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Biomedical applications with emphasis on the design of smart materials, specifically magnetic nanoparticles (MNPs) are considered to have technological benefits because they can be manipulated using magnetic fields. Magnetic NPs have been widely used in hyperthermia, target drug delivery system, imaging, and extraction of biomolecules, postulating them also as an important tool in cancer treatment. Morphological structures of magnetic materials have drawn tremendous attention from diverse scientific fields due to their unique surface chemistry, nontoxicity, biocompatibility, and particularly their inducible magnetic moment. This review features recent research accomplishments made in the biomedical field using magnetic nanoparticles. The first part gives a comprehensive overview of magnetic nanoparticles in the treatment of chronic diseases and drug targeting. The second part includes the role of magnetic nanoparticles in electrochemical, optical-based immunoassays. The review also outlines the current challenges and future research perspectives for fostering advanced and high-performance magnetic nanoparticles in technological applications.

In recent years microfluidics and lab-on-a-chip havecome to the forefront in diagnostics and detection [...]

Lab-on-a-Disc (LoaD) biosensors are increasingly a promising solution for many biosensing applications. In the search for a perfect match between point-of-care (PoC) microfluidic devices and biosensors, the LoaD platform has the potential to be reliable, sensitive, low-cost, and easy-to-use. The present global pandemic draws attention to the importance of rapid sample-to-answer PoC devices for minimising manual intervention and sample manipulation, thus increasing the safety of the health professional while minimising the chances of sample contamination. A biosensor is defined by its ability to measure an analyte by converting a biological binding event to tangible analytical data. With evolving manufacturing processes for both LoaDs and biosensors, it is becoming more feasible to embed biosensors within the platform and/or to pair the microfluidic cartridges with low-cost detection systems. This review considers the basics of the centrifugal microfluidics and describes recent developments in common biosensing methods and novel technologies for fluidic control and automation. Finally, an overview of current devices on the market is provided. This review will guide scientists who want to initiate research in LoaD PoC devices as well as providing valuable reference material to researchers active in the field.

We present for the first time an integrated wirelessly powered Arduino processor and Bluetooth interface that are co-rotated with the cartridge to allow large-scale process integration on a centrifugal microfluidic platform. This highly modular, electronically controlled “Lab-on-a-Disc” system (eLoaD) can independently actuate up to 128 normally-closed valves by an array of microheaters during rotation for comprehensive, highly parallelized sample-to-answer automation. Additionally, we implement real-time optical (colour intensity) measurement for closed-loop control of liquid handling, sample preparation and detection.

Made available in DSpace on 2014-12-03T13:11:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-07-01Bitstream added on 2014-12-03T13:22:30Z : No. of bitstreams: 1 WOS000322171700003.pdf: 2384407 bytes, checksum: dfa25986b34c0796f1380f916148eb78 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) rede nBioNet (Brazil) We report on optimized architectures containing layer-by-layer (LbL) films of natural rubber latex (NRL), carboxymethyl-chitosan (CMC) and magnetite (Fe3O4) nanoparticles (MNPs) deposited on flexible substrates, which could be easily bent by an external magnetic field. The mechanical response depended on the number of deposited layers and was explained semi-quantitatively with a fully atomistic model, where the LbL film was represented as superposing layers of hexagonal graphene-like atomic arrangements deposited on a stiffer substrate. The bending with no direct current or voltage being applied to a supramolecular structure containing biocompatible and antimicrobial materials represents a proof-of-principle experiment that is promising for tissue engineering applications in biomedicine. Fed Univ ABC, Ctr Nat & Human Sci, BR-09210170 Santo Andre, SP, Brazil Univ Estadual Campinas, UNICAMP, Gleb Wataghin Inst Phys, Dept Appl Phys, BR-13083970 Campinas, SP, Brazil Univ Sao Paulo, Sao Carlos Inst Phys, BR-13560970 Sao Carlos, SP, Brazil Sao Paulo State Univ, UNESP, Fac Sci & Technol, BR-19060900 Presidente Prudente, SP, Brazil UNICEP, Paulista Univ Ctr, BR-13563470 Sao Carlos, SP, Brazil Sao Paulo State Univ, UNESP, Dept Phys, IGCE, BR-13506900 Rio Claro, SP, Brazil Sao Paulo State Univ, UNESP, Fac Sci & Technol, BR-19060900 Presidente Prudente, SP, Brazil Sao Paulo State Univ, UNESP, Dept Phys, IGCE, BR-13506900 Rio Claro, SP, Brazil

Made available in DSpace on 2018-12-11T17:29:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Empresa Brasileira de Pesquisa Agropecuária Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Reliable gas sensors operating at room temperature are in demand for monitoring the environment for hazardous pollutants, such as ammonia (NH3) gas that may become toxic to humans and animals above a threshold concentration. In this paper we report on the combination of three materials, namely polyaniline (PANI), graphene oxide (GO) and zinc oxide (ZnO), to produce hybrid layer-by-layer (LbL) films used for sensing NH3 with impedance spectroscopy measurements. The deposition of tetralayered PANI/GO/PANI/ZnO LbL films was confirmed with UV–vis. absorption and Raman spectroscopies, while atomic force microscopy (AFM) served to investigate film morphology. Exposure of these LbL films to NH3 caused film roughness to vary, in an effect that depended on the number of tetralayers. Because of synergy in the materials properties, the films with 3 tetralayers were found to be the most adequate for detecting NH3 in the range from 25 ppm to 500 ppm with a response time of 30 s. These figures of merit are adequate for monitoring working environments regarding gas exposure, and highlight the usefulness of the control of film architecture provided by the LbL technique. National Laboratory for Nanotechnology in Agribusiness (LNNA) Embrapa Instrumentation Center for Exact Sciences and Technology Department of Chemistry Federal University of São Carlos (UFSCar) São Carlos Institute of Physics (IFSC) University of São Paulo (USP), P.O. Box 369 CCTS Federal University of São Carlos (UFSCar) Institute of Physics Gleb Wataghin Unicamp Institute of Chemistry São Paulo State University (UNESP) Institute of Chemistry São Paulo State University (UNESP) CNPq: 141894/2013-0 FAPESP: 2012/15543-7 FAPESP: 2012/23880-3 FAPESP: 2013/14262-7 FAPESP: 2014/16789-5 CNPq: 502391/2014-6