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3 results on '"Carlo, Foglia"'

1. Is multifocality a prognostic factor in childhood hepatoblastoma?

Author

Francesco, Saettini, Valentino, Conter, Massimo, Provenzi, Matteo, Rota, Eugenia, Giraldi, Carlo, Foglia, Laura, Cavalleri, Lorenzo, D'Antiga, Saettini, F, Conter, V, Provenzi, M, Rota, M, Giraldi, E, Foglia, C, Cavalleri, L, and D'Antiga, L

Subjects
Male, hepatoblastoma, liver tumors, multifocality, risk factors, survival, liver tumors, survival, Antineoplastic Combined Chemotherapy Protocols, Humans, risk factors, Neoplasm Metastasis, hepatoblastoma, multifocality, Child, MED/01 - STATISTICA MEDICA, Neoplasm Staging, Retrospective Studies, Liver Neoplasms, Infant, Newborn, Infant, MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Prognosis, Combined Modality Therapy, Survival Rate, Child, Preschool, Multivariate Analysis, Female, Follow-Up Studies
Abstract

Background The aim of this study was to assess the prognostic value of multifocality and the effectiveness of two different therapeutic strategies in patients with newly diagnosed hepatoblastoma. Procedures Between 1998 and 2011, 31 patients diagnosed with hepatoblastoma were referred to Ospedale Papa Giovanni XXIII, Bergamo, Italy. Patients were stratified according to SIOPEL protocols into high-risk (HR if AFP

Published
2014

2. Ruptured hepatoblastoma: A case report and literature review

Author

Carlo Foglia, Daisuke Hasegawa, Massimo Provenzi, Valentino Conter, Giorgio Perilongo, Lorenzo D'Antiga, Eugenia Giraldi, Liviana Da Dalt, Laura Cavalleri, Francesco Saettini, Saettini, F, Conter, V, Da Dalt, L, Perilongo, G, Hasegawa, D, Giraldi, E, Cavalleri, L, Foglia, C, D'Antiga, L, and Provenzi, M

Subjects
Spontaneous rupture, Hepatoblastoma, Cancer Research, Pediatrics, medicine.medical_specialty, medicine.medical_treatment, Rupture, Solid Tumors, Rare Tumors, Surgical treatment, Clinical history, Spontaneous tumor, Long term survival, medicine, Radiology, Nuclear Medicine and imaging, Chemotherapy, business.industry, Hepatoblastoma, rupture, rare tumors, surgical treatment, MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, medicine.disease, Surgery, Tumor recurrence, Tumor rupture, Oncology, MED/06 - ONCOLOGIA MEDICA, business
Abstract

The spontaneous rupture of hepatoblastoma in childhood is a rare life-threatening event. Despite never being firmly documented this event is considered to play a negative impact on long term survival. Herewith the clinical history of a 6-month-old child with a very large mass and intratumoral bleeding at the diagnosis, who suffered of spontaneous tumor rupture after two cycles of pre-operative chemotherapy and ultimately died of tumor recurrence despite appropriate treatment, is reported. In addition to this case the pertinent literature regarding the prognostic implication of tumor rupture in childhood hepatoblastoma (at the time of diagnosis or during treatment) is reviewed. This report is meant to focus the problem of the clinical and prognostic relevance of tumor rupture and to stimulate appropriate large scale studies aimed to investigate the prognostic value of this event, and to identify the clinical tumor characteristics which may predict its occurrence.

Published
2013

3. Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review

Author

Eugenia Giraldi, Francesco Saettini, Michele Colledan, Laura Cavalleri, Valentino Conter, Lorenzo D'Antiga, Carlo Foglia, Giorgio Perilongo, Liviana Da Dalt, and Massimo Provenzi

Subjects
Hepatoblastoma, Oncology, medicine.medical_specialty, Lung Neoplasms, Time Factors, DOXORUBICIN, Liver tumor, medicine.medical_treatment, Case Report, INTERNATIONAL SOCIETY, Hematopoietic stem cell transplantation, Risk Assessment, STANDARD-RISK HEPATOBLASTOMA, CISPLATIN, PEDIATRIC-ONCOLOGY-GROUP, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Biopsy, medicine, Humans, Neoplasm Invasiveness, Doxorubicin, Neoplasm Staging, Lung, Dose-Response Relationship, Drug, medicine.diagnostic_test, TRANSPLANTATION, business.industry, Biopsy, Needle, Liver Neoplasms, Hematopoietic Stem Cell Transplantation, medicine.disease, Combined Modality Therapy, Immunohistochemistry, SOLID TUMORS, Surgery, Irinotecan, Transplantation, Treatment Outcome, medicine.anatomical_structure, LIVER-TUMOR, Child, Preschool, PHASE-II, Tomography, X-Ray Computed, business, Follow-Up Studies, medicine.drug
Abstract

We report the use of high dose chemotherapy with peripheral blood stem cell rescue as a consolidation treatment for a 3-year-old child affected by metastatic hepatoblastoma, who achieved complete lung response only after conventional treatment. The patient is presently alive 27 months after high dose chemotherapy with blood stem cell rescue with no evidence of disease. The role of high dose chemotherapy with blood stem cell rescue to consolidate the complete clearing of lung disease in metastatic hepatoblastoma remains controversial; the data available in the literature and our experience seems to suggest to keep this treatment option open to further consideration in the clinical setting of high-risk patients.

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