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To improve the force endurance capacity of plate breakwaters, a step‐type plate breakwater was proposed. The performance of the step‐type breakwater was investigated by numerical simulation method. First, a two‐dimensional numerical regular wave tank was constructed using FLUENT software, and the effectiveness of the tank application was verified by comparing with theoretical value and test data. Then, the numerical tank was used to simulate various working conditions, and the variation rules of the breakwater transmission coefficient with wave height, period, perforation rate, relative plate width, wave steepness, and number of layers were obtained. Finally, the difference in the wave dissipation mechanism between the step‐type breakwater and the ""‐type breakwater was discussed. The results indicated that the transmission coefficient of the step‐type breakwater was small, which also proved to be good at dissipating long‐period waves. In general, the wave dissipation performance of the step‐type breakwater was better than that of the ""‐type breakwater. The research can provide some clues for the research and design of corresponding breakwaters. [ABSTRACT FROM AUTHOR]

Cancer information in the media often contains ambiguous, conflicting, or contestable knowledge, which may lead to the cultivation of cancer fatalism. Many believe cancer fatalism poses a significant barrier to cancer prevention and detection behaviors in the population. This meta-analysis synthesized empirical results from 100 studies regarding the associations between cancer fatalism and four categories of communicative and behavioral correlates: (a) media exposure, (b) cancer beliefs, (c) cancer prevention and detection engagement, and (d) cancer information management. Our findings show that cancer fatalism is positively linked to TV exposure and negatively linked to radio or Internet exposure. Cancer fatalism is also positively associated with information avoidance and negatively associated with cancer detection behaviors. This study demonstrates the nature and magnitude of the relationships between cancer fatalism and its antecedents or outcomes and offers useful insights for future investigation and theoretical development in understanding the role of cancer fatalism in communication. [ABSTRACT FROM AUTHOR]

News-finds-me (NFM) perception is a belief that, in the era of social media, individuals can remain adequately well-informed about current events even if they do not actively seek news. While it has been examined in the context of general and political news, NFM perception has not been explored in the context of other genres of news. Through an online survey involving 1,001 Singaporeans, with the Planned Risk Information Seeking Model, this study examines how NFM perception is related to information seeking and COVID-19 knowledge. An issue-specific NFM perception was also proposed and tested in order to determine whether NFM perception and its associated effects differ when operationalized as general news exposure or issue-specific news relating to COVID-19. The negative relationship between general NFM perception and knowledge and the mediating role of information seeking on social media in this relationship are detected. It is also found that when the NFM perception is issue-specific (i.e. COVID-NFM perception), information insufficiency and intentions of information seeking on social media fully mediated the relationship between NFM perception and knowledge. Theoretical and practical implications are discussed. [ABSTRACT FROM AUTHOR]

The H6 subtype of avian influenza virus (H6 AIV) is the most detected AIV subtype in poultry and wild birds. It causes economic losses to the poultry industry, and the most important, H6 AIV may have the ability to infect mammals, which is a great threat to public health security. In addition, the H6 subtype can serve as a precursor to providing internal genes for other highly pathogenic AIVs, posing a potential threat. H6 AIV currently face to the high positive detection rate and harmless nature of H6 AIV and because not highly effective H6 subtype vaccine available on the market. In this study, we focused on the prevalence of H6 AIV in poultry and wild birds, phylogenetic analysis, genetic variation characteristics, selection analysis, and prevention and control to provide relevant references for the scientific prevention and control of H6 AIV in future. [ABSTRACT FROM AUTHOR]

Public health emergencies pose considerable threats to global health and safety. The control of these emergencies requires the efforts of healthcare professionals and calls for the public to take protective actions. The present study not only puts fear back in the extended parallel process model (EPPM) but also considers another similarly productive emotion: hope. We examined the mechanisms behind the effects of four cognitive perceptions on protective actions (i.e., danger control) and information avoidance (i.e., fear control). A national online survey was conducted with 1676 participants during the outbreak of COVID‐19 in China from February 1 to 29, 2020. The results revealed that perceived severity and susceptibility could lead to fear, positively affecting protective actions. On the other hand, perceived response efficacy and self‐efficacy induced hope, which was positively associated with protective actions but negatively associated with information avoidance. Furthermore, the mechanisms behind the relationships among cognitions, emotions, and behaviors varied across levels of trust in healthcare systems. [ABSTRACT FROM AUTHOR]

Fractional exhaled nitric oxide (FeNO) is a significant biological signaling molecule. However, the detection of ppb-level nitric oxide (NO) still faces great challenges. Herein, we designed and prepared a porphyrin-based MOF (Co-TCPP(Fe)) with rod-like morphology which was assembled with MXene (Ti3C2Tx) through hydrogen bonding to offer a kind of chemiresistive NO sensing hybrid (Co-TCPP(Fe)/Ti3C2Tx). The Co-TCPP(Fe)/Ti3C2Tx-20 based sensor showed superior NO sensing performance at room temperature including high response (Ra/Rg = 2.0, 10 ppm), reliable repeatability, high selectivity, low practical limit of detection (pLOD, 200 ppb), and fast room temperature NO sensing response/recovery speed (95 s/15 s, 10 ppm). The study of the gas sensing mechanism demonstrated that reviving more unoccupied Fe–N4 units to sense NO by forming a rod-like MOF architecture and facilitating charge transfer by constructing a Schottky junction of Co-TCPP(Fe)/Ti3C2Tx jointly contribute to the superior performance of the obtained Co-TCPP(Fe)/Ti3C2Tx based NO sensor. This work not only paves an avenue for fabricating bimetallic porphyrin-based rod-like MOFs, but also proposes a facile strategy of constructing Schottky junctions between MOFs and MXenes for high-performance chemiresistive gas sensors, which acts as a guide for fabricating MOF-based hybrid sensing materials in the future. [ABSTRACT FROM AUTHOR]

Nutraceuticals provide many biological benefits besides their basic nutritional value. However, their biological efficacies are often limited by poor absorption and low bioavailability. Nanomaterials have received much attention as potential delivery systems of nutrients and phytonutrients for multiple applications. Nanomicelles are nanosized colloidal structures with a hydrophobic core and hydrophilic shell. Due to their unique characteristics, they have shown great perspectives in food and nutraceutical science. In this review, we discussed the unique properties of nanomicelles. We also emphasized the latest advances on the design of different nanomicelles for efficient delivery and improved bioavailability of various nutrients. The role of nanomicelles in the efficacy improvement of bioactive components from nutraceutical and health foods has been included. Importantly, the safety concerns on nano-processed food products were highlighted. [ABSTRACT FROM AUTHOR]

Supercritical fluid extraction (SFE) is an eco‐friendly technology that has attracted a great amount of attention in the food and nutraceutical industries due to its considerable benefits over conventional techniques. It has high selectivity and can be employed to extract heat sensitive, easily oxidized compounds with high efficiency. Less organic solvent is used during extraction, leaving no toxic residues in the product. With these advantages, SFE has been widely applied in bioactive compound extraction from natural plant materials or by‐products. This review summarizes the recent application of SFE in nutraceutical industries including recovery of carotenoids, phenolic compounds, lipids, flavor and fragrance, and decaffeination of tea and coffee. The key parameters affecting SFE are also discussed with focuses on pretreatment, temperature and pressure, flow rate, extraction time, and cosolvent/modifier. Overall, this review builds a comprehensive picture of SFE application in the nutraceutical industry. It is anticipated that this article can provide useful information for researchers to pursue more applications of this technology in the food and nutraceutical industries. [ABSTRACT FROM AUTHOR]

Data-driven journalism is gaining a presence in news organizations. Most existing studies on journalists' adoption of and media's discourse around data-driven journalism have focused on Western contexts. The present study focuses on Hong Kong, a non-Western society where data-driven journalism is nascent. This study applies the diffusion of innovation theory, the technology acceptance model, and the trading zone framework to explain how journalists adopt data-driven journalism and how this journalistic practice is communicated to the public through media coverage. An online survey was conducted with news professionals in local media organizations (n = 255), as was a supplementary content analysis of news articles on data-driven journalism published in Hong Kong media in 2009–2019 (n = 57). Survey results revealed that perceived ease of use and perceived popularity were positively associated with the adoption of data-driven journalism. The more designers were involved in the news production process, the more likely it was for participants to adopt data-driven journalism. Additionally, most media coverage highlighted the positive outcomes of data-driven journalism—particularly its observability and usefulness—as well as the importance of interdisciplinary collaboration. The implications of applying data science to news production and the sociotechnical context of Hong Kong are discussed. [ABSTRACT FROM AUTHOR]

Degenerative disc disease (DDD) can cause severe low back pain, which will have a serious negative impact on the ability to perform daily tasks or activities. For the past few years, mesenchymal stem cell (MSC) transplantation has emerged as a promising strategy for the treatment of DDD. However, the clinical efficacy of MSC in the treatment of DDD still lacks clinical evidence and is controversial. We conducted a meta-analysis with randomized controlled trials (RCTs) to evaluate the clinical efficacy and safety of MSC transplantation in patients with DDD. We searched major databases using terms from the database's inception through March 2021. The Cochrane bias risk assessment tool was used to assess quality. The analysis showed that MSC therapy could decrease visual analog scale (VAS) scores (SMD = − 0.50 , 95 % CI = − 0.68 ~ − 0.33 , P < 0.00001) and Oswestry Disability Index (ODI) scores (SMD = − 0.27 , 95 % CI = − 0.44 ~ − 0.09 , P = 0.003). The outcomes with subgroup analysis showed that MSC therapy could decrease VAS scores in 3 months (P = 0.001), 6 months (P = 0.01), 12 months (P = 0.02), and ≥24 months (P = 0.002) and ODI scores in ≥24 months (P = 0.006). Pooled analysis showed that MSC therapy has a higher ratio of patients at most thresholds but particularly at the MIC (minimally important change) (P = 0.0002) and CSC (clinically significant change) (P = 0.0002) in VAS and MIC (P = 0.0005) and CSC (P = 0.001) pain responders in ODI. Adverse events (AE) of treatment-emergent adverse events (TEAE), back pain, arthralgia, and muscle spasms were not statistically significant between the two groups. However, our further statistical analysis showed that MSC therapy may induce AE of TEAE related to study treatment (OR = 3.05 , 95 % CI = 1.11 ~ 8.40 , P = 0.03). In conclusion, this study pooled the main outcomes and showed that MSC therapy could significantly decrease VAS and ODI scores in patients with DDD. Distinctly, the findings of this meta-analysis suggest a novel therapeutic strategy for patients with chronic low back pain (LBP) and lumbar dysfunction by DDD. [ABSTRACT FROM AUTHOR]

Diabetes mellitus and osteoporosis are closely related and have complex influencing factors. The impact of anti-diabetic drugs on bone metabolism has received more and more attention. Type 2 diabetes mellitus (T2DM) would lead to bone fragility, high risk of fracture, poor bone repair and other bone-related diseases. Furthermore, hypoglycemic drugs used to treat T2DM may have notable detrimental effects on bones. Thus, the clinically therapeutic strategy for T2DM should not only effectively control the patient's glucose levels, but also minimize the complications of bone metabolism diseases. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are novel and promising drug for the treatment of T2DM. Some studies have found that GLP-1RAs may play an anti-osteoporotic effect by controlling blood sugar levels, promoting bone formation and inhibiting bone resorption. However, in clinical practice, the specific effects of GLP-1RA on fracture risk and osteoporosis have not been clearly defined and evidenced. This review summarizes the current research findings by which GLP-1RAs treatment of diabetic osteoporosis, postmenopausal osteoporosis and glucocorticoid-induced osteoporosis and describes possible mechanisms, such as GLP-1R/MAPK signaling pathway, GLP-1R/PI3K/AKT signaling pathway and Wnt/β-catenin pathway, that are associated with GLP-1RAs and osteoporosis. The specific role and related mechanisms of GLP-1RAs in the bone metabolism of patients with different types of osteoporosis need to be further explored and clarified. [ABSTRACT FROM AUTHOR]

This study explored strategies to increase Chinese smokers' cessation intentions, using the extended parallel processing model, or EPPM. A 2 × 2 × 2 factorial experiment was designed to examine the effects of self-oriented threat (present vs. absent), other-oriented threat (present vs. absent), and efficacy (present vs. absent) on smoking cessation intention. A total of 324 Chinese smokers aged 18-64 years participated in this study. The results revealed significant main effects of self-oriented threat, other-oriented threat, and efficacy on cessation intentions. Moreover, the presence of other-oriented threat was important, and the combination of presence of other-oriented threat and the presence of efficacy led to the greatest willingness to quit smoking, regardless of the presence of a self-oriented threat. [ABSTRACT FROM AUTHOR]

Mitogen‐activated protein kinase 6 (MAPK6) represents an atypical MAPK also known as extracellular signal‐regulated kinase 3 (ERK3), which has been shown to play roles in cell motility and metastasis. ERK3 promotes migration and invasion of lung cancer cells and head and neck cancer cells by regulating the expression and/or activity of proteins involved in cancer progression. For instance, ERK3 upregulates matrix metallopeptidases and thereby promotes cancer cell invasiveness, and it phosphorylates tyrosyl‐DNA phosphodiesterase 2, thereby enhancing chemoresistance in lung cancer. Here we discovered that ERK3 plays a converse role in melanoma. We observed that BRAF, an oncogenic Ser/Thr kinase, upregulates ERK3 expression levels by increasing both ERK3 messenger RNA levels and protein stability. Interestingly, although BRAF's kinase activity was required for upregulating ERK3 gene transcription, BRAF stabilized ERK3 protein in a kinase‐independent fashion. We further demonstrate that ERK3 inhibits the migration, proliferation and colony formation of melanoma cells. In line with this, high level of ERK3 predicted increased survival among patients with melanomas. Taken together, these results indicate that ERK3 acts as a potent suppressor of melanoma cell growth and invasiveness. [ABSTRACT FROM AUTHOR]

Background:Although a number of studies have examined social support needs among women with breast cancer, little attention has been paid to the burden and needs for social support among their family caregivers, who often report mental and physical problems associated with caregiving. Objective:This study aims to examine the role of social media in providing social support for offspring caregivers of breast cancer patients. Methods:A peer support group, "Having a breast cancer patient in my family," was created on Douban (www.douban.com), one of China's most popular social media sites, to provide social support to family caregivers of women with breast cancer. We analyzed the content of 784 messages in the discussion threads where the latest update fell between January 2017 and July 2017. Results:The results revealed that the majority of messages (n = 690, 88.0%) provided or requested social support, and more than 64.5% of these messages (n = 445) were posted by caregivers who were offspring of the cancer patients. The results also suggested that these caregivers requested and provided informational support more frequently than they did emotional and instrumental support. Conclusions:This study suggests that social media could be a plausible platform for offspring caregivers of breast cancer patients to share caregiving experiences, access informational resources for their care recipients, gain knowledge about breast cancer prevention, and obtain emotional encouragement. Theoretical as well as practical implications are discussed. [ABSTRACT FROM AUTHOR]

Background: Intersubspecific autotetraploid rice hybrids possess high hybrid vigor; however, low pollen fertility is a critical hindrance in its commercial utilization. Our previous study demonstrated that polyploidy could increase the multi-loci interaction and cause high pollen abortion in autotetraploid rice hybrids. However, there is little known about the critical role of pollen sterility locus or loci in the intersubspecific hybrids. We developed autotetraploid rice hybrids harboring heterozygous genotypes ( S S S S ) at different pollen sterility loci by using the near isogenic lines of Taichung65-4×. Moreover, autotetraploid lines carrying double neutral genes, Sa and Sb , were used to assess their effect on fertility restoration. Results: Cytological studies showed that the deleterious genetic interactions at Sa and Sb pollen sterility loci resulted in higher pollen sterility (76.83%) and abnormal chromosome behavior (24.59%) at metaphase I of meiosis in autotetraploid rice hybrids. Transcriptome analysis revealed 1092 differentially expressed genes (DEG) in a hybrid with the pervasive interactions at Sa and Sb pollen sterility loci, and most of the genes (about 83%) exhibited down regulation. Of the DEG, 60 were associated with transcription regulation and 18 genes were annotated as meiosis-related genes. Analysis on the hybrids developed by using autotetraploid rice harboring double neutral genes, Sa and Sb , revealed normal pollen fertility, and transcriptome analysis showed non-significant difference in number of DEG among different hybrids. Conclusions: Our finding revealed that pervasive interactions at Sa and Sb pollen sterility loci cause high sterility in the autotetraploid hybrids that lead to the down-regulation of important meiosis-related genes and transcription regulation factors. Moreover, we also found that the hybrids sterility could be overcome by double neutral genes, Sa and Sb , in autotetraploid rice hybrids. The present study provided a strong evidence for the utilization of heterosis in autotetraploid rice hybrids. [ABSTRACT FROM AUTHOR]

Extracellular signal-regulated kinase 3 ( ERK3) is an atypical mitogen-activated protein kinase ( MAPK), whose biological activity is tightly regulated by its cellular abundance. Recent studies have revealed that ERK3 is upregulated in multiple cancers and promotes cancer cell migration/invasion and drug resistance. Little is known, however, about how ERK3 expression level is upregulated in cancers. Here, we have identified the oncogenic polycomb group protein BMI1 as a positive regulator of ERK3 level in head and neck cancer cells. Mechanistically, BMI1 upregulates ERK3 expression by suppressing the tumor suppressive micro RNA (mi RNA) let-7i, which directly targets ERK3 mRNA. ERK3 then acts as an important downstream mediator of BMI1 in promoting cancer cell migration. Importantly, ERK3 protein level is positively correlated with BMI1 level in head and neck tumor specimens of human patients. Taken together, our study revealed a molecular pathway consisting of BMI1, mi RNA let-7i, and ERK3, which controls the migration of head and neck cancer cells, and suggests that ERK3 kinase is a potential new therapeutic target in head and neck cancers, particularly those with BMI1 overexpression. [ABSTRACT FROM AUTHOR]

Polyploidy could increase the interactions of pollen sterility loci and Sb locus interaction cause higher pollen abortion than other loci. Therefore, we focused on the interaction at Sb pollen sterility locus in autotetraploid rice compared to diploid rice hybrid using the near-isogenic lines in the present study. Cytological observations indicated that interaction at Sb locus cause high pollen sterility (69.9%) and abnormal chromosome behavior (37.02%) at Metaphase II in autotetraploid rice hybrid. A total of 139 meiosis-related or meiosis stage-specific genes were detected in the autotetraploid rice hybrid harboring interaction at Sb locus and 27 of these meiosis-related or specific genes displayed significant down-regulation, including four pollen fertility related genes (Rad51 , XRI1 , PSS1 and MIL1). These results revealed a stronger interaction at Sb pollen sterility locus than other loci, which cause down-regulation of many important meiosis-related genes that were associated with higher pollen sterility in autotetraploid rice hybrids. • Sb locus cause high pollen sterility and abnormal chromosome behavior in autotetraploid rice. • Transcriptome analysis revealed that Sb locus play a critical role in autotetraploid rice hybrid sterility. • 446 differentially expressed genes (DEGs) were specifically expressed in a hybrid harboring interaction at Sb locus. • 27 meiosis-related genes displayed significant down-regulation, which might be the primary cause of high pollen sterility. [ABSTRACT FROM AUTHOR]

Vesicle-associated membrane protein (VAMP) belongs to the receptor protein on the membrane of the secretory transport vesicle and involves in host immune function. The intracellular pathogen Spiroplasma eriocheiris could cause Eriocheir sinensis tremor disease. In a previous study, it was found E. sinensis VAMP (EsVAMP) was differently expressed in S. eriocheiris infection by proteomics analysis. This study mainly aims at the function of EsVAMP in the process of the S. eriocheiris infection. The length of EsVAMP gene was 1681 bp, which contained a 395 bp open reading frame, 90 bp 5′-non-coding region (UTR) and 1277 bp 3′-UTR. The results of qPCR showed that EsVAMP was expressed highly in hemocytes and nerves, followed by gills, intestines and hepatopancreas, and lowly expressed in heart and muscles. EsVAMP in hemocytes was up-regulated after S. eriocheiris infection. After EsVAMP over-expression and S. eriocheiris infection, the RAW264.7 cell morphology and cell viability of the experiment group were significantly better than the control group. Meanwhile, the copy number of S. eriocheiris in the experiment group was significantly lower than that in the control group. After EsVAMP and pCMV-Cre-mCherry were ligated and transfected into RAW264.7 cells, it was found that EsVAMP and lysosome co-localized. Meanwhile, the phagocytosed inactivated S. eriocheiris number and phagocytosed efficiency in RAW264.7 cells were increased significantly. The interference experiment was carried out by synthesizing EsVAMP dsRNA to verify that the EsVAMP transcriptions were successfully suppressed. The S. eriocheiris copy number and the mortality of crab increased significantly after EsVAMP RNAi and S. eriocheiris infection. Meanwhile, the phagocytosed inactivated S. eriocheiris number and phagocytosed efficiency in hemocytes decreased significantly after EsVAMP RNAi and S. eriocheiris infection. These results showed that VAMP was involved in the cell phagocytosis to resist pathogen infection. • A vesicle-associated membrane protein, EsVAMP, was obtained from Eriocheir sinensis and related with Spiroplasma eriocheiris infection. • The cell morphology, cell viability was induced to resist S. eriocheiris infection after EsVAMP over-expression in RAW264.7 cells. • EsVAMP and lysosome was co-localized to increase the phagocytosis of RAW264.7 cells after EsVAMP over-expression in RAW264.7 cells. • The S. eriocheiris copy number and the mortality of crab was increased significantly and the hemocytes phagocytosis to inactivated S.eriocheiris decreased significantly after EsVAMP RNAi. [ABSTRACT FROM AUTHOR]

Reactive oxygen species, endothelial dysfunction, inflammation, and mitogen-activated protein kinases have important roles in the pathogenesis of ischemia/reperfusion kidney injury. Stanniocalcin-1 (STC1) suppresses superoxide generation in many systems through the induction of mitochondrial uncoupling proteins and blocks the cytokine-induced rise in endothelial permeability. Here we tested whether transgenic overexpression of STC1 protects from bilateral ischemia/reperfusion kidney injury. This injury in wild-type mice caused a halving of the creatinine clearance; severe tubular vacuolization and cast formation; increased infiltration of macrophages and T cells; higher vascular permeability; greater production of superoxide and hydrogen peroxide; and higher ratio of activated extracellular regulated kinase/activated Jun-N-terminal kinase and p38, all compared to sham-treated controls. Mice transgenic for human STC1 expression, however, had resistance to equivalent ischemia/reperfusion injury indicated as no significant change from controls in any of these parameters. Tubular epithelial cells in transgenic mice expressed higher mitochondrial uncoupling protein 2 and lower superoxide generation. Pre-treatment of transgenic mice with paraquat, a generator of reactive oxygen species, before injury restored the susceptibility to ischemia/reperfusion kidney injury, suggesting that STC1 protects by an anti-oxidant mechanism. Thus, STC1 may be a therapeutic target for ischemia/reperfusion kidney injury. [ABSTRACT FROM AUTHOR]

[Display omitted] • VTs and FADVs were the main aroma compounds accumulated in green tea during spreading. • The degree of aroma accumulation promoted by moderate spreading was genotype dependent. • The aroma accumulation induced by spreading mainly derived from de novo synthesis rather than glycoside hydrolysis. • Two co-expression networks highly related to accumulation of aroma compounds were identified. Spreading is an indispensable process in the aroma formation of premium green tea. In this study, volatile metabolomics and transcriptomics were performed for three tea plant cultivars to investigate the mechanism of changes occurring in volatile compounds during green tea spreading. The content of primary aroma compounds significantly increased after spreading, the Wickremasinghe-Yamanishi ratio decreased and the Owuor's flavor index increased with the extension of spreading time, and the degree of aroma production was genotype-dependent. Volatile terpenes and fatty acid-derived volatiles were the principal aroma volatiles that accumulated during the spreading of green tea, and the trends of their changes were consistent with the expression pattern of related synthesis pathway genes, indicating that they were primarily derived from de novo synthesis rather than glycoside hydrolysis. Two co-expression networks that were highly correlated with variations in the volatile component contents during the spreading process were identified via WGCNA. Our results provide insights into spreading that can be considered to improve the quality of green tea. [ABSTRACT FROM AUTHOR]

Public health emergencies pose considerable threats to global health and safety. The control of these emergencies requires the efforts of healthcare professionals and calls for the public to take protective actions. The present study not only puts fear back in the extended parallel process model (EPPM) but also considers another similarly productive emotion: hope. We examined the mechanisms behind the effects of four cognitive perceptions on protective actions (i.e., danger control) and information avoidance (i.e., fear control). A national online survey was conducted with 1676 participants during the outbreak of COVID-19 in China from February 1 to 29, 2020. The results revealed that perceived severity and susceptibility could lead to fear, positively affecting protective actions. On the other hand, perceived response efficacy and self-efficacy induced hope, which was positively associated with protective actions but negatively associated with information avoidance. Furthermore, the mechanisms behind the relationships among cognitions, emotions, and behaviors varied across levels of trust in healthcare systems., (© 2022 Society for Risk Analysis.)

Secondary osteoporosis is triggered mostly by glucocorticoid (GC) therapy. Dexamethasone (DEX) was reported to inhibit osteogenic differentiation in zebrafish larvae and MC3T3-E1 cells in prior research. In this research, we primarily examined the protective impacts of epimedin C on the osteogenic inhibition impact of MC3T3-E1 cells and zebrafish larvae mediated by DEX. The findings illustrated no apparent toxicity for MC3T3-E1 cells after administering epimedin C at increasing dosages from 1 to 60 μM and no remarkable proliferation in MC3T3-E1 cells treated using DEX. In MC3T3-E1 cells that had been treated using DEX, we discovered that epimedin C enhanced alkaline phosphatase activities and mineralization. Epimedin C could substantially enhance the protein expression of osterix (OSX), Runt-related transcription factor 2 (RUNX2), and alkaline phosphatase (ALPL) in MC3T3-E1 cells subjected to DEX treatment. Additionally, epimedin C stimulated PI3K and AKT signaling pathways in MC3T3-E1 cells that had been treated using DEX. Furthermore, in a zebrafish larvae model, epimedin C was shown to enhance bone mineralization in DEX-mediated bone impairment. We also found that epimedin C enhanced ALPL activity and mineralization in MC3T3-E1 cells treated using DEX, which may be reversed by PI3K inhibitor (LY294002). LY294002 can also reverse the protective impact of epimedin C on DEX-mediated bone impairment in zebrafish larval. These findings suggested that epimedin C alleviated the suppressive impact of DEX on the osteogenesis of zebrafish larval and MC3T3-E1 cells via triggering the PI3K and AKT signaling pathways. Epimedin C has significant potential in the development of innovative drugs for the treatment of glucocorticoid-mediated osteoporosis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Xu, Chen, Huang, Han, Shao, Chen, Zhang, He and Xie.)

The tea plant ( Camellia sinensis ) is an evergreen woody plant with a high economic value. Guangxi Province is adjacent to the origin center of the tea plant in southern China. It has abundant germplasm resources and is a historically important tea-producing province. However, there is little information about the genetic diversity, genetic introgression, and fingerprints of the tea germplasms from Guangxi Province. Here, we constructed a phylogenetic tree of 126 tea accessions from Guangxi Province using 20 SSR markers. This tree classified these tea accessions into three subgroups containing 19, 47, and 60 members, respectively. High genetic similarity was observed among the three subgroups, and the genetic diversity of the populations was ranked as follows: subgroup 3 > subgroup 2 > subgroup 1. Furthermore, we analyzed the genetic relationships among 168 tea accessions from Guangxi Province and neighboring provinces. The results of the population structure analysis were highly consistent with the clustering results, and genetic introgression was observed. We identified six SSRs as the core marker set, because they could sufficiently distinguish between all 126 tea accessions. The results provide a crucial theoretical basis for utilization and protection of tea germplasms from Guangxi Province, and will help improve the breeding and popularization of elite tea cultivars., (Copyright © 2021 by JAPANESE SOCIETY OF BREEDING.)

Background: Although a number of studies have examined social support needs among women with breast cancer, little attention has been paid to the burden and needs for social support among their family caregivers, who often report mental and physical problems associated with caregiving. Objective: This study aims to examine the role of social media in providing social support for offspring caregivers of breast cancer patients. Methods: A peer support group, "Having a breast cancer patient in my family," was created on Douban (www.douban.com), one of China's most popular social media sites, to provide social support to family caregivers of women with breast cancer. We analyzed the content of 784 messages in the discussion threads where the latest update fell between January 2017 and July 2017. Results: The results revealed that the majority of messages ( n  = 690, 88.0%) provided or requested social support, and more than 64.5% of these messages ( n  = 445) were posted by caregivers who were offspring of the cancer patients. The results also suggested that these caregivers requested and provided informational support more frequently than they did emotional and instrumental support. Conclusions: This study suggests that social media could be a plausible platform for offspring caregivers of breast cancer patients to share caregiving experiences, access informational resources for their care recipients, gain knowledge about breast cancer prevention, and obtain emotional encouragement. Theoretical as well as practical implications are discussed.