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14 results on '"Bretonniere, Cedric"'

1. Characteristics and Prognosis Factors of Pneumocystis jirovecii Pneumonia According to Underlying Disease: A Retrospective Multicenter Study

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Emmanuel Canet, Jean Reignier, Blanc, François Xavier, Bretonniere, Cédric, Morin, Paul, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Cady, Anne, Auger, Myriam, Pouedras, Pascal, Lavergne, Rose-anne, Canet, Emmanuel, Raffi, François, Néel, Antoine, Tessoulin, Benoît, and Gaborit, Benjamin

Published
2024
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4. Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial

Author

Chochrad, Didier, Dive, Alain, Foret, Frédéric, Simon, Marc, Spapen, Herbert, Creteur, Jacques, Bouckaert, Yves, Biston, Patrick, Bourgeois, Marc, Novacek, Martin, Vymazal, Tomas, Svoboda, Petr, Pachl, Jan, Sramek, Vladimir, Hanauer, Michal, Hruby, Tomas, Balik, Martin, Suchy, Tomas, Lepape, Alain, Argaud, Laurent, Dailler, Frédéric, Desachy, Arnaud, Guitton, Christophe, Mercat, Alain, Meziani, Ferhat, Navellou, Jean-Christophe, Robert, Rene, Souweine, Bertrand, Tadie, Jean-Marc, Maamar, Adel, Annane, Djillali, Tamion, Fabienne, Gros, Antoine, Nseir, Saad, Schwebel, Carole, Francony, Gilles, Lefrant, Jean-Yves, Schneider, Francis, Gründling, Matthias, Motsch, Johann, Reill, Lorenz, Rolfes, Caroline, Welte, Tobias, Cornely, Oliver, Bloos, Frank, Deja, Maria, Schmidt, Katrin, Wappler, Frank, Meier-Hellmann, Andreas, Komnos, Apostolos, Bekos, Vasileios, Koulouras, Vasilios, Soultati, Ioanna, Baltopoulos, Georgios, Filntisis, Georgios, Zakynthinos, Epaminondas, Zakynthinos, Spyros, Pnevmatikos, Ioannis, Krémer, Ildikó, Szentkereszty, Zoltán, Sarkany, Agnes, Marjanek, Zsuzsa, Moura, Pedro, Pintado Delgado, Maria Consuelo, Montejo González, Juan Carlos, Ramirez, Paula, Torres Marti, Antonio, Valia, Juan Carlos, Lorente, Jose, Loza Vazquez, Ana, De Pablo Sanchez, Raúl, Escudero, Dolores, Ferrer Roca, Ricard, Pagani, Jean-Luc, Maggiorini, Marco, François, Bruno, Jafri, Hasan S, Chastre, Jean, Sánchez-García, Miguel, Eggimann, Philippe, Dequin, Pierre-François, Huberlant, Vincent, Viña Soria, Lucia, Boulain, Thierry, Bretonnière, Cédric, Pugin, Jérôme, Trenado, Josep, Hernandez Padilla, Ana Catalina, Ali, Omar, Shoemaker, Kathryn, Ren, Pin, Coenjaerts, Frank E, Ruzin, Alexey, Barraud, Olivier, Timbermont, Leen, Lammens, Christine, Pierre, Vadryn, Wu, Yuling, Vignaud, Julie, Colbert, Susan, Bellamy, Terramika, Esser, Mark T, Dubovsky, Filip, Bonten, Marc J, Goossens, Herman, and Laterre, Pierre-François

Published
2021
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5. Community-acquired bacterial meningitis in adults: in-hospital prognosis, long-term disability and determinants of outcome in a multicentre prospective cohort

Author

Duval, Xavier, Hoen, Bruno, Mourvillier, Bruno, Ploy, Marie-Cécile, Tubiana, Sarah, Varon, Emmanuelle, Caron, François, Bollaert, Pierre-Edouard, Gaillot, Olivier, Taha, Muhamed-Kheir, Poyart, Claire, Bonacorsi, Stephane, Vandenesch, François, Cambau, Emmanuelle, Lecuit, Marc, Gravet, Alain, Frachet, Bruno, Broucker, Thomas De, Levy Bruhl, Daniel, Raffi, François, Anguel, Nadia, Argaud, Laurent, Arista, Sophie, Armand-Lefevre, Laurence, Balavoine, Stéphanie, Baraduc, Régine, Barnaud, Guilène, Beraud, Guillaume, Bernard, Louis, Bernars, Georges, Bertei, Dominique, Bessede, Emilie, Billard Pomares, Typhaine, Biron, Charlotte, Bland, Stéphane, Boileau, Julien, Boubeau, Patrice, Bourdon, Sandra, Bousquet, Aurore, Boyer, Sophie, Bozorg-Grayeli, Alexis, Bret, Laurent, Bretonniere, Cédric, Bricaire, François, Brocas, Elsa, Brun, Michel, Buret, Jennifer, Burucoa, Christophe, Cabalion, Jean, Cabon, Mathieu, Camuset, Guillaume, Canevet, Christophe, Carricajo, Anne, Castan, Bernard, Caumes, Eric, Cazanave, Charles, Chabrol, Amélie, Challan-Belval, Thibaut, Chanteperdrix-Marillier, Vanessa, Chaplain, Chantal, Charlier-Woerther, Caroline, Chaussade, Hélène, Chirouze, Catherine, Clair, Bernard, Colot, Julien, Conil, Jean-Marie, Cordel, Hugues, Cormier, Philippe, Cousson, Joël, Cronier, Pierrick, Cua, Eric, Dao-Dubremetz, Anne, Dargere, Sylvie, Degand, Nicolas, Dekeyser, Sophie, Delaune, Deborah, Denes, Eric, Dequin, Pierre-Francois, Descamps, Diane, Descloux, Elodie, Desmaretz, Jean-Luc, Diehl, Jean-Luc, Dimet, Jérôme, Dinh, Aurélien, Escaut, Lelia, Fabe, Claude, Faibis, Frédéric, Flateau, Clara, Fonsale, Nathalie, Forestier, Emmanuel, Fortineau, Nicolas, Gagneux-Brunon, Amandine, Garandeau, Garcia, Magali, Garot, Denis, Gaudry, Stéphane, Goehringer, François, Gregoire-Faucher, Valérie, Grosset, Marine, Gubavu, Camélia, Gueit, Isabelle, Guelon, Dominique, Guimard, Thomas, Guinard, Jérôme, Hadou, Tahar, Helene, Jean-Pierre, Henard, Sandrine, Henry, Benoit, Hochart, Anne-Cécile, Illes, Gabriela, Jaffuel, Sylvain, Jarrin, Irène, Jaureguy, Françoise, Joseph, Cédric, Juvin, Marie-Emmanuelle, Kayal, Samer, Lacassin, Flore, Lamaury, Isabelle, Lanotte, Philippe, Laurens, Etienne, Laurichesse, Henri, Le Brun, Cécile, Le Moing, Vincent, Le Turnier, Paul, Lecuyer, Hervé, Ledru, Sylvie, Legrix, Céline, Lemaignen, Adrien, Lemble, Chantal, Lemee, Ludovic, Lesens, Olivier, Levast, Marion, Lhommet, Claire, Males, Silvija, Malpote, Edith, Martin-Blondel, Guillaume, Marx, Matthieu, Masson, Raphael, Matray, Olivier, Mbadi, Aurore, Mechai, Frédéric, Mellon, Guillaume, Merens, Audrey, Meyohas, Marie Caroline, Michon, Adrien, Mootien Yoganaden, Joy, Morquin, David, Mouly, Stéphane, Mrozek, Natacha, Nguyen, Sophie, Nguyen, Yohan, Ogielska, Maja, Oziol, Eric, Page, Bernard, Patrat-Delon, Solène, Patry, Isabelle, Pechinot, André, Picot, Sandrine, Pierrejean, Piroth, Lionel, Plassart, Claire, Plessis, Patrice, Portel, Laurent, Poubeau, Patrice, Poupard, Marie, Prazuck, Thierry, Quaesaet, Luc, Ramanantsoa, Adriatsiferana, Rapp, Christophe, Raskine, Laurent, Raymond, Josette, Revest, Matthieu, Riche, Agnès, Robaday-Voisin, Stéphanie, Robin, Frédéric, Romaszko, Jean-Pierre, Rousseau, Florence, Roux, Anne-Laure, Royer, Cecile, Saada, Matthieu, Salmon, Dominique, Saroufim, Carlo, Schmit, Jean-Luc, Sebire, Manuela, Segonds, Christine, Sivadon-Tardy, Valérie, Soismier, Nathalie, Kerneis, Solen, Son, Olivia, Sunder, Simon, Suy, Florence, Tande, Didier, Tankovic, Jacques, Valin, Nadia, Van Grunderbeeck, Nicolas, Verdon, Renaud, Vergnaud, Michel, Vernet-Garnier, Véronique, Vidal, Magali, Vitrat, Virginie, Vittecoq, Daniel, Vuotto, Fanny, Coordination and statistical analyses, Gorenne, Isabelle, Laouenan, Cédric, Marcault, Estelle, Mentre, France, Pasquet, Blandine, Roy, Carine, Tubiana, S., Varon, E., Biron, C., Ploy, M.-C., Mourvillier, B., Taha, M.-K., Revest, M., Poyart, C., Martin-Blondel, G., Lecuit, M., Cua, E., Pasquet, B., Preau, M., Hoen, B., and Duval, X.

Published
2020
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6. Should We Reconsider Pneumocystis Pneumonia Presentation and Treatment According to Its Underlying Disease?: An Unsupervised Cluster Analysis of a Retrospective Multicenter Study

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Pineau, Valentin, Prime, Marie, Delaunay, Clarisse, Essid, Hakim, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Jean Reignier, Mickael Vourc’h, Canet, Emmanuel, Blanc, François Xavier, Bretonniere, Cédric, Morin, Jean, Le Blanc, Camille, Alami, Hakim, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Anne Cady, Romain Lécuyerand, Auger, Myriam, Pouedras, Pascal, Gaborit, Benjamin, Lavergne, Rose-anne, Raffi, François, Cady, Anne, Néel, Antoine, and Tessoulin, Benoît

Published
2024
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7. Multicentric Standardized Flow Cytometry Routine Assessment of Patients With Sepsis to Predict Clinical Worsening

Author

Di Vittorio, Adollës, Lachot, Sébastien, Georget, Marie-Thérèse, Hanna, Joelle, Bretonnière, Cédric, Zambon, Olivier, Nicolet, Laurent, Brule, Noëlle, Debord, Camille, Le Bris, Yannick, Robillard, Nelly, Dargent, Auguste, Bretagnol, Anne, Mathonnet, Armelle, Boulain, Thierry, Barbier, François, Benzekri, Dalila, Runge, Isabelle, Kamel, Toufik, Cecchini, Jérôme, Bouyer, Sabrina, Robert, René, Ouattara, Alexandre, Daix, Thomas, Guerin, Estelle, Tavernier, Elsa, Mercier, Emmanuelle, Gissot, Valérie, Hérault, Olivier, Mira, Jean-Paul, Dumas, Florence, Chapuis, Nicolas, Guitton, Christophe, Béné, Marie C., Quenot, Jean-Pierre, Tissier, Cindy, Guy, Julien, Piton, Gaël, Roggy, Anne, Muller, Grégoire, Legac, Éric, de Prost, Nicolas, Khellaf, Mehdi, Wagner-Ballon, Orianne, Coudroy, Rémi, Dindinaud, Elodie, Uhel, Fabrice, Roussel, Mikaël, Lafon, Thomas, Jeannet, Robin, Vargas, Frédéric, Fleureau, Catherine, Roux, Mickaël, Allou, Kaoutar, Vignon, Philippe, Feuillard, Jean, and François, Bruno

Published
2018
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10. Improving the Diagnosis of the Frontal Variant of Alzheimer's Disease with the DAPHNE Scale.

Author

Lehingue, Elsa, Gueniat, Julien, Jourdaa, Sandra, Hardouin, Jean Benoît, Pallardy, Amandine, Courtemanche, Hélène, Rocher, Laetitia, Etcharry-Bouyx, Frédérique, Auriacombe, Sophie, Mollion, Hélène, Formaglio, Maite, Rouaud, Olivier, Bretonniere, Cedric, Thomas-Anterion, Catherine, Boutoleau-Bretonniere, Claire, Hardouin, Jean BenoÎt, Rocher, Laëtitia, Formaglio, Maité, Bretonnière, Cédric, and Thomas-Antérion, Catherine

Subjects
ALZHEIMER'S disease, SENSITIVITY & specificity (Statistics), FRONTAL lobe, MEDICAL personnel, CAREGIVERS, FRONTAL lobe diseases
Abstract

Background: The frontal variant of Alzheimer's disease (fAD) is poorly understood and poorly defined. The diagnosis remains challenging. The main differential diagnosis is the behavioral variant of frontotemporal degeneration (bvFTD). For fAD, there is some dissociation between the clinical frontal presentation and imaging and neuropathological studies, which do not always find a specific involvement of the frontal lobes. DAPHNE is a behavioral scale, which demonstrated excellent performance to distinguish between bvFTD and AD.Objective: The aim of the present study was to assess the reliability of this new tool to improve the clinical diagnosis of fAD.Methods: Twenty fAD patients and their caregivers were prospectively included and were compared with 36 bvFTD and 22 AD patients.Results: The three main behavioral disorders in the fAD patients were apathy, loss of empathy, and disinhibition. Three disorders were discriminant because they were less frequent and less severe in the fAD patients than in the bvFTD patients, namely hyperorality, neglect, and perseverations. This specific pattern of behavioral disorders was corroborated by SPECT or 18FDG PET-CT scan that showed that patients with fAD could have a medial frontal hypoperfusion, whereas in bvFTD patients the orbitofrontal cortex was the main involved region, with more diffuse hypoperfusion.Conclusion: We demonstrated that DAPHNE had good sensitivity and good specificity to discriminate between the three groups and in particular between fAD and bvFTD patients. DAPHNE is a quick tool that could help clinicians in memory clinics not only to differentiate bvFTD from typical AD but also from fAD. [ABSTRACT FROM AUTHOR]

Published
2021
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11. Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Asseray, Nathalie, Gregoire, Matthieu, Bellouard, Ronan, Deslandes, Guillaume, Dailly, Eric, Leroy, Anne-Gaëlle, Corvec, Stéphane, Bémer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Lakhal, Karim, Cinotti, Raphaël, Canet, Emmanuel, Bretonniere, Cédric, Guimard, Thomas, Brochard, Julia, Talarmin, Jean Philippe, Katchatourian, Lydie, Le Turnier, P., Gregoire, M., Deslandes, G., Lakhal, K., Deschanvres, C., Lecomte, R., Talarmin, J.-P., Dubée, V., Bellouard, R., Boutoille, D., Leroy, A.-G., and Gaborit, B.J.

Published
2020
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13. Determinants of Recovery from Severe Posterior Reversible Encephalopathy Syndrome.

Author

Legriel, Stephane, Schraub, Olivier, Azoulay, Elie, Hantson, Philippe, Magalhaes, Eric, Coquet, Isaline, Bretonniere, Cedric, Gilhodes, Olivier, Anguel, Nadia, Megarbane, Bruno, Benayoun, Laurent, Schnell, David, Plantefeve, Gaetan, Charpentier, Julien, Argaud, Laurent, Mourvillier, Bruno, Galbois, Arnaud, Chalumeau-Lemoine, Ludivine, Rivoal, Michel, and Durand, François

Subjects
CLINICAL trials, SEIZURES (Medicine), BRAIN imaging, DRUG toxicity, PREECLAMPSIA, HEMORRHAGE
Abstract

Objective: Few outcome data are available about posterior reversible encephalopathy syndrome (PRES). We studied 90-day functional outcomes and their determinants in patients with severe PRES. Design: 70 patients with severe PRES admitted to 24 ICUs in 2001-2010 were included in a retrospective cohort study. The main outcome measure was a Glasgow Outcome Scale (GOS) of 5 (good recovery) on day 90. Main Results: Consciousness impairment was the most common clinical sign, occurring in 66 (94%) patients. Clinical seizures occurred in 57 (81%) patients. Median mean arterial pressure was 122 (105-143) mmHg on scene. Cerebral imaging abnormalities were bilateral (93%) and predominated in the parietal (93%) and occipital (86%) white matter. Median number of brain areas involved was 4 (3-5). Imaging abnormalities resolved in 43 (88%) patients. Ischaemic and/or haemorrhagic complications occurred in 7 (14%) patients. The most common causes were drug toxicity (44%) and hypertensive encephalopathy (41%). On day 90, 11 (16%) patients had died, 26 (37%) had marked functional impairments (GOS, 2 to 4), and 33 (56%) had a good recovery (GOS, 5). Factors independently associated with GOS<5 were highest glycaemia on day 1 (OR, 1.22; 95%CI, 1.02-1.45, p = 0.03) and time to causative-factor control (OR, 3.3; 95%CI, 1.04-10.46, p = 0.04), whereas GOS = 5 was associated with toxaemia of pregnancy (preeclampsia/eclampsia) (OR, 0.06; 95%CI, 0.01-0.38, p = 0.003). Conclusions: By day 90 after admission for severe PRES, 44% of survivors had severe functional impairments. Highest glycaemia on day 1 and time to causative-factor control were strong early predictors of outcomes, suggesting areas for improvement. [ABSTRACT FROM AUTHOR]

Published
2012
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14. Performance of the Cepheid Methicillin-Resistant Staphylococcus aureus/S. aureus Skin and Soft Tissue Infection PCR Assay on Respiratory Samples from Mechanically Ventilated Patients for S. aureus Screening during the Phase 2 Double-Blind SAATELLITE Study.

Author

Ruzin A, Barraud O, Yu L, François B, Sánchez-Garcia M, Eggimann P, Dequin PF, Laterre PF, Huberlant V, Viña L, Boulain T, Bretonniere C, Pugin J, Trenado J, Hernandez Padilla AC, Vignaud J, Vandamme D, Goossens H, Lammens C, Ali SO, Shoemaker K, Ren P, Colbert S, Bellamy T, Sellman BR, McCarthy M, Jafri HS, and Esser MT

Subjects
Humans, Real-Time Polymerase Chain Reaction, Respiration, Artificial adverse effects, Staphylococcus aureus genetics, Methicillin-Resistant Staphylococcus aureus genetics, Soft Tissue Infections, Staphylococcal Infections diagnosis, Staphylococcal Infections drug therapy
Abstract

We investigated the performance of the Xpert methicillin-resistant Staphylococcus aureus (MRSA)/S. aureus skin and soft tissue (SSTI) quantitative PCR (qPCR) assay in SAATELLITE, a multicenter, double-blind, phase 2 study of suvratoxumab, a monoclonal antibody (MAb) targeting S. aureus alpha-toxin, for reducing the incidence of S. aureus pneumonia. The assay was used to detect methicillin-susceptible S. aureus (MSSA) and MRSA in lower respiratory tract (LRT) samples from mechanically ventilated patients. LRT culture results were compared with S. aureus protein A ( spa ) gene cycle threshold ( C T ) values. Receiver operating characteristic (ROC) and Youden index were used to determine the C T cutoff for best separation of culture-S. aureus-negative and S. aureus-positive patients. Of 720 screened subjects, 299 (41.5%) were S. aureus positive by qPCR, of whom 209 had culture data: 162 (77.5%) were S. aureus positive and 47 (22.5%) were S. aureus negative. Culture results were negatively affected by antibiotic use and cross-laboratory variability. An inverse linear correlation was observed between C T values and quantitative S. aureus culture results. A spa C T value of 29 (≈2 × 10 3 CFU/mL) served as the best cutoff for separation between culture-negative and culture-positive samples. The associated area under the ROC curve was 83.8% (95% confidence interval [CI], 78 to 90%). Suvratoxumab provided greater reduction in S. aureus pneumonia or death than placebo in subjects with low S. aureus load ( C T  ≥ 29; relative risk reduction [RRR], 50.0%; 90% CI, 2.7 to 74.4%) versus the total study population (RRR, 25.2%; 90% CI, -4.3 to 46.4%). The qPCR assay was easy to perform, sensitive, and standardized and provided better sensitivity than conventional culture for S. aureus detection. Quantitative PCR C T output correlated with suvratoxumab efficacy in reducing S. aureus pneumonia incidence or death in S. aureus-colonized, mechanically ventilated patients.

Published
2022
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