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1. A global inventory of photovoltaic solar energy generating units

Author

Kruitwagen, L., Story, K. T., Friedrich, J., Byers, L., Skillman, S., and Hepburn, C.

Subjects
Electric power production -- Environmental aspects, Photovoltaic power generation -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Photovoltaic (PV) solar energy generating capacity has grown by 41 per cent per year since 2009.sup.1. Energy system projections that mitigate climate change and aid universal energy access show a nearly ten-fold increase in PV solar energy generating capacity by 2040.sup.2,3. Geospatial data describing the energy system are required to manage generation intermittency, mitigate climate change risks, and identify trade-offs with biodiversity, conservation and land protection priorities caused by the land-use and land-cover change necessary for PV deployment. Currently available inventories of solar generating capacity cannot fully address these needs.sup.1-9. Here we provide a global inventory of commercial-, industrial- and utility-scale PV installations (that is, PV generating stations in excess of 10 kilowatts nameplate capacity) by using a longitudinal corpus of remote sensing imagery, machine learning and a large cloud computation infrastructure. We locate and verify 68,661 facilities, an increase of 432 per cent (in number of facilities) on previously available asset-level data. With the help of a hand-labelled test set, we estimate global installed generating capacity to be 423 gigawatts (-75/+77 gigawatts) at the end of 2018. Enrichment of our dataset with estimates of facility installation date, historic land-cover classification and proximity to vulnerable areas allows us to show that most of the PV solar energy facilities are sited on cropland, followed by aridlands and grassland. Our inventory could aid PV delivery aligned with the Sustainable Development Goals. A global inventory of utility-scale solar photovoltaic generating units, produced by combining remote sensing imagery with machine learning, has identified 68,661 facilities -- an increase of over 400% on previously available asset-level data -- the majority of which were sited on cropland., Author(s): L. Kruitwagen [sup.1] , K. T. Story [sup.2] , J. Friedrich [sup.3] , L. Byers [sup.3] , S. Skillman [sup.2] , C. Hepburn [sup.1] Author Affiliations: (1) Smith School [...]

Published
2021
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2. Video-Based, Patient-Focused Opioid Education in the Perioperative Period Increases Self-Perceived Opioid-Related Knowledge: A Pilot Study

Author

Goree JH, Srinivasan N, Cucciare MA, Zaller N, Byers L, Boateng B, and Hayes CJ

Subjects
opioids, perioperative, video education, acute pain, chronic pain, ambulatory surgery, Medicine (General), R5-920
Abstract

Johnathan H Goree,1 Nivetha Srinivasan,2 Michael A Cucciare,3– 5 Nickolas Zaller,6 Lauren Byers,1 Beatrice Boateng,7 Corey J Hayes4,8 1Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 2College of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA; 3Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 4Center for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Affairs Healthcare System, North Little Rock, AR, USA; 5Veterans Affairs South Central Mental Illness Research, Education and Clinical Center, Central Arkansas Veterans Healthcare System, North Little Rock, AR, USA; 6Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 7Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 8Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USACorrespondence: Johnathan H GoreeUniversity of Arkansas for Medical Sciences, Department of Anesthesiology, 4301 West Markham Street, Box 515, Little Rock, AR, 72205, USATel +1 501-686-8818Fax +1 501-526-7217Email Jhgoree@uams.eduObjective: The aim of this study was to evaluate whether a video-based, patient-focused opioid education tool delivered in the perioperative period would decrease acute and chronic post-operative opioid prescription dispensations and increase self-rated knowledge about opioids.Methods: We enrolled 110 patients with no reported opioid use in the previous 30 days, undergoing ambulatory surgery for breast, orthopedic, gynecologic, or other outpatient procedures for which opioids would be prescribed. Patients were randomized to receive either post-operative opioid education by the surgical team (control arm) or pre-operative education via a novel 5-minute video plus post-operative education by the surgical team (intervention arm). All patients received follow-up phone calls on post-operative day (POD) 7 to assess self-rated knowledge of opioids on a scale of 1 to 10, 10 being most informed, and self-reported opioid use (primary outcome). Arkansas Prescription Drug Monitoring Program (AR PDMP) data were obtained to assess opioid dispensations at POD 90– 150 days.Results: Seventy-seven percent of participants completed POD7 survey. Participants in the intervention arm rated their knowledge of opioids after surgery significantly higher than those in the control arm (p=0.013). Data from the AR PDMP reveal trends (non-significant) that show increased use of opioids in the control group when compared to the video intervention group at POD 30 (88.7% vs 76%) and POD 90– 150 (22.6% vs 10%).Conclusion: Video-based, patient-focused opioid education can be effectively implemented in a large university hospital during the perioperative period and is effective for increasing a patient’s perception of opioid-related knowledge. A fully powered, randomized control trial is needed to further explore observed trends and determine if this novel tool can decrease chronic post-operative opioid dispensations.Keywords: opioids, perioperative, video education, acute pain, chronic pain, ambulatory surgery

Published
2021

16. Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

Author

Lazar, AJ, McLellan, MD, Bailey, MH, Miller, CA, Appelbaum, EL, Cordes, MG, Fronick, CC, Fulton, LA, Fulton, RS, Mardis, ER, Schmidt, HK, Wong, W, Wilson, RK, Yellapantula, V, Radenbaugh, AJ, Hoadley, KA, Hayes, DN, Parker, JS, Wilkerson, MD, Auman, JT, Balu, S, Bodenheimer, T, Hoyle, AP, Jefferys, SR, Jones, CD, Lehmann, K-V, Meng, S, Mieczkowski, PA, Mose, LE, Perou, CM, Roach, J, Senbabaoglu, Y, Shi, Y, Simons, JV, Skelly, T, Soloway, MG, Tan, D, Veluvolu, U, Davis, IJ, Hepperla, AJ, Brohl, AS, Kasaian, K, Mungall, K, Sadeghi, S, Barthel, FP, Verhaak, R, Hu, X, Chibon, F, Cherniack, AD, Shih, J, Beroukhim, R, Meyerson, M, Cibulskis, C, Gabriel, SB, Saksena, G, Schumacher, SE, Gao, Q, Wyczalkowski, M, Bowlby, R, Robertson, AG, Ally, A, Balasundaram, M, Brooks, D, Carlsen, R, Chuah, E, Dhalla, N, Holt, RA, Jones, SJM, Lee, D, Li, I, Ma, Y, Marra, MA, Mayo, M, Moore, RA, Mungall, AJ, Schein, JE, Sipahimalani, P, Tam, A, Thiessen, N, Wong, T, Danilova, L, Cope, L, Baylin, SB, Bootwalla, MS, Lai, PH, Laird, PW, Maglinte, DT, Van Den Berg, DJ, Weisenberger, DJ, Wrangle, J, Drill, E, Shen, R, Iype, L, Reynolds, SM, Shmulevich, I, Yau, C, Armenia, J, Liu, EM, Benz, C, Pastore, A, Sanchez-Vega, F, Schultz, N, Akbani, R, Hegde, AM, Liu, W, Lu, Y, Mills, GB, Weinstein, JN, Roszik, J, Anur, P, Spellman, P, Abeshouse, A, Chen, H-W, Gao, J, Heins, Z, Kundra, R, Larsson, E, Ochoa, A, Sander, C, Socci, N, Zhang, H, Noble, MS, Heiman, DI, Kim, J, Chin, L, Getz, G, Cho, J, Defreitas, T, Frazer, S, Gehlenborg, N, Lawrence, MS, Lin, P, Meier, S, Voet, D, Byers, L, Diao, L, Gay, CM, Wang, J, Newton, Y, Cooper, LAD, Gutman, DA, Lee, S, Nalisnik, M, Bowen, J, Gastier-Foster, JM, Gerken, M, Helsel, C, Hobensack, S, Leraas, KM, Lichtenberg, TM, Ramirez, NC, Wise, L, Zmuda, E, Anderson, ML, Castro, P, Ittmann, M, Gordienko, E, Paklina, O, Setdikova, G, Raut, CP, Karlan, BY, Lester, J, Belyaev, D, Fulidou, V, Potapova, O, Voronina, O, Demetri, GD, Ramalingam, SS, Behera, M, Delman, K, Owonikoko, TK, Sica, GL, Boyd, J, Magliocco, A, Salner, A, Bennett, J, Iacocca, M, Swanson, P, Dottino, P, Kalir, T, Pereira, E, Akeredolu, T, Crain, D, Curley, E, Gardner, J, Mallery, D, Morris, S, Paulauskis, J, Penny, R, Shelton, C, Shelton, T, Thompson, E, Hoon, DB, Parfitt, J, Birrer, M, Karseladze, A, Mariamidze, A, Dao, F, Levine, DA, Olvera, N, Maki, RG, Bartlett, J, Eschbacher, J, Dubina, M, Mozgovoy, E, Fedosenko, K, Manikhas, G, Sekhon, H, Ramirez, N, Ingram, DR, Torres, KE, DiSaia, P, Godwin, AK, Godwin, EM, Kuo, H, Madan, R, Reilly, C, Adebamowo, C, Adebamowo, SN, Bocklage, T, Higgins, K, Martinez, C, Boice, L, Grilley-Olson, JE, Huang, M, Perou, AH, Thorne, LB, Rathmell, WK, Gutmann, DH, Singer, S, Chudamani, S, Liu, J, Lolla, L, Naresh, R, Pihl, T, Sun, Q, Wan, Y, Wu, Y, Felau, I, Zenklusen, JC, Demchok, JA, Ferguson, ML, Hutter, CM, Sofia, HJ, Tarnuzzer, R, Wang, Z, Yang, L, Zhang, JJ, Demicco, EG, Doyle, LA, Hornick, JL, Rubin, BP, de Rijn, MV, Baker, L, Riedel, RF, Ding, L, Ladanyi, M, Novak, JE, Van Tine, BA, Davis, LE, Grilley-Olsen, JE, Pollock, RE, Jones, KB, Martignetti, JA, Tong, P, and Network, CGAR

Subjects
0301 basic medicine, Leiomyosarcoma, Adult, Epigenomics, DNA Copy Number Variations, Genomics, Biology, General Biochemistry, Genetics and Molecular Biology, Undifferentiated Pleomorphic Sarcoma, Article, 03 medical and health sciences, Young Adult, 0302 clinical medicine, medicine, Cluster Analysis, Humans, ATRX, Aged, Comparative genomics, Aged, 80 and over, Genome, Human, Sarcoma, Middle Aged, medicine.disease, Synovial sarcoma, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, DNA methylation, Mutation, Cancer research, Genome-Wide Association Study
Abstract

Summary Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes ( TP53 , ATRX , RB1 ) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types.

Published
2017
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19. OA13.06 Surgical Outcomes Following Neoadjuvant Nivolumab or Nivolumab Plus Ipilimumab in Non-Small Cell Lung Cancer - NEOSTAR Study

Author

Sepesi, B., Cascone, T., William, W., Lin, H., Leung, C., Weissferdt, A., Walsh, G., Rice, D., Roth, J., Mehran, R., Hofstetter, W., Antonoff, M., Fossella, F., Mott, F., Le, X., Skoulidis, F., Zhang, J., Byers, L., Lam, V., Glisson, B., Kurie, J., Blumenschein, G., Tsao, A., Lu, C., Altan, M., Elamin, Y., Gibbons, D., Papadimitrakopoulou, V., Lee, J., Heymach, J., Vaporciyan, A., and Swisher, S.

Published
2019
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39. Stories told and lessons learned from African American female caregivers' vignettes for empowerment practice.

Author

Chadiha LA, Adams P, Phorano O, Ong SL, and Byers L

Abstract

In a group context, African American women told stories about their caregiving experiences. We audiotaped these stories and constructed vignettes that served as cases from the field. Lessons learned from vignettes about challenges and strengths in caregiving inform empowerment group practice with African American women caregivers of African American elders. [ABSTRACT FROM AUTHOR]

Published
2002

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