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10. The role of the claustrum in the acquisition, consolidation and reconsolidation of memories in mice

Author

Candela Medina, Santiago Ojea Ramos, Amaicha M Depino, Arturo G Romano, María C Krawczyk, and Mariano M Boccia

Subjects
Mice, Lidocaine, Claustrum, Habituation, Memory reconsolidation, Memory consolidation, Medicine, Science
Abstract

Abstract The claustrum is a brain structure that remains shrouded in mystery due to the limited understanding of its cellular structure, neural pathways, functionality and physiological aspects. Significant research has unveiled connections spanning from the claustrum to the entire cortex as well as subcortical areas. This widespread connectivity has led to speculations of its role in integrating information from different brain regions, possibly contributing to processes such as attention, consciousness, learning and memory. Our working hypothesis posits that claustrum neural activity contributes to the acquisition, consolidation and reconsolidation of long-term memories in mice. We found evidence in CF-1 mice of a decline in behavioral performance in an inhibitory avoidance task due to intra-claustral administration of 2% lidocaine immediately after a training session or memory recall. Nevertheless, this does not seem to be the case for the acquisition or retrieval of this type of memory, although its neural activity is significantly increased after training, evaluated through c-Fos expression. Moreover, inhibition of the claustrum’s synaptic activity appears to impair the consolidation but not acquisition or retrieval of an unconditioned memory formed in a nose-poke habituation task.

Published
2024
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23. Provisional recommendations for SARS-CoV-2 vaccination in patients with cryoglobulinaemic vasculitis

Author

Scarpato, S., Sebastiani, M., Luca Quartuccio, Marson, P., Fraticelli, P., Castelnovo, L., Visentini, M., Candela, M., Mazzaro, C., Saccardo, F., Pioltelli, P., Casato, M., Filippini, D., Monti, G., and Galli, M.

Subjects
Vasculitis, COVID-19 Vaccines, Autoimmunity, COVID-19, Cryoglobulinaemia, SARS-CoV-2 vaccination, SARS-CoV-2, Vaccination, Immunology, autoimmunity, cryoglobulinaemia, COVID-19, SARS-CoV-2 vaccination, autoimmunity, cryoglobulinaemia, Cryoglobulinemia, Italy, Rheumatology, Humans, Immunology and Allergy
Abstract

People with cryoglobulinaemic vasculitis (CV) have an increased risk of infections, attributed to different causes: impairment of the immune system due to the disease itself, comorbidities, and immunosuppressive therapy. Therefore, these patients may be at high risk for a more severe course of COVID-19, including hospitalisation and death. Concerns about efficacy, immunogenicity and safety of vaccines, as well as doubts, not yet fully clarified in patients with systemic autoimmune diseases, represent other important factors for a low vaccination rate in people with (CV). Indeed, providing an expert position on the issues related to SARS-CoV-2 vaccination in patients suffering from CV is of critical relevance in order to help both patients and clinicians who are treating them in making the best choice in each case. A multidisciplinary task force of the Italian Group for the Study of Cryoglobulinaemia (GISC) was convened, and through a Delphi technique produced provisional recommendations regarding SARS-CoV-2 vaccination in cryoglobulinaemic patients.

Published
2021

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