1. Megastigmane glycosides from the traditional Uighur medicine Cydonia oblonga Mill.
- Author
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Jiao SS, Ding RF, Yuan X, He XP, Liu Y, Guo K, and Li SH
- Subjects
- Mice, RAW 264.7 Cells, Animals, Molecular Structure, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents isolation & purification, Interleukin-6 antagonists & inhibitors, Interleukin-6 metabolism, Tumor Necrosis Factor-alpha antagonists & inhibitors, Structure-Activity Relationship, Dose-Response Relationship, Drug, Glucosides, Norisoprenoids chemistry, Norisoprenoids pharmacology, Norisoprenoids isolation & purification, Glycosides chemistry, Glycosides isolation & purification, Glycosides pharmacology, Cyclohexanones chemistry, Cyclohexanones pharmacology, Cyclohexanones isolation & purification, Lipopolysaccharides pharmacology, Lipopolysaccharides antagonists & inhibitors
- Abstract
Phytochemical investigation on the fruits of Cydonia oblonga Mill., a traditional Uighur medicine, led to the isolation of seven undescribed and nine known megastigmane glycosides. Their structures including absolute configurations were characterized by an extensive analysis of spectroscopic data including HRESIMS and NMR, combined with ECD calculations. Additionally, compounds 1, 2, 4, and 6-16 exhibited anti-inflammatory activity by inhibiting the secretion of cytokines TNF-α and IL-6 in RAW264.7 cells induced by lipopolysaccharides (LPS) with inhibitory rates of 10.79%-44.58% at 20 μM., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
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