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1. Patient care pathway hypnosedation in endo urology: An innovative alternative to general anesthesia

Author

S. Fakhfakh, C. Pouliquen, J. Campagna, K. Loverde, P. Treacy, T. Maubon, S. Rybikowski, S. Cambon, L. Nguyen, J. Deguibert, M.A. Laurent, J. Aveno, E. Bokor, C. Demontis, C. Forestier, F. Bereni, J. Galland, C. Montoya, I. Mejri, C. Cea, M. Faucher, D. Mokart, G. Pignot, and J. Walz

Subjects
Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2020
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2. Valorization of Agricultural Rice Straw as a Sustainable Feedstock for Rigid Polyurethane/Polyisocyanurate Foam Production

Author

Roger G. Dingcong, Mary Ann N. Ahalajal, Leanne Christie C. Mendija, Rosal Jane G. Ruda-Bayor, Felrose P. Maravillas, Applegen I. Cavero, Evalyn Joy C. Cea, Kaye Junelle M. Pantaleon, Kassandra Jayza Gift D. Tejas, Edison A. Limbaga, Gerard G. Dumancas, Roberto M. Malaluan, and Arnold A. Lubguban

Subjects
Chemistry, QD1-999
Published
2024
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6. Transverse target spin asymmetries in exclusive $\rho^0$ muoproduction

Author

Adolph, C.Universität Erlangen–Nürnberg, Physikalisches Institut, 91054 Erlangen, Germany 10, Akhunzyanov, R.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Alekseev, M.G.(Trieste Section of INFN, 34127 Trieste, Italy), Alexakhin, V.Yu.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Alexandrov, Yu.(Lebedev Physical Institute, 119991 Moscow, Russia), Alexeev, G.D.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Amoroso, A.(University of Turin, Department of Physics, 10125 Turin, Italy), Andrieux, V.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Anosov, V.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Austregesilo, A.(CERN, 1211 Geneva 23, Switzerland), Badełek, B.(University of Warsaw, Faculty of Physics, 00-681 Warsaw, Poland 19), Balestra, F.(University of Turin, Department of Physics, 10125 Turin, Italy), Barth, J.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Baum, G.(Universität Bielefeld Fakultät für Physik, 33501 Bielefeld, Germany 10 10 Supported by the German Bundesministerium für Bildung und Forschung.), Beck, R.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Bedfer, Y.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Berlin, A.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Bernhard, J.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Bertini, R.(University of Turin, Department of Physics, 10125 Turin, Italy), Bicker, K.(CERN, 1211 Geneva 23, Switzerland), Bieling, J.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Birsa, R.(Trieste Section of INFN, 34127 Trieste, Italy), Bisplinghoff, J.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Bodlak, M.(Charles University in Prague, Faculty of Mathematics and Physics, 18000 Prague, Czech Republic 11), Boer, M.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Bordalo, P.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Bradamante, F.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Braun, C.(Universität Erlangen–Nürnberg, Physikalisches Institut, 91054 Erlangen, Germany 10), Bravar, A.(Trieste Section of INFN, 34127 Trieste, Italy), Bressan, A.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Büchele, M.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Burtin, E.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Capozza, L.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Chiosso, M.(University of Turin, Department of Physics, 10125 Turin, Italy), Chung, S.U.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Cicuttin, A.(Abdus Salam ICTP, 34151 Trieste, Italy), Crespo, M.L.(Abdus Salam ICTP, 34151 Trieste, Italy), Curiel, Q.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Dalla Torre, S.(Trieste Section of INFN, 34127 Trieste, Italy), Dasgupta, S.S.(Matrivani Institute of Experimental Research & Education, Calcutta-700 030, India 12 12 Supported by SAIL (CSR), Govt. of India.), Dasgupta, S.(Trieste Section of INFN, 34127 Trieste, Italy), Denisov, O.Yu.(Torino Section of INFN, 10125 Turin, Italy), Donskov, S.V.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Doshita, N.(Yamagata University, Yamagata, 992-8510, Japan 15), Duic, V.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Dünnweber, W.(Ludwig-Maximilians-Universität München, Department für Physik, 80799 Munich, Germany 10 16 16 Supported by the DFG cluster of excellence ‘Origin and Structure of the Universe’ ( www.universe-cluster.de ).), Dziewiecki, M.(Warsaw University of Technology, Institute of Radioelectronics, 00-665 Warsaw, Poland 19), Efremov, A.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Elia, C.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Eversheim, P.D.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Eyrich, W.(Universität Erlangen–Nürnberg, Physikalisches Institut, 91054 Erlangen, Germany 10), Faessler, M.(Ludwig-Maximilians-Universität München, Department für Physik, 80799 Munich, Germany 10 16 16 Supported by the DFG cluster of excellence ‘Origin and Structure of the Universe’ ( www.universe-cluster.de ).), Ferrero, A.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Filin, A.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Finger, M.(Charles University in Prague, Faculty of Mathematics and Physics, 18000 Prague, Czech Republic 11), Fischer, H.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Franco, C.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), du Fresne von Hohenesche, N.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Friedrich, J.M.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Frolov, V.(CERN, 1211 Geneva 23, Switzerland), Garfagnini, R.(University of Turin, Department of Physics, 10125 Turin, Italy), Gautheron, F.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Gavrichtchouk, O.P.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Gerassimov, S.(Lebedev Physical Institute, 119991 Moscow, Russia), Geyer, R.(Ludwig-Maximilians-Universität München, Department für Physik, 80799 Munich, Germany 10 16 16 Supported by the DFG cluster of excellence ‘Origin and Structure of the Universe’ ( www.universe-cluster.de ).), Giorgi, M.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Gnesi, I.(University of Turin, Department of Physics, 10125 Turin, Italy), Gobbo, B.(Trieste Section of INFN, 34127 Trieste, Italy), Goertz, S.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Gorzellik, M.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Grabmüller, S.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Grasso, A.(University of Turin, Department of Physics, 10125 Turin, Italy), Grube, B.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Gushterski, R.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Guskov, A.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Guthörl, T.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Haas, F.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), von Harrach, D.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Hahne, D.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Hashimoto, R.(Yamagata University, Yamagata, 992-8510, Japan 15), Heinsius, F.H.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Herrmann, F.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Heß, C.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Hinterberger, F.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Höppner, Ch.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Horikawa, N.(Nagoya University, 464 Nagoya, Japan 15), d'Hose, N.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Huber, S.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Ishimoto, S.(Yamagata University, Yamagata, 992-8510, Japan 15), Ivanov, A.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Ivanshin, Yu.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Iwata, T.(Yamagata University, Yamagata, 992-8510, Japan 15), Jahn, R.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Jary, V.(Czech Technical University in Prague, 16636 Prague, Czech Republic 11), Jasinski, P.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Joerg, P.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Joosten, R.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Kabuß, E.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Kang, D.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Ketzer, B.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Khaustov, G.V.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Khokhlov, Yu.A.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Kisselev, Yu.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Klein, F.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Klimaszewski, K.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Koivuniemi, J.H.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Kolosov, V.N.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Kondo, K.(Yamagata University, Yamagata, 992-8510, Japan 15), Königsmann, K.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Konorov, I.(Lebedev Physical Institute, 119991 Moscow, Russia), Konstantinov, V.F.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Kotzinian, A.M.(University of Turin, Department of Physics, 10125 Turin, Italy), Kouznetsov, O.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Kral, Z.(Czech Technical University in Prague, 16636 Prague, Czech Republic 11), Krämer, M.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Kroumchtein, Z.V.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Kuchinski, N.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Kunne, F.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Kurek, K.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Kurjata, R.P.(Warsaw University of Technology, Institute of Radioelectronics, 00-665 Warsaw, Poland 19), Lednev, A.A.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Lehmann, A.(Universität Erlangen–Nürnberg, Physikalisches Institut, 91054 Erlangen, Germany 10), Levorato, S.(Trieste Section of INFN, 34127 Trieste, Italy), Lichtenstadt, J.(Tel Aviv University, School of Physics and Astronomy, 69978 Tel Aviv, Israel 18 18 Supported by the Israel Science Foundation, founded by the Israel Academy of Sciences and Humanities.), Maggiora, A.(Torino Section of INFN, 10125 Turin, Italy), Magnon, A.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Makke, N.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Mallot, G.K.(CERN, 1211 Geneva 23, Switzerland), Marchand, C.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Martin, A.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Marzec, J.(Warsaw University of Technology, Institute of Radioelectronics, 00-665 Warsaw, Poland 19), Matousek, J.(Charles University in Prague, Faculty of Mathematics and Physics, 18000 Prague, Czech Republic 11), Matsuda, H.(Yamagata University, Yamagata, 992-8510, Japan 15), Matsuda, T.(University of Miyazaki, Miyazaki 889-2192, Japan 15 15 Supported by the MEXT and the JSPS under the Grants Nos. 18002006, 20540299 and 18540281, Daiko Foundation and Yamada Foundation.), Meshcheryakov, G.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Meyer, W.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Michigami, T.(Yamagata University, Yamagata, 992-8510, Japan 15), Mikhailov, Yu.V.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Miyachi, Y.(Yamagata University, Yamagata, 992-8510, Japan 15), Nagaytsev, A.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Nagel, T.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Nerling, F.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Neubert, S.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Neyret, D.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Nikolaenko, V.I.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Novy, J.(Czech Technical University in Prague, 16636 Prague, Czech Republic 11), Nowak, W.-D.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Nunes, A.S.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Orlov, I.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Olshevsky, A.G.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Ostrick, M.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Panknin, R.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Panzieri, D.(University of Eastern Piedmont, 15100 Alessandria, Italy), Parsamyan, B.(University of Turin, Department of Physics, 10125 Turin, Italy), Paul, S.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Pesek, M.(Charles University in Prague, Faculty of Mathematics and Physics, 18000 Prague, Czech Republic 11), Peshekhonov, D.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Piragino, G.(University of Turin, Department of Physics, 10125 Turin, Italy), Platchkov, S.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Pochodzalla, J.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Polak, J.(Technical University in Liberec, 46117 Liberec, Czech Republic 11), Polyakov, V.A.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Pretz, J.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Quaresma, M.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Quintans, C.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Ramos, S.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Reicherz, G.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Rocco, E.(CERN, 1211 Geneva 23, Switzerland), Rodionov, V.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Rondio, E.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Rossiyskaya, N.S.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Ryabchikov, D.I.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Samoylenko, V.D.(State Research Center of the Russian Federation, Institute for High Energy Physics, 142281 Protvino, Russia), Sandacz, A.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Sapozhnikov, M.G.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Sarkar, S.(Matrivani Institute of Experimental Research & Education, Calcutta-700 030, India 12 12 Supported by SAIL (CSR), Govt. of India.), Savin, I.A.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Sbrizzai, G.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Schiavon, P.(University of Trieste, Department of Physics, 34127 Trieste, Italy), Schill, C.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Schlüter, T.(Ludwig-Maximilians-Universität München, Department für Physik, 80799 Munich, Germany 10 16 16 Supported by the DFG cluster of excellence ‘Origin and Structure of the Universe’ ( www.universe-cluster.de ).), Schmidt, A.(Universität Erlangen–Nürnberg, Physikalisches Institut, 91054 Erlangen, Germany 10), Schmidt, K.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Schmitt, L.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Schmïden, H.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, 53115 Bonn, Germany 10), Schönning, K.(CERN, 1211 Geneva 23, Switzerland), Schopferer, S.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Schott, M.(CERN, 1211 Geneva 23, Switzerland), Shevchenko, O.Yu.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Silva, L.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Sinha, L.(Matrivani Institute of Experimental Research & Education, Calcutta-700 030, India 12 12 Supported by SAIL (CSR), Govt. of India.), Sirtl, S.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Slunecka, M.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Sosio, S.(University of Turin, Department of Physics, 10125 Turin, Italy), Sozzi, F.(Trieste Section of INFN, 34127 Trieste, Italy), Srnka, A.(Institute of Scientific Instruments, AS CR, 61264 Brno, Czech Republic 11 11 Supported by Czech Republic MEYS Grants ME492 and LA242.), Steiger, L.(Trieste Section of INFN, 34127 Trieste, Italy), Stolarski, M.(LIP, 1000-149 Lisbon, Portugal 14 14 Supported by the Portuguese FCT – Fundação para a Ciência e Tecnologia, COMPETE and QREN, Grants CERN/FP/109323/2009, CERN/FP/116376/2010 and CERN/FP/123600/2011.), Sulc, M.(Technical University in Liberec, 46117 Liberec, Czech Republic 11), Sulej, R.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Suzuki, H.(Yamagata University, Yamagata, 992-8510, Japan 15), Szabelski, A.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Szameitat, T.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Sznajder, P.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Takekawa, S.(Torino Section of INFN, 10125 Turin, Italy), Ter Wolbeek, J.(Universität Freiburg, Physikalisches Institut, 79104 Freiburg, Germany 10 17), Tessaro, S.(Trieste Section of INFN, 34127 Trieste, Italy), Tessarotto, F.(Trieste Section of INFN, 34127 Trieste, Italy), Thibaud, F.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Uhl, S.(Technische Universität München, Physik Department, 85748 Garching, Germany 10 16), Uman, I.(Ludwig-Maximilians-Universität München, Department für Physik, 80799 Munich, Germany 10 16 16 Supported by the DFG cluster of excellence ‘Origin and Structure of the Universe’ ( www.universe-cluster.de ).), Vandenbroucke, M.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Virius, M.(Czech Technical University in Prague, 16636 Prague, Czech Republic 11), Vondra, J.(Czech Technical University in Prague, 16636 Prague, Czech Republic 11), Wang, L.(Universität Bochum, Institut für Experimentalphysik, 44780 Bochum, Germany 10 17 17 Supported by EU FP7 (HadronPhysics3, Grant Agreement number 283286).), Weisrock, T.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Wilfert, M.(Universität Mainz, Institut für Kernphysik, 55099 Mainz, Germany 10), Windmolders, R.(Universität Bonn, Physikalisches Institut, 53115 Bonn, Germany 10), Wiślicki, W.(National Centre for Nuclear Research, 00-681 Warsaw, Poland 19 19 Supported by the Polish NCN Grant DEC-2011/01/M/ST2/02350.), Wollny, H.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Zaremba, K.(Warsaw University of Technology, Institute of Radioelectronics, 00-665 Warsaw, Poland 19), Zavertyaev, M.(Lebedev Physical Institute, 119991 Moscow, Russia), Zemlyanichkina, E.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), Zhuravlev, N.(Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia 13 13 Supported by CERN-RFBR Grants 08-02-91009 and 12-02-91500.), and Ziembicki, M.(Warsaw University of Technology, Institute of Radioelectronics, 00-665 Warsaw, Poland 19)

Subjects
GENERALIZED PARTON DISTRIBUTIONS, SCATTERING, ddc:530, High Energy Physics::Experiment, VECTOR-MESON ELECTROPRODUCTION, QCD, Nuclear Experiment, Particle Physics - Experiment, High Energy Physics - Experiment
Abstract

Exclusive production of $\rho^0$ mesons was studied at the COMPASS experiment by scattering 160 GeV/$c$ muons off transversely polarised protons. Five single-spin and three double-spin azimuthal asymmetries were measured as a function of $Q^2$, $x_{Bj}$, or $p_{T}^{2}$. The $\sin \phi_S$ asymmetry is found to be $-0.019 \pm 0.008(stat.) \pm 0.003(syst.)$. All other asymmetries are also found to be of small magnitude and consistent with zero within experimental uncertainties. Very recent calculations using a GPD-based model agree well with the present results. The data is interpreted as evidence for the existence of chiral-odd, transverse generalized parton distributions., Comment: 14 pages, two tables, 5 figures, bibliography updated

Published
2013
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39. Impact of Omega-3 Fatty Acid Supplementation in Parenteral Nutrition on Inflammatory Markers and Clinical Outcomes in Critically Ill COVID-19 Patients: A Randomized Controlled Trial.

Author

Berlana D, Albertos R, Barquin R, Pau-Parra A, Díez-Poch M, López-Martínez R, Cea C, Cantenys-Molina S, and Ferrer-Costa R

Subjects
Humans, Male, Female, Middle Aged, Double-Blind Method, Aged, Inflammation blood, Intensive Care Units, Treatment Outcome, Interleukin-6 blood, SARS-CoV-2, Length of Stay, Parenteral Nutrition, Fatty Acids, Omega-3 administration & dosage, Critical Illness therapy, COVID-19 blood, COVID-19 therapy, C-Reactive Protein metabolism, C-Reactive Protein analysis, Dietary Supplements, Biomarkers blood
Abstract

The heightened inflammatory response observed in COVID-19 patients suggests that omega-3 fatty acids (O3FA) may confer anti-inflammatory benefits. This randomized, double-blind, single-center clinical trial aimed to evaluate the effect of O3FA supplementation in parenteral nutrition (PN) on inflammatory markers in COVID-19 patients admitted to the intensive care unit (ICU). A total of 69 patients were randomized into three groups: one received standard lipid emulsion, and two received O3FA (Omegaven ® ) at doses of 0.1 g/kg/day and 0.2 g/kg/day, respectively, in addition to Smoflipid ® . The primary outcomes measured were serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6) on days 1, 5, and 10 of PN initiation. Secondary outcomes included additional inflammatory markers (TNF-α, IFN-γ, IL-1Ra, CXCL10), hepatic function, triglyceride levels, and clinical outcomes such as mortality and length of ICU and hospital stay. Results indicated a significant reduction in CRP, IL-6, and CXCL10 levels in the group receiving 0.1 g/kg/day O3FA compared to the control. Additionally, the higher O3FA dose was associated with a shorter ICU and hospital stay. These findings suggest that O3FA supplementation in PN may reduce inflammation and improve clinical outcomes in critically ill COVID-19 patients.

Published
2024
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40. High-Density, Conformable Conducting Polymer-Based Implantable Neural Probes for the Developing Brain.

Author

Ma L, Wisniewski DJ, Cea C, Khodagholy D, and Gelinas JN

Subjects
Animals, Mice, Electrodes, Implanted, Action Potentials physiology, Brain physiology, Brain growth & development, Polymers chemistry
Abstract

Neurologic and neuropsychiatric disorders substantially impact the pediatric population, but there is a lack of dedicated devices for monitoring the developing brain in animal models, leading to gaps in mechanistic understanding of how brain functions emerge and their disruption in disease states. Due to the small size, fragility, and high water content of immature neural tissue, as well as the absence of a hardened skull to mechanically support rigid devices, conventional neural interface devices are poorly suited to acquire brain signals without inducing damage. Here, the authors design conformable, implantable, conducting polymer-based probes (NeuroShanks) for precise targeting in the developing mouse brain without the need for skull-attached, rigid mechanical support structures. These probes enable the acquisition of high spatiotemporal resolution neurophysiologic activity from superficial and deep brain regions across unanesthetized behavioral states without causing tissue disruption or device failure. Once implanted, probes are mechanically stable and permit precise, stable signal monitoring at the level of the local field potential and individual action potentials. These results support the translational potential of such devices for clinically indicated neurophysiologic recording in pediatric patients. Additionally, the role of organic bioelectronics as an enabling technology to address questions in developmental neuroscience is revealed., (© 2024 The Authors. Advanced Healthcare Materials published by Wiley‐VCH GmbH.)

Published
2024
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41. Formation of Anisotropic Conducting Interlayer for High-Resolution Epidermal Electromyography Using Mixed-Conducting Particulate Composite.

Author

Zhao Z, Yu H, Wisniewski DJ, Cea C, Ma L, Trautmann EM, Churchland MM, Gelinas JN, and Khodagholy D

Subjects
Animals, Mice, Anisotropy, Humans, Epidermis physiology, Electrodes, Electric Conductivity, Electromyography methods
Abstract

Epidermal electrophysiology is a non-invasive method used in research and clinical practices to study the electrical activity of the brain, heart, nerves, and muscles. However, electrode/tissue interlayer materials such as ionically conducting pastes can negatively affect recordings by introducing lateral electrode-to-electrode ionic crosstalk and reducing spatial resolution. To overcome this issue, biocompatible, anisotropic-conducting interlayer composites (ACI) that establish an electrically anisotropic interface with the skin are developed, enabling the application of dense cutaneous sensor arrays. High-density, conformable electrodes are also microfabricated that adhere to the ACI and follow the curvilinear surface of the skin. The results show that ACI significantly enhances the spatial resolution of epidermal electromyography (EMG) recording compared to conductive paste, permitting the acquisition of single muscle action potentials with distinct spatial profiles. The high-density EMG in developing mice, non-human primates, and humans is validated. Overall, high spatial-resolution epidermal electrophysiology enabled by ACI has the potential to advance clinical diagnostics of motor system disorders and enhance data quality for human-computer interface applications., (© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)

Published
2024
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42. Integrated internal ion-gated organic electrochemical transistors for stand-alone conformable bioelectronics.

Author

Cea C, Zhao Z, Wisniewski DJ, Spyropoulos GD, Polyravas A, Gelinas JN, and Khodagholy D

Abstract

Organic electronics can be biocompatible and conformable, enhancing the ability to interface with tissue. However, the limitations of speed and integration have, thus far, necessitated reliance on silicon-based technologies for advanced processing, data transmission and device powering. Here we create a stand-alone, conformable, fully organic bioelectronic device capable of realizing these functions. This device, vertical internal ion-gated organic electrochemical transistor (vIGT), is based on a transistor architecture that incorporates a vertical channel and a miniaturized hydration access conduit to enable megahertz-signal-range operation within densely packed integrated arrays in the absence of crosstalk. These transistors demonstrated long-term stability in physiologic media, and were used to generate high-performance integrated circuits. We leveraged the high-speed and low-voltage operation of vertical internal ion-gated organic electrochemical transistors to develop alternating-current-powered conformable circuitry to acquire and wirelessly communicate signals. The resultant stand-alone device was implanted in freely moving rodents to acquire, process and transmit neurophysiologic brain signals. Such fully organic devices have the potential to expand the utility and accessibility of bioelectronics to a wide range of clinical and societal applications., (© 2023. The Author(s).)

Published
2023
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43. Plant electrophysiology with conformable organic electronics: Deciphering the propagation of Venus flytrap action potentials.

Author

Armada-Moreira A, Dar AM, Zhao Z, Cea C, Gelinas J, Berggren M, Costa A, Khodagholy D, and Stavrinidou E

Subjects
Action Potentials, Signal Transduction, Electricity, Cardiac Electrophysiology, Droseraceae physiology
Abstract

Electrical signals in plants are mediators of long-distance signaling and correlate with plant movements and responses to stress. These signals are studied with single surface electrodes that cannot resolve signal propagation and integration, thus impeding their decoding and link to function. Here, we developed a conformable multielectrode array based on organic electronics for large-scale and high-resolution plant electrophysiology. We performed precise spatiotemporal mapping of the action potential (AP) in Venus flytrap and found that the AP actively propagates through the tissue with constant speed and without strong directionality. We also found that spontaneously generated APs can originate from unstimulated hairs and that they correlate with trap movement. Last, we demonstrate that the Venus flytrap circuitry can be activated by cells other than the sensory hairs. Our work reveals key properties of the AP and establishes the capacity of organic bioelectronics for resolving electrical signaling in plants contributing to the mechanistic understanding of long-distance responses in plants.

Published
2023
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44. Aluminum blood concentration in adult patients: effect of multichamber-bag versus hospital-compounded parenteral nutrition.

Author

Berlana D, Pau-Parra A, Albertos R, Cea C, Zabalegui A, Barquin R, Montoro-Ronsano JB, and López-Hellín J

Subjects
Humans, Adult, Retrospective Studies, Parenteral Nutrition, Hospitals, Inpatients, Aluminum, Parenteral Nutrition Solutions
Abstract

Introduction: Background: the administration of aluminum-contaminated parenteral nutrition (PN) leads to an accumulation of aluminum. The aim of this study was to assess blood aluminum concentrations (BACs) of inpatients receiving multichamber-bag (MCB) PN compared to those receiving compounded PN. Methods: available BACs were retrospectively gathered from patient charts of adult inpatients receiving PN from 2015 to 2020, and compared depending on the type of PN administered. Long-term PN patients, defined as ≥ 20 days of PN, receiving at least > 10 days of compounded PN, were compared to long-term patients receiving only MCB. Results: a total of 160 BACs were available from 110 patients. No differences were found according to type of PN (mean BAC: 3.11 ± 2.75 for MCB versus 3.58 ± 2.08 µg/L for compounded PN). Baseline total bilirubin, surgery and days with PN were related to higher BACs (coefficient: 0.30 [95 % CI, 0.18-0.42], 1.29 [95 % CI, 0.52-2.07], and 0.06 [95 % CI: 0.01-0.11], respectively). Regarding long-term PN, patients receiving only MCB (n = 21) showed lower BACs compared to the compounded PN (n = 17) [2.99 ± 1.55 versus 4.35 ± 2.17 µg/L, respectively; p < 0.05]. Conclusions: although there were no differences in BAC according to type of PN administered, in long-term PN, MCB PN was associated with lower BACs as compared to compounded PN.

Published
2023
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45. Complete Chloroplast Genome of an Endophytic Ostreobium sp. (Ostreobiaceae) from the U.S. Virgin Islands.

Author

Alesmail M, Becerra Y, Betancourt KJ, Bracy SM, Castro AT, Cea C, Chavez J, Del Angel J, Diaz E, Diaz-Guzman Y, Dominguez J, Estrada JG, Frei LG, Gabrielson PW, Gallardo A, Garcia MR, Gonzalez E, Gonzalez Rocha A, Guzman-Bermudez D, Hebert CR, Hernandez M, Hughey JR, Lee Z, Leyva Romero A, Martinez E, Martinez N, Medina KH, Morales M, Moreno AM, Nava I, Nono AN, Ochoa SA, Perez A, Perez N, Perez Pulido E, Poduska S, Ramirez KN, Reyes D, Richardson K, Rodriguez J, Rodriguez AM, Serrano-Lopez C, Velasquez AG, and Villanueva G

Abstract

We present the complete chloroplast genome sequence of an endophytic Ostreobium sp. isolated from a 19th-century coralline red algal specimen from St. Croix, U.S. Virgin Islands. The chloroplast genome is 84,848 bp in length, contains 114 genes, and has a high level of gene synteny to other Ostreobiaceae., Competing Interests: The authors declare no conflict of interest.

Published
2023
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46. Detailed stratified GWAS analysis for severe COVID-19 in four European populations.

Author

Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Blandino Ortiz A, de Salazar A, Garrido Chercoles A, Palom A, Ruiz A, Garcia-Fernandez AE, Blanco-Grau A, Mantovani A, Zanella A, Holten AR, Mayer A, Bandera A, Cherubini A, Protti A, Aghemo A, Gerussi A, Ramirez A, Braun A, Nebel A, Barreira A, Lleo A, Teles A, Kildal AB, Biondi A, Caballero-Garralda A, Ganna A, Gori A, Glück A, Lind A, Tanck A, Hinney A, Carreras Nolla A, Fracanzani AL, Peschuck A, Cavallero A, Dyrhol-Riise AM, Ruello A, Julià A, Muscatello A, Pesenti A, Voza A, Rando-Segura A, Solier A, Schmidt A, Cortes B, Mateos B, Nafria-Jimenez B, Schaefer B, Jensen B, Bellinghausen C, Maj C, Ferrando C, de la Horra C, Quereda C, Skurk C, Thibeault C, Scollo C, Herr C, Spinner CD, Gassner C, Lange C, Hu C, Paccapelo C, Lehmann C, Angelini C, Cappadona C, Azuure C, Bianco C, Cea C, Sancho C, Hoff DAL, Galimberti D, Prati D, Haschka D, Jiménez D, Pestaña D, Toapanta D, Muñiz-Diaz E, Azzolini E, Sandoval E, Binatti E, Scarpini E, Helbig ET, Casalone E, Urrechaga E, Paraboschi EM, Pontali E, Reverter E, Calderón EJ, Navas E, Solligård E, Contro E, Arana-Arri E, Aziz F, Garcia F, García Sánchez F, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Kurth F, Blasi F, Malvestiti F, Medrano FJ, Mesonero F, Rodriguez-Frias F, Hanses F, Müller F, Hemmrich-Stanisak G, Bellani G, Grasselli G, Pezzoli G, Costantino G, Albano G, Cardamone G, Bellelli G, Citerio G, Foti G, Lamorte G, Matullo G, Baselli G, Kurihara H, Neb H, My I, Kurth I, Hernández I, Pink I, de Rojas I, Galván-Femenia I, Holter JC, Afset JE, Heyckendorf J, Kässens J, Damås JK, Rybniker J, Altmüller J, Ampuero J, Martín J, Erdmann J, Banales JM, Badia JR, Dopazo J, Schneider J, Bergan J, Barretina J, Walter J, Hernández Quero J, Goikoetxea J, Delgado J, Guerrero JM, Fazaal J, Kraft J, Schröder J, Risnes K, Banasik K, Müller KE, Gaede KI, Garcia-Etxebarria K, Tonby K, Heggelund L, Izquierdo-Sanchez L, Bettini LR, Sumoy L, Sander LE, Lippert LJ, Terranova L, Nkambule L, Knopp L, Gustad LT, Garbarino L, Santoro L, Téllez L, Roade L, Ostadreza M, Intxausti M, Kogevinas M, Riveiro-Barciela M, Berger MM, Schaefer M, Niemi MEK, Gutiérrez-Stampa MA, Carrabba M, Figuera Basso ME, Valsecchi MG, Hernandez-Tejero M, Vehreschild MJGT, Manunta M, Acosta-Herrera M, D'Angiò M, Baldini M, Cazzaniga M, Grimsrud MM, Cornberg M, Nöthen MM, Marquié M, Castoldi M, Cordioli M, Cecconi M, D'Amato M, Augustin M, Tomasi M, Boada M, Dreher M, Seilmaier MJ, Joannidis M, Wittig M, Mazzocco M, Ciccarelli M, Rodríguez-Gandía M, Bocciolone M, Miozzo M, Imaz Ayo N, Blay N, Chueca N, Montano N, Braun N, Ludwig N, Marx N, Martínez N, Cornely OA, Witzke O, Palmieri O, Faverio P, Preatoni P, Bonfanti P, Omodei P, Tentorio P, Castro P, Rodrigues PM, España PP, Hoffmann P, Rosenstiel P, Schommers P, Suwalski P, de Pablo R, Ferrer R, Bals R, Gualtierotti R, Gallego-Durán R, Nieto R, Carpani R, Morilla R, Badalamenti S, Haider S, Ciesek S, May S, Bombace S, Marsal S, Pigazzini S, Klein S, Pelusi S, Wilfling S, Bosari S, Volland S, Brunak S, Raychaudhuri S, Schreiber S, Heilmann-Heimbach S, Aliberti S, Ripke S, Dudman S, Wesse T, Zheng T, Bahmer T, Eggermann T, Illig T, Brenner T, Pumarola T, Feldt T, Folseraas T, Gonzalez Cejudo T, Landmesser U, Protzer U, Hehr U, Rimoldi V, Monzani V, Skogen V, Keitel V, Kopfnagel V, Friaza V, Andrade V, Moreno V, Albrecht W, Peter W, Poller W, Farre X, Yi X, Wang X, Khodamoradi Y, Karadeniz Z, Latiano A, Goerg S, Bacher P, Koehler P, Tran F, Zoller H, Schulte EC, Heidecker B, Ludwig KU, Fernández J, Romero-Gómez M, Albillos A, Invernizzi P, Buti M, Duga S, Bujanda L, Hov JR, Lenz TL, Asselta R, de Cid R, Valenti L, Karlsen TH, Cáceres M, and Franke A

Subjects
Humans, SARS-CoV-2 genetics, Genome-Wide Association Study, Haplotypes, Polymorphism, Genetic, COVID-19 genetics
Abstract

Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung., (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Published
2022
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47. Translational Organic Neural Interface Devices at Single Neuron Resolution.

Author

Hassan AR, Zhao Z, Ferrero JJ, Cea C, Jastrzebska-Perfect P, Myers J, Asman P, Ince NF, McKhann G, Viswanathan A, Sheth SA, Khodagholy D, and Gelinas JN

Subjects
Action Potentials physiology, Animals, Brain, Humans, Interneurons, Neurons physiology, Pyramidal Cells
Abstract

Recording from the human brain at the spatiotemporal resolution of action potentials provides critical insight into mechanisms of higher cognitive functions and neuropsychiatric disease that is challenging to derive from animal models. Here, organic materials and conformable electronics are employed to create an integrated neural interface device compatible with minimally invasive neurosurgical procedures and geared toward chronic implantation on the surface of the human brain. Data generated with these devices enable identification and characterization of individual, spatially distribute human cortical neurons in the absence of any tissue penetration (n = 229 single units). Putative single-units are effectively clustered, and found to possess features characteristic of pyramidal cells and interneurons, as well as identifiable microcircuit interactions. Human neurons exhibit consistent phase modulation by oscillatory activity and a variety of population coupling responses. The parameters are furthermore established to optimize the yield and quality of single-unit activity from the cortical surface, enhancing the ability to investigate human neural network mechanisms without breaching the tissue interface and increasing the information that can be safely derived from neurophysiological monitoring., (© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.)

Published
2022
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48. Ionic communication for implantable bioelectronics.

Author

Zhao Z, Spyropoulos GD, Cea C, Gelinas JN, and Khodagholy D

Abstract

Implanted bioelectronic devices require data transmission through tissue, but ionic conductivity and inhomogeneity of this medium complicate conventional communication approaches. Here, we introduce ionic communication (IC) that uses ions to effectively propagate megahertz-range signals. We demonstrate that IC operates by generating and sensing electrical potential energy within polarizable media. IC was tuned to transmit across a range of biologically relevant tissue depths. The radius of propagation was controlled to enable multiline parallel communication, and it did not interfere with concurrent use of other bioelectronics. We created a fully implantable IC-based neural interface device that acquired and noninvasively transmitted neurophysiologic data from freely moving rodents over a period of weeks with stability sufficient for isolation of action potentials from individual neurons. IC is a biologically based data communication that establishes long-term, high-fidelity interactions across intact tissue.

Published
2022
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49. Anisotropic Ion Conducting Particulate Composites for Bioelectronics.

Author

Yao DR, Yu H, Rauhala OJ, Cea C, Zhao Z, Gelinas JN, and Khodagholy D

Subjects
Anisotropy, Electrons, Humans, Polymers chemistry, Electrolytes chemistry, Transistors, Electronic
Abstract

Acquisition, processing, and manipulation of biological signals require transistor circuits capable of ion to electron conversion. However, use of this class of transistors in integrated sensors or circuits is limited due to difficulty in patterning biocompatible electrolytes for independent operation of transistors. It is hypothesized that it would be possible to eliminate the need for electrolyte patterning by enabling directional ion conduction as a property of the material serving as electrolyte. Here, the anisotropic ion conductor (AIC) is developed as a soft, biocompatible composite material comprised of ion-conducting particles and an insulating polymer. AIC displays strongly anisotropic ion conduction with vertical conduction comparable to isotropic electrolytes over extended time periods. AIC allows effective hydration of conducting polymers to establish volumetric capacitance, which is critical for the operation of electrochemical transistors. AIC enables dense patterning of transistors with minimal leakage using simple solution-based deposition techniques. Lastly, AIC can be utilized as a dry, anisotropic interface with human skin that is capable of non-invasive acquisition of individual motor action potentials. The properties of AIC position it to enable implementation of a wide range of large-scale organic bioelectronics and enhance their translation to human health applications., (© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.)

Published
2022
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50. Electrically Conducting Elastomeric Fibers with High Stretchability and Stability.

Author

Zokaei S, Craighero M, Cea C, Kneissl LM, Kroon R, Khodagholy D, Lund A, and Müller C

Subjects
Elasticity, Electric Conductivity, Electricity, Ferric Compounds, Wearable Electronic Devices
Abstract

Stretchable conducting materials are appealing for the design of unobtrusive wearable electronic devices. Conjugated polymers with oligoethylene glycol side chains are excellent candidate materials owing to their low elastic modulus and good compatibility with polar stretchable polymers. Here, electrically conducting elastomeric blend fibers with high stretchability, wet spun from a blend of a doped polar polythiophene with tetraethylene glycol side chains and a polyurethane are reported. The wet-spinning process is versatile, reproducible, scalable, and produces continuous filaments with a diameter ranging from 30 to 70 µm. The fibers are stretchable up to 480% even after chemical doping with iron(III) p-toluenesulfonate hexahydrate and exhibit an electrical conductivity of up to 7.4 S cm -1 , which represents a record combination of properties for conjugated polymer-based fibers. The fibers remain conductive during elongation until fiber fracture and display excellent long-term stability at ambient conditions. Cyclic stretching up to 50% strain for at least 400 strain cycles reveals that the doped fibers exhibit high cyclic stability and retain their electrical conductivity. Finally, a directional strain sensing device, which makes use of the linear increase in resistance of the fibers up to 120% strain is demonstrated., (© 2021 The Authors. Small published by Wiley-VCH GmbH.)

Published
2022
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