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The 12 Principles of Green Chemistry act as a guide for chemists for the design and synthesis of sustainable products. Adoption by chemists is essential for the transition. We chose the use of solvents (Principle #3) as an example of our commitment towards improved sustainabilty in chemical synthesis. Herein, we report on how our chemistry department – a community of ca. 300 chemists – reduced its usage by half of seven hazardous solvents over a period of two years. In this report, we provide a selection of the actions we set up to achieve our objective, as well as a few learnings observed during our journey. We hope that our example on transitioning and shifting mindsets towards a complete adoption of green chemistry principles will inspire others as well. [ABSTRACT FROM AUTHOR]

High‐throughput experimentation (HTE) is a growing, enabling technology that allows the execution of large, parallel sets of experiments. Often, automation is required to dose compounds on milligram to sub‐milligram scale, to run many parallel reactions, and to analyse large datasets. Unique approaches to screen design, implementation, and analysis are required, distinct from traditional synthetic organic chemistry. The discipline also presents a profitable opportunity for individual scientists to learn about and explore fields adjacent to chemistry, including data science, robotics and equipment engineering, and computer programming. This perspective presents the author's viewpoints on the field of HTE, its implementation within a chemistry career, and the automated future of organic chemistry technology. [ABSTRACT FROM AUTHOR]

Attempts to reproduce eight, putative, enantioselective dibromination and chlorohydroxylation reactions from oft-cited literature studies are described. The reactions were performed with full fidelity to the original report wherever possible. Analysis of the enantiomeric composition was performed by chiral stationary phase HPLC or SFC (CSP-HPLC or CSP-SFC), as opposed to the original report, which used chiral shift reagent NMR spectroscopy. After careful study, the reported levels of enantioselectivity were found to be incorrect. Possible explanations for the false positive results are discussed. [ABSTRACT FROM AUTHOR]

Thorough reinvestigation of the title reactions reveals that in contrast to previously published results the reactions do not deliver the products in very high yields and with high to very high enantiomeric excesses, but in often significantly lower yields and with no enantioselectivity at all. [ABSTRACT FROM AUTHOR]

Increased molecular complexity correlates with improved chances of success in the drug development process. Here, a strategy for the creation of sp 3 -rich, non-planar heterocyclic scaffolds suitable for drug discovery is described that obviates the need to generate multiple stereogenic centers with independent control. Asymmetric transfer hydrogenation using a tethered Ru-catalyst is used to efficiently produce a range of enantiopure cyclic hydrazine building blocks (up to 99% ee). Iterative C-N functionalization at the two nitrogen atoms of these compounds produces novel hydrazine and hydrazide based chemical libraries. Wide chemical diversification is possible through variation in the hydrazine structure, use of different functionalization chemistries and coupling partners, and controlled engagement of each nitrogen of the hydrazine in turn. Principal Moment of Inertia (PMI) analysis of this small hydrazine library reveals excellent shape diversity and three-dimensionality. NMR and crystallographic studies confirm these frameworks prefer to orient their substituents in three-dimensional space under the control of a single stereogenic center through exploitation of the fluxional behavior of the two nitrogen atoms., (This journal is © The Royal Society of Chemistry 2020.)