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2. Publisher Correction: Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo

Author

Fu, Cynthia H. Y., Antoniades, Mathilde, Erus, Guray, Garcia, Jose A., Fan, Yong, Arnone, Danilo, Arnott, Stephen R., Chen, Taolin, Choi, Ki Sueng, Fatt, Cherise Chin, Frey, Benicio N., Frokjaer, Vibe G., Ganz, Melanie, Godlewska, Beata R., Hassel, Stefanie, Ho, Keith, McIntosh, Andrew M., Qin, Kun, Rotzinger, Susan, Sacchet, Matthew D., Savitz, Jonathan, Shou, Haochang, Singh, Ashish, Stolicyn, Aleks, Strigo, Irina, Strother, Stephen C., Tosun, Duygu, Victor, Teresa A., Wei, Dongtao, Wise, Toby, Zahn, Roland, Anderson, Ian M., Craighead, W. Edward, Deakin, J. F. William, Dunlop, Boadie W., Elliott, Rebecca, Gong, Qiyong, Gotlib, Ian H., Harmer, Catherine J., Kennedy, Sidney H., Knudsen, Gitte M., Mayberg, Helen S., Paulus, Martin P., Qiu, Jiang, Trivedi, Madhukar H., Whalley, Heather C., Yan, Chao-Gan, Young, Allan H., and Davatzikos, Christos

Published
2024
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3. Metabolomics signatures of serotonin reuptake inhibitor (escitalopram), serotonin norepinephrine reuptake inhibitor (duloxetine) and cognitive-behavioral therapy on key neurotransmitter pathways in major depressive disorder

Author

Bhattacharyya, Sudeepa, MahmoudianDehkordi, Siamak, Sniatynski, Matthew J., Belenky, Marina, Marur, Vasant R., Rush, A. John, Craighead, W. Edward, Mayberg, Helen S., Dunlop, Boadie W., Kristal, Bruce S., and Kaddurah-Daouk, Rima

Published
2025
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5. Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo

Author

Fu, Cynthia H. Y., Antoniades, Mathilde, Erus, Guray, Garcia, Jose A., Fan, Yong, Arnone, Danilo, Arnott, Stephen R., Chen, Taolin, Choi, Ki Sueng, Fatt, Cherise Chin, Frey, Benicio N., Frokjaer, Vibe G., Ganz, Melanie, Godlewska, Beata R., Hassel, Stefanie, Ho, Keith, McIntosh, Andrew M., Qin, Kun, Rotzinger, Susan, Sacchet, Matthew D., Savitz, Jonathan, Shou, Haochang, Singh, Ashish, Stolicyn, Aleks, Strigo, Irina, Strother, Stephen C., Tosun, Duygu, Victor, Teresa A., Wei, Dongtao, Wise, Toby, Zahn, Roland, Anderson, Ian M., Craighead, W. Edward, Deakin, J. F. William, Dunlop, Boadie W., Elliott, Rebecca, Gong, Qiyong, Gotlib, Ian H., Harmer, Catherine J., Kennedy, Sidney H., Knudsen, Gitte M., Mayberg, Helen S., Paulus, Martin P., Qiu, Jiang, Trivedi, Madhukar H., Whalley, Heather C., Yan, Chao-Gan, Young, Allan H., and Davatzikos, Christos

Published
2024
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14. ERICH3: vesicular association and antidepressant treatment response

Author

Liu, Duan, Zhuang, Yongxian, Zhang, Lingxin, Gao, Huanyao, Neavin, Drew, Carrillo-Roa, Tania, Wang, Yani, Yu, Jia, Qin, Sisi, Kim, Daniel C., Liu, Erica, Nguyen, Thanh Thanh Le, Biernacka, Joanna M., Kaddurah-Daouk, Rima, Dunlop, Boadie W., Craighead, W. Edward, Mayberg, Helen S., Binder, Elisabeth B., Frye, Mark A., Wang, Liewei, and Weinshilboum, Richard M.

Published
2021
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16. Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes

Author

Ahmed, Ahmed T., MahmoudianDehkordi, Siamak, Bhattacharyya, Sudeepa, Arnold, Matthias, Liu, Duan, Neavin, Drew, Moseley, M. Arthur, Thompson, J. Will, Williams, Lisa St John, Louie, Gregory, Skime, Michelle K., Wang, Liewei, Riva-Posse, Patricio, McDonald, William M., Bobo, William V., Craighead, W. Edward, Krishnan, Ranga, Weinshilboum, Richard M., Dunlop, Boadie W., Millington, David S., Rush, A. John, Frye, Mark A., and Kaddurah-Daouk, Rima

Published
2020
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21. Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

Author

Ahmed, Ahmed T., Frye, Mark A., Rush, A John, Biernacka, Joanna M., Craighead, W. Edward, McDonald, William M., Bobo, William V., Riva-Posse, Patricio, Tye, Susannah J., Mayberg, Helen S., Hall-Flavin, Daniel K., Skime, Michelle K., Jenkins, Greg D., Wang, Liewei, Krishnan, Ranga Rama, Weinshilboum, Richard M., Kaddurah-Daouk, Rima, and Dunlop, Boadie W.

Published
2018
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23. Combined effects of genotype and childhood adversity shape variability of DNA methylation across age

Author

Czamara, Darina, Tissink, Elleke, Tuhkanen, Johanna, Martins, Jade, Awaloff, Yvonne, Drake, Amanda J., Khulan, Batbayar, Palotie, Aarno, Winter, Sibylle M., Nemeroff, Charles B., Craighead, W. Edward, Dunlop, Boadie W., Mayberg, Helen S., Kinkead, Becky, Mathew, Sanjay J., Iosifescu, Dan V., Neylan, Thomas C., Heim, Christine M., Lahti, Jari, Eriksson, Johan G., Räikkönen, Katri, Ressler, Kerry J., Provençal, Nadine, and Binder, Elisabeth B.

Published
2021
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26. Psychotherapy or medication for depression? Using individual symptom meta-analyses to derive a Symptom-Oriented Therapy (SOrT) metric for a personalised psychiatry

Author

Kappelmann, Nils, Rein, Martin, Fietz, Julia, Mayberg, Helen S., Craighead, W. Edward, Dunlop, Boadie W., Nemeroff, Charles B., Keller, Martin, Klein, Daniel N., Arnow, Bruce A., Husain, Nusrat, Jarrett, Robin B., Vittengl, Jeffrey R., Menchetti, Marco, Parker, Gordon, Barber, Jacques P., Bastos, Andre G., Dekker, Jack, Peen, Jaap, Keck, Martin E., and Kopf-Beck, Johannes

Published
2020
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27. The protective effects of Swedish COVID-19 pandemic strategies on adolescents' mental health: a longitudinal cohort study.

Author

Lilja, Josefine L., Augustsson, Pia, Praetorius Björk, Marcus, Marteinsdottir, Ina, Craighead, W. Edward, Örn Arnarson, Eiríkur, Sveinsdottir, Gudny, and Wikberg, Carl

Subjects
MENTAL depression risk factors, MENTAL health, RESEARCH funding, HEALTH policy, STRUCTURAL equation modeling, STAY-at-home orders, COVID-19 pandemic, ADOLESCENCE
Abstract

Aim: The aim of this study was to investigate a cohort of Swedish eighth graders' mental health and experiences during the COVID-19 pandemic. Methods: Participants were 157 eighth graders recruited in junior high schools during 2020 who completed a depression questionnaire and a survey about their psychosocial health in relation to the COVID-19 pandemic, alongside a follow-up assessment in 2021. Analyses were conducted using latent change score and cross-lagged models. Results: Participants' depressive symptoms did not substantially increase during the COVID-19 pandemic. The level of depressive symptoms in 2020 was significantly associated with participants' perceptions of the pandemic in 2020 and spring 2021. Participants with higher depression scores reported worse experiences of the pandemic. Conclusions: The stable level of depressive symptoms among this cohort of eighth graders suggested that keeping schools open during a nationwide lockdown could mitigate some mental health consequences. Adolescents in this study with higher self-assessed depressive symptoms were more likely to experience increased depression after 6 months and had worse experiences during the pandemic than others. This suggests that the pandemic may not immediately affect mental well-being, but those at risk may be affected over time. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Treatment-Specific Hippocampal Subfield Volume Changes With Antidepressant Medication or Cognitive-Behavior Therapy in Treatment-Naive Depression

Author

Tai, Hua-Hsin, Cha, Jungho, Vedaei, Faezeh, Dunlop, Boadie W., Craighead, W. Edward, Mayberg, Helen S., and Choi, Ki Sueng

Subjects
cognitive behavioral theory, Psychiatry, Psychiatry and Mental health, hippocampal atrophy, nervous system, depression, RC435-571, antidepressant medication, hippocampal tail, Original Research
Abstract

Background: Hippocampal atrophy has been consistently reported in major depressive disorder with more recent focus on subfields. However, literature on hippocampal volume changes after antidepressant treatment has been limited. The first-line treatments for depression include antidepressant medication (ADM) or cognitive-behavior therapy (CBT). To understand the differential effects of CBT and ADM on the hippocampus, we investigated the volume alterations of hippocampal subfields with treatment, outcome, and chronicity in treatment-naïve depression patients.Methods: Treatment-naïve depressed patients from the PReDICT study were included in this analysis. A total of 172 patients who completed 12 weeks of randomized treatment with CBT (n = 45) or ADM (n = 127) were included for hippocampal subfield volume analysis. Forty healthy controls were also included for the baseline comparison. Freesurfer 6.0 was used to segment 26 hippocampal substructures and bilateral whole hippocampus from baseline and week 12 structural MRI scans. A generalized linear model with covariates of age and gender was used for group statistical tests. A linear mixed model for the repeated measures with covariates of age and gender was used to examine volumetric changes over time and the contributing effects of treatment type, outcome, and illness chronicity.Results: Of the 172 patients, 85 achieved remission (63/127 ADM, 22/45 CBT). MDD patients showed smaller baseline volumes than healthy controls in CA1, CA3, CA4, parasubiculum, GC-ML-DG, Hippocampal Amygdala Transition Area (HATA), and fimbria. Over 12 weeks of treatment, further declines in the volumes of CA1, fimbria, subiculum, and HATA were observed regardless of treatment type or outcome. CBT remitters, but not ADM remitters, showed volume reduction in the right hippocampal tail. Unlike ADM remitters, ADM non-responders had a decline in volume in the bilateral hippocampal tails. Baseline volume of left presubiculum (regardless of treatment type) and right fimbria and HATA in CBT patients were correlated with a continuous measure of clinical improvement. Chronicity of depression had no effect on any measures of hippocampal subfield volumes.Conclusion: Two first-line antidepressant treatments, CBT and ADM, have different effects on hippocampal tail after 12 weeks. This finding suggests that remission achieved via ADM may protect against progressive hippocampal atrophy by altering neuronal plasticity or supporting neurogenesis. Studies with multimodal neuroimaging, including functional and structural analysis, are needed to assess further the impact of two different antidepressant treatments on hippocampal subfields.

Published
2021
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38. Factor Analysis of the Children's Depression Inventory in a Community Sample.

Author

Craighead, W. Edward, Smucker, Mervin R., Wilcoxon Craighead, Linda, and Ilardi, Stephen S.

Abstract

The factor structure of the Children's Depression Inventory (CDI) (M. Kovacs, 1992) was evaluated in a community sample of 1777 children and 924 adolescents. There were five first-order factors for the child group, and the same five plus one more for the adolescents. Results support the stability and predictability of the obtained factor structures. (SLD)

Published
1998

39. Shared and Unique Changes in Brain Connectivity Among Depressed Patients After Remission With Pharmacotherapy Versus Psychotherapy.

Author

Dunlop, Boadie W., Cha, Jungho, Choi, Ki Sueng, Rajendra, Justin K., Nemeroff, Charles B., Craighead, W. Edward, and Mayberg, Helen S.

Abstract

The authors sought to determine the shared and unique changes in brain resting-state functional connectivity (rsFC) between patients with major depressive disorder who achieved remission with cognitive-behavioral therapy (CBT) or with antidepressant medication. The Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) trial randomized adults with treatment-naive major depressive disorder to 12 weeks of treatment with CBT (16 1-hour sessions) or medication (duloxetine 30–60 mg/day or escitalopram 10–20 mg/day). Resting-state functional MRI scans were performed at baseline and at week 12. The primary outcome was change in the whole-brain rsFC of four seeded brain networks among participants who achieved remission. Of the 131 completers with usable MRI data (74 female; mean age, 39.8 years), remission was achieved by 19 of 40 CBT-treated and 45 of 91 medication-treated patients. Three patterns of connectivity changes were observed. First, those who remitted with either treatment shared a pattern of reduction in rsFC between the subcallosal cingulate cortex and the motor cortex. Second, reciprocal rsFC changes were observed across multiple networks, primarily increases in CBT remitters and decreases in medication remitters. And third, in CBT remitters only, rsFC increased within the executive control network and between the executive control network and parietal attention regions. Remission from major depression via treatment with CBT or medication is associated with changes in rsFC that are mostly specific to the treatment modality, providing biological support for the clinical practice of switching between or combining these treatment approaches. Medication is associated with broadly inhibitory effects. In CBT remitters, the increase in rsFC strength between networks involved in cognitive control and attention provides biological support for the theorized mechanism of CBT. Reducing affective network connectivity with motor systems is a shared process important for remission with both CBT and medication. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Relationship of Children's Depression Inventory Factors to Major Depression among Adolescents.

Author

Craighead, W. Edward

Abstract

The relationship between Children's Depression Inventory (CDI) scores and major depression, conduct disorder, and anxiety disorders was studied for 107 psychiatric inpatients aged 12 to 18 years. Findings support total CDI score, rather than factor scores, as the most practical measure for classifying participants as depressed or not. (SLD)

Published
1995

42. Attributional Style in Clinically Depressed and Conduct Disordered Adolescents.

Author

Curry, John F. and Craighead, W. Edward

Abstract

Tested reformulated learned helplessness theory of depression with adolescent inpatients (N=63) diagnosed as depressed, conduct disordered, or both. Adolescents with major depressive diagnosis differed from nondepressed adolescents with significantly lower attributional style scores for positive events. Subjects who reported more severe depression had significantly lower composite score for internal, stable, and global attributions for positive events. (Author/NB)

Published
1990

46. Family-focused treatment for adolescents with bipolar disorder: results of a 2-year randomized trial

Author

Miklowitz, David J., Axelson, David A., Birmaher, Boris, George, Elizabeth L., Taylor, Dawn O., Schneck, Christopher D., Beresford, Carol A., Dickinson, L. Miriam, Craighead, W. Edward, and Brent, David A.

Subjects
Bipolar disorder -- Care and treatment, Bipolar disorder -- Research, Family psychotherapy -- Usage, Family psychotherapy -- Research, Health, Psychology and mental health
Published
2008

48. Cognitive-behavioral intervention for depressed, substance-abusing adolescents: development and pilot testing

Author

Curry, John F., Wells, Karen C., Lochman, John E., Craighead, W. Edward, and Nagy, Paul D.

Subjects
Depression in adolescence -- Care and treatment, Youth -- Psychological aspects, Youth -- Health aspects, Youth -- Drug use, Cognitive therapy -- Testing, Cognitive therapy -- Evaluation, Drugs and youth -- Care and treatment, Teenagers, Family and marriage, Psychology and mental health
Published
2003

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