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3. Comment on “Association between COVID 19 exposure and expression of malignant pathological features in oral cancer: A retrospective cohort study”
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da Mota Santana, Lucas Alves, Simões, João Marcos Dias, Santos, Gilmagno Amado, Gopalsamy, Rajiv Gandhi, Borges, Lysandro Pinto, Brasileiro, Bernardo Ferreira, and Trento, Cleverson Luciano
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- 2024
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4. The Impact of Diabetes Education on Continuous Glucose Monitoring in SUS-Dependent Patients in a Northeastern Brazilian City.
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Borges, Lysandro Pinto, de Jesus, Pamela Chaves, de Souza, Jessiane Bispo, Silva, Deise Maria Rego Rodrigues, Moura, Pedro Henrique Macedo, Santos, Ronaldy Santana, Barreto, Marina dos Santos, Guimarães, Adriana Gibara, da Mota Santana, Lucas Alves, da Fonseca, Dennyson Leandro Mathias, Barreto, Ikaro Daniel de Carvalho, de Mello Silva, Breno, Oliveira, Carla Raquel Pereira, Rezende, Karla Freire, Melo, Naira Horta, Santos, Elenalda Ferreira dos, Queiroz, Carmem Lúcia Matias de, Xavier, Lucia Helena Modesto, Cabral-Marques, Otávio, and Silva, Eloia Emanuelly Dias
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CONTINUOUS glucose monitoring , *INSULIN , *HYPERGLYCEMIA , *PATIENT monitoring , *GLYCOSYLATED hemoglobin , *HIGH performance liquid chromatography , *GLYCEMIC control - Abstract
Background: Diabetes Mellitus (DM) is an important chronic disease that occurs worldwide. Aims: This study aims to investigate how the use of the FreeStyle® Libre system in Unified Health System (SUS) patients impacts diabetes parameters in patients who receive education on proper insulin administration and the use of the continuous monitoring device, as well as how this affects patients without any concomitant multidisciplinary support in Sergipe, Brazil. Methods: We conducted a prospective randomized study in a diabetes clinic in Sergipe, Brazil, using the flash method FreeStyle® Libre (Abbott). The participants were divided into two groups: one receiving diabetes education on CGM (continuous glucose monitoring), while the other did not. Before the intervention, the patient's treatment motivation and quality of life were assessed using a questionnaire, and baseline levels of glycated hemoglobin were measured using high-performance liquid chromatography (HPLC) and the point of care AlereTM Afinion with boronate fixation. We compared first- and second-phase data with respect to glycated hemoglobin, mean interstitial blood glucose, time on and above target for hypoglycemic and hyperglycemic events, and mean hypoglycemic duration. Results: In group A, which received the diabetes education intervention, there was a significant reduction in average HbA1c levels from 8.6% to 7.9% after 3 months (p = 0.001). However, there was no significant difference in average glycemic values. Time above target decreased significantly from 50.62% to 29.43% (p = 0.0001), while time below target decreased from 22.90% to 20.21% (p = 0.002). There was no significant change in the number of hypoglycemic events, but the duration of hypoglycemia decreased significantly from 130.35 min to 121.18 min after 3 months (p = 0.0001). In Group B, there was no significant difference in mean HbA1c levels before (7.07%) and after (7.28%) sensor installation. This group maintained lower HbA1c levels compared to the other group. Average blood glucose levels also remained similar before (148.37 mg/dL) and after (154.65 mg/dL) the intervention. Although the time above the target glucose level increased significantly from 35.94% to 48.17%, the time at target decreased from 50.40% to 37.97%. No significant changes were observed in the time below target, the number of hypoglycemic events, or the duration of hypoglycemia. Conclusions: Our findings indicate that utilizing continuous glucose monitoring technology can enhance glycemic control, particularly in motivated, educated, low-income patients dependent on the SUS. To achieve positive results with FreeStyle Libre, it is imperative to allocate resources for multidisciplinary support. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Transforming Diabetes Supplies in the Prison System: An Example of Environmental Social Innovation.
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Moura, Pedro Henrique Macedo, Silva, Deise Maria Rego Rodrigues, Silva, Eloia Emanuelly Dias, de Souza, Jessiane Bispo, Barreto, Marina dos Santos, Santos, Ronaldy Santana, de Jesus, Pamela Chaves, Santos, Leticia Milena Machado dos, Santana, Lucas Alves da Mota, Guimarães, Adriana Gibara, and Borges, Lysandro Pinto
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Background: The disposal of plastic material has been gaining negative attention due to its impact on the environment and people's health. Insulin pens used by people living with diabetes are disposed of through landfills or incineration, negatively impacting the environment and generating costs for the state. Methods: In an attempt to reduce the disposal of plastic in the environment and reduce disposal costs, the "Insulinadiamor" project was created, which uses handicrafts as a means of re-socializing women deprived of their liberty. In this project, female inmates in the state of Sergipe turn insulin pens into ballpoint pens. Results: During the year 2022, 2000 insulin pens were transformed into ballpoint pens. We estimate a loss of around USD 37,150.28 for the state due to the inappropriate use of medicines, which was reflected in the return of complete insulins. In addition, by avoiding landfill or incineration of the plastic content collected, we contributed to an estimated saving of almost USD 603.91 for the state and more than 80 kg of CO
2 -equivalent emissions. Conclusions: This project brings a sustainable and transformative approach involving financial savings, rehabilitation of inmates, and contribution to the environment. It also raises the importance of creating more sustainable initiatives to reduce plastic waste in the health sector and other areas. [ABSTRACT FROM AUTHOR]- Published
- 2024
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6. COVID-19 Crisis in Brazil: Post-Vaccination Seroprevalence and Infection in More and Less Vaccinated Municipalities in a Northeastern State.
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Santos, Ronaldy Santana, Barreto, Marina dos Santos, Silva, Eloia Emanuelly Dias, Silva, Beatriz Soares da, Jesus, Pamela Chaves de, Silva, Deise Maria Rego Rodrigues, Moura, Pedro Henrique Macedo, Souza, Jessiane Bispo de, Santos, Leticia Milena Machado dos, Guimarães, Adriana Gibara, Santana, Lucas Alves da Mota, and Borges, Lysandro Pinto
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COVID-19 pandemic ,SARS-CoV-2 Omicron variant ,VACCINATION ,VACCINATION coverage ,CITIES & towns - Abstract
Background: Given the impact of the pandemic in Brazil, vaccination is essential to prevent illness and death. Thus, this study sought to compare, after vaccination, the circulation of SARS-CoV-2 and the response to vaccination in the least and most vaccinated municipalities of a Brazilian state during the height of the pandemic when the Omicron variant was dominant. Methods: We tested for the SARS-CoV-2 antigen and confirmed infection using an RT-qPCR and measured IgM and IgG antibodies in fully vaccinated participants from municipalities with higher and lower vaccination rates. Results: We showed that participants from the least vaccinated municipalities were more likely to have detectable IgM antibodies and a positive antigen/RT-qPCR result for SARS-CoV-2 than participants from the most vaccinated municipalities. There were no differences between the vaccines used (BNT162b2, Ad26.COV2.S, AZD1222, and CoronaVac) and antibody production. Conclusions: Our study evaluated municipal vaccination coverage and its effects on mortality, infections, and anti-SARS-CoV-2 antibodies during a critical phase of the pandemic. The results suggest that higher vaccination coverage reduces acute cases and confers higher memory antibody levels against SARS-CoV-2. Even with a full vaccination schedule, individuals living in places with low vaccination rates are more susceptible to infection. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Advancing oral cancer diagnosis in Brazil: Integrating artificial intelligence with teledentistry for enhanced patient outcomes
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Santana, Lucas Alves da Mota, Floresta, Lara Góis, Alves, Êmilly Victória Maciel, Melo, Lucas Morais Rodrigues, Ferreira, Ramomm Rocha Tavares, Couto, Graziane Ribeiro, de Arruda, José Alcides Almeida, Valadares, Carolina Vieira, Roque-Torres, Gina Delia, Santos, Gilmagno Amado, Gopalsamy, Rajiv Gandhi, Martins-Filho, Paulo Ricardo, and Borges, Lysandro Pinto
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- 2024
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8. Virtual surgical planning in orthognathic surgery and ChatGPT-4: how artificial intelligence can optimize patient care
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Santana, Lucas Alves da Mota, Floresta, Lara Góis, Alves, Êmilly Victória Maciel, Barbosa, Breno Ferreira, Borges, Lysandro Pinto, Barreto, Marina dos Santos, Santos, Ronaldy Santana, Silva, Deise Maria Rego Rodrigues, Palanch Repeke, Carlos Eduardo, Brasileiro, Bernardo Ferreira, and Trento, Cleverson Luciano
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- 2024
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9. Technological Scenario for Masks in Patent Database During Covid-19 Pandemic
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de Araújo Andrade, Tatianny, Nascimento Junior, José Adão Carvalho, Santos, Anamaria Mendonça, Borges, Lysandro Pinto, Quintans-Júnior, Lucindo José, Walker, Cristiani Isabel Banderó, Frank, Luiza Abrahão, and Serafini, Mairim Russo
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- 2021
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10. Integrating ChatGPT in oral cytopathology: Enhancing fine needle aspiration diagnostic accuracy for malignant lesions
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da Mota Santana, Lucas Alves, Gonçalo, Rani Iani Costa, Floresta, Lara Góis, de Oliveira, Eduardo Morato, Trindade, Leda Maria Delmondes Freitas, Borges, Lysandro Pinto, Ribeiro, Daniel Araki, Martins-Filho, Paulo Ricardo, and Takeshita, Wilton Mitsunari
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- 2024
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11. COVID-19 Vaccination and Serological Profile of a Brazilian University Population.
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Barreto, Marina dos Santos, Silva, Beatriz Soares da, Santos, Ronaldy Santana, Silva, Deise Maria Rego Rodrigues, Silva, Eloia Emanuelly Dias, Moura, Pedro Henrique Macedo, Souza, Jessiane Bispo de, Santana, Lucas Alves da Mota, Fonseca, Dennyson Leandro M., Filgueiras, Igor Salerno, Guimarães, Adriana Gibara, Cabral-Marques, Otavio, Schimke, Lena F., and Borges, Lysandro Pinto
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COVID-19 vaccines ,IMMUNOGLOBULINS ,VACCINATION ,COVID-19 ,IMMUNOGLOBULIN G ,IMMUNITY - Abstract
Background: COVID-19 led to the suspension academic activities worldwide, affecting millions of students and staff. Methods: In this study, we evaluated the presence of IgM and IgG anti-SARS-CoV-2 antibodies in an academic population during the return to classes after a one-year suspension. The study took place over five months at a Brazilian university and included 942 participants. Results: We found that most participants had reactive IgG and non-reactive IgM. All received at least one dose, and 940 received two or more doses, of different COVID-19 vaccines. We obtained a higher average of memory antibodies (IgG) in participants who received the CoronaVac/ChAdOx1 combination. IgG was consistently distributed for each vaccine group, but individuals who completed the vaccination schedule had higher levels. There were no differences between antibodies and gender, presence of symptoms, and previous COVID-19 infection, but older participants (>53 years) and contacts of infected individuals had higher IgM levels. Conclusion: This study makes significant contributions to the assessment of antibodies in the academic environment, allowing us to infer that most participants had memory immunity and low indications of recent infection when returning to face-to-face classes, as well as demonstrating the need to monitor immunity and update vaccinations. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Comment on: "The emerging meanings of spirituality in oral medicine practice".
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Santana, Lucas Alves da Mota, Borges, Lysandro Pinto, Marqueti, Antônio Carlos, Brasileiro, Bernardo Ferreira, and Trento, Cleverson Luciano
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ANXIETY , *IMMUNE system , *ORAL medicine , *SPIRITUALITY , *RELIGION , *PSYCHOLOGICAL stress , *SPIRITUAL care (Medical care) , *QUALITY of life , *ORAL health , *MEDICAL practice - Published
- 2024
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13. Respostas políticas de países com o maior número de mortes por COVID-19 no mundo: uma revisão de escopo
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Costa, Alana Teles, Borges, Lysandro Pinto, Figueiredo, Renata Ferraz, Vieira, Marcio Lima da Conceição, Serafini, Mairim Russo, and Walker, Cristiani Isabel Banderó
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Health policy ,Política de salud ,Política de saúde ,COVID-19 ,Public Health ,Salud Pública ,Infecciones por Coronavirus ,Coronavirus Infections ,Saúde Pública ,Pandemics ,Infecções por coronavírus ,Pandemias - Abstract
The COVID-19 pandemic has been declared since March 11, 2020. Until December 2020, the absence of specific treatments or vaccines for COVID-19 implied the need to use non-pharmacological strategies to reduce infection rates. This study aimed to track and compare the policy responses of countries with the highest number of COVID-19 deaths in the world. Was performed a scoping search in five databases (PubMed, Scopus, LILACS, Web of Science and Google Scholar) between December 1, 2019 and April 30, 2020. Information on policy and health on official websites of the listed countries was also searched. After the selection process, which was carried out independently by two evaluators following the previously established criteria, 55 titles were included. Of the 18 documents of national health societies, 13 addressed the prevention of COVID-19. The most reported country was Italy (17). The strategies most cited by the studies are: traveler monitoring, international travel controls, social distancing orders, closure schools and universities, partial and total lockdown. Until the end of April, all countries evaluated, United States, Italy, the United Kingdom, Spain, France, Belgium, Germany, Iran, Brazil and the Netherlands, have adopted measures such as social distancing orders and the closure of schools and universities. Except for Iran, all these countries have adopted some type of lockdown. So far (August, 2022), Germany has already been cited as an example of a successful country in controlling the pandemic, while the United States still has the highest numbers in the world in total cases, total deaths and new deaths weekly from COVID-19. La pandemia de COVID-19 fue declarada el 11 de marzo de 2020. Hasta diciembre de 2020, la ausencia de tratamientos o vacunas específicas para COVID-19 implicó la necesidad de utilizar estrategias no farmacológicas para reducir las tasas de infección. Este estudio tuvo como objetivo rastrear y comparar las respuestas políticas de los países con el mayor número de muertes por COVID-19 en el mundo. Realizamos una búsqueda de alcance en cinco bases de datos (PubMed, Scopus, LILACS, Web of Science y Google Scholar) entre el 1 de diciembre de 2019 y el 30 de abril de 2020. También se buscó información sobre políticas y salud en los sitios web oficiales de los países enumerados. Tras el proceso de selección, que se llevó a cabo de forma independiente por dos evaluadores siguiendo los criterios previamente establecidos, se incluyeron 55 títulos. De los 18 documentos de las sociedades nacionales de salud, 13 abordaron la prevención de la COVID-19. El país más informado fue Italia (17). Las estrategias más citadas por los estudios fueron: monitoreo de viajeros, controles de viajes internacionales, órdenes de distanciamiento social, cierre de escuelas y universidades, bloqueo parcial y total. A fine de abril, todos los países evaluados, Estados Unidos, Italia, Reino Unido, España, Francia, Bélgica, Alemania, Irán, Brasil y Holanda, habían adoptado medidas como órdenes de distanciamiento social y cierre de escuelas y universidades. A excepción de Irán, todos estos países han adoptado algún tipo de bloqueo. Hasta el momento (Agosto de 2022), Alemania ya ha sido citada como ejemplo de país exitoso en el control de la pandemia, mientras que Estados Unidos aún tiene las cifras más altas del mundo en casos totales, muertes totales y nuevas muertes semanales por contagios de COVID-19. A pandemia de COVID-19 foi declarada em 11 de Março de 2020. Até dezembro de 2020, a ausência de tratamentos ou vacinas específicas para COVID-19 implicou na necessidade de utilização de estratégias não farmacológicas para redução das taxas de infecção. Este estudo teve como objetivo rastrear e comparar as respostas políticas dos países com o maior número de mortes por COVID-19 no mundo. Realizamos uma busca de escopo em cinco bases de dados (PubMed, Scopus, LILACS, Web of Science e Google acadêmico) entre 1º de Dezembro de 2019 e 30 de Abril de 2020. Também foram pesquisadas informações em sites oficiais dos países listados, sobre políticas e saúde. Após o processo de seleção, que foi realizado independentemente por dois avaliadores seguindo os critérios previamente estabelecidos, 55 títulos foram incluídos. Dos 18 documentos das sociedades nacionais de saúde, 13 abordaram a prevenção da COVID-19. O país mais relatado foi a Itália (17). As estratégias mais citadas pelos estudos foram: monitoramento de viajantes, controles de viagens internacionais, ordens de distanciamento social, fechamento de escolas e universidades, bloqueio parcial e total. Até o final de Abril, todos os países avaliados, Estados Unidos, Itália, Reino Unido, Espanha, França, Bélgica, Alemanha, Irã, Brasil e Holanda, adotaram medidas como ordens de distanciamento social e fechamento de escolas e universidades. Com exceção do Irã, todos esses países adotaram algum bloqueio. Até o momento (Agosto de 2022), a Alemanha já foi citada como exemplo de país bem-sucedido no controle da pandemia, enquanto os Estados Unidos ainda apresentam os maiores números do mundo em total de casos, total de óbitos e novas mortes semanais por COVID- 19.
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- 2022
14. Challenges in Direct Detection of Flaviviruses: A Review.
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Dias, Bruna de Paula, Barbosa, Camila Cavadas, Ferreira, Cyntia Silva, Mayra Soares Alves dos Santos, Samara, Arrieta, Orlando Alfredo Pineda, Malta, Wellington Carvalho, Gomes, Maria Laura Maximiano Dias, Alves e Silva, Mariela, Fonseca, Júlia de Matos, Borges, Lysandro Pinto, and Silva, Breno de Mello
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ARBOVIRUSES ,FLAVIVIRUSES ,SERS spectroscopy ,SURFACE plasmon resonance ,MOSQUITOES ,AEDES aegypti ,PUBLIC interest ,DETECTION limit - Abstract
Arthropods transmit arboviruses via mosquito and tick bites to humans and other animals. The genus flavivirus, which causes diseases, sequelae, and thousands of deaths, mainly in developing and underdeveloped countries, is among the arboviruses of interest to public health. Given the importance of early and accurate diagnosis, this review analyzes the methods of direct detection of flaviviruses, such as reverse transcription loop-mediated isothermal amplification, microfluidics, localized surface plasmon resonance, and surface-enhanced Raman scattering, and presents the advantages, disadvantages, and detection limits identified in studies reported in the literature for each methodology. Among the different methods available, it is essential to balance four fundamental indicators to determine the ideal test: good sensitivity, high specificity, low false positive rate, and rapid results. Among the methods analyzed, reverse transcription loop-mediated isothermal amplification stands out, owing to result availability within a few minutes, with good sensitivity and specificity; in addition, it is the best-characterized methodology. [ABSTRACT FROM AUTHOR]
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- 2023
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15. Oral microbiota's effect on burning mouth syndrome's pathogenesis: Microbiota‐chronic diseases axis.
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Santana, Lucas Alves da Mota, Borges, Lysandro Pinto, Gopalsamy, Rajiv Gandhi, Amado Santos, Gilmagno, Brasileiro, Bernardo Ferreira, and Trento, Cleverson Luciano
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- 2024
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16. SARS-CoV-2 has been circulating in northeastern Brazil since February 2020: evidence for antibody detection in asymptomatic patients
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Gurgel, Ricardo Queiroz, de Sá, Laís Catarine, Souza, Daniela Raguer Valadão, Martins, Aline Fagundes, Matos, Igor Leonardo Santos, Lima, Alexandra Giovanna Aragão, Vieira, Sarah Cristina Fontes, Neto, José Melquiades de Rezende, Cuevas, Luis Eduardo, and Borges, Lysandro Pinto
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- 2021
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17. Is it possible to contain COVID-19 in a female prison in Brazil? A pilot study
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Dias Silva, Eloia Emanuelly, Chaves de Jesus, Pamela, Macedo Moura, Pedro Henrique, Rego Rodrigues da Silva, Deise Maria, Teles dos Santos, Raquel, Cabral-Marques, Otávio, Alves da Mota Santana, Lucas, and Borges, Lysandro Pinto
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- 2023
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18. Mapping the technological landscape of SARS, MERS, and SARS-CoV-2 vaccines.
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Nascimento Júnior, José Adão Carvalho, Santos, Anamaria Mendonça, Cavalcante, Rafael Ciro Marques, Quintans-Júnior, Lucindo José, Walker, Cristiani Isabel Banderó, Borges, Lysandro Pinto, Frank, Luiza Abrahão, and Serafini, Mairim Russo
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COVID-19 ,SARS-CoV-2 ,MIDDLE East respiratory syndrome ,SARS disease ,COVID-19 vaccines ,GENETIC vectors - Abstract
The last two decades have seen the emergence of several viral outbreaks. Some of them are the severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and severe acute respiratory syndrome 2 (SARS-CoV2) – the cause of the coronavirus disease 2019 (COVID-19). Ever, vaccines for emergency use have been authorized for the control and prevention of COVID-19. Currently, there is an urgent need to develop a vaccine for prophylaxis of COVID-19 and for other future epidemics. This review describes patented vaccines for SARS and MERS-CoV and vaccines developed and approved for emergency use against the new coronavirus (COVID-19). The European Patent Office and the World Intellectual Property Organization were the patent databases used using specific terms. In addition, another search was carried out in the Clinical Trials in search of ongoing clinical studies focused on the COVID-19 vaccine. The patent search showed that most vaccines are based on viral vector platforms, nucleic acids, or protein subunits. The review also includes an overview of completed and ongoing clinical trials for SARS-CoV-2 in several countries. The information provided here lists vaccines for other types of coronavirus that have been used in the development of vaccines for COVID-19. [ABSTRACT FROM AUTHOR]
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- 2021
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19. Concomitant administration of sodium 2,3-dimercapto-1-propanesulphonate (DMPS) and diphenyl diselenide reduces effectiveness of DMPS in restoring damage induced by mercuric chloride in mice
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Brandão, Ricardo, Borges, Lysandro Pinto, and Nogueira, Cristina Wayne
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SULFONATES , *BIPHENYL compounds , *MERCURIC chloride , *PHYSIOLOGICAL effects of chlorides , *LABORATORY mice , *COMBINATION drug therapy , *MERCURY poisoning , *GLUTATHIONE transferase , *HEMATOLOGY , *CREATININE , *KIDNEY injuries , *WOUND care - Abstract
Abstract: The effect of combined therapy with diphenyl diselenide (PhSe)2 and sodium 2,3-dimercapto-propane-1-sulphonate (DMPS) against alterations induced by mercury (Hg2+) was evaluated. Mice were exposed to mercuric chloride (HgCl2) (1mg/kg, subcutaneously) for two weeks. After that, mice received (PhSe)2 (15.6mg/kg), or DMPS (12.6mg/kg), or a combination of both for one week. Thiobarbituric acid-reactive substances (TBARS), ascorbic acid and Hg2+ levels and glutathione S-transferase (GST) and catalase (CAT) activities were carried out in kidney. Hematological parameters, plasmatic billirubin, uric acid, urea and creatinine levels as well as lactate dehydrogenase (LDH) activity were determined. (PhSe)2 or DMPS restored the increase in LDH activity and TBARS, bilirubin, uric acid, urea and creatinine levels caused by HgCl2. The levels of erythrocytes, hemoglobin and hematocrit reduced by HgCl2 exposure were restored by (PhSe)2 or DMPS administration in mice. Leukocyte and platelet counts modified by HgCl2 exposure were restored by (PhSe)2 or DMPS therapy. DMPS restored the increase in Hg2+ levels induced by exposure to HgCl2. Concomitant administration of (PhSe)2 and DMPS reduced the effectiveness of DMPS in restoring damage induced by HgCl2. Combined therapy with (PhSe)2 and DMPS was less effective than isolated therapies in restoring the damage induced by HgCl2 in mice. [Copyright &y& Elsevier]
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- 2009
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20. Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats.
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Nogueira, Cristina W., Borges, Lysandro Pinto, and Souza, Ana Cristina Guerra
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MEDICAL research ,BIPHENYL compounds ,HEPATOTOXICOLOGY ,CARBON tetrachloride ,RAT diseases ,LIVER diseases ,CYANOBACTERIAL toxins ,ENZYME inhibitors ,TOXIC hepatitis - Abstract
The article presents a study which examines the link of the oral administration of diphenyl diselenide (PhSe) and hepatotoxicity induced by carbon tetrachloride (CCl
4 ) in rats. (CCl4 ) is a model for studying free radical-induced liver injury and analyzing hepato-protective drugs. As part of the study, male Wistar rats received PHSe by oral route at the dosage of 31.2 miligrams/kilograms for one or two days. Results found that PhSe prevented animal death suggesting an activator action of PhSe in cyanobacterial LPS antagonist (CYPs).- Published
- 2009
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21. Rapid diagnosis of COVID-19 in the first year of the pandemic: A systematic review.
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Borges, Lysandro Pinto, Martins, Aline Fagundes, Silva, Breno de Mello, Dias, Bruna de Paula, Gonçalves, Ricardo Lemes, Souza, Daniela Raguer Valadão de, Oliveira, Makson Gleydson Brito de, Jesus, Pamela Chaves de, Serafini, Mairim Russo, Quintans, Jullyana Souza Siqueira, Coutinho, Henrique Douglas Melo, Martins, Natália, and Júnior, Lucindo José Quintans
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COVID-19 testing , *COVID-19 , *PANDEMICS , *POINT-of-care testing , *DISEASE outbreaks , *SCIENCE publishing - Abstract
• Most tests analyzed were not adequately validated; • For the extensive use of these rapid tests the validation should be immediate; • More studies are needed to determine cross reactivity in these tests.. COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health threat and remains a challenge for modern medicine. Rapid and accurate diagnosis of COVID-19 is vital for proper disease and outbreak management. Our review aimed to analyze scientific articles published in the literature addressing the rapid tests available for COVID-19 diagnosis at the first year of the pandemic. Methods: A systematic review was performed from October 22 to 27, 2020, searching data published in PubMed and Google Scholar databases, using subject headings or keywords related to point of care and rapid test diagnostic for SARS-CoV-2 and COVID-19. Results: The first survey identified 403 articles, but only 23 met the defined criteria for the systematic analysis. The sensitivity and specificity parameters were assessed in 19 studies, and the data suggested that there was lower sensitivity in the period 1 to 7 days after the emergence of symptoms (∼38%) higher sensitivity at 8 to 14 days (∼90%), and the highest at 15 to 39 days (∼98%). Accuracy was reported in six studies, reporting values above 50%. Only three studies reported a possible cross-reaction. Conclusions: Our findings indicate that the rapid tests used in the first year of the pandemic were tested with a small number of samples and not adequately validated. And the studies that described them were conducted with little scientific rigor. [ABSTRACT FROM AUTHOR]
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- 2021
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22. Does In-Person Visiting Affect the Number of COVID-19 Cases in Prisons?
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Borges, Lysandro Pinto, Martins, Aline Fagundes, de Souza, Daniela Raguer Valadão, de Rezende Neto, José Melquiades, Santos, Aryanne Araujo, Oliveira, Brenda Morais, Matos, Igor Leonardo Santos, da Invenção, Grazielly Bispo, dos Santos, Kezia Alves, Souza, Nicolas Alessandro Alves, de Jesus, Pamela Chaves, dos Santos, Cliomar Alves, de Oliveira Goes, Marco Aurélio, de Souza, Mércia Simone Feitosa, de Carvalho Barreto, Ikaro Daniel, Guimarães, Adriana Gibara, and Quintans-Júnior, Lucindo José
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COVID-19 pandemic , *COVID-19 , *SARS-CoV-2 , *PRISONS , *VACCINATION , *IMMUNOGLOBULIN M - Abstract
Even with the current advances that have been made in regard to COVID-19, such as a better understanding of the disease and the steady growth in the number of vaccinated individuals, it remains a challenge for humanity. Dealing with the disease in prison settings has been particularly difficult. This study sought to discover whether in-person visiting affected the number of cases of SARS-CoV-2 infection in the penitentiaries in the state of Sergipe (Brazil). We conducted a two-phase study (when visiting was suspended and after it recommenced) in seven penitentiaries in Sergipe using immunochromatography and nasopharyngeal swab testing to evaluate whether visiting affects the number of COVID-19 cases. In the first phase (n = 778), 57.6% of inmates reported risk factors and 32.5% were positive for COVID-19 (18.9% IgM, 24.2% IgG, 1% antigen). In the second phase, 19.6% tested positive (13.9% IgM, 7.9% IgG, 0.2% antigen). The occurrence of positive cases of COVID-19 and positive results (IgM and IgG) were significantly higher in the first phase. In the second phase, 56.7% of inmates had received visits and 18.7% were positive for COVID-19 (14% IgM, 7% IgG). Among those who had not received visits, 20.9% tested positive (13.8% IgM, 9.2% IgG, 0.5% antigen). There was no significant difference in positive cases/results between inmates that had and had not received visits. These findings suggest that, under the conditions assessed, visiting does not seem to affect the number of COVID-19 cases in prisons and reinforces the importance of sanitary measures to control dissemination. [ABSTRACT FROM AUTHOR]
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- 2021
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23. Diphenyl diselenide protects against hematological and immunological alterations induced by mercury in mice.
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Brandão, Ricardo, Borges, Lysandro Pinto, Oliveira, Renata de, Rocha, João B. T., and Nogueira, Cristina W.
- Abstract
Mercury is a heavy metal that can cause a variety of toxic effects on the organism, such as hematological and immunological alterations. In the present investigation, deleterious effects of mercury-intoxication in mice and a possible protective effect of diphenyl diselenide (PhSe)
2 were studied. Male adult Swiss albino mice received daily a pretreatment with (PhSe)2 (15.6 mg/kg, orally) for 1 week. After this week, mice received daily mercuric chloride (1 mg/kg, subcutaneously) for 2 weeks. A number of hematological (erythrocytes, leukocytes, platelets, hemoglobin, hematocrit, reticulocytes, and leukocytes differential) and immunological (immunoglobulin G and M plasma concentration) parameters were evaluated. Another biomarker of tissue damage, lactate dehydrogenase (LDH), was also determined. The results demonstrated that mercury exposure caused a reduction in the erythrocyte, hematocrit, hemoglobin, leukocyte, and platelet counts and an increase in the reticulocyte percentages. (PhSe)2 was effective in protecting against the reduction in hematocrit, hemoglobin, and leukocyte levels. (PhSe)2 ameliorated reticulocyte percentages increased by mercury. However, (PhSe)2 was partially effective in preventing against the decrease in erythrocyte and platelet counts. Immunoglobulin G and M concentrations and LDH activity were increased by mercury exposure, and (PhSe)2 was effective in protecting against these effects. In conclusion, (PhSe)2 was effective in protecting against hematological and immunological alterations induced by mercury in mice. © 2008 Wiley Periodicals, Inc. J Biochem Mol Toxicol 22:311-319, 2008; Published online in Wiley InterScience (). DOI 10.1002/jbt.20242 [ABSTRACT FROM AUTHOR]- Published
- 2008
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24. Oral administration of diphenyl diselenide protects against cadmium-induced liver damage in rats
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Borges, Lysandro Pinto, Brandão, Ricardo, Godoi, Benhur, Nogueira, Cristina W., and Zeni, Gilson
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BIPHENYL compounds , *CADMIUM , *LABORATORY rats , *HAZARDOUS substances - Abstract
Abstract: Cadmium is an environmental toxic metal implicated in human diseases. In the present study, the effect of diphenyl diselenide, (PhSe)2, on sub-chronic exposure with cadmium chloride (CdCl2) was investigated in rats. Male adult Swiss albino rats received CdCl2 (10μmol/kg, orally) and (PhSe)2 (5μmol/kg, orally) for a period of 30 days. A number of parameters were examined as indicators of toxicity, including hepatic and renal damage, glucose and glycogen levels and markers of oxidative stress. Cadmium content, liver histology, δ-aminolevulinate dehydratase (δ-ALA-D) activity, metallothionein (MT) levels were also evaluated. Cadmium content determined in the tissue of rats exposed to CdCl2 provides evidence that the liver is the major cadmium target where (PhSe)2 acts. The concentration of cadmium in liver was about three fold higher than that in kidney, and (PhSe)2 reduced about six fold the levels of this metal in liver of rats exposed. Rats exposed to CdCl2 showed histological alterations abolished by (PhSe)2 administration. (PhSe)2 administration ameliorated plasma malondialdehyde (MDA) levels, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma-glutamyl transferase (GGT) activities increased by CdCl2 exposure. Urea and bilirubin levels increased by CdCl2 exposure were also reduced by (PhSe)2. In conclusion, this study demonstrated that co-treatment with (PhSe)2 ameliorated hepatotoxicity and cellular damage in rat liver after sub-chronic exposure with CdCl2. The proposed mechanisms by which (PhSe)2 acts in this experimental protocol are its antioxidant properties and its capacity to form a complex with cadmium. [Copyright &y& Elsevier]
- Published
- 2008
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25. Rapid antigen detection of severe acute respiratory syndrome coronavirus-2 in stray cats: A cross-sectional study.
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Santos, Ronaldy Santana, Braga Lee, Daniel Antônio, Barreto, Marina dos Santos, Dias Silva, Eloia Emanuelly, de Jesus, Pamela Chaves, Macedo Moura, Pedro Henrique, Rego Rodrigues Silva, Deise Maria, de Souza, Jessiane Bispo, Bezerra, Taynar Lima, Meira Santos, Patricia Oliveira, Guimarães, Adriana Gibara, da Mota Santana, Lucas Alves, Prudencio, Carlos Roberto, and Borges, Lysandro Pinto
- Subjects
- *
SARS-CoV-2 , *ANIMAL disease control , *CATS , *ANIMAL populations , *ANTIGEN analysis - Abstract
Background and Aim: Although reverse zoonotic transmission events from humans to domestic cats have been described, there is currently little evidence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) circulation in stray cats. Due to the evidence of natural and experimental infections in cats and the capacity to disseminate the virus among them, this study aimed to identify the SARS-CoV-2 antigen in stray cats from the Federal University of Sergipe in Brazil. Materials and Methods: One hundred twenty six stray cats from the university were screened for SARS-CoV-2 antigens by random sampling. Throat swab samples were tested for the virus using rapid antigen detection tests. Results: Of the 126 animals tested, 30 (23.60%) were positive for SARS-CoV-2 antigens. To our knowledge, for the first time, this study detected the SARS-CoV-2 antigen in stray cats and confirmed the presence of SARS-CoV-2 infections in Brazil's stray cat population. Conclusion: The detection of SARS-CoV-2 in stray cats poses a risk for infected and healthy animals and possibly for humans who attend the university daily. As a limitation of the study, the small sample size necessitates caution when interpreting the results. This underscores the need for further research in this area to help control diseases in stray animals during potential pandemics. This highlights the need for monitoring and controlling the spread of the virus in stray animal populations. [ABSTRACT FROM AUTHOR]
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- 2024
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26. Revolutionizing oral and maxillofacial surgery: The role of DALL-E's AI-generated realistic images in enhancing surgical precision
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da Mota Santana, Lucas Alves, do Nascimento-Júnior, Edmundo Marques, Floresta, Lara Góis, Alves, Êmilly Victória Maciel, dos Santos Barreto, Marina, dos Santos, Jessiane Bispo, Valadares, Carolina Vieira, Roque-Torres, Gina Delia, Gopalsamy, Rajiv Gandhi, Martins-Filho, Paulo Ricardo, and Borges, Lysandro Pinto
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27. Proposing a New Frontier in Diabetes Treatment: The Integration of Biotechnology and Artificial Intelligence.
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Borges LP, Barreto MDS, Santos RS, Silva EED, Silva DMRR, Moura PHM, Jesus PC, Souza JB, Santana LADM, and Gibara Guimarães A
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- Humans, Biotechnology trends, Artificial Intelligence, Diabetes Mellitus therapy, Diabetes Mellitus drug therapy
- Abstract
Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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28. Revolutionizing oral and maxillofacial surgery: The role of DALL-E's AI-generated realistic images in enhancing surgical precision.
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da Mota Santana LA, do Nascimento-Júnior EM, Floresta LG, Alves ÊVM, Dos Santos Barreto M, Dos Santos JB, Valadares CV, Roque-Torres GD, Gopalsamy RG, Martins-Filho PR, and Borges LP
- Abstract
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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- 2024
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29. Neutralizing Antibodies Response for SARS-CoV-2 Among Young Inmates and Staff From a Juvenile Offender Institution in Brazil.
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Borges LP, Vieira SCF, Gurgel RQ, Silva BM, Ferreira CS, Santos SMSAD, and Santana LADM
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- Humans, SARS-CoV-2, Brazil epidemiology, Criminals, COVID-19 epidemiology
- Published
- 2023
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30. A higher number of SARS-COV-2 infections in quilombola communities than in the local population in Brazil.
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Martins AF, de Souza DRV, de Rezende Neto JM, Santos AA, da Invenção GB, Matos ILS, Dos Santos KA, de Jesus PC, da Silva FA, de Almeida FHO, do Vale FYN, Fonseca DLM, Schimke LF, Matos SS, Oliveira BM, Ferreira CS, de Paula Dias B, Dos Santos SMSA, Barbosa CC, de Carvalho Barreto ID, Moreno AKM, Gonçalves RL, de Mello Silva B, Cabral-Marques O, and Borges LP
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- Female, Male, Humans, Brazil epidemiology, SARS-CoV-2, Pandemics, Immunoglobulin G, Immunoglobulin M, COVID-19 epidemiology
- Abstract
The historical and social vulnerability of quilombola communities in Brazil can make them especially fragile in the face of COVID-19, considering that several individuals have precarious health systems and inadequate access to water. This work aimed to characterize the frequency of SARS-COV-2 infections and the presence of IgM and IgG SARS-CoV-2 antibodies in quilombola populations and their relationship with the presence of risk factors or preexisting chronic diseases in the quilombola communities. We analyzed the sociodemographic and clinical characteristics, serological status, comorbidities, and symptoms of 1,994 individuals (478 males and 1,536 females) from 18 Brazilian municipalities in the State of Sergipe of quilombola communities, which were evaluated at different epidemiological weeks, starting at the 32nd (August 6th) and ending at the 40th (October 3rd) epidemiological week. More than 70% of studied families live in rural areas and they have an extreme poverty social status. Although we found a higher number of SARS-COV-2 infections in quilombola communities than in the local population, their SARS-CoV-2 reactivity and IgM and IgG positivity varied across the communities investigated. Arterial hypertension was the most risk factor, being found in 27.8% of the individuals (9.5% in stage 1, 10.8% in stage 2, and 7.5% in stage 3). The most common COVID-19 symptoms and comorbidities were headache, runny nose, flu, and dyslipidemia. However, most individuals were asymptomatic (79.9%). Our data indicate that mass testing must be incorporated into public policy to improve the health care system available to quilombola populations during a future pandemic or epidemic., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Martins, de Souza, de Rezende Neto, Santos, da Invenção, Matos, dos Santos, de Jesus, da Silva, de Almeida, do Vale, Fonseca, Schimke, Matos, Oliveira, Ferreira, de Paula Dias, dos Santos, Barbosa, de Carvalho Barreto, Moreno, Gonçalves, de Mello Silva, Cabral-Marques and Borges.)
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- 2023
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31. Trends in MERS-CoV, SARS-CoV, and SARS-CoV-2 (COVID-19) Diagnosis Strategies: A Patent Review.
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Nascimento Junior JAC, Santos AM, Oliveira AMS, Guimarães AG, Quintans-Júnior LJ, Coutinho HDM, Martins N, Borges LP, and Serafini MR
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- China, Humans, Reproducibility of Results, Republic of Korea, SARS-CoV-2, Sensitivity and Specificity, COVID-19, Middle East Respiratory Syndrome Coronavirus genetics
- Abstract
The emergence of a new coronavirus (SARS-CoV-2) outbreak represents a challenge for the diagnostic laboratories responsible for developing test kits to identify those infected with SARS-CoV-2. Methods with rapid and accurate detection are essential to control the sources of infection, to prevent the spread of the disease and to assist decision-making by public health managers. Currently, there is a wide variety of tests available with different detection methodologies, levels of specificity and sensitivity, detection time, and with an extensive range of prices. This review therefore aimed to conduct a patent search in relation to tests for the detection of SARS-CoV, MERS-CoV, and SARS-CoV-2. The greatest number of patents identified in the search were registered between 2003 and 2011, being mainly deposited by China, the Republic of Korea, and the United States. Most of the patents used the existing RT-PCR, ELISA, and isothermal amplification methods to develop simple, sensitive, precise, easy to use, low-cost tests that reduced false-negative or false-positive results. The findings of this patent search show that an increasing number of materials and diagnostic tests for the coronavirus are being produced to identify infected individuals and combat the growth of the current pandemic; however, there is still a question in relation to the reliability of the results of these tests., (Copyright © 2020 Nascimento Junior, Santos, Oliveira, Guimarães, Quintans-Júnior, Coutinho, Martins, Borges and Serafini.)
- Published
- 2020
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32. Seroprevalence of SARS-CoV-2 IgM and IgG antibodies in an asymptomatic population in Sergipe, Brazil.
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Borges LP, Martins AF, de Melo MS, de Oliveira MGB, Neto JMR, Dósea MB, Cabral BCM, Menezes RF, Santos AA, Matos ILS, Borges PC, Dos Santos KA, Ribeiro AA, Menendez AIM, Serafini MR, Walker CB, Quintans Junior LJ, Araújo AAS, and de Souza DRV
- Abstract
Objective: To estimate the prevalence of SARS-CoV-2 antibodies in an asymptomatic population in the state of Sergipe, Brazil. ., Methods: This cross-sectional study with stratified sampling (sex and age) included serological immunofluorescent tests for IgM and IgG on samples from 3 046 asymptomatic individuals. Sample collection was performed in wet-markets of the 10 most populous cities of Sergipe, Brazil. Exclusion criteria included symptomatic individuals and health workers. The presence of comorbidities was registered. ., Results: Of the 3 046 participants, 1 577 (51.8%) were female and 1 469 (48.2%) were male; the mean age was 39.76 (SD 16.83) years old. 2 921 tests were considered valid for IgM and 2 635 for IgG. Of the valid samples, 347 (11.9% [CI 10.7%-13.1%]) tested positive for IgM and 218 (8.3% [CI 7.2%-9.4%]) tested positive for IgG. Women over 40 had the highest prevalence for IgM (group C, p=0.006; group D p=0.04). The capital Aracaju displayed the highest prevalence for both antibodies; 83 (26.3% [CI 21.6%-31.6%]) tested positive for IgM and 35 (14.6% [CI 10.4%-19.7%]) for IgG. The most prevalent comorbidities were hypertension (64/123 individuals) and diabetes (29/123). ., Conclusions: A high prevalence of SARS-CoV-2 antibodies was found among asymptomatic persons in Sergipe. Women over 40 showed the highest rates. The capital, Aracaju, displayed the highest seroprevalence. Surveys like this one are important to understand how the virus spreads and to help authorities to plan measures to control it. Repeated serologic testing are required to track the progress of the epidemic.
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- 2020
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33. SARS, MERS and SARS-CoV-2 (COVID-19) treatment: a patent review.
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Nascimento Junior JAC, Santos AM, Quintans-Júnior LJ, Walker CIB, Borges LP, and Serafini MR
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- Animals, Antiviral Agents adverse effects, Betacoronavirus pathogenicity, COVID-19, Coronavirus Infections diagnosis, Coronavirus Infections virology, Drug Development, Drug Discovery, Host-Pathogen Interactions, Humans, Middle East Respiratory Syndrome Coronavirus pathogenicity, Pandemics, Pneumonia, Viral diagnosis, Pneumonia, Viral virology, Severe acute respiratory syndrome-related coronavirus pathogenicity, SARS-CoV-2, Severe Acute Respiratory Syndrome diagnosis, Severe Acute Respiratory Syndrome virology, Treatment Outcome, COVID-19 Drug Treatment, Antiviral Agents therapeutic use, Betacoronavirus drug effects, Coronavirus Infections drug therapy, Middle East Respiratory Syndrome Coronavirus drug effects, Patents as Topic, Pneumonia, Viral drug therapy, Severe acute respiratory syndrome-related coronavirus drug effects, Severe Acute Respiratory Syndrome drug therapy
- Abstract
Introduction: Coronavirus has been responsible for several virus outbreaks since 2003, caused by SARS-CoV-1, MERS-CoV, and currently SARS-CoV-2 (COVID-19), the causative agent of coronavirus disease in 2019. COVID-19 has become a global public health emergency because of its high virulence and mortality capacity. This patent review aims to provide an overview of the patents that present possible treatments for SARS-CoV-1, SARS-CoV-2 and MERS-CoV., Areas Covered: To treat SARS, MERS and SARS-CoV-2, researchers have filed patents for a number of therapeutic agents. Most of the treatments found were protease inhibitors aimed at proteases such as PLpro, 3 CLpro, RNA helicase, and Spike protein, or used monoclonal antibodies and interferons. In addition, the use of Chinese folk medicine and its multitude of medicinal plants with strong antiviral properties was reinforced. Thus, these therapies used in previous epidemics can serve as an aid in the new pandemic by SARS-CoV-2 and be a starting point for new treatments., Expert Opinion: The various antiviral alternatives presented in this review offer therapeutic options to fight coronavirus infections. If shown to be effective, these drugs may be extremely important in the current pandemic.
- Published
- 2020
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