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165 results on '"Calo', Lorenzo"'

1. Diagnosis and management of Bartter syndrome: executive summary of the consensus and recommendations from the European Rare Kidney Disease Reference Network Working Group for Tubular Disorders

Author

Konrad, Martin, Nijenhuis, Tom, Ariceta, Gema, Bertholet-Thomas, Aurelia, Calo, Lorenzo A., Capasso, Giovambattista, Emma, Francesco, Schlingmann, Karl P., Singh, Mandeep, Trepiccione, Francesco, Walsh, Stephen B., Whitton, Kirsty, Vargas-Poussou, Rosa, and Bockenhauer, Detlef

Published
2021
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12. Potential role of phytochemicals in metabolic syndrome prevention and therapy

Author

FRANCINI PESENTI, Francesco, Spinella, Paolo, and Calo', Lorenzo

Subjects
cardiovascular risk, bioactive substances, nutrition, Review, metabolic syndrome
Abstract

Metabolic syndrome (MetS) is a set of cardiovascular risk factors which severely increases the risk of type II diabetes, renal disease and cardiovascular disease. Over the last decades, the role of dietary bioactive substances in features of MetS has been extensively investigated. Due to their multiple properties, these plant-derived natural compounds have demonstrated to provide positive effects in obesity, diabetes, renal and in cardiovascular disease. Catechins of green tea and caffeine reduce body mass index and waist circumference. Catechins, anthocyanins and proanthocyanidins of cocoa reduce blood pressure and blood glucose. Curcumin and silymarin exert hepatoprotective effects. Monacolins of red yeast rice are effective cholesterol-lowering agents. However, inconsistent or conflicting results have been found in clinical trials when other promising compounds in vitro or in animal studies, such as policosanol, curcumin or silymarin, were used. Low oral bioavailability of substances, ineffective dosages, inadequate treatment duration and insufficient statistical approach may explain the lack of effectiveness observed in some human studies. Further clinical studies are needed to better understand the role of bioactive compounds in the prevention and management of MetS.

Published
2019

18. Walnuts reduce aortic ET-1 mRNA levels in hamsters fed a high-fat, atherogenic diet

Author

Davis, Paul, Valacchi, Giuseppe, Pagnin, Elisa, Shao, Qiming, Gross, Heidrun B., Calo, Lorenzo, and Yokoyama, Wallace

Subjects
Walnut -- Nutritional aspects, Walnut -- Research, Coronary heart disease -- Risk factors, Coronary heart disease -- Research, Food/cooking/nutrition
Abstract

Walnut consumption is associated with reduced coronary vascular disease (CVD) risk; however, the mechanisms responsible remain incompletely understood. Recent clinical studies suggested that these mechanisms involve nonplasma lipid--related effects on endothelial function. Male Golden Syrian hamsters (12 groups, n = 10-15) were fed for 26 wk atherosclerotic, high-fat, hyperlipidemic diets with increasing concentrations of whole walnuts (61-150 g/kg diet), or [alpha]-tocopherol ([alpha]-T, 8.1-81 mg/kg diet) and single diets with either walnut oil (32g/kg diet) or pure [alpha]-tocopherol ([gamma]-T; 81 mg/kg diet) added. Aortic endothelin 1 (ET-1), an important endothelial regulator, was assayed as mRNA. Aortic cholesterol ester (CE) concentration along with other vascular stress markers (Cu/Zn and Mn superoxide dismutase, biliverdin reductase) and plasma lipid concentrations were determined. Hyperlipidemia (plasma LDL cholesterol ~6 times normal) occurred in ali groups. Aortic CE concentration, a measure of atherosclerotic plaque, was highest in the lowest [alpha]-T only group and declined significantly with increasing [alpha]-T. The aortic CE of all walnut groups was decreased significantly relative to the lowest [alpha]-T only group but showed no dose response. The diets did not produce changes in the other vascular stress markers, whereas aortic ET-1 mRNA levels declined dramatically with increasing dietary walnuts (to a 75% reduction in the highest walnut content group compared with the lowest [alpha]-T group) but were unaltered in the [alpha]-T groups or [gamma]-T group. The study results are consistent with those of human walnut feeding studies and suggest that the mechanisms underlying those results are mediated in part by ET-1--dependent mechanisms. The contrasting results between the [alpha]-tocopherol or [gamma]-tocopherol diets and the walnut diets also make it unlikely that the nonplasma lipid-related CVD effects of walnuts are due to their [alpha]-tocopherol or [gamma]-tocopherol content. Finally, the results indicate that the walnut fat compartment is a likely location for the components responsible for the reduced aortic CE concentration. KEY WORDS: * walnuts * endothelin * hamsters * tocopherol * atherosclerosis

Published
2006

24. Research update for articles published in EJCI in 2008

Author

Anderwald, Christian, Ankersmit, Hendrik J., Badaoui, Abdenor, Beneduce, Luca, Buko, Vyacheslav U., Calo, Lorenzo A., Carrero, Juan J., Chang, Chun-Yi, Chang, Kuo-Chu, Chen, Yi-Jen, Cnotliwy, Miloslaw, Costelli, Paola, Crujeiras, Ana B., Cuocolo, Alberto, Davis, Paul A., de Boer, Onno J., Ebenbichler, Christoph F., Erridge, Clett, Fassina, Giorgio, Felix, Stephan B., García-Gómez, María C., Guerrero-Romero, Fernando, Haider, Dominik G., Heinemann, Akos, Herda, Lars R., Hoogeveen, Ellen K., Hörl, Walter H., Iglseder, Bernhard, Huang, Kuo-Chin, Kaser, Susanne, Kastrati, Adnan, Kuzniatsova, Nadzeya, Latella, Giovanni, Lichtenauer, Michael, Lin, Yung-Kuo, Lip, Gregory Y. H., Lu, Nong-Hua, Lukivskaya, Oxana, Luschnig, Petra, Maniscalco, Mauro, Martinez, Alfredo J., Müller-Krebs, Sandra, Ndrepepa, Gjin, Nicolaou, Giovanna, Peck-Radosavljevic, Markus, Penna, Fabio, Pintó, Xavier, Reiberger, Thomas, Rodriguez-Moran, Martha, Schmidt, Annette, Schwenger, Vedat, Spinelli, Letizia, Starkel, Peter, Stehouwer, Coen D. A., Stenvinkel, Peter, Strasser, Peter, Suzuki, Hiroshi, Tschoner, Alexander, van der Wal, Allard C., Vesely, David L., Wen, Chiung-Jung, Wiernicki, Ireneusz, Zanninelli, Giuliana, and Zhu, Y.

Published
2010
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40. Insulin signaling, glucose metabolism, and the angiotensin II signaling system: studies in Bartter's/Gitelman's syndromes

Author

Davis, Paul A., Pagnin, Elisa, Semplicini, Andrea, Avogaro, Angelo, and Calo, Lorenzo A.

Subjects
Research, Health aspects, Diabetes research -- Health aspects, Glucose metabolism -- Research -- Health aspects, Hormone receptors -- Research -- Health aspects, Insulin -- Health aspects -- Research, Diabetes -- Research
Abstract

Taniyama et al. (1) have recently reported that angiotensin II (Ang II) in vitro decreases insulin receptor substrate-1 protein levels via Src, phosphoinositide-dependent kinase-1, and reactive oxygen species-mediated phosphorylation of [...]

Published
2006

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