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283 results on '"Butel, Janet S."'

19. Cell Transformation by Viruses

Author

Melnick, Joseph L., Butel, Janet S., Tevethia, Satvir S., Biswal, Nilambar, and Benyesh-Melnick, Matilda

Published
1971

21. Lymphotropism of Merkel cell polyomavirus infection, Nova Scotia, Canada

Author

Toracchio, Sonia, Foyle, Annette, Sroller, Vojtech, Reed, Jon A., Wu, Jun, Kozinetz, Claudia A., and Butel, Janet S.

Subjects
Merkel cell carcinoma -- Diagnosis -- Development and progression, Lymph nodes -- Research -- Physiological aspects, Lymphocytes -- Research -- Physiological aspects, Disease susceptibility -- Research, Virus diseases -- Diagnosis -- Development and progression, Health
Abstract

Merkel cell polyomavirus (MCPyV) was first described in 2008 (1) as a new human virus associated with Merkel cell carcinoma (MCC), an uncommon but aggressive form of skin cancer. Subsequent [...]

Published
2010
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23. Bed rest and immunity

Author

Sonnenfeld, Gerald, Aviles, Hernan, Butel, Janet S., Shearer, William T., Niesel, David, Pandya, Utpal, Allen, Christopher, Ochs, Hans D., Blancher, Antoine, and Abbal, Michel

Published
2007
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42. Simian Virus 40 in human Cancers

Author

Vilchez, Regis A., Kozinetz, Claudia A., Arrington, Amy S., Madden, Charles R., and Butel, Janet S.

Subjects
Non-Hodgkin's lymphomas -- Causes of, Brain cancer -- Causes of, SV40 (Virus) -- Risk factors, SV40 (Virus) -- Analysis, Medicine, Experimental, Medical research, Health, Health care industry
Published
2003

44. Effects of the space flight environment on the immune system

Author

Sonnenfeld, Gerald, Butel, Janet S, and Shearer, William T

Subjects
Life Sciences (General)
Abstract

Space flight conditions have a dramatic effect on a variety of physiologic functions of mammals, including muscle, bone, and neurovestibular function. Among the physiological functions that are affected when humans or animals are exposed to space flight conditions is the immune response. The focus of this review is on the function of the immune system in space flight conditions during actual space flights, as well as in models of space flight conditions on the earth. The experiments were carried out in tissue culture systems, in animal models, and in human subjects. The results indicate that space flight conditions alter cell-mediated immune responses, including lymphocyte proliferation and subset distribution, and cytokine production. The mechanism(s) of space flight-induced alterations in immune system function remain(s) to be established. It is likely, however, that multiple factors, including microgravity, stress, neuroendocrine factors, sleep disruption, and nutritional factors, are involved in altering certain functions of the immune system. Such alterations could lead to compromised defenses against infections and tumors.

Published
2003

46. Association between simian virus 40 and non-Hodgkin lymphoma

Author

Vilchez, Regis A, Madden, Charles R, Kozinetz, Claudia A, Halvorson, Steven J, White, Zoe S, Jorgensen, Jeffrey L, Finch, Chris J, and Butel, Janet S

Subjects
Life Sciences (General)
Abstract

BACKGROUND: Non-Hodgkin lymphoma has increased in frequency over the past 30 years, and is a common cancer in HIV-1-infected patients. Although no definite risk factors have emerged, a viral cause has been postulated. Polyomaviruses are known to infect human beings and to induce tumours in laboratory animals. We aimed to identify which one of the three polyomaviruses able to infect human beings (simian virus 40 [SV40], JC virus, and BK virus) was associated with non-Hodgkin lymphoma. METHODS: We analysed systemic non-Hodgkin lymphoma from 76 HIV-1-infected and 78 HIV-1-uninfected patients, and non-malignant lymphoid samples from 79 HIV-1-positive and 107 HIV-1-negative patients without tumours; 54 colon and breast carcinoma samples served as cancer controls. We used PCR followed by Southern blot hybridisation and DNA sequence analysis to detect DNAs of polyomaviruses and herpesviruses. FINDINGS: Polyomavirus T antigen sequences, all of which were SV40-specific, were detected in 64 (42%) of 154 non-Hodgkin lymphomas, none of 186 non-malignant lymphoid samples, and none of 54 control cancers. This difference was similar for HIV-1-infected patients and HIV-1-uninfected patients alike. Few tumours were positive for both SV40 and Epstein-Barr virus. Human herpesvirus type 8 was not detected. SV40 sequences were found most frequently in diffuse large B-cell and follicular-type lymphomas. INTERPRETATION: SV40 is significantly associated with some types of non-Hodgkin lymphoma. These results add lymphomas to the types of human cancers associated with SV40.

Published
2002
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47. PCR detection and DNA sequence analysis of the regulatory region of lymphotropic papovavirus in peripheral blood mononuclear cells of an immunocompromised rhesus macaque

Author

Lednicky, John A, Halvorson, Steven J, and Butel, Janet S

Subjects
Life Sciences (General)
Abstract

A lymphotropic papovavirus (LPV) archetypal regulatory region was amplified from DNA from the blood of an immunocompromised rhesus monkey. We believe this is the first nonserological evidence of LPV infection in rhesus monkeys.

Published
2002
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