Search

Your search keyword '"Chen, Edward S."' showing total 272 results
Start Over Author "Chen, Edward S." Language english
272 results on '"Chen, Edward S."'

6. Factors driving provider adoption of the TREWS machine learning-based early warning system and its effects on sepsis treatment timing

Author

Henry, Katharine E., Adams, Roy, Parent, Cassandra, Soleimani, Hossein, Sridharan, Anirudh, Johnson, Lauren, Hager, David N., Cosgrove, Sara E., Markowski, Andrew, Klein, Eili Y., Chen, Edward S., Saheed, Mustapha O., Henley, Maureen, Miranda, Sheila, Houston, Katrina, Linton, II, Robert C., Ahluwalia, Anushree R., Wu, Albert W., and Saria, Suchi

Published
2022
Full Text
View/download PDF

7. Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis

Author

Adams, Roy, Henry, Katharine E., Sridharan, Anirudh, Soleimani, Hossein, Zhan, Andong, Rawat, Nishi, Johnson, Lauren, Hager, David N., Cosgrove, Sara E., Markowski, Andrew, Klein, Eili Y., Chen, Edward S., Saheed, Mustapha O., Henley, Maureen, Miranda, Sheila, Houston, Katrina, Linton, Robert C., Ahluwalia, Anushree R., Wu, Albert W., and Saria, Suchi

Published
2022
Full Text
View/download PDF

9. The association of baseline sarcoidosis measurements with 6-month outcomes that are of interest to patients: Results from the On-line Sarcoidosis Assessment Platform Study (OSAP)

Author

Judson, Marc A., Yucel, Recai, Preston, Sara, Chen, Edward S., Culver, Daniel A., Hamzeh, Nabeel, Lower, Elyse E., Sweiss, Nadera J., Valeyre, Dominique, Veltkamp, Marcel, Victorson, David E., Beaumont, Jennifer L., Singh, Noopur, Shivas, Tricha, Vancavage, Rachel, and Baughman, Robert P.

Published
2022
Full Text
View/download PDF

10. Pulmonary sarcoidosis: differences in lung function change over time.

Author

Sharp, Michelle, Psoter, Kevin J., Mustafa, Ali M., Chen, Edward S., Lin, Nancy W., Mathai, Stephen C., Gilotra, Nisha A., Eakin, Michelle N., Wise, Robert A., Moller, David R., and McCormack, Meredith C.

Subjects
INDOOR air pollution, CHIEF technical officers, SARCOIDOSIS, VITAL capacity (Respiration), DUST diseases, PULMONARY function tests
Published
2024
Full Text
View/download PDF

14. The effect of telemedicine employing telemonitoring instruments on readmissions of patients with heart failure and/or COPD: a systematic review.

Author

Stergiopoulos, Georgios M., Elayadi, Anissa N., Chen, Edward S., and Galiatsatos, Panagis

Subjects
VITAL signs, HEART rate monitoring, PATIENT readmissions, BODY weight, HEART failure, EVALUATION of medical care, TELEMEDICINE, SYSTEMATIC reviews, MEDLINE, ELECTROCARDIOGRAPHY, BODY temperature, ISOLATION (Hospital care), OBSTRUCTIVE lung diseases, RESPIRATORY measurements, PATIENT monitoring, ONLINE information services
Abstract

Background: Hospital readmissions pose a challenge for modern healthcare systems. Our aim was to assess the efficacy of telemedicine incorporating telemonitoring of patients' vital signs in decreasing readmissions with a focus on a specific patient population particularly prone to rehospitalization: patients with heart failure (HF) and/or chronic obstructive pulmonary disease (COPD) through a comparative effectiveness systematic review. Methods: Three major electronic databases, including PubMed, Scopus, and ProQuest's ABI/INFORM, were searched for English-language articles published between 2012 and 2023. The studies included in the review employed telemedicine incorporating telemonitoring technologies and quantified the effect on hospital readmissions in the HF and/or COPD populations. Results: Thirty scientific articles referencing twenty-nine clinical studies were identified (total of 4,326 patients) and were assessed for risk of bias using the RoB2 (nine moderate risk, six serious risk) and ROBINS-I tools (two moderate risk, two serious risk), and the Newcastle-Ottawa Scale (three good-quality, four fair-quality, two poor-quality). Regarding the primary outcome of our study which was readmissions: the readmission-related outcome most studied was all-cause readmissions followed by HF and acute exacerbation of COPD readmissions. Fourteen studies suggested that telemedicine using telemonitoring decreases the readmission-related burden, while most of the remaining studies suggested that it had a neutral effect on hospital readmissions. Examination of prospective studies focusing on all-cause readmission resulted in the observation of a clearer association in the reduction of all-cause readmissions in patients with COPD compared to patients with HF (100% vs. 8%). Conclusions: This systematic review suggests that current telemedicine interventions employing telemonitoring instruments can decrease the readmission rates of patients with COPD, but most likely do not impact the readmissionrelated burden of the HF population. Implementation of novel telemonitoring technologies and conduct of more high-quality studies as well as studies of populations with =2 chronic disease are necessary to draw definitive conclusions. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Megabase Length Hypermutation Accompanies Human Structural Variation at 17p11.2

Author

Beck, Christine R., Carvalho, Claudia M.B., Akdemir, Zeynep C., Sedlazeck, Fritz J., Song, Xiaofei, Meng, Qingchang, Hu, Jianhong, Doddapaneni, Harsha, Chong, Zechen, Chen, Edward S., Thornton, Philip C., Liu, Pengfei, Yuan, Bo, Withers, Marjorie, Jhangiani, Shalini N., Kalra, Divya, Walker, Kimberly, English, Adam C., Han, Yi, Chen, Ken, Muzny, Donna M., Ira, Grzegorz, Shaw, Chad A., Gibbs, Richard A., Hastings, P.J., and Lupski, James R.

Published
2019
Full Text
View/download PDF

26. Joint SNMMI–ASNC expert consensus document on the role of 18F-FDG PET/CT in cardiac sarcoid detection and therapy monitoring

Author

Chareonthaitawee, Panithaya, Beanlands, Rob S., Chen, Wengen, Dorbala, Sharmila, Miller, Edward J., Murthy, Venkatesh L., Birnie, David H., Chen, Edward S., Cooper, Leslie T., Tung, Roderick H., White, Eric S., Borges-Neto, Salvador, Di Carli, Marcelo F., Gropler, Robert J., Ruddy, Terrence D., Schindler, Thomas H., and Blankstein, Ron

Published
2017
Full Text
View/download PDF

32. Standardization of flow cytometry and cell sorting to enable a transcriptomic analysis in a multi-site sarcoidosis study.

Author

Magallon, Roman E., Harmacek, Laura D., Arger, Nicholas K., Grewal, Pineet, Powers, Linda, Werner, Brenda R., Barkes, Briana Q., Li, Li, MacPhail, Kristyn, Gillespie, May, White, Elizabeth K., Collins, Sarah E., Brown, Talyor, Cardenas, Jessica, Chen, Edward S., Maier, Lisa A., Leach, Sonia M., Hamzeh, Nabeel Y., Koth, Laura L., and O'Connor, Brian P.

Subjects
SARCOIDOSIS, NUCLEOTIDE sequencing, FLOW cytometry, RNA sequencing, STANDARDIZATION, DENATURATION of proteins, LIFTING & carrying (Human mechanics)
Abstract

The contribution and regulation of various CD4+ T cell lineages that occur with remitting vs progressive courses in sarcoidosis are poorly understood. We developed a multiparameter flow cytometry panel to sort these CD4+ T cell lineages followed by measurement of their functional potential using RNA-sequencing analysis at six-month intervals across multiple study sites. To obtain good quality RNA for sequencing, we relied on chemokine receptor expression to identify and sort lineages. To minimize gene expression changes induced by perturbations of T cells and avoid protein denaturation caused by freeze/thaw cycles, we optimized our protocols using freshly isolated samples at each study site. To accomplish this study, we had to overcome significant standardization challenges across multiple sites. Here, we detail standardization considerations for cell processing, flow staining, data acquisition, sorting parameters, and RNA quality control analysis that were performed as part of the NIH-sponsored, multi-center study, BRonchoscopy at Initial sarcoidosis diagnosis Targeting longitudinal Endpoints (BRITE). After several rounds of iterative optimization, we identified the following aspects as critical for successful standardization: 1) alignment of PMT voltages across sites using CS&T/rainbow bead technology; 2) a single template created in the cytometer program that was used by all sites to gate cell populations during data acquisition and cell sorting; 3) use of standardized lyophilized flow cytometry staining cocktails to reduce technical error during processing; 4) development and implementation of a standardized Manual of Procedures. After standardization of cell sorting, we were able to determine the minimum number of sorted cells necessary for next generation sequencing through analysis of RNA quality and quantity from sorted T cell populations. Overall, we found that implementing a multi-parameter cell sorting with RNA-seq analysis clinical study across multiple study sites requires iteratively tested standardized procedures to ensure comparable and high-quality results. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

33. Heterogeneity of Lung Function Phenotypes in Sarcoidosis: Role of Race and Sex Differences.

Author

Sharp, Michelle, Psoter, Kevin J., Balasubramanian, Aparna, Pulapaka, Anuhya V., Chen, Edward S., Brown, Stacey-Ann Whittaker, Mathai, Stephen C., Gilotra, Nisha A., Chrispin, Jonathan, Bascom, Rebecca, Bernstein, Richard, Eakin, Michelle N., Wise, Robert A., Moller, David R., and McCormack, Meredith C.

Abstract

Rationale: Historically, sarcoidosis was described as a restrictive lung disease, but several alternative phenotypes of pulmonary function have been observed. Pulmonary function phenotypes in sarcoidosis may represent different clinical and/or molecular phenotypes. Objectives: To characterize the prevalence of different pulmonary function phenotypes in a large and diverse sarcoidosis cohort from a tertiary care referral center. Methods: We identified individuals seen between 2005-2015 with a confirmed diagnosis of sarcoidosis. Data were collected from the first pulmonary function test (PFT) performed at our institution which included spirometry and diffusing capacity of the lung for carbon monoxide (DLCO). Demographics and clinical data were collected. Chi-squared analyses and multiple linear regressions were done to assess statistical differences and associations. Global Lung Function Initiative equations were used to calculate percent predicted measurements for spirometry and DLCO. Results: Of 602 individuals with sarcoidosis, 93% (562) had pulmonary involvement, 64% (385) were female, and 57% (341) were Black. Of those with pulmonary involvement, 56% had abnormal pulmonary function. Lung function impairment phenotypes included: 47% restriction, 22% obstruction, 15% isolated reduction in DLCO, and 16% combined obstructive restrictive phenotype. Restriction was the most common PFT phenotype among Black individuals (41%), while no lung impairment was most common among White individuals (66%) (P,0.001). Males more frequently had obstruction (19%) compared with females (9%) P = 0.001, and females had more restriction (30%) compared with males (21%) P = 0.031. Conclusions: Among individuals with sarcoidosis and pulmonary function impairment, less than half demonstrated a restrictive phenotype. There were significant differences in pulmonary function phenotypes by race and sex. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

34. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c

Author

Edelstein, Leonard C., Simon, Lukas M., Montoya, Raul Teruel, Holinstat, Michael, Chen, Edward S., Bergeron, Angela, Kong, Xianguo, Nagalla, Srikanth, Mohandas, Narla, Cohen, David E., Dong, Jing-fei, Shaw, Chad, and Bray, Paul F.

Subjects
Carrier proteins -- Identification and classification, Blood platelets -- Demographic aspects, Cell receptors -- Genetic aspects, Biological sciences, Health
Abstract

Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n = 70) and white (n = 84) subjects. [...]

Published
2013
Full Text
View/download PDF

45. Semiempirical characterization of homonuclear diatomic ions: 6. group VI and VII anions

Author

Chen, Edward S. and Chen, Edward C.M.

Subjects
Ions -- Research, Electrons -- Thermal properties, Anions -- Research, Chemicals, plastics and rubber industries
Abstract

Molecular ion formation M or dissociation D in a vertical transition is used for classifying sixteen Herschback ionic morse potential energy curves (HIMPEC). Two curves are calculated from experimental data for anions of S(sub 2), Se(sub 2) and, Te(sub 2).

Published
2003

Catalog

Books, media, physical & digital resources
See catalog results