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Synthesis of novel (E)‐N‐(4‐(substituted)benzylidene)‐6‐substituted‐1H‐pyrazolo[3,4‐b]quinoline‐1‐carbothioamides/carboxamides was achieved by the condensation of 6‐substituted‐1H‐pyrazolo[3,4‐b]quinoline‐1‐carbothioamides/carboxamides with substituted benzaldehydes in alcoholic medium in the presence of acetic acid. The structures of synthesized compounds are assigned on the basis of FT IR, 1H NMR, 13C NMR and Mass Spectral data. The compounds are subjected for their antibacterial, antifungal and DFT studies. Compounds, (E)‐6‐chloro‐N‐(4‐(dimethylamino)benzylidene)‐1H‐pyrazolo[3,4‐b]quinoline‐1‐carbothioamide (5 b), (E)‐6‐chloro‐N‐(4‐(dimethylamino)benzylidene)‐1H‐pyrazolo[3,4‐b]quinoline‐1‐carboxamide (5 f), and (E)‐6‐chloro‐N‐(4‐hydroxybenzylidene)‐1H‐pyrazolo[3,4‐b]quinoline‐1‐carboxamide (5 j) possessed pronounced antibacterial and antifungal activities due to their chemical structure. [ABSTRACT FROM AUTHOR]

A novel series of 2‐(4‐substituted phenyl)‐6/8‐substituted‐ [1,3,4] oxadiazolo[2′,3′:2,3][1,3]thiazino[6,5‐b]quinolin‐11(3aH)‐ones were synthesized. Their structures have been characterized using standard spectroscopic techniques such as Infrared, Nuclear Magnetic Resonance, and Mass Spectroscopy. All the newly synthesized compounds were screened for their antibacterial and antifungal activities by the cup plate diffusion method. Antimicrobial studies revealed that compounds showed good to significant activity against tested strains. One of the compounds was evaluated for corrosion inhibition studies by potentiodynamic polarization and electrochemical impedance method in 0.1 M hydrochloric acid solution for mild steel. The tested compound had exhibited a good inhibitory action against corrosion of mild steel in the medium investigated. [ABSTRACT FROM AUTHOR]