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Although different studies have found that exposure to intimate partner violence (IPV) in childhood is linked to IPV perpetration in adulthood, others have revealed null effects. Previous research has also found that some factors might mediate the relationship between exposure to IPV in childhood and later IPV perpetration. As far as we know, no studies examined the role of aggression in this relationship. This study aimed to analyze the link between exposure to IPV in childhood and IPV perpetration in adulthood and verify whether this relationship was mediated by aggression and its components (verbal and physical aggression, anger, and hostility). Two hundred and forty five men convicted of domestic violence, from prison and community, were recruited. Correlation analysis revealed a positive link between exposure to IPV in childhood, aggression traits, and specifically physical aggression, and IPV frequency in adulthood. Overall aggression traits and physical aggression traits were statistically significant mediator variables explaining almost 15% of the overall effect of exposure to IPV in childhood on overall IPV frequency in adulthood. These findings unravel the role of aggression in the perpetration of physical and total IPV, claiming our attention to the need to include strategies to increase emotion regulation and problem-solving strategies in intervention programs. [ABSTRACT FROM AUTHOR]

Child sexual abuse (CSA) is a global problem with severe consequences for victims and their development, with various resulting consequences. Sentences regarding CSA crimes can be unconsciously influenced by extralegal factors. This study aimed to understand how Portuguese CSA victims are represented in judges' sentencing of offenders. Twenty-seven sentences of CSA, from a Portuguese database, were thoroughly analyzed through thematic analysis. Six main themes pertaining to the victim, emerged from the sentences' analysis: (i) emotional response during statements; (ii) reported details and reactions; (iii) credibility and reliability of statements; (iv) revelation and secret-keeping; (v) victim's trajectory; and (vi) impact on the victim. The assessment of the credibility of the victim's statements proved to be central across all sentences. Data related to external sources, namely judges' personal beliefs, physical evidence, and witnesses, emerged. Legal and psychosocial factors were identified, with the latter consisting of victim-blaming and legitimization of sexual violence. As for the practical implications of these findings, we argue that a fair exercise of justice, and improvement of the efficacy of prosecution of CSA is only possible through identification of these sensitive issues and adequate addressal of them during magistrates' training. [ABSTRACT FROM AUTHOR]

There are many reasons to perpetrate intimate partner violence (IPV). This study analyzes the attributions and perceptions of Portuguese men who perpetrate IPV to understand their justifications for violence against their female partners. In-depth interviews were conducted with seven male perpetrators. Through thematic analysis, three main categories emerged: self, partner, and situational factors. Perpetrators identified self attributes as justifications to abuse, such as individual characteristics, emotional disturbances, and jealousy; partner attributes, such as partners' characteristics and the use of violence against them; and situational factors, such as alcohol abuse and relational stressors. Perpetrators' narratives evidenced a tendency to conceive violence as an unintentional and unplanned action, attributing violence to uncontrollable factors, and an attitude of non-accountability for their behaviors/actions. A deeper understanding of perpetrators' perceptions and attributions for IPV will help to develop more effective intervention programs with offenders or to improve the existent ones, for example, in terms of dropout prevention, to reduce violence against women. [ABSTRACT FROM AUTHOR]

Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequency of administration and thereby potentially patient compliance. Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice. In addition, the Fc-engineered variant improves on-target complement-mediated killing of cancer cells as well as both gram-positive and gram-negative bacteria. Hence, this versatile Fc technology should be broadly applicable in antibody design aiming for long-acting prophylactic or therapeutic interventions.Antibody based biologics are a rapidly growing class of therapeutics with interest to enhance their performance, distribution, longevity and effectivity. Here, authors report the engineering of human IgG Fc to enhance plasma half-life, mucosal distribution and killing of cancer cells and bacteria. [ABSTRACT FROM AUTHOR]

Batterer intervention programs (BIPs) are some of the most relevant strategies to reduce intimate partner violence (IPV). However, the rate of dropout is significantly high, which may impact the effectiveness of such strategies. Literature has identified several factors associated with BIPs' dropout; nonetheless findings remain inconsistent. Thus, the aims of this study were to analyse the differences between perpetrators who completed the program and those who droped out, in terms of sociodemographic, violence-related and intrapersonal variables, as well as identify the predictors of dropout. Eighty-three IPV perpetrators completed a set of measures that assessed attitudes toward domestic violence, physical and psychological abuse of a partner, aggression, coping skills, and readiness to change. Variables related to past criminal history and sociodemographics were also colletected. 42.2% of IPV perpetrators failed to complete the intervention program. The results revealed that age and previous convictions by other crimes than IPV discriminated perpetrators who completed the program from those who droped out, such that, being young and having a previous conviction predicted dropout. These findings reveal a need to further analyse the impact of these factors so BIPs can be tailored to meet the specificities of IPV perpetrators and prevent treatment dropout. [ABSTRACT FROM AUTHOR]

The latest issue of the journal "Cities, Communities & Territories" includes a tribute to one of its founders, Vítor Matias Ferreira, who passed away. The issue also features articles on various topics, including the student accommodation crisis in Portugal, the consumption and disposal patterns of electric devices among university students in Argentina, the daily living conditions of young migrants in São Paulo, the revitalization policies of the central area of Recife, and the role of creative dynamics in Brazilian metropolises. The essays section explores the skills of urban planners in times of uncertainty, the need for inclusive urban spaces for neurodivergent individuals in smart cities, and the interplay between grassroots initiatives and institutionalized planning practices. The policy briefs discuss access to land within international agendas and the role of social participation in land regularization processes in Brazil. [Extracted from the article]

Creative tourism is starting in Portugal as a labelled and structured alternative aiming to produce a boosting effect in peripheral areas. By linking places, host communities and tourists in the cocreation of differentiated experiences, this tourism offer challenges destinations and communities to be creative and reinvent themselves as placemaking agents in the coproduction of territorial amenities. As such, creative tourism can be a useful tool to complement placemaking strategies in peripheral areas, once it has the ability to engage local communities and generate territorial benefits. This hypothesis is explored through a case study and preliminary findings, obtained through focus group, in-depth interviews and content analysis, show the advantages of planned placemaking strategies for the territorial promotion. The comparisons in terms of intervention focus by types of entities and placemaking strategies confirm the complexity of these dynamics, pointing relevant factors used to mobilize local tangible and intangible resources. [ABSTRACT FROM AUTHOR]

Staphylococcal protein A (SpA) is a multifunctional, highly conserved virulence factor of Staphylococcus aureus. By binding the Fc portion of all human IgG subclasses apart from IgG3, SpA interferes with antibody and complement deposition on the bacterial surface, impairing staphylococcal clearance by phagocytosis. Because of its anti-opsonic properties, SpA is not investigated as a surface antigen to mediate bacterial phagocytosis. Herein we investigate human sera for the presence of SpA-opsonizing antibodies. The screening revealed that sera containing IgG3 against SpA were able to correctly opsonize the target and drive Fcγ receptor-mediated interactions and phagocytosis. We demonstrated that IgG3 Fc is significantly more efficient in inducing phagocytosis of SpA-expressing S. aureus as compared to IgG1 Fc in an assay resembling physiological conditions. Furthermore, we show that the capacity of SpA antibodies to induce phagocytosis depends on the specific epitope recognized by the IgGs on SpA molecules. Overall, our results suggest that anti-SpA IgG3 antibodies could favor the anti-staphylococcal response in humans, paving the way towards the identification of a correlate of protection against staphylococcal infections. [ABSTRACT FROM AUTHOR]

This study aimed to analyze the fit of the four-factor model of the 29-item and 12-item Buss-Perry Aggression Questionnaire (BPAQ) on a sample of Portuguese male perpetrators of intimate partner violence (IPV; N = 279) and to test the measurement invariance between sample type (forensic and non-forensic) and sentence type (prison and community). Confirmatory factor analysis (CFA) did not support the four-factor model of the BPAQ 29-item version. The four-factor model of the BPAQ–short form (BPAQ-SF) showed a good fit. Sufferable values for internal consistency and good values for convergent and discriminant validity were found. Cross-sentence measurement invariance using the present sample and cross-sample measurement invariance of the BPAQ-SF using a previously collected sample of students was established. Overall, our results support BPAQ-SF as a valuable brief and psychometrically reliable measure of aggression for use with both individuals from the community and IPV perpetrators with different sentences. [ABSTRACT FROM AUTHOR]

This study explores the narrative contents obtained from the description of autobiographical memories reported by a sample of incarcerated males that exemplified their most aggressive, transgressive, or criminal selves. Participants were 110 men serving a prison sentence for different types of crimes. Three main phenomena were identified from their stories: the narration of the criminal self, description of the crime (or crimes) committed, and the criminal responsibility attributional processes. The results showed the existence of mechanisms to justify the crime among a large section of participants, whereas the assumption of personal responsibility for the commission of the crime and the consideration of an unfair or excessive sentence were not as frequent. Also, some specific crimes concurred with concrete responsibility attributional processes, especially with the justification of criminal behavior. These findings generate useful information regarding recidivism, resocialization, and the attribution of responsibility among inmates. [ABSTRACT FROM AUTHOR]

Intimate partner violence (IPV) is a highly prevalent phenomenon worldwide and is considered a severe violation of human rights. Intimate partner homicide (IPH) and attempted intimate partner homicide (AIPH) although less frequent have a severe direct or indirect impact on victims. Despite the vast literature on IPV and IPH, there is still scarce research on AIPH. Thus, this study aimed to analyze whether perpetrators of IPV, IPH, and AIPH differ from each other, as well as to identify the factors that predict violence in intimacy. For those purposes, we performed a comparative analysis between 50 male individuals convicted of IPH, 27 convicted of AIPH, and 168 convicted of IPV from Portugal. The data were collected using an interview and a set of psychological measures. Results revealed that, although IPV, IPH, and AIPH perpetrators' share some characteristics, significant differences were found between them. IPV perpetrators were more prone to perpetrate violent behaviors against an intimate partner or ex-partner than IPH or AIPH offenders. The use of weapons and separation from the victim increases the probability of committing IPH or AIPH. Being divorced, having no children, and committing other crimes than domestic violence are predictors of AIPH. These results have some practical implications, in terms of both risk prediction and risk management. Accurate and comprehensive tools should be included as a routine in the primary care services, as well as in the child care services and in victim support services. Prevention and intervention efforts must be comprehensive, involving work with perpetrators and victims. [ABSTRACT FROM AUTHOR]

Objective: This study aims to assess the feasibility and meaningfulness of a home-based individual cognitive stimulation (iCS) program delivered by caregivers to persons with cognitive impairment (PwCIs). It also aims to assess whether the older adults receiving this program improved their cognitive, neuropsychiatric, and depressive symptoms and quality of life and whether their caregivers improved their mental and physical health. Methods: A randomized controlled trial (RCT) was conducted with PwCI-caregiver dyads recruited from the community. Participants were allocated to two groups: intervention (n = 28) and control (n = 24). The intervention group received the European Portuguese version of the Individual Cognitive Stimulation Program—Making a Difference 3 (MD3-P). The control group received usual care. The iCS therapy program was implemented three times a week for 12 weeks. Caregivers were supported by the researchers to deliver the sessions at home. Participants were assessed at baseline and at the end of the intervention (week 13). Feasibility and meaningfulness were assessed through the attrition rate, adherence, and degree of satisfaction with the sessions. Four interviews were conducted (after week 13) to understand participants' experiences. Results: The attrition rate was 23.1%. The dyads reported that they did not have high expectations about the iCS program before starting the study. Nevertheless, as the program evolved, caregivers noted that their family members had improved some areas of functioning. Intention-to-treat analysis based on group differences revealed a significant improvement in PwCIs' cognition, specifically in their orientation and ability to follow commands. The intervention had no impact on other variables such as caregivers' physical and mental health. Conclusion: The iCS program implemented by caregivers showed promising results in improving PwCIs' cognition. The participants who completed the intervention attributed a positive meaning to the MD3-P, confirming it as a valid non-pharmacological therapeutic approach to reducing frailty in PwCIs in community settings. Clinical Trial Registration: www.ClinicalTrials.gov, identifier [NCT03514095]. [ABSTRACT FROM AUTHOR]

The study of innovation dynamics has expanded widely in recent decades. However, it has failed to include research focusing on the social process and demonstrating the mechanisms of a given system's innovative capacity, thus resulting in the fragmentation of theoretical approaches rather than the construction of a cohesive framework. Based on the assumption that innovation depends not only on the structural conditions of the context in which a system is inserted but also on the relationships established between the key actors in a given system, this article analyses the innovation system in Pernambuco (Brazil) as a strategic research material which highlights agency and the structural aspects of innovation dynamics. It presents a mixed-method approach to understanding the innovation structure, based on social network analysis and the expectations of innovation actors regarding systemic failures and desired change. The results show the interconnections between the two methods and emphasise the need to overcome conceptual and methodological agency-structure dilemmas to ensure that public policy is better informed. [ABSTRACT FROM AUTHOR]

Exposure to intimate partner violence during childhood has been linked to both intimate partner violence perpetration in adulthood and psychopathy. However, the role of psychopathy in the connection between exposure to intimate partner violence during childhood and later intimate partner violence perpetration is less understood. This study aimed to analyze the relationship between exposure to intimate partner violence during childhood, psychopathy, and the frequency of intimate partner violence perpetration while examining the mediating role of psychopathy. A sample of 245 men convicted of intimate partner violence in Portugal was recruited from prison and the community. Exposure to intimate partner violence was significantly associated with both the frequency of intimate partner violence perpetration in adulthood and psychopathy, and psychopathy was correlated with the frequency of intimate partner violence perpetration. Psychopathy did not act as a mediator in the relationship between exposure to intimate partner violence and the frequency of intimate partner violence perpetration. These findings underscore the significance of exposure to intimate partner violence during childhood and emphasize the necessity for increased attention to early adverse experiences that precede the development of maladaptive traits and behaviors. [ABSTRACT FROM AUTHOR]

This study analyzed offenders' perceptions about distinct sanctions and their adequacy for different crimes, checking if these ideas apply to their crime. We covered a total of 163 adult offenders who were sanctioned with a non-custodial order. The results show that participants tended to express a punitive attitude toward crime, apart from their offenses. Participants who committed driving or drug trafficking offenses were those that revealed congruence regarding the adequacy of the sentence and the usefulness of the sanction imposed. Regarding sentences' purposes, we noticed most participants considered punishment and general deterrence as the primary purposes. The main contribution of this study lies in its educational value about the cognitive particularities and specific needs of each type of offender. Not attending to offenders' perceptions regarding sanctions may function as an obstacle for an efficient implementation of the Justice, in terms of their adherence to the sanctions, and consequently their rehabilitation. [ABSTRACT FROM AUTHOR]

Staphylococcus aureus is the main cause of human skin and soft tissue infections. However, S. aureus pathogenicity within the skin is not fully characterized. Here, we implemented an S. aureus cutaneous infection model using human skin explants and performed a time-course infection to study the gene expression profile of a large panel of virulence-related factors of S. aureus USA300 LAC strain, by high-throughput RT-PCR. We pinpointed the genes that were differentially regulated by the bacteria in the skin tissues and identified 12 virulence factors that were upregulated at all time points assessed. Finally, using confocal microscopy, we show that the expression of alpha-hemolysin by S. aureus varies dependent on the skin niche and that the bacteria preferentially accumulates inside sweat glands and ducts. Taken together, our study gives insights about the pathogenic lifestyle of S. aureus within human skin tissues, which may contribute for the development of anti- S. aureus therapeutic strategies. [ABSTRACT FROM AUTHOR]

The skin is an immunocompetent tissue that harbors several kinds of immune cells and a plethora of commensal microbes constituting the skin microbiome. Staphylococcus aureus is a prominent skin pathogen that colonizes a large proportion of the human population. We currently have an incomplete understanding of the correlates of protection against S. aureus infection, however genetic and experimental evidence has shown that CD4+ T cells play a key role in orchestrating a protective anti- S. aureus immune response. A high S. aureus -specific memory CD4+ T cell response has been reported in the blood of healthy subjects. Since T cells are more abundant in the skin than in blood, we hypothesized that S. aureus -specific CD4+ T cells could be present in the skin of healthy individuals. Indeed, we observed proliferation of tissue-resident memory CD4+ T cells and production of IL-17A, IL-22, IFN-γ and TNF-β by cells isolated from abdominal skin explants in response to heat-killed S. aureus. Remarkably, these cytokines were produced also during an ex vivo epicutaneous S. aureus infection of human skin explants. These findings highlight the importance of tissue-resident memory CD4+ T cells present at barrier sites such as the skin, a primary entry site for S. aureus. Further phenotypical and functional characterization of these cells will ultimately aid in the development of novel vaccine strategies against this elusive pathogen. [ABSTRACT FROM AUTHOR]

Research on a topic as intricate as climate change and adaptation can be seen as a complex ecosystem combining thousands of projects by a large set of actors. This article studies the EU Seventh Framework Program funded projects to understand how research has been funded and managed in Europe to develop a specific knowledge ecosystem around climate change and adaptation. The theoretical background offers an overview of the topics of climate change and knowledge ecosystems. The research projects database was used to construct and make sense of a complex ecosystem. A synthetic description of the technical work conducted and the results obtained are presented. The data is analyzed using social network analysis to provide evidence of structural characteristics of the networks, the relevance of different sub‐domains in climate change and adaptation research, and the emergence of entrepreneurial ecosystems through knowledge. [ABSTRACT FROM AUTHOR]