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Your search keyword '"Czuzoj‐Shulman, Nicholas"' showing total 354 results
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354 results on '"Czuzoj‐Shulman, Nicholas"'

7. Maternal and newborn outcomes in pregnancies complicated by Guillain-Barré syndrome.

Author

Taylor, Samantha, Czuzoj-Shulman, Nicholas, Spence, Andrea R., and Abenhaim, Haim A.

Subjects
*RISK factors of preeclampsia, *FETAL growth retardation, *POLYNEURITIS, *CESAREAN section, *CHILD health services, *MULTIPLE regression analysis, *PREMATURE infants, *GUILLAIN-Barre syndrome, *PREGNANCY outcomes, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *POSTPARTUM hemorrhage, *LONGITUDINAL method, *ODDS ratio, *MEDICAL records, *ACQUISITION of data, *PREGNANCY complications, *CONFIDENCE intervals, *BLOOD transfusion, *LENGTH of stay in hospitals, *FETAL distress, *DISEASE risk factors, *DISEASE complications, *PREGNANCY, RISK factors
Abstract

Guillain-Barré syndrome (GBS) is a rare autoimmune disorder that affects the peripheral nervous system. The purpose of our study was to evaluate maternal and fetal/neonatal outcomes among pregnancies complicated by GBS. We performed a retrospective cohort study using the Healthcare Cost and Utilization Project – National Inpatient Sample from the United States. ICD-9 codes were used to identify all pregnant women who delivered between 1999 and 2015 and had a diagnosis of GBS. The remaining women without GBS who delivered during that time period constituted the comparison group. The associations between maternal GBS and obstetrical and fetal/neonatal outcomes were evaluated using multivariate logistic regression, while adjusting for the confounding effects of maternal characteristics. Of 13,792,544 births included in our study, 291 were to women with GBS, for an overall incidence of 2.1/100,000 births. A steady increase in maternal GBS was observed over the study period (from 1.26 to 3.8/100,000 births, p=0.02). Further, women with GBS were more likely to have pregnancies complicated by preeclampsia, OR 1.69 (95 % CI 1.06–2.69), sepsis, 9.30 (2.33–37.17), postpartum hemorrhage, 1.83 (1.07–3.14), and to require a transfusion, 4.39 (2.39–8.05). They were also at greater risk of caesarean delivery, 2.07 (1.58–2.72) and increased length of hospital stay, 4.48 (3.00–6.69). Newborns of women with GBS were more likely to be growth restricted, 2.50 (1.48–4.23). GBS in pregnancy is associated with maternal and newborn adverse outcomes. These patients would benefit from close follow-up throughout their pregnancy and in the postpartum period. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Obstetrical and neonatal outcomes in women with gestational Lyme disease.

Author

Courville, Julien M., Czuzoj‐Shulman, Nicholas, Spence, Andrea R., and Abenhaim, Haim A.

Subjects
*LYME disease, *PREGNANT women, *PREGNANCY outcomes, *ABRUPTIO placentae, *PREMATURE labor
Abstract

Objective: The incidence of Lyme disease (LD) infections has risen in recent decades. Gestational LD has been associated with adverse pregnancy outcomes; however, the results have been contradictory. The study objective was to examine the effects of gestational LD on obstetrical and neonatal outcomes. Methods: Using the Healthcare Cost & Utilization Project National (Nationwide) Inpatient Sample from the United States, we conducted a retrospective cohort study of pregnant patients admitted to the hospital between 2016 and 2019. The exposed group consisted of pregnant patients with gestational LD infection (International Classification of Diseases, Tenth Revision [ICD‐10] code A692x), while the comparison group consisted of pregnant patients without gestational LD. Descriptive statistics and multivariate logistic regression models, adjusted for baseline maternal characteristics, were used to determine the associations between gestational LD and obstetrical and neonatal outcomes. Results: The cohort included 2 943 575 women, 226 of whom were diagnosed with LD during pregnancy. The incidence of LD was 7.67 per 100 000 pregnancy admissions. The incidence of gestational LD was stable over the study period. Pregnant patients with LD were more likely white, older, to have private health insurance, and to belong to a higher income quartile. Gestational LD was associated with an increased risk of placental abruption (adjusted odds ratio [aOR], 3.45 [95% confidence interval (CI), 1.53–7.80]) and preterm birth (aOR, 1.58 [95% CI, 1.03–2.42]). Conclusion: Gestational LD is associated with a higher risk of placental abruption and preterm birth. Pregnancies complicated by LD, while associated with a higher risk of certain adverse outcomes, can be followed in most healthcare settings. Synopsis: Lyme disease in pregnancy is associated with an increased risk of placental abruption and preterm birth. [ABSTRACT FROM AUTHOR]

Published
2024
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