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4 results on '"Chang, Q. M."'

1. Long noncoding RNA MAFG-AS1 facilitates the progression of hepatocellular carcinoma targeting miR-3196/OTX1 axis.

Author

HU, Z.-Q., LI, H.-C., TENG, F., CHANG, Q.-M., WU, X.-B., FENG, J.-F., and ZHANG, Z.-P.

Abstract

OBJECTIVE: Hepatocellular carcinoma (HCC) is an invasive malignant tumor with high mortality rate. Long non-coding RNA (IncRNA) MAFG-AS1 has been showed to play an oncogenic role in several malignant tumors. Nonetheless, the exact role of MAFG-AS1 in the progression of HCC has not been fully elucidated. PATIENTS AND METHODS: Real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot were used to detect the mRNA and protein expression of MAFG-AS1 in HCC tissues and cells. Cell counting kit-8 (CCK-8), transwell and tubule formation assays were applied to uncover the proliferation, migration, invasion and tumor angiogenesis of HCC cells, respectively. RNA binding protein immunoprecipitation (RIP) assay and Luciferase reporter gene assay were employed to explore the molecular mechanism. In addition, Xenograft assay was used to investigate the effect of MAFG-AS1 in vivo. RESULTS: MAFG-AS1 was highly expressed in HCC tissues and cells. Attenuation of MAFG-AS1 evidently suppressed the proliferation, migration, invasion and tumor angiogenesis of HCC cells, suggesting that MAFG-AS1 played an oncogenic role in HCC. MiR-3196 was sponged by MAFG-AS1, and OTX1 was a downstream target of miR-3196 in HCC. In addition, OTX1 expression was negatively associated with miR-3196 but positively associated with MAFG-AS1 in HCC tissues. Overexpression of OTX1 could abolish the repressive influence of MAFG-AS1 inhibition on the proliferation, migration, invasion and tumor angiogenesis of HCC cells. CONCLUSIONS: MAFG-AS1 facilitated the progression of HCC via targeting miR-3196/ OTX1 axis, which might be used as a new insight for HCC treatment. [ABSTRACT FROM AUTHOR]

Published
2020

2. Experimental study and design calculation for compressive strengths of cold formed thick-wall sections.

Author

Hu, S D, Li, L X, Wang, X Y, and Chang, Q M

Subjects
MATERIALS compression testing, THICKNESS measurement, STEEL tubes, MECHANICAL behavior of materials, STRENGTH of materials
Abstract

In order to investigate section capacities of thick-wall cold formed steel with square and rectangular hollow cross-sections, experiments were carried out on mechanical properties of the flat coupons, corner coupons, parent steel coupons and full section stub columns. Strain hardening of cold forming thick-wall cold formed sections was investigated. The stub column test strengths were compared with the design compressive strengths specified by the Australian/New Zealand and Chinese standards for the design of the cold formed steel structural members respectively. It has been shown that the strength predicted by the Australian/New Zealand standard using material properties and that forecasted by the Chinese standard based on the average design yield stress of the full section are a little conservative. The two mean strengths predicted by Australian/New Zealand standard based on the mean design yield stress and forecasted by the Chinese standard using material properties tests are identical, which are superior to the present thick-wall cold formed steel tubes because of their safety and economy. [ABSTRACT FROM AUTHOR] </p></dd> <dt class="blacklight-eds_authors col-md-3">Published</dt> <dd class="col-md-9 blacklight-eds_authors">2011</dd> <dt class="blacklight-eds_authors col-md-3"><span class="tags-custom">Full Text</span></dt> <dd class="col-md-9 blacklight-eds_authors"><a class="pdf-blue-icon" target="_blank" href="https://doi.org/10.1179/143307511X12858957675679">View/download PDF</a></dd> </dl> </article><article data-document-id="asx__47602567" data-document-counter="3" itemscope="itemscope" itemtype="http://schema.org/Thing" class="blacklight-academic-journal document document-position-3"> <header class="documentHeader row"> <h3 class="index_title document-title-heading col-sm-9 col-lg-10"> <span class="document-counter"> 3. </span> <a data-context-href="/articles/asx__47602567/track?counter=3&document_id=asx__47602567&search_id=9597975" href="/articles/asx__47602567">Effects of process parameters on quality of squeeze casting A356 alloy.</a> </h3> <div class="index-document-functions col-sm-3 col-lg-2"> <form class="bookmark-toggle" data-doc-id="asx__47602567" data-present="In Bookmarks" data-absent="Bookmark" data-inprogress="Saving..." action="/bookmarks/asx__47602567" accept-charset="UTF-8" method="post"><input type="hidden" name="_method" value="put" /><input type="hidden" name="authenticity_token" value="OVJanx+57OTb217+NwSa0LaMEeuNL8SMCj4XgYA52zzVP/vUxjuJuUmyrat1iFAOOcQ/UHYr9touqbjiwDEiOA==" /> <input type="hidden" name="catalog_type" id="catalog_type" value="articles" /> <input type="submit" name="commit" value="Bookmark" id="bookmark_toggle_asx__47602567" class="bookmark-add btn btn-outline-secondary" data-disable-with="Bookmark" /> </form> </div> </header> <dl class="document-metadata dl-invert row"> <dt class="blacklight-eds_authors col-md-3">Author</dt> <dd class="col-md-9 blacklight-eds_authors mb-0"> <p class="truncate-text"> Chang, Q. M., Chen, C. J., Zhang, S. C., Schwam, D., and Wallace, J. F.</p></dd> <dt class="blacklight-eds_authors col-md-3">Subjects</dt> <dd class="col-md-9 blacklight-eds_authors">*<searchLink fieldCode="DE" term="%22ALUMINUM+alloys%22">ALUMINUM alloys</searchLink>, *<searchLink fieldCode="DE" term="%22PHASE+equilibrium%22">PHASE equilibrium</searchLink>, *<searchLink fieldCode="DE" term="%22DIE+castings%22">DIE castings</searchLink>, *<searchLink fieldCode="DE" term="%22METAL+castings%22">METAL castings</searchLink>, *<searchLink fieldCode="DE" term="%22SOLIDIFICATION%22">SOLIDIFICATION</searchLink></dd> <dt class="blacklight-eds_languages col-md-3">Abstract</dt> <dd class="col-md-9 blacklight-eds_languages"><p class="truncate-text"> This investigation has studied the influence of the various casting variables on the quality of indirect squeeze castings primarily of aluminium alloys. The variables studied include gating design, filling velocity and squeezing pressure. The quality of the die casting was assessed by an analysis of both their surface condition and internal soundness. The cavity filling patterns with fanned gates and straight gate are compared. Straight gates are prone to cause jetting of the metal stream even at low velocities while fanned gates allow use of higher fill velocity without excessive jetting. A higher metal pressure provides a more complete fill of the die including improved compensation for solidification shrinkage. The gate velocity for cavity filling process is one of the most important factors for attaining a sound casting. Either too slow velocity or too rapid gate velocity can cause such defects as misrun, indications, jetting vortex, air entrapment, etc. Furthermore, the computer models using the UES ProCast software are conducted. [ABSTRACT FROM AUTHOR] </p></dd> <dt class="blacklight-eds_authors col-md-3">Published</dt> <dd class="col-md-9 blacklight-eds_authors">2010</dd> <dt class="blacklight-eds_authors col-md-3"><span class="tags-custom">Full Text</span></dt> <dd class="col-md-9 blacklight-eds_authors"><a class="pdf-blue-icon" target="_blank" href="https://doi.org/10.1179/174313309X449309">View/download PDF</a></dd> </dl> </article><article data-document-id="cmedm__33336731" data-document-counter="4" itemscope="itemscope" itemtype="http://schema.org/Thing" class="blacklight-academic-journal document document-position-4"> <header class="documentHeader row"> <h3 class="index_title document-title-heading col-sm-9 col-lg-10"> <span class="document-counter"> 4. </span> <a data-context-href="/articles/cmedm__33336731/track?counter=4&document_id=cmedm__33336731&search_id=9597975" href="/articles/cmedm__33336731">Long noncoding RNA MAFG-AS1 facilitates the progression of hepatocellular carcinoma via targeting miR-3196/OTX1 axis.</a> </h3> <div class="index-document-functions col-sm-3 col-lg-2"> <form class="bookmark-toggle" data-doc-id="cmedm__33336731" data-present="In Bookmarks" data-absent="Bookmark" data-inprogress="Saving..." action="/bookmarks/cmedm__33336731" accept-charset="UTF-8" method="post"><input type="hidden" name="_method" value="put" /><input type="hidden" name="authenticity_token" value="zgOyauWuBccDSB9xAg7aKRbPZsvWg8h6Bj9F0pwV3jr3xgI2cQYJ8Gt892dhyILBxEa7zujYtXtKyR0zbRUpkg==" /> <input type="hidden" name="catalog_type" id="catalog_type" value="articles" /> <input type="submit" name="commit" value="Bookmark" id="bookmark_toggle_cmedm__33336731" class="bookmark-add btn btn-outline-secondary" data-disable-with="Bookmark" /> </form> </div> </header> <dl class="document-metadata dl-invert row"> <dt class="blacklight-eds_authors col-md-3">Author</dt> <dd class="col-md-9 blacklight-eds_authors mb-0"> <p class="truncate-text"> Hu ZQ, Li HC, Teng F, Chang QM, Wu XB, Feng JF, and Zhang ZP</p></dd> <dt class="blacklight-eds_authors col-md-3">Subjects</dt> <dd class="col-md-9 blacklight-eds_authors">Carcinoma, Hepatocellular pathology, Cells, Cultured, Humans, Liver Neoplasms pathology, MicroRNAs genetics, Otx Transcription Factors genetics, RNA, Long Noncoding genetics, Carcinoma, Hepatocellular metabolism, Liver Neoplasms metabolism, MicroRNAs metabolism, Otx Transcription Factors metabolism, RNA, Long Noncoding metabolism</dd> <dt class="blacklight-eds_languages col-md-3">Abstract</dt> <dd class="col-md-9 blacklight-eds_languages"><p class="truncate-text"> Objective: Hepatocellular carcinoma (HCC) is an invasive malignant tumor with high mortality rate. Long non-coding RNA (lncRNA) MAFG-AS1 has been showed to play an oncogenic role in several malignant tumors. Nonetheless, the exact role of MAFG-AS1 in the progression of HCC has not been fully elucidated., Patients and Methods: Real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot were used to detect the mRNA and protein expression of MAFG-AS1 in HCC tissues and cells. Cell counting kit-8 (CCK-8), transwell and tubule formation assays were applied to uncover the proliferation, migration, invasion and tumor angiogenesis of HCC cells, respectively. RNA binding protein immunoprecipitation (RIP) assay and Luciferase reporter gene assay were employed to explore the molecular mechanism. In addition, Xenograft assay was used to investigate the effect of MAFG-AS1 in vivo., Results: MAFG-AS1 was highly expressed in HCC tissues and cells. Attenuation of MAFG-AS1 evidently suppressed the proliferation, migration, invasion and tumor angiogenesis of HCC cells, suggesting that MAFG-AS1 played an oncogenic role in HCC. MiR-3196 was sponged by MAFG-AS1, and OTX1 was a downstream target of miR-3196 in HCC. In addition, OTX1 expression was negatively associated with miR-3196 but positively associated with MAFG-AS1 in HCC tissues. Overexpression of OTX1 could abolish the repressive influence of MAFG-AS1 inhibition on the proliferation, migration, invasion and tumor angiogenesis of HCC cells., Conclusions: MAFG-AS1 facilitated the progression of HCC via targeting miR-3196/OTX1 axis, which might be used as a new insight for HCC treatment. </p></dd> <dt class="blacklight-eds_authors col-md-3">Published</dt> <dd class="col-md-9 blacklight-eds_authors">2020</dd> <dt class="blacklight-eds_authors col-md-3"><span class="tags-custom">Full Text</span></dt> <dd class="col-md-9 blacklight-eds_authors"><a class="pdf-blue-icon" target="_blank" href="https://doi.org/10.26355/eurrev_202012_24002">View/download PDF</a></dd> </dl> </article> </div> </div> </div> <div class='alternate-catalog' data-alternate-catalog="/catalog?q=%22Chang%2C+Q.+M.%22"> <button type='button' class='alternate-catalog-close close' aria-label="Close"> <i class='fa fa-times-circle'></i> </button> <h3 class='alternate-catalog-title'></h3> <div class='alternate-catalog-body'> <div class='row'> <div class='col-md-6'> <h4 class="alternate-catalog-name"> Catalog </h4> <div class='alternate-catalog-desc'> Books, media, physical & digital resources </div> </div> <div class='col-md-6'> <a class="btn btn-primary" href="/catalog?q=%22Chang%2C+Q.+M.%22"> See <span class="alternate-catalog-count"%></span> catalog results </a> </div> </div> <div class='row alternate-catalog-facet-section'> <div class='col-md-12'> <ul class="alternate-catalog-facets list-inline"> </ul> </div> </div> </div> </div> <div class="modal fade" id="loginModal" tabindex="-1" role="dialog"> <button type="button" id="loginclose" class="close" data-dismiss="modal" aria-label="Close"> <span aria-hidden="true">×</span> </button> <div class="modal-dialog" role="document"> <h5>Discovery Service for Jio Institute Digital Library</h5> <br /> <p>For full access to our library's resources, please sign in.</p> </div> <div class="login-modal-button-wrapper"> <button class="login-modal-sign-in"> <a rel="nofollow" data-method="post" href="/users/auth/saml">Sign In</a> </button> </div> </div> </section> </div> </main> <footer class="navbar navbar-inverse site-footer" style="position: static;"> <div class="container footer-container"> <div class="row"> <div class="col-xs-12 col-md-3 py-4 align-self-center site-footer-links-column"> <div class="footer-logo center-block"> <a href="https://library.jioinstitute.edu.in"> <img class="logo-img" src="/assets/Jio-DLLogo-b5a8a0808ea64b7ff5d156e304a4a034eee76224caf66c04cead90a411971fad.png" /> </a> </div> </div> <div class="col-xs-12 col-md-8 py-3 pb-5 pb-md-3 site-footer-links-column align-self-center"> <div class="row text-center footer-links-row"> <div class="col-4 col-sm-2"> <div class="navlink"><a href="https://library.jioinstitute.edu.in/contact">Contact</a></div> </div> <div class="col-4 col-sm-3"> <div class="navlink"><a href="https://library.jioinstitute.edu.in/access/covid-19-advisory">Covid-19 Advisory</a></div> </div> <div class="col-4 col-sm-2"> <div class="navlink"><a href="https://library.jioinstitute.edu.in/access/policies">Policies</a></div> </div> </div> </div> </div> </div> <div class="row text-center secondary-footer"> <div class="container"> <div class="col-xs-12 col-md-2 px-0"> <div class="footer-logo"> <a href="https://jioinstitute.edu.in/"> <img class="logo-img" src="/assets/JioLogoWhite-3a250c43ad67a5117225db9885c1ac0b116f92a0df0839e850e68dfbbce66ae7.png" /> </a> </div> </div> <div class="col-md-1 col-4 py-1 py-md-3"> <div class="navlink footer-navlink"><a href="https://jioinstitute.edu.in/about">About Us</a></div> </div> <div class="col-md-1 col-4 py-1 py-md-3"> <div class="navlink footer-navlink"><a href="https://jioinstitute.edu.in/academics">Academics</a></div> </div> <div class="col-md-1 col-4 py-1 py-md-3"> <div class="navlink footer-navlink"><a href="https://jioinstitute.edu.in/research-overview">Research</a></div> </div> <div class="col-md-1 col-4 py-1 py-md-3 pl-0 pr-0"> <div class="navlink footer-navlink"><a href="https://jioinstitute.edu.in/campus-life"> Campus Life</a></div> </div> <div class="col-md-1 col-4 py-1 py-md-3"> <div class="navlink footer-navlink"><a href="https://jioinstitute.edu.in/contacts"> Contact</a></div> </div> <div class="col-md-4 col-4 py-1 py-md-3"> <div class="navlink footer-navlink float-right"><a href="https://jioinstitute.edu.in/terms-conditions">T&C</a></div> </div> <div class="col-md-1 col py-1 py-md-3 pl-0"> <div class="navlink footer-navlink float-right"><a href="https://jioinstitute.edu.in/privacy-policy"> Privacy Policy</a></div> </div> </div> </div> <!-- Global site tag (gtag.js) - Google Analytics --> <script async src=https://www.googletagmanager.com/gtag/js?id=G-R4B0KJQ5EY></script> <script> window.dataLayer = window.dataLayer || []; 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