8 results on '"Cobos-Siles, Marta"'
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2. Gender-Based Differences by Age Range in Patients Hospitalized with COVID-19: A Spanish Observational Cohort Study
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Josa Laorden, Claudia, Crestelo Vieitez, Anxela, García Andreu, María, Rubio-Rivas, Manuel, Sánchez, Marcos, Toledo Samaniego, Neera, Arnalich Fernández, Francisco, Iguaran Bermudez, Rosario, Fonseca Aizpuru, Eva, Vargas Núñez, Juan Antonio, Pesqueira Fontan, Paula Maria, Serrano Ballesteros, Jorge, Freire Castro, Santiago, Pestaña Fernández, Melani, Viana García, Alba, Nuñez Rodriguez, Victoria, Giner Galvañ, Vicente, Carrasco Sánchez, Francisco, Hernández Milián, Almudena, Cobos Siles, Marta, Napal Lecumberri, Jose, Herrero García, Virginia, Pascual Pérez, Maria, Millán Núñez-Cortés, Jesús, Casas Rojo, José, SEMI-COVID-19 Network, UAM. Departamento de Medicina, and Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)
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medicine.medical_specialty ,Multivariate analysis ,Medicina ,medicine.medical_treatment ,coronavirus ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Lower risk ,Article ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,medicine ,Factors sexuals en les malalties ,030212 general & internal medicine ,Espanya ,Mechanical ventilation ,business.industry ,SARS-CoV-2 ,Mortality rate ,lcsh:R ,COVID-19 ,General Medicine ,Intensive care unit ,gender differences ,Spain ,Sex factors in disease ,Observational study ,Complication ,business ,Cohort study - Abstract
There is some evidence that male gender could have a negative impact on the prognosis and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of the present study was to compare the characteristics of coronavirus disease 2019 (COVID-19) between hospitalized men and women with confirmed SARS-CoV-2 infection. This multicenter, retrospective, observational study is based on the SEMI-COVID-19 Registry. We analyzed the differences between men and women for a wide variety of demographic, clinical, and treatment variables, and the sex distribution of the reported COVID-19 deaths, as well as intensive care unit (ICU) admission by age subgroups. This work analyzed 12,063 patients (56.8% men). The women in our study were older than the men, on average (67.9 vs. 65.7 years; p < 001). Bilateral condensation was more frequent among men than women (31.8% vs. 29.9%; p = 0.007). The men needed non-invasive and invasive mechanical ventilation more frequently (5.6% vs. 3.6%, p < 0.001, and 7.9% vs. 4.8%, p < 0.001, respectively). The most prevalent complication was acute respiratory distress syndrome, with severe cases in 19.9% of men (p < 0.001). In men, intensive care unit admission was more frequent (10% vs. 6.1%; p < 0.001) and the mortality rate was higher (23.1% vs. 18.9%; p < 0.001). Regarding mortality, the differences by gender were statistically significant in the age groups from 55 years to 89 years of age. A multivariate analysis showed that female sex was significantly and independently associated with a lower risk of mortality in our study. Male sex appears to be related to worse progress in COVID-19 patients and is an independent prognostic factor for mortality. In order to fully understand its prognostic impact, other factors associated with sex must be considered.
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- 2021
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3. Palliative Sedation in Patients Hospitalized in Internal Medicine Departments
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Díez-Manglano, Jesús, de Isasmendi Pérez, Soledad Isasi, Gómez, Marta Rubio, Pérez, Magdalena Martín, Díez García, Luis Felipe, Maroto, Ignacio Vallejo, Losada, Cristina Ocaña, Roldán, Susana Moya, Pérez, Catalina Díaz, Granado, Javier Caballero, García Font, Resfa María, Jódar Lorente, Francisco J., Vázquez, Gloria Pérez, Expósito, Ana belén Ferro, Amaya González, María Luisa, Antiñolo, Fernando Gamboa, Molina, Álvaro González, Hernández, Mercedes Gómez, García, Marcos Guzmán, León, Lola Benítez, Rivas, Lorena Montero, Mariscal, María Ruiz, Aguirre, Noelia Gómez, González García, María Pilar, Algora, Isabel Martín, Bueno Castel, María Carmen, Laiglesia, Fernando Ruiz, Tello, Esperanza Bejarano, Cabrerizo García, José Luis, Fernández, Nuria Guiral, Camera, Luis, Gauna, Carla, Requejo, Pedro Abad, Gutiérrez, Rocío Martínez, Regueiro, Rebeca Fernández, Sánchez Vidal, María Teresa, Mejido, Joaquín Alfonso, Carús, Enrique García, Calvo Rodríguez, Carmen Elena, García, Paula Martínez, Olivares, Sixto Ruiz, Fullana Barcelo, María Isabel, Arencibia, Carmen González, Vilamajó, Rosa Ros, José Monedero Prieto, María, Becerra, Concepción González, Pérez, Sofía, Plata, Andrea Martín, Chocarro, Raquel Portilla, Gutiérrez, Carlos Dueñas, Álvarez, Francisco Estrada, Balbuena, Sonia Peña, Galindo, Raúl Rodríguez, Cobos Siles, Marta María, Sánchez Muñoz, Luis Ángel, López, Ana Castañón, Lobo, Celia Sanz, Chimeno Viñas, María Montserrat, Contreras Uriel, María Ángeles, Domínguez, Judit Gil, González, Francisco Medrano, Machín Lázaro, José Manuel, Gamboa, Jeffrey Magallanes, Galdeano, Mónica Rodríguez, Giménez, Joaquín Castro, Barberá Farré, José Ramón, Aragón, Raquel Núñez, Torán, Ferrán Masanés, Barbé, José, Farré, Elena Güell, Bonafonte, Olga Torres, Miñana, Ana lozano, Sarabia, Desirée Moras, Pérez, Rosa, Arnau i Fernández, Dolors, Formiga, Francesc, Fernández, Javier Fernández, Salomó, Antoni Castro, Qanneta, Rami, Pardo Ortega, María Victoria, Díaz, Cristina Estrada, Pintado, Yasmina Monterroso, Cors, Montserrat García, Almendros Rivas, María Cruz, Albin, Dolors Domingo, Morera, Jaume Roig, Álvaro, Nuria Galofré, Parodi, Aythami Toro, Sánchez, Mario Loureiro, Acebal, Carla de la Guerra, García, Javier Zubizarreta, Claveras, Iasone Benavente, Cabanes, Juan Martí, Lázaro, Ignacio Sanz, Romero, José Barquero, López-Alegría, Leticia Nevado, Arévalo Lorido, José Carlos, Vales, Emilio Casariego, Lorenzo Vizcaya, Ana María, Rodríguez, Cristina Macía, Fernández, Silvia Pérez, Sánchez, Pascual Sesma, Jiménez-Beatty, María Dolores, Vázquez, Laura González, Hernando, Ángel Brea, Herrero, Jesús Castiella, González Anglada, María Isabel, Gracia Lorenzo, Virginia M., Martín, Alejandro Pérez, Melcón, Gerardo García, Antúnez, María Gómez, Quesada Simón, María Angustias, Gil, Fuensanta Gil, Martínez, María Asenjo, Aragoneses, Lourdes Mancebo, Parra, Jorge Calderón, Pérez, María del Carmen Romero, García, José Curbelo, Cuesta, Fernando Laguna, Segovia Abad, María Eugenia, Ortega, María Fontecha, Martínez, Guillermina Lara, Blanco, Ana Pinos, Fraile, Raquel Rodil, Litago, Elisabel Martínez, Echeverría, Aitziber Echeverría, Valladares, Manuel Priego, Serrano, Carlos Trescoli, Mas, Josep Vicente, Suau, Óscar Torregrosa, Tomás, Eva Gil, Rubio, Rafael Castillo, Murcia Zaragoza, José Manuel, Sánchez, Pilar Román, Herola, Ana García, Tenllado Doblas, Pedro Pablo, Blázquez Encinar, Julio César, Vela, Enrique Castellano, Carrizo, Néstor, Galvañ, Vicente Giner, Roca Villanueva, Bernardino Manuel, Liaño, Francisco Pasquau, Pascual Izuel, José María, Isasi de Isasmendi Pérez, Soledad, García Fenoll, Rosa, Sánchez, Luis Ángel, Formiga, Françesc, Giner Galvañ, Vicente, Dueñas, Carlos, Roca, Bernardino, Estrada Díaz, Cristina, and Casariego Vales, Emilio
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- 2020
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4. GLUCOCOVID: A controlled trial of methylprednisolone in adults hospitalized with COVID-19 pneumonia
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Corral-Gudino, Luis, Bahamonde, Alberto, Arnaiz-Revillas, Francisco, Gómez-Barquero, Julia, Abadía-Otero, Jesica, García-Ibarbia, Carmen, Mora, Víctor, Cerezo-Hernández, Ana, Hernández, José L., López-Muñíz, Graciela, Hernández-Blanco, Fernando, Cifrián, Jose M., Olmos, Jose M., Carrascosa, Miguel, Nieto, Luis, Fariñas, María Carmen, Riancho, José A., Buelta-González, Cristina, Marcos-Martínez, Luis A., Martínez-Vidal, Ana I., Dosantos-Gallego, Pilar R.l, Pérez-Sagredo, Jesús, Sandomingo-Freire, Silvia, Muñumer-Blázquez, Rebeca, Paredes-Mogollo, Antonio, Brague-Allegue, Elena, García-Rivero, Juan L., Olmos, José M., Fariñas, Carmen, Cifrian, José M., Hernández, Jose L., Mora, Victor, Nieto, Sara, Ruiz-Cubillán, Juan, Bermúdez, Arancha, Pardo, Javier, Amado, Carlos, Insunza, Andrés, Gil, Aritz, Diaz-Terán, Teresa, Fayos, Marina, Zabaleta, Miguel A., Parra, Juan J., Ruíz-de-Temiño-de-la-Peña, Angela, Arroyo-Domingo, C. Ainhoa, Mena-Martín, Javier, Miramontes-González, Pablo, Jiménez-Masa, Ana E, Pastor-Mancisidor, Luis, Álvaro-de-Castro, Tanía M, Pérez-Panizo, María Cruz, Ruíz-Albi, Tomás, de-la-Colina-Rojo, C Gema, Andrés-Calvo, María, Crespo-Sedano, Andrea, Morejón-Huerta, Begoña, Briongos-Figuero, Laisa S., Frutos-Arriba, Julio F, Pagán-Buzo, Javier, Gabella-Martín, Miriam, Cobos-Siles, Marta, and Gómez-García, Ana
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ARDS ,medicine.medical_specialty ,business.industry ,medicine.disease ,Intensive care unit ,law.invention ,Pneumonia ,Randomized controlled trial ,Methylprednisolone ,law ,Internal medicine ,Relative risk ,medicine ,Breathing ,Clinical endpoint ,business ,medicine.drug - Abstract
BackgroundWe aimed to determine whether a 6-day course of intravenous methylprednisolone (MP) improves outcome in patients with SARS CoV-2 infection at risk of developing Acute Respiratory Distress Syndrome (ARDS).MethodsMulticentric, partially randomized, preference, open-label trial, including adults with COVID-19 pneumonia, impaired gas exchange and biochemical evidence of hyper-inflammation. Patients were assigned to standard of care (SOC), or SOC plus intravenous MP [40mg/12h 3 days, then 20mg/12h 3 days]. The primary endpoint was a composite of death, admission to the intensive care unit (ICU) or requirement of non-invasive ventilation (NIV).ResultsWe analyzed 85 patients (34, randomized to MP; 22, assigned to MP by clinician’s preference; 29, control group). Patients’ age (mean 68±12 yr) was related to outcome. The use of MP was associated with a reduced risk of the composite endpoint in the intention-to-treat, age-stratified analysis (combined risk ratio -RR-0.55 [95% CI 0.33-0.91]; p=0.024). In the per-protocol analysis, RR was 0.11 (0.01-0.83) in patients aged 72 yr or less, 0.61 (0.32-1.17) in those over 72 yr, and 0.37 (0.19-0.74, p=0.0037) in the whole group after age-adjustment by stratification. The decrease in C-reactive protein levels was more pronounced in the MP group (p=0.0003). Hyperglycemia was more frequent in the MP group.ConclusionsA short course of MP had a beneficial effect on the clinical outcome of severe COVID-19 pneumonia, decreasing the risk of the composite end point of admission to ICU, NIV or death.
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- 2020
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5. Evaluation and characterization of multimorbidity profiles, resource consumption and healthcare needs in extremely elderly people.
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Briongos-Figuero, Laisa Socorro, Cobos-Siles, Marta, Gabella-Martín, Miriam, Abadía-Otero, Jesica, Lobo-Valentin, Rosa, Aguado-De-La-Fuente, Ana, Vargas-Ruiz, Beatriz, and Martín-Escudero, Juan Carlos
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OLDER people , *ACTIVITIES of daily living , *QUALITY of life , *COMORBIDITY , *COGNITION disorders , *CROSS-sectional method , *MEDICAL care use , *QUESTIONNAIRES , *LONGITUDINAL method - Abstract
Objectives: Spanish population lifespan is one of the longest in the world. Moreover, it is known that elderly people have less chronic illnesses associated with aging. Our aims were to determine how Clinical Risk Group (CRG) predicts future use of healthcare resources in extremely elderly people without diabetes (T2DM) and to explore CRG correlation with health conditions.Design: Prospective cross-sectional study.Setting: Rio Hortega University Hospital.Participants: Hospitalized patients >80 years old without T2DM, during 2017.Main Outcome Measures: Mental status was evaluated using Pfeiffer test (SPMQS), Basic Activities of Daily Living (BADLs) and Instrumental Activities of Daily Living (IADLs) were estimated using the Older Americans Resources and Services questionnaire. Comorbidity was evaluated using Charlson index (CI) and health-related quality of life (HRQoL) with EuroQoL (EQ5D3L). CRG classification system was obtained from electronic clinical records. Data were analyzed using SPSS v.15.0.Results: In total, 305 patients were identified (59% women), mean age 88 ± 5 and 38% were aged >90. Estimated HRQoL was 0.43 ± 0.33 for EQ5D3L-index-value. Mean dependence level was 6.2 ± 5 for BADLs and 9.2 ± 5 for IADLs. In total, 31.6% of patients had severe cognitive impairment with a mean score of 5.4 ± 3.6 in SPMQS. In total, 30.2% of patients were categorized as G3, and presented high comorbidity more frequently than the rest. Corrected CI mean score was 6.2 ± 1.7. Significant relationship was founded in survival time, number of admissions and CI score.Conclusions: Using predictive risk models like CRG is supposed to assess the complexity of morbidity but in our extremely elderly population partially fail in stratify and predict health resource consumption. [ABSTRACT FROM AUTHOR]- Published
- 2020
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6. The Importance of Dependence in Global Assessment of Hospitalized Patient
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Briongos-Figuero, Laisa Socorro, Cobos Siles, Marta, Gabella Martín, Miriam, Abadía Otero, Jesica, and Martín Escudero, Juan Carlos
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- 2020
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7. Respiratory chain polymorphisms and obesity in the Spanish population, a cross-sectional study.
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de Marco, Griselda, Garcia-Garcia, Ana Barbara, Real, Jose Tomas, Gonzalez-Albert, Veronica, Briongos-Figuero, Laisa-Socorro, Cobos-Siles, Marta, Lago-Sampedro, Ana, Corbaton, Arturo, Martinez-Larrad, Maria Teresa, Carmena, Rafael, Martin-Escudero, Juan Carlos, Rojo-Martínez, Gemma, and Javier Chaves, Felipe
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Objective To study the association of genes involved in the mitochondrial respiratory chain (MRC) pathway with body mass index (BMI) and obesity risk. Design This work studies three cross-sectional populations from Spain, representing three provinces: HORTEGA (Valladolid, Northwest/Centre), SEGOVIA (Segovia, Northwest/centre) and PIZARRA (Malaga,South). Setting Forty-eight single nucleotide polymorphisms (SNPs) from MRC genes were selected and genotyped by SNPlex method. Association studies with BMI and obesity risk were performed for each population. These associations were then verified by analysis of the studied population as a whole (3731 samples). Participants A total of 3731 Caucasian individuals: 1502 samples from HORTEGA, 988 from PIZARRA and 1241 from SEGOVIA. Results rs4600063 (SDHC), rs11205591 (NDUFS5) and rs10891319 (SDHD) SNPs were associated with BMI and obesity risk (p values for BMI were 0.04, 0.0011 and 0.0004, respectively, and for obesity risk, 0.0072, 0.039 and 0.0038). However, associations between rs4600063 and BMI and between these three SNPs and obesity risk are not significant if Bonferroni correction is considered. In addition, rs11205591 and rs10891319 polymorphisms showed an additive interaction with BMI and obesity risk. Conclusions Several polymorphisms from genes coding MRC proteins may be involved in BMI variability and could be related to the risk to become obese in the Spanish general population. [ABSTRACT FROM AUTHOR]
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- 2019
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8. Respiratory syncytial virus burden of disease in hospitalized patients in a Spanish tertiary hospital.
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Abadía Otero, Jésica, López Muñiz, Graciela, Gabella Martín, Miriam, Dominguez-Gil González, Marta, Cobos Siles, Marta, and Briongos Figuero, Laisa
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RESPIRATORY syncytial virus infections ,HOSPITAL patients ,RESPIRATORY infections ,HEALTH facilities ,INFLUENZA ,RESPIRATORY infections in children ,HUMAN metapneumovirus infection - Abstract
To the Editor, A study of respiratory syncytial virus (RSV) infection in adult patients visiting an emergency department was recently published in this journal [[1]]. We here contribute with a retrospective clinical study of RSV infection including 60 adult hospitalized patients over two consecutive flu seasons. 511 ht When patients with RSV infection were compared with the ones in our hospital influenza register ( I N i = 314), we found that RSV patients were older (75.52 years vs 72.77) and lived more often in long-term facilities (25% vs 11%, I p i =.009). Symptoms in RSV are similar to those experienced in influenza patients, with slightly higher frequency of shortness of breath due to bronchospasm that required corticoid therapy. [Extracted from the article]
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- 2020
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