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5 results on '"Catherine Delamare"'

1. Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France

Author

Tom Woudenberg, Stéphane Pelleau, François Anna, Mikael Attia, Françoise Donnadieu, Alain Gravet, Caroline Lohmann, Hélène Seraphin, Raphaël Guiheneuf, Catherine Delamare, Karl Stefic, Julien Marlet, Etienne Brochot, Sandrine Castelain, Olivier Augereau, Jean Sibilia, François Dubos, Damia Meddour, Christèle Gras-Le Guen, Marianne Coste-Burel, Berthe-Marie Imbert-Marcille, Anne Chauvire-Drouard, Cyril Schweitzer, Amélie Gatin, Sandra Lomazzi, Aline Joulié, Hervé HAAS, Aymeric Cantais, Frederique Bertholon, Marie-France Chinazzo-Vigouroux, Mohamed SI Abdallah, Laurence Arowas, Pierre Charneau, Bruno Hoen, Caroline Demeret, Sylvie Van Der Werf, Arnaud Fontanet, and Michael White

Subjects
SARS-CoV-2, COVID-19, seroprevalence, sero-epidemiology, seasonal coronaviruses, antibody response, Medicine, Medicine (General), R5-920
Abstract

Background: Children are underrepresented in the COVID-19 pandemic and often experience milder disease than adolescents and adults. Reduced severity is possibly due to recent and more frequent seasonal human coronaviruses (HCoV) infections. We assessed the seroprevalence of SARS-CoV-2 and seasonal HCoV specific antibodies in a large cohort in north-eastern France. Methods: In this cross-sectional seroprevalence study, serum samples were collected from children and adults requiring hospital admission for non-COVID-19 between February and August 2020. Antibody responses to SARS-CoV-2 and seasonal HCoV (229E, HKU1, NL63, OC43) were assessed using a bead-based multiplex assay, Luciferase-Linked ImmunoSorbent Assay, and a pseudotype neutralisation assay. Findings: In 2,408 individuals, seroprevalence of SARS-CoV-2-specific antibodies was 7-8% with three different immunoassays. Antibody levels to seasonal HCoV increased substantially up to the age of 10. Antibody responses in SARS-CoV-2 seropositive individuals were lowest in adults 18-30 years. In SARS-CoV-2 seronegative individuals, we observed cross-reactivity between antibodies to the four HCoV and SARS-CoV-2 Spike. In contrast to other antibodies to SARS-CoV-2, specific antibodies to sub-unit 2 of Spike (S2) in seronegative samples were highest in children. Upon infection with SARS-CoV-2, antibody levels to Spike of betacoronavirus OC43 increased across the whole age spectrum. No SARS-CoV-2 seropositive individuals with low levels of antibodies to seasonal HCoV were observed. Interpretation: Our findings underline significant cross-reactivity between antibodies to SARS-CoV-2 and seasonal HCoV, but provide no significant evidence for cross-protective immunity to SARS-CoV-2 infection due to a recent seasonal HCoV infection. In particular, across all age groups we did not observe SARS-CoV-2 infected individuals with low levels of antibodies to seasonal HCoV. Funding: This work was supported by the « URGENCE COVID-19 » fundraising campaign of Institut Pasteur, by the French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases (Grant No. ANR-10-LABX-62-IBEID), and by the REACTing (Research & Action Emerging Infectious Diseases), and by the RECOVER project funded by the European Union's Horizon 2020 research and innovation programme under grant agreement No. 101003589, and by a grant from LabEx IBEID (ANR-10-LABX-62-IBEID).

Published
2021
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2. Challenges, solutions and lessons learnt in 7 years of Service Management at CERN

Author

Nicole Cremel, Eric Lienard, Reinoud Martens, Isabel Fernandez Gonzalez, Wayne Salter, David Martín Clavo, Olaf Van der Vossen, Zhechka Toteva, Barbara Brugger, Catherine Delamare, and Mats Moller

Subjects
Service (business), ComputerSystemsOrganization_COMPUTERSYSTEMIMPLEMENTATION, business.industry, Physics, QC1-999, Service management, Information technology, Onboarding, Computing and Computers, Information Technology Infrastructure Library, Engineering management, Upgrade, User experience design, Service catalog, business, Hardware_REGISTER-TRANSFER-LEVELIMPLEMENTATION
Abstract

CERN has been using ITIL Service Management methodologies and ServiceNow since early 2011. Initially a joint project between just the Information Technology and the General Services Departments, now most of CERN is using this common methodology and tool, and all departments are represented totally or partially in the CERN Service Catalogue. We introduce a summary of the current situation of Service Management at CERN, as well as its recent evolution. We discuss service onboarding, user experience, and tool configuration, outlining the challenges faced, solutions adopted and some important lessons learnt. Some of the most important points relate to CERN’s common process and service catalogue, which have enabled scalability; hiding complexity from users in order to improve user experience; and the good practices to configure CERN’s Service Management application which have been learnt in the 8 years of the project. Finally, we present ongoing and future work, such as the upgrade of the CERN Service Portal and bringing even more new services board.

Published
2019

4. Fatal Case of Listeria innocua Bacteremia

Author

Catherine Delamare, Michel Bemer, and Monique Perrin

Subjects
Microbiology (medical), Fatal outcome, biology, Listeria, Sequence Analysis, RNA, Bacteremia, Case Reports, Middle Aged, biology.organism_classification, medicine.disease, Virology, Microbiology, Human disease, Fatal Outcome, RNA, Ribosomal, 16S, medicine, Humans, RNA, Female, Listeriosis, RNA RIBOSOMAL 16S, Probability
Abstract

Listeria innocua is widespread in the environment and in food. This species has to date never been described in association with human disease. We report a case of fatal bacteremia caused by L. innocua in a 62-year-old patient.

Published
2003

5. SoDa: a project for the integration and exploitation of networked solar radiation databases

Author

Lucien Wald, Michel Albuisson, Clive Best, Catherine Delamare, Dominique Dumortier, Elena Gaboardi, Anette Hammer, Detlev Heinnemann, Richard Kift, Stefan Kunz, Mireille Lefèvre, Sébastien Leroy, Mario Martinoli, Lionel Ménard, John Page, Tamas Prager, Corrado Ratto, Christian Reise, Jan Remund, Aniko Rimoczi-Paal, Eric van der Goot, Franz Vanroy, Ann Webb, CEP/Sophia, Centre Énergétique et Procédés (CEP), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Joint Research Center Institute for the Protection and Security of the Citizen, École Nationale des Travaux Publics de l'État (ENTPE), École Nationale des Travaux Publics de l'État (ENTPE)-Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement, icons, Department of Physics (EHF), University of Oldenburg, University of Manchester, School of Earth, Meteotest, Armines - DAE, ARMINES, Respiratory Research Group, University of Manchester [Manchester]-School of Translational Medicine, Hungarian Meteorological Service (OMSz), Dipartimento di Fisica, Universita degli studi di Genova, Fraunhofer Institute for Solar Energy Systems (Fraunhofer ISE), Fraunhofer (Fraunhofer-Gesellschaft), and W. Pillmann, K. Tochtermann

Subjects
[SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, [INFO.INFO-WB]Computer Science [cs]/Web, [SDE]Environmental Sciences, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences
Abstract

International audience; The project SoDa (solar data) answers the needs of industry and research for information on solar radiation parameters with a satisfactory quality. The methodology is user-driven with a large involvement of users in the project, who gauge the progresses and achievements. A prototype service has been developed, using Internet technology, that integrates and efficiently exploits diverse networked information sources to supply value-added information. Access to data and applications has been greatly improved; efforts were made on interpolation methods and satellite data processing to achieve better quality and increase time and space coverage of the information. Applications were developed or networked to supply information actually needed by customers, and not only raw data.

Published
2002

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