7 results on '"Dai, Jinwei"'
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2. Integrated ecological floating bed treating wastewater treatment plant effluents: effects of influent nitrogen forms and sediments
- Author
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Dai, Jinwei, He, Shengbing, Zhou, Weili, Huang, Jungchen, Chen, Sheng, and Zeng, Xinhua
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- 2018
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3. Synthesis of Novel Xanthone Analogues and Their Growth Inhibitory Activity Against Human Lung Cancer A549 Cells
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Wu, Junqi, Dai, Jinwei, Zhang, Yuyang, Wang, Jing, Huang, Lei, Ding, Hongmei, Li, Tiejun, Zhang, Yuefan, Mao, Junqin, and Yu, Shichong
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Drug Design, Development and Therapy ,synthesis ,Dose-Response Relationship, Drug ,Molecular Structure ,Xanthones ,apoptosis ,Antineoplastic Agents ,Structure-Activity Relationship ,A549 Cells ,xanthone ,derivatives ,Humans ,Drug Screening Assays, Antitumor ,lung cancer cell ,Original Research ,Cell Proliferation - Abstract
Junqi Wu,1,2,* Jinwei Dai,1,3,* Yuyang Zhang,1,3 Jing Wang,1 Lei Huang,1 Hongmei Ding,1 Tiejun Li,1,4 Yuefan Zhang,1,5 Junqin Mao,6 Shichong Yu1 1College of Pharmacy, Naval Medical University, Shanghai 200433, People’s Republic of China; 2Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, People’s Republic of China; 3Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; 4Department of Pharmacy, Punan Hospital, Shanghai 200125, People’s Republic of China; 5Biomedical Innovation R&D Center, School of Medicine, Shanghai University, Shanghai, 20444, People’s Republic of China; 6Department of Pharmacy, Shanghai Pudong New Area People’s Hospital, Shanghai 201299, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junqin Mao Email maojq204@163.comShichong Yu Tel/Fax +86-21-81871228Email yuscc1008@163.comPurpose: Xanthones demonstrated an array of pharmacological activities via non-covalent DNA interaction and have been widely utilized in new drug research. The introduction of the polar 1,2,3-triazole ring located at the C3-position of xanthone has not been reported thus far.Methods: In the present study, a series of xanthone derivatives were designed, synthesized, and characterized through 1H NMR, 13C NMR, and MS. The methyl thiazolyl tetrazolium method was used to evaluate the cytotoxic activity of compounds. Furthermore, the structure–activity relationship and the potential mechanism of target compounds were investigated.Results: The IC50 showed that the inhibitory activity of 18 target compounds was higher than that of the original xanthone intermediate 4. In particular, compound 1j was the most active agent against A549 cancer cells (IC50 = 32.4 ± 2.2 μM). Moreover, apoptosis analysis indicated different contributions of early/late apoptosis to cell death for compounds 1h and 1j. The results of Western blotting analysis showed that compound 1j significantly increased the expression of caspase 3, Bax, and c-Jun N-terminal kinase, and regulated p53 to a better healthy state in cancer cells.Conclusion: We synthesized several derivatives of xanthone and evaluated their cytotoxicity. The evidence suggested that compound 1j possessed greater anticancer potential for further evaluations.Keywords: synthesis, xanthone, derivatives, lung cancer cell, apoptosis
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- 2019
4. Anti-Inflammatory Dipeptide, a Metabolite from Ambioba Secretion, Protects Cerebral Ischemia Injury by Blocking Apoptosis Via p-JNK/Bax Pathway.
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Zhang, Qian, Dai, Jinwei, Song, Zhibing, Guo, Yuchen, Deng, Shanshan, Yu, Yongsheng, Li, Tiejun, and Zhang, Yuefan
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CEREBRAL ischemia ,ISCHEMIC stroke ,PATHOLOGICAL physiology ,CEREBRAL infarction ,SURVIVAL rate ,ANIMAL disease models ,CEREBRAL arteries ,BLOOD flow - Abstract
MQ (l-methionyl-l-glutamic acid), anti-inflammatory dipeptide, is one of the metabolites of monocyte locomotion inhibitory factor, a thermostable pentapeptide secreted by Entamoeba histolytica. Monocyte locomotion inhibitory factor injection has been approved as an investigational drug for the potential neural protection in acute ischemic stroke. This study further investigated the neuroprotective effect of MQ in ischemic brain damage. Ischemia-reperfusion injury of the brain was induced in the rat model by middle cerebral artery occlusion. 2,3,5-triphenyltetrazolium chloride staining assay was used to measure cerebral infarction areas in rats. Laser Doppler measurement instrument was used to detect blood flow changes in the rat model. Nissl staining and NeuN staining were utilized to observe the numbers and structures of neuron cells, and the pathological changes in the brain tissues were examined by hematoxylin–eosin staining. Terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling (TUNEL) staining was used to assess cell apoptosis. The changes in oxidative stress indexes, superoxide dismutase and malondialdehyde (MDA), were measured in serum. Methyl thiazolyl tetrazolium was used to measure the survival rates of PC12 cells. Flow cytometry assessed the apoptosis rates and the levels of reactive oxygen species. Real-time PCR was used to evaluate the mRNA expression levels, and Western blotting was used to analyze the changes in protein levels of p-JNK, Bax, cleaved Caspase3. We revealed that MQ improved neurobehavior, decreased cerebral infarction areas, altered blood flow volume, and the morphology of the cortex and hippocampus. On the other hand, it decreased the apoptosis of cortical neurons and the levels of MDA, and increased the levels of superoxide dismutase. In vitro studies demonstrated that MQ enhanced the cell survival rates and decreased the levels of reactive oxygen species. Compared to the oxygen-glucose deprivation/reperfusion group, the protein and mRNA expressions of p-JNK, Bax, cleaved Caspase3 was decreased significantly. These findings suggested that MQ exerts a neuroprotective effect in cerebral ischemia by blocking apoptosis via the p-JNK/Bax pathway. [ABSTRACT FROM AUTHOR]
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- 2021
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5. Visual Analytic Method for Students' Association via Modularity Optimization.
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Li, XiaoYong, Yu, QinYang, Zhang, Yong, Dai, JinWei, and Yin, BaoCai
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STUDENT organizations ,PSYCHOLOGY of students ,SHARED housing - Abstract
Students spend most of their time living and studying on campus, especially in Asia, and they form various types of associations in addition to those with classmates and roommates. It is necessary for university authorities to master these types of associations, so as to provide appropriate services, such as psychological guidance and academic advice. With the rapid development of the "smart campus," many kinds of student behavior data are recorded, which provides an unprecedented opportunity to deeply analyze students' associations. In this paper, we propose a visual analytic method to construct students' association networks by computing the similarity of their behavior data. We discover student communities using the popular Louvain (or BGLL) algorithm, which can extract community structures based on modularity optimization. Using various visualization charts, we visualized associations among students so as to intuitively express them. We evaluated our method using the real behavior data of undergraduates in a university in Beijing. The experimental results indicate that this method is effective and intuitive for student association analysis. [ABSTRACT FROM AUTHOR]
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- 2020
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6. Equality-Constrained Detector Using Probabilistic Approach for Massive GSSK-MIMO Systems.
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Gao, Yuanlong, Zhao, Guannan, Dai, Jinwei, Liu, Wenlong, and Jin, Minglu
- Abstract
In this letter, we propose an equality-constrained detector using probabilistic approaches for massive multiple-input multiple-output (MIMO) systems with generalized space shift keying (GSSK) modulation. Probabilistic approaches derived from the Bayesian iteration can provide the soft decision for achieving the near-optimal performance and some other benefits such as combination of detection and channel decoding. However, these methods cannot be directly adopted to GSSK modulated MIMO systems without considering the equality-constraint of GSSK signals. To address this problem, we develop an augmented system model with a weighting parameter. Moreover, the relation between the augmented model and the quadratic penalty function is also derived to determine the value of weighting parameter. Consequently, probabilistic approaches based on the augmented system model can be directly used to solve the equality-constrained problems. Simulation results substantiate the high-performance and extensibility of the proposed detector. [ABSTRACT FROM AUTHOR]
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- 2019
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7. Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats.
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Yang, Jinna, Zhou, Wangyi, Gu, Yaru, Dai, Jinwei, Li, Xinxin, Tai, Ping, Li, Yanchuan, Ma, Xiaohui, and Zhang, Yuyang
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GASTRIC mucosa ,THERAPEUTIC use of plant extracts ,ETHANOL ,MYELOPEROXIDASE ,THERAPEUTIC use of tea ,LABORATORY rats ,DISEASES - Abstract
Pu-erh tea has become a focus of research due to its reported biological activities, including anti-oxidation, anti-inflammation and anti-immunosenescence. The present study was performed to evaluate the potential gastroprotective function of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats. Sprague Dawley rats were randomly divided into seven groups: A normal control, a model control, a cimetidine (0.08 g/kg) group, three Pu-erh tea extracts groups (low, moderate and high-dose; 0.50, 1.00 and 1.50 g/kg, respectively, and a green tea powder (1.00 g/kg) group. The normal and model groups were pre-treated with distilled water while the other groups were respectively administered cimetidine, Pu-erh tea extracts and green tea powder for 14 days. Then, absolute ethanol was orally administered to the rats of all groups excluding the normal controls. The effects of the pretreatments on gastric mucosal injury were evaluated by gross assessment of gastric lesions, examination of histopathology and determination of myeloperoxidase (MPO) activity and asymmetric arginine (ADMA) concentration in gastric mucosal homogenate. Pre-treatment with cimetidine or Pu-erh tea extracts markedly suppressed the formation of ethanol-induced gastric lesions. Furthermore, clear decreases in MPO activity and ADMA concentration in the gastric mucosal homogenate were observed following pretreatment with cimetidine or Pu-erh tea extracts. The anti-gastric ulcer activity of green tea was less than that of Pu-erh tea. Overall, these effects of Pu-erh tea extracts may be due to potential functions in protecting the gastric mucus layer and suppressing inflammation. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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