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1. The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project

Author

Lawrence N. Hudson, Tim Newbold, Sara Contu, Samantha L. L. Hill, Igor Lysenko, Adriana De Palma, Helen R. P. Phillips, Tamera I. Alhusseini, Felicity E. Bedford, Dominic J. Bennett, Hollie Booth, Victoria J. Burton, Charlotte W. T. Chng, Argyrios Choimes, David L. P. Correia, Julie Day, Susy Echeverría‐Londoño, Susan R. Emerson, Di Gao, Morgan Garon, Michelle L. K. Harrison, Daniel J. Ingram, Martin Jung, Victoria Kemp, Lucinda Kirkpatrick, Callum D. Martin, Yuan Pan, Gwilym D. Pask‐Hale, Edwin L. Pynegar, Alexandra N. Robinson, Katia Sanchez‐Ortiz, Rebecca A. Senior, Benno I. Simmons, Hannah J. White, Hanbin Zhang, Job Aben, Stefan Abrahamczyk, Gilbert B. Adum, Virginia Aguilar‐Barquero, Marcelo A. Aizen, Belén Albertos, E. L. Alcala, Maria delMar Alguacil, Audrey Alignier, Marc Ancrenaz, Alan N. Andersen, Enrique Arbeláez‐Cortés, Inge Armbrecht, Víctor Arroyo‐Rodríguez, Tom Aumann, Jan C. Axmacher, Badrul Azhar, Adrián B. Azpiroz, Lander Baeten, Adama Bakayoko, András Báldi, John E. Banks, Sharad K. Baral, Jos Barlow, Barbara I. P. Barratt, Lurdes Barrico, Paola Bartolommei, Diane M. Barton, Yves Basset, Péter Batáry, Adam J. Bates, Bruno Baur, Erin M. Bayne, Pedro Beja, Suzan Benedick, Åke Berg, Henry Bernard, Nicholas J. Berry, Dinesh Bhatt, Jake E. Bicknell, Jochen H. Bihn, Robin J. Blake, Kadiri S. Bobo, Roberto Bóçon, Teun Boekhout, Katrin Böhning‐Gaese, Kevin J. Bonham, Paulo A. V. Borges, Sérgio H. Borges, Céline Boutin, Jérémy Bouyer, Cibele Bragagnolo, Jodi S. Brandt, Francis Q. Brearley, Isabel Brito, Vicenç Bros, Jörg Brunet, Grzegorz Buczkowski, Christopher M. Buddle, Rob Bugter, Erika Buscardo, Jörn Buse, Jimmy Cabra‐García, Nilton C. Cáceres, Nicolette L. Cagle, María Calviño‐Cancela, Sydney A. Cameron, Eliana M. Cancello, Rut Caparrós, Pedro Cardoso, Dan Carpenter, Tiago F. Carrijo, Anelena L. Carvalho, Camila R. Cassano, Helena Castro, Alejandro A. Castro‐Luna, Cerda B. Rolando, Alexis Cerezo, Kim Alan Chapman, Matthieu Chauvat, Morten Christensen, Francis M. Clarke, Daniel F.R. Cleary, Giorgio Colombo, Stuart P. Connop, Michael D. Craig, Leopoldo Cruz‐López, Saul A. Cunningham, Biagio D'Aniello, Neil D'Cruze, Pedro Giovâni daSilva, Martin Dallimer, Emmanuel Danquah, Ben Darvill, Jens Dauber, Adrian L. V. Davis, Jeff Dawson, Claudio deSassi, Benoit deThoisy, Olivier Deheuvels, Alain Dejean, Jean‐Louis Devineau, Tim Diekötter, Jignasu V. Dolia, Erwin Domínguez, Yamileth Dominguez‐Haydar, Silvia Dorn, Isabel Draper, Niels Dreber, Bertrand Dumont, Simon G. Dures, Mats Dynesius, Lars Edenius, Paul Eggleton, Felix Eigenbrod, Zoltán Elek, Martin H. Entling, Karen J. Esler, Ricardo F. deLima, Aisyah Faruk, Nina Farwig, Tom M. Fayle, Antonio Felicioli, Annika M. Felton, Roderick J. Fensham, Ignacio C. Fernandez, Catarina C. Ferreira, Gentile F. Ficetola, Cristina Fiera, Bruno K. C. Filgueiras, Hüseyin K. Fırıncıoğlu, David Flaspohler, Andreas Floren, Steven J. Fonte, Anne Fournier, Robert E. Fowler, Markus Franzén, Lauchlan H. Fraser, Gabriella M. Fredriksson, Geraldo B. Freire Jr, Tiago L. M. Frizzo, Daisuke Fukuda, Dario Furlani, René Gaigher, Jörg U. Ganzhorn, Karla P. García, Juan C. Garcia‐R, Jenni G. Garden, Ricardo Garilleti, Bao‐Ming Ge, Benoit Gendreau‐Berthiaume, Philippa J. Gerard, Carla Gheler‐Costa, Benjamin Gilbert, Paolo Giordani, Simonetta Giordano, Carly Golodets, Laurens G. L. Gomes, Rachelle K. Gould, Dave Goulson, Aaron D. Gove, Laurent Granjon, Ingo Grass, Claudia L. Gray, James Grogan, Weibin Gu, Moisès Guardiola, Nihara R. Gunawardene, Alvaro G. Gutierrez, Doris L. Gutiérrez‐Lamus, Daniela H. Haarmeyer, Mick E. Hanley, Thor Hanson, Nor R. Hashim, Shombe N. Hassan, Richard G. Hatfield, Joseph E. Hawes, Matt W. Hayward, Christian Hébert, Alvin J. Helden, John‐André Henden, Philipp Henschel, Lionel Hernández, James P. Herrera, Farina Herrmann, Felix Herzog, Diego Higuera‐Diaz, Branko Hilje, Hubert Höfer, Anke Hoffmann, Finbarr G. Horgan, Elisabeth Hornung, Roland Horváth, Kristoffer Hylander, Paola Isaacs‐Cubides, Hiroaki Ishida, Masahiro Ishitani, Carmen T. Jacobs, Víctor J. Jaramillo, Birgit Jauker, F. Jiménez Hernández, McKenzie F. Johnson, Virat Jolli, Mats Jonsell, S. Nur Juliani, Thomas S. Jung, Vena Kapoor, Heike Kappes, Vassiliki Kati, Eric Katovai, Klaus Kellner, Michael Kessler, Kathryn R. Kirby, Andrew M. Kittle, Mairi E. Knight, Eva Knop, Florian Kohler, Matti Koivula, Annette Kolb, Mouhamadou Kone, Ádám Kőrösi, Jochen Krauss, Ajith Kumar, Raman Kumar, David J. Kurz, Alex S. Kutt, Thibault Lachat, Victoria Lantschner, Francisco Lara, Jesse R. Lasky, Steven C. Latta, William F. Laurance, Patrick Lavelle, Violette Le Féon, Gretchen LeBuhn, Jean‐Philippe Légaré, Valérie Lehouck, María V. Lencinas, Pia E. Lentini, Susan G. Letcher, Qi Li, Simon A. Litchwark, Nick A. Littlewood, Yunhui Liu, Nancy Lo‐Man‐Hung, Carlos A. López‐Quintero, Mounir Louhaichi, Gabor L. Lövei, Manuel Esteban Lucas‐Borja, Victor H. Luja, Matthew S. Luskin, M Cristina MacSwiney G, Kaoru Maeto, Tibor Magura, Neil Aldrin Mallari, Louise A. Malone, Patrick K. Malonza, Jagoba Malumbres‐Olarte, Salvador Mandujano, Inger E. Måren, Erika Marin‐Spiotta, Charles J. Marsh, E. J. P. Marshall, Eliana Martínez, Guillermo Martínez Pastur, David Moreno Mateos, Margaret M. Mayfield, Vicente Mazimpaka, Jennifer L. McCarthy, Kyle P. McCarthy, Quinn S. McFrederick, Sean McNamara, Nagore G. Medina, Rafael Medina, Jose L. Mena, Estefania Mico, Grzegorz Mikusinski, Jeffrey C. Milder, James R. Miller, Daniel R. Miranda‐Esquivel, Melinda L. Moir, Carolina L. Morales, Mary N. Muchane, Muchai Muchane, Sonja Mudri‐Stojnic, A. Nur Munira, Antonio Muoñz‐Alonso, B. F. Munyekenye, Robin Naidoo, A. Naithani, Michiko Nakagawa, Akihiro Nakamura, Yoshihiro Nakashima, Shoji Naoe, Guiomar Nates‐Parra, Dario A. Navarrete Gutierrez, Luis Navarro‐Iriarte, Paul K. Ndang'ang'a, Eike L. Neuschulz, Jacqueline T. Ngai, Violaine Nicolas, Sven G. Nilsson, Norbertas Noreika, Olivia Norfolk, Jorge Ari Noriega, David A. Norton, Nicole M. Nöske, A. Justin Nowakowski, Catherine Numa, Niall O'Dea, Patrick J. O'Farrell, William Oduro, Sabine Oertli, Caleb Ofori‐Boateng, Christopher Omamoke Oke, Vicencio Oostra, Lynne M. Osgathorpe, Samuel Eduardo Otavo, Navendu V. Page, Juan Paritsis, Alejandro Parra‐H, Luke Parry, Guy Pe'er, Peter B. Pearman, Nicolás Pelegrin, Raphaël Pélissier, Carlos A. Peres, Pablo L. Peri, Anna S. Persson, Theodora Petanidou, Marcell K. Peters, Rohan S. Pethiyagoda, Ben Phalan, T. Keith Philips, Finn C. Pillsbury, Jimmy Pincheira‐Ulbrich, Eduardo Pineda, Joan Pino, Jaime Pizarro‐Araya, A. J. Plumptre, Santiago L. Poggio, Natalia Politi, Pere Pons, Katja Poveda, Eileen F. Power, Steven J. Presley, Vânia Proença, Marino Quaranta, Carolina Quintero, Romina Rader, B. R. Ramesh, Martha P. Ramirez‐Pinilla, Jai Ranganathan, Claus Rasmussen, Nicola A. Redpath‐Downing, J. Leighton Reid, Yana T. Reis, José M. Rey Benayas, Juan Carlos Rey‐Velasco, Chevonne Reynolds, Danilo Bandini Ribeiro, Miriam H. Richards, Barbara A. Richardson, Michael J. Richardson, Rodrigo Macip Ríos, Richard Robinson, Carolina A. Robles, Jörg Römbke, Luz Piedad Romero‐Duque, Matthias Rös, Loreta Rosselli, Stephen J. Rossiter, Dana S. Roth, T'ai H. Roulston, Laurent Rousseau, André V. Rubio, Jean‐Claude Ruel, Jonathan P. Sadler, Szabolcs Sáfián, Romeo A. Saldaña‐Vázquez, Katerina Sam, Ulrika Samnegård, Joana Santana, Xavier Santos, Jade Savage, Nancy A. Schellhorn, Menno Schilthuizen, Ute Schmiedel, Christine B. Schmitt, Nicole L. Schon, Christof Schüepp, Katharina Schumann, Oliver Schweiger, Dawn M. Scott, Kenneth A. Scott, Jodi L. Sedlock, Steven S. Seefeldt, Ghazala Shahabuddin, Graeme Shannon, Douglas Sheil, Frederick H. Sheldon, Eyal Shochat, Stefan J. Siebert, Fernando A. B. Silva, Javier A. Simonetti, Eleanor M. Slade, Jo Smith, Allan H. Smith‐Pardo, Navjot S. Sodhi, Eduardo J. Somarriba, Ramón A. Sosa, Grimaldo Soto Quiroga, Martin‐Hugues St‐Laurent, Brian M. Starzomski, Constanti Stefanescu, Ingolf Steffan‐Dewenter, Philip C. Stouffer, Jane C. Stout, Ayron M. Strauch, Matthew J. Struebig, Zhimin Su, Marcela Suarez‐Rubio, Shinji Sugiura, Keith S. Summerville, Yik‐Hei Sung, Hari Sutrisno, Jens‐Christian Svenning, Tiit Teder, Caragh G. Threlfall, Anu Tiitsaar, Jacqui H. Todd, Rebecca K. Tonietto, Ignasi Torre, Béla Tóthmérész, Teja Tscharntke, Edgar C. Turner, Jason M. Tylianakis, Marcio Uehara‐Prado, Nicolas Urbina‐Cardona, Denis Vallan, Adam J. Vanbergen, Heraldo L. Vasconcelos, Kiril Vassilev, Hans A. F. Verboven, Maria João Verdasca, José R. Verdú, Carlos H. Vergara, Pablo M. Vergara, Jort Verhulst, Massimiliano Virgilio, Lien Van Vu, Edward M. Waite, Tony R. Walker, Hua‐Feng Wang, Yanping Wang, James I. Watling, Britta Weller, Konstans Wells, Catrin Westphal, Edward D. Wiafe, Christopher D. Williams, Michael R. Willig, John C. Z. Woinarski, Jan H. D. Wolf, Volkmar Wolters, Ben A. Woodcock, Jihua Wu, Joseph M. Wunderle Jr, Yuichi Yamaura, Satoko Yoshikura, Douglas W. Yu, Andrey S. Zaitsev, Juliane Zeidler, Fasheng Zou, Ben Collen, Rob M. Ewers, Georgina M. Mace, Drew W. Purves, Jörn P. W. Scharlemann, and Andy Purvis

Subjects
data sharing, global biodiversity modeling, global change, habitat destruction, land use, Ecology, QH540-549.5
Abstract

Abstract The PREDICTS project—Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (https://www.nhm.ac.uk/our-science/our-work/biodiversity/predicts.html)—has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.

Published
2017
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2. The PREDICTS database: a global database of how local terrestrial biodiversity responds to human impacts

Author

Lawrence N. Hudson, Tim Newbold, Sara Contu, Samantha L. L. Hill, Igor Lysenko, Adriana De Palma, Helen R. P. Phillips, Rebecca A. Senior, Dominic J. Bennett, Hollie Booth, Argyrios Choimes, David L. P. Correia, Julie Day, Susy Echeverría‐Londoño, Morgan Garon, Michelle L. K. Harrison, Daniel J. Ingram, Martin Jung, Victoria Kemp, Lucinda Kirkpatrick, Callum D. Martin, Yuan Pan, Hannah J. White, Job Aben, Stefan Abrahamczyk, Gilbert B. Adum, Virginia Aguilar‐Barquero, Marcelo A. Aizen, Marc Ancrenaz, Enrique Arbeláez‐Cortés, Inge Armbrecht, Badrul Azhar, Adrián B. Azpiroz, Lander Baeten, András Báldi, John E. Banks, Jos Barlow, Péter Batáry, Adam J. Bates, Erin M. Bayne, Pedro Beja, Åke Berg, Nicholas J. Berry, Jake E. Bicknell, Jochen H. Bihn, Katrin Böhning‐Gaese, Teun Boekhout, Céline Boutin, Jérémy Bouyer, Francis Q. Brearley, Isabel Brito, Jörg Brunet, Grzegorz Buczkowski, Erika Buscardo, Jimmy Cabra‐García, María Calviño‐Cancela, Sydney A. Cameron, Eliana M. Cancello, Tiago F. Carrijo, Anelena L. Carvalho, Helena Castro, Alejandro A. Castro‐Luna, Rolando Cerda, Alexis Cerezo, Matthieu Chauvat, Frank M. Clarke, Daniel F. R. Cleary, Stuart P. Connop, Biagio D'Aniello, Pedro Giovâni daSilva, Ben Darvill, Jens Dauber, Alain Dejean, Tim Diekötter, Yamileth Dominguez‐Haydar, Carsten F. Dormann, Bertrand Dumont, Simon G. Dures, Mats Dynesius, Lars Edenius, Zoltán Elek, Martin H. Entling, Nina Farwig, Tom M. Fayle, Antonio Felicioli, Annika M. Felton, Gentile F. Ficetola, Bruno K. C. Filgueiras, Steven J. Fonte, Lauchlan H. Fraser, Daisuke Fukuda, Dario Furlani, Jörg U. Ganzhorn, Jenni G. Garden, Carla Gheler‐Costa, Paolo Giordani, Simonetta Giordano, Marco S. Gottschalk, Dave Goulson, Aaron D. Gove, James Grogan, Mick E. Hanley, Thor Hanson, Nor R. Hashim, Joseph E. Hawes, Christian Hébert, Alvin J. Helden, John‐André Henden, Lionel Hernández, Felix Herzog, Diego Higuera‐Diaz, Branko Hilje, Finbarr G. Horgan, Roland Horváth, Kristoffer Hylander, Paola Isaacs‐Cubides, Masahiro Ishitani, Carmen T. Jacobs, Víctor J. Jaramillo, Birgit Jauker, Mats Jonsell, Thomas S. Jung, Vena Kapoor, Vassiliki Kati, Eric Katovai, Michael Kessler, Eva Knop, Annette Kolb, Ádám Kőrösi, Thibault Lachat, Victoria Lantschner, Violette Le Féon, Gretchen LeBuhn, Jean‐Philippe Légaré, Susan G. Letcher, Nick A. Littlewood, Carlos A. López‐Quintero, Mounir Louhaichi, Gabor L. Lövei, Manuel Esteban Lucas‐Borja, Victor H. Luja, Kaoru Maeto, Tibor Magura, Neil Aldrin Mallari, Erika Marin‐Spiotta, E. J. P. Marshall, Eliana Martínez, Margaret M. Mayfield, Grzegorz Mikusinski, Jeffrey C. Milder, James R. Miller, Carolina L. Morales, Mary N. Muchane, Muchai Muchane, Robin Naidoo, Akihiro Nakamura, Shoji Naoe, Guiomar Nates‐Parra, Dario A. Navarrete Gutierrez, Eike L. Neuschulz, Norbertas Noreika, Olivia Norfolk, Jorge Ari Noriega, Nicole M. Nöske, Niall O'Dea, William Oduro, Caleb Ofori‐Boateng, Chris O. Oke, Lynne M. Osgathorpe, Juan Paritsis, Alejandro Parra‐H, Nicolás Pelegrin, Carlos A. Peres, Anna S. Persson, Theodora Petanidou, Ben Phalan, T. Keith Philips, Katja Poveda, Eileen F. Power, Steven J. Presley, Vânia Proença, Marino Quaranta, Carolina Quintero, Nicola A. Redpath‐Downing, J. Leighton Reid, Yana T. Reis, Danilo B. Ribeiro, Barbara A. Richardson, Michael J. Richardson, Carolina A. Robles, Jörg Römbke, Luz Piedad Romero‐Duque, Loreta Rosselli, Stephen J. Rossiter, T'ai H. Roulston, Laurent Rousseau, Jonathan P. Sadler, Szabolcs Sáfián, Romeo A. Saldaña‐Vázquez, Ulrika Samnegård, Christof Schüepp, Oliver Schweiger, Jodi L. Sedlock, Ghazala Shahabuddin, Douglas Sheil, Fernando A. B. Silva, Eleanor M. Slade, Allan H. Smith‐Pardo, Navjot S. Sodhi, Eduardo J. Somarriba, Ramón A. Sosa, Jane C. Stout, Matthew J. Struebig, Yik‐Hei Sung, Caragh G. Threlfall, Rebecca Tonietto, Béla Tóthmérész, Teja Tscharntke, Edgar C. Turner, Jason M. Tylianakis, Adam J. Vanbergen, Kiril Vassilev, Hans A. F. Verboven, Carlos H. Vergara, Pablo M. Vergara, Jort Verhulst, Tony R. Walker, Yanping Wang, James I. Watling, Konstans Wells, Christopher D. Williams, Michael R. Willig, John C. Z. Woinarski, Jan H. D. Wolf, Ben A. Woodcock, Douglas W. Yu, Andrey S. Zaitsev, Ben Collen, Rob M. Ewers, Georgina M. Mace, Drew W. Purves, Jörn P. W. Scharlemann, and Andy Purvis

Subjects
Data sharing, global change, habitat destruction, land use, Ecology, QH540-549.5
Abstract

Abstract Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project – and avert – future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local‐scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups – including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems – https://www.nhm.ac.uk/our-science/our-work/biodiversity/predicts.html). We make site‐level summary data available alongside this article. The full database will be publicly available in 2015.

Published
2014
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3. Mesenchymal Stem Cells Restore Lung Function by Recruiting Resident and Nonresident Proteins

Author

Philipp Jungebluth, Mark Luedde, Elisabet Ferrer, Tom Luedde, Mihael Vucur, Victor I. Peinado, Tetsuhiko Go, Catharina Schreiber, Maximilian Von Richthofen, Augustinus Bader, Johannes Haag, Kai H. Darsow, Sebastian J. Bartel, Harald A. Lange, Dario Furlani, Gustav Steinhoff, and Paolo Macchiarini M.D., Ph.D.

Subjects
Medicine
Abstract

Because human lungs are unlikely to repair or regenerate beyond the cellular level, cell therapy has not previously been considered for chronic irreversible obstructive lung diseases. To explore whether cell therapy can restore lung function, we administered allogenic intratracheal mesenchymal stem cells (MSCs) in the trachea of rats with chronic thromboembolic pulmonary hypertension (CTEPH), a disease characterized by single or recurrent pulmonary thromboembolic obliteration and progressive pulmonary vascular remodeling. MSCs were retrieved only in high pressure-exposed lungs recruited via a homing stromal derived factor-1α/ CXCR4 pathway. After MSC administration, a marked and long-lasting improvement of all clinical parameters and a significant change of the proteome level were detected. Beside a variation of liver proteome, such as caspase-3, NF-κB, collagen1A1, and α-SMA, we also identified more than 300 resident and nonresident lung proteins [e.g., myosin light chain 3 (P16409) or mitochondrial ATP synthase subunit alpha (P15999)]. These results suggest that cell therapy restores lung function and the therapeutic effects of MSCs may be related to protein-based tissue reconstituting effects.

Published
2011
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4. Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration.

Author

Ralf Gaebel, Dario Furlani, Heiko Sorg, Bianca Polchow, Johannes Frank, Karen Bieback, Weiwei Wang, Christian Klopsch, Lee-Lee Ong, Wenzhong Li, Nan Ma, and Gustav Steinhoff

Subjects
Medicine, Science
Abstract

The possible different therapeutic efficacy of human mesenchymal stem cells (hMSC) derived from umbilical cord blood (CB), adipose tissue (AT) or bone marrow (BM) for the treatment of myocardial infarction (MI) remains unexplored. This study was to assess the regenerative potential of hMSC from different origins and to evaluate the role of CD105 in cardiac regeneration. Male SCID mice underwent LAD-ligation and received the respective cell type (400.000/per animal) intramyocardially. Six weeks post infarction, cardiac catheterization showed significant preservation of left ventricular functions in BM and CD105(+)-CB treated groups compared to CB and nontreated MI group (MI-C). Cell survival analyzed by quantitative real time PCR for human GAPDH and capillary density measured by immunostaining showed consistent results. Furthermore, cardiac remodeling can be significantly attenuated by BM-hMSC compared to MI-C. Under hypoxic conditions in vitro, remarkably increased extracellular acidification and apoptosis has been detected from CB-hMSC compared to BM and CD105 purified CB-derived hMSC. Our findings suggests that hMSC originating from different sources showed a different healing performance in cardiac regeneration and CD105(+) hMSC exhibited a favorable survival pattern in infarcted hearts, which translates into a more robust preservation of cardiac function.

Published
2011
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5. Autologous Umbilical Cord Blood Mononuclear Cell Transplantation Preserves Right Ventricular Function in a Novel Model of Chronic Right Ventricular Volume Overload

Author

Can Yerebakan M.D., Eugen Sandica, Stephanie Prietz, Christian Klopsch, Murat Ugurlucan, Alexander Kaminski, Sefer Abdija, Björn Lorenzen, Johannes Boltze, Björn Nitzsche, Dietmar Egger, Malte Barten, Dario Furlani, Nan Ma, Brigitte Vollmar, Andreas Liebold, and Gustav Steinhoff

Subjects
Medicine
Abstract

We aimed to evaluate the feasibility and efficacy of autologous umbilical cord blood mononuclear cell (UCMNC) transplantation on right ventricular (RV) function in a novel model of chronic RV volume overload. Four-month-old sheep ( n = 20) were randomized into cell ( n = 10) and control groups ( n = 10). After assessment of baseline RV function by the conductance catheter method, a transannular patch (TAP) was sutured to the right ventricular outflow tract (RVOT). Following infundibulotomy the ring of the pulmonary valve was transected without cardiopulmonary bypass. UCMNC implantation (8.22 ± 6.28 × 10 7 ) in the cell group and medium injection in the control group were performed into the RV myocardium around the TAP. UCMNCs were cultured for 2 weeks after fluorescence-activated cell sorting (FACS) analysis for CD34 antigen. Transthoracic echocardiography (TTE) and computed tomography were performed after 6 weeks and 3 months, respectively. RV function was assessed 3 months postoperatively before the hearts were excised for immunohistological examinations. FACS analysis revealed 1.2 ± 0.22% CD34 + cells within the isolated UCMNCs from which AcLDL + endothelial cells were cultured in vitro. All animals survived surgery. TTE revealed grade II–III pulmonary regurgitation in both groups. Pressure-volume loops under dobutamine stress showed significantly improved RV diastolic function in the cell group (dP/dt min : p = 0.043; E ed : p = 0.009). CD31 staining indicated a significantly enhanced number of microvessels in the region of UCMNC implantation in the cell group ( p < 0.001). No adverse tissue changes were observed. TAP augmentation and pulmonary annulus distortion without cardiopulmonary bypass constitutes a valid large animal model mimicking the surgical repair of tetralogy of Fallot. Our results indicate that the chronically volume-overloaded RV profits from autologous UCMNC implantation by enhanced diastolic properties with a probable underlying mechanism of increased angiogenesis.

Published
2009
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6. A Transformed Cell Population Derived from Cultured Mesenchymal Stem Cells has no Functional Effect after Transplantation into the Injured Heart

Author

Dario Furlani, Wenzhong Li, Erik Pittermann, Christian Klopsch, Liang Wang, Agnes Knopp, Philipp Jungebluth, Elke Thedinga, Carolin Havenstein, Ingeborg Westien, Murat Ugurlucan, Ren-Ke Li, Nan Ma FKGO, and Gustav Steinhoff

Subjects
Medicine
Abstract

Bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells characterized by their self-renewal and differentiation potential. Accumulating clinical and preclinical evidence indicate MSCs are a promising cell source for regenerative medical therapies. However, undesirable immortalization, spontaneous transformation, and tumorigenic potential from long-term cultured MSCs have been reported in human and mouse. We report rat MSCs isolated from young donors could undergo transformation in early passage culture. We aimed to characterize the transformed population and determine their therapeutic effects after intracardiac transplantation in the infarcted myocardium. MSCs were isolated from bone marrow of Lewis rats according to standard protocols and cultured under standard conditions. Phenotype of growing cells was assessed by flow cytometry. Following acute myocardial infarction in rats, cells were delivered by intracardiac injection. Cardiac functions were assessed by pressure–volume loops. Infarction size and pathologic effects were evaluated after 6 weeks. The abnormal colonies were detected in culture as early at passage 3. They were noted to appear as distinctly different morphology from typical MSCs, which changed from a normal elongated spindle shape to a compact abnormal morphology. They exhibited rapid cell proliferation. Some subclones lost contact inhibition of cell division and formed multilayer aggregates. Chromosomal instability was detected. They were devoid of surface markers CD29, CD44, CD90, and CD117. Furthermore, there was no significant improvement on infarction size and cardiac function 6 weeks after cell transplantation. Our study highlights the need for establishment of biosafety criteria in regulating culture-expanded MSCs to achieve the full clinical therapeutic benefits.

Published
2009
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7. HMGB-1 induces c-kit+ cell microvascular rolling and adhesion via both toll-like receptor-2 and toll-like receptor-4 of endothelial cells

Author

Murat Ugurlucan, Erik Pittermann, Brigitte Vollmar, Gustav Steinhoff, Dario Furlani, Weiwei Wang, Wenzhong Li, Nan Ma, Alexander Kaminski, Ingeborg Westien, and Peter Donndorf

Subjects
Male, Nitric Oxide Synthase Type III, Cell, Leukocyte Rolling, Biology, high-mobility group box 1, Mice, Cell Movement, intravital microscopy, medicine, Cell Adhesion, Animals, HMGB1 Protein, Cell adhesion, Muscle, Skeletal, Mice, Knockout, Toll-like receptor, Mice, Inbred C3H, Cell adhesion molecule, cremaster muscle, Cell Biology, Original Articles, Molecular biology, In vitro, Toll-Like Receptor 2, Mice, Inbred C57BL, Toll-Like Receptor 4, Proto-Oncogene Proteins c-kit, medicine.anatomical_structure, Microvessels, Molecular Medicine, Stem cell, c-kit+
Abstract

High-mobility group box 1 (HMGB-1) is a strong chemo-attractive signal for both inflammatory and stem cells. The aim of this study is to evaluate the mechanisms regulating HMGB-1-mediated adhesion and rolling of c-kit(+) cells and assess whether toll-like receptor-2 (TLR-2) and toll-like receptor-4 (TLR-4) of endothelial cells or c-kit(+) cells are implicated in the activation of downstream migration signals to peripheral c-kit(+) cells. Effects of HMGB-1 on the c-kit(+) cells/endothelial interaction were evaluated by a cremaster muscle model in wild-type (WT), TLR-2 (-/-) and Tlr4 (LPS-del) mice. The mRNA and protein expression levels of endothelial nitric oxide synthase were determined by quantitative real-time PCR and immunofluorescence staining. Induction of crucial adhesion molecules for rolling and adhesion of stem cells and leukocytes were monitored in vivo and in vitro. Following local HMGB-1 administration, a significant increase in cell rolling was detected (32.4 ± 7.1% in 'WT' versus 9.9 ± 3.2% in 'control', P0.05). The number of firmly adherent c-kit(+) cells was more than 13-fold higher than that of the control group (14.6 ± 5.1 cells/mm(2) in 'WT' versus 1.1 ± 1.0 cells/mm(2) in 'control', P0.05). In knockout animals, the fraction of rolling cells did not differ significantly from control levels. Firm endothelial adhesion was significantly reduced in TLR-2 (-/-) and Tlr4 (LPS-del) mice compared to WT mice (1.5 ± 1.4 cells/mm(2) in 'TLR-2 (-/-)' and 2.4 ± 1.4 cells/mm(2) in 'Tlr4 (LPS-del)' versus 14.6 ± 5.1 cells/mm(2) in 'WT', P0.05). TLR-2 (-/-) and Tlr4 (LPS-del) stem cells in WT mice did not show significant reduction in rolling and adhesion compared to WT cells. HMGB-1 mediates c-kit(+) cell recruitment via endothelial TLR-2 and TLR-4.

Published
2012

8. Intracardiac injection of matrigel induces stem cell recruitment and improves cardiac functions in a rat myocardial infarction model

Author

Lailiang Ou, Wenzhong Li, Yue Zhang, Weiwei Wang, Jun Liu, Heiko Sorg, Dario Furlani, Ralf Gäbel, Peter Mark, Christian Klopsch, Liang Wang, Karola Lützow, Andreas Lendlein, Klaus Wagner, Doris Klee, Andreas Liebold, Ren-Ke Li, Deling Kong, Gustav Steinhoff, and Nan Ma

Subjects
Male, medicine.medical_specialty, Ischemia, Myocardial Infarction, Hemodynamics, Infarction, Neovascularization, Physiologic, Aorta, Thoracic, ischemia, Hematocrit, Injections, Intramuscular, Intracardiac injection, Ventricular Function, Left, Cell Movement, Internal medicine, medicine, matrigel, Animals, Myocardial infarction, Ligation, medicine.diagnostic_test, Troponin T, business.industry, Myocardium, Stem Cells, cardiac regeneration, Rats, Inbred Strains, Cell Biology, Articles, medicine.disease, Surgery, stem and progenitor cells, Rats, Disease Models, Animal, Drug Combinations, Erythropoietin, Cardiology, Molecular Medicine, Proteoglycans, Collagen, Laminin, business, medicine.drug
Abstract

Erythropoietin (EPO) protects the myocardium from ischaemic injury and promotes beneficial remodelling. We assessed the therapeutic efficacy of intracardiac EPO injection and EPO-mediated stem cell homing in a rat myocardial infarction (MI) model. Following MI, EPO (3000 U/kg) or saline was delivered by intracardiac injection. Compared to myocardial infarction control group (MIC), EPO significantly improved left ventricular function (n= 11–14, P< 0.05) and decreased right ventricular wall stress (n= 8, P< 0.05) assessed by pressure-volume loops after 6 weeks. MI-EPO hearts exhibited smaller infarction size (20.1 ± 1.1%versus 27.8 ± 1.2%; n= 6–8, P< 0.001) and greater capillary density (338.5 ± 14.7 versus 259.8 ± 9.2 vessels per mm; n= 6–8, P< 0.001) than MIC hearts. Direct EPO injection reduced post-MI myocardial apoptosis by approximately 41% (0.27 ± 0.03%versus 0.42 ± 0.03%; n= 6, P= 0.005). The chemoattractant SDF-1 was up-regulated significantly assessed by quantitative realtime PCR and immunohistology. c-Kit+ and CD34+ stem cells were significantly more numerous in MI-EPO than in MIC at 24 hrs in peripheral blood (n= 7, P< 0.05) and 48 hrs in the infarcted hearts (n= 6, P< 0.001). Further, the mRNAs of Akt, eNOS and EPO receptor were significantly enhanced in MI-EPO hearts (n= 7, P< 0.05). Intracardiac EPO injection restores myocardial functions following MI, which may attribute to the improved early recruitment of c-Kit+ and CD34+ stem cells via the enhanced expression of chemoattractant SDF-1.

Published
2010

9. Cell Origin of Human Mesenchymal Stem Cells Determines a Different Healing Performance in Cardiac Regeneration

Author

Lee-Lee Ong, Karen Bieback, Weiwei Wang, Christian Klopsch, Ralf Gaebel, Dario Furlani, Nan Ma, Bianca Polchow, Wenzhong Li, Gustav Steinhoff, Heiko Sorg, and Johannes Frank

Subjects
Male, Pathology, Mouse, Cellular differentiation, medicine.medical_treatment, Myocardial Infarction, lcsh:Medicine, Adipose tissue, Cardiovascular, Mice, Signaling Lymphocytic Activation Molecule Family Member 1, Molecular Cell Biology, Medicine, lcsh:Science, Multidisciplinary, Stem Cells, Cell Differentiation, Heart, Stem-cell therapy, Animal Models, medicine.anatomical_structure, Cellular Types, Research Article, Cardiac function curve, medicine.medical_specialty, Clinical Research Design, Preclinical Models, Cell Survival, Neovascularization, Physiologic, Receptors, Cell Surface, Model Organisms, Antigens, CD, Animals, Humans, Regeneration, Animal Models of Disease, Biology, Ligation, Cell Proliferation, Wound Healing, business.industry, Regeneration (biology), lcsh:R, Mesenchymal stem cell, Mesenchymal Stem Cells, equipment and supplies, Capillaries, lcsh:Q, Bone marrow, business, Wound healing
Abstract

The possible different therapeutic efficacy of human mesenchymal stem cells (hMSC) derived from umbilical cord blood (CB), adipose tissue (AT) or bone marrow (BM) for the treatment of myocardial infarction (MI) remains unexplored. This study was to assess the regenerative potential of hMSC from different origins and to evaluate the role of CD105 in cardiac regeneration. Male SCID mice underwent LAD-ligation and received the respective cell type (400.000/per animal) intramyocardially. Six weeks post infarction, cardiac catheterization showed significant preservation of left ventricular functions in BM and CD105(+)-CB treated groups compared to CB and nontreated MI group (MI-C). Cell survival analyzed by quantitative real time PCR for human GAPDH and capillary density measured by immunostaining showed consistent results. Furthermore, cardiac remodeling can be significantly attenuated by BM-hMSC compared to MI-C. Under hypoxic conditions in vitro, remarkably increased extracellular acidification and apoptosis has been detected from CB-hMSC compared to BM and CD105 purified CB-derived hMSC. Our findings suggests that hMSC originating from different sources showed a different healing performance in cardiac regeneration and CD105(+) hMSC exhibited a favorable survival pattern in infarcted hearts, which translates into a more robust preservation of cardiac function.

Published
2011

10. The PREDICTS database: a global database of how local terrestrial biodiversity responds to human impacts

Author

Hudson, Lawrence N., Newbold, Tim, Contu, Sara, Hill, Samantha L. L., Lysenko, Igor, De Palma, Adriana, Phillips, Helen R. P., Senior, Rebecca A., Bennett, Dominic J., Booth, Hollie, Choimes, Argyrios, Correia, David L. P., Day, Julie, Echeverria-Londono, Susy, Garon, Morgan, Harrison, Michelle L. K., Ingram, Daniel J., Jung, Martin, Kemp, Victoria, Kirkpatrick, Lucinda, Martin, Callum D., Pan, Yuan, White, Hannah J., Aben, Job, Abrahamczyk, Stefan, Adum, Gilbert B., Aguilar-Barquero, Virginia, Aizen, Marcelo, Ancrenaz, Marc, Arbelaez-Cortes, Enrique, Armbrecht, Inge, Azhar, Badrul, Azpiroz, Adrian B., Baeten, Lander, Báldi, András, Banks, John E., Barlow, Jos, Batáry, Péter, Bates, Adam J., Bayne, Erin M., Beja, Pedro, Berg, Ake, Berry, Nicholas J., Bicknell, Jake E., Bihn, Jochen H., Böhning-Gaese, Katrin, Boekhout, Teun, Boutin, Celine, Bouyer, Jeremy, Brearley, Francis Q., Brito, Isabel, Brunet, Jörg, Buczkowski, Grzegorz, Buscardo, Erika, Cabra-Garcia, Jimmy, Calvino-Cancela, Maria, Cameron, Sydney A., Cancello, Eliana M., Carrijo, Tiago F., Carvalho, Anelena L., Castro, Helena, Castro-Luna, Alejandro A., Cerda, Rolando, Cerezo, Alexis, Chauvat, Matthieu, Clarke, Frank M., Cleary, Daniel F. R., Connop, Stuart P., D'Aniello, Biagio, da Silva, Pedro Giovani, Darvill, Ben, Dauber, Jens, Dejean, Alain, Diekötter, Tim, Dominguez-Haydar, Yamileth, Dormann, Carsten F., Dumont, Bertrand, Dures, Simon G., Dynesius, Mats, Edenius, Lars, Elek, Zoltán, Entling, Martin H., Farwig, Nina, Fayle, Tom M., Felicioli, Antonio, Felton, Annika M., Ficetola, Gentile F., Filgueiras, Bruno K. C., Fonte, Steve J., Fraser, Lauchlan H., Fukuda, Daisuke, Furlani, Dario, Ganzhorn, Jörg U., Garden, Jenni G., Gheler-Costa, Carla, Giordani, Paolo, Giordano, Simonetta, Gottschalk, Marco S., Goulson, Dave, Gove, Aaron D., Grogan, James, Hanley, Mick E., Hanson, Thor, Hashim, Nor R., Hawes, Joseph E., Hébert, Christian, Helden, Alvin J., Henden, John-André, Hernández, Lionel, Herzog, Felix, Higuera-Diaz, Diego, Hilje, Branko, Horgan, Finbarr G., Horváth, Roland, Hylander, Kristoffer, Isaacs-Cubides, Paola, Ishitani, Mashiro, Jacobs, Carmen T., Jaramillo, Victor J., Jauker, Birgit, Jonsell, Matts, Jung, Thomas S., Kapoor, Vena, Kati, Vassiliki, Katovai, Eric, Kessler, Michael, Knop, Eva, Kolb, Annette, Körösi, Àdám, Lachat, Thibault, Lantschner, Victoria, Le Féon, Violette, LeBuhn, Gretchen, Légaré, Jean-Philippe, Letcher, Susan G., Littlewood, Nick A., López-Quintero, Carlos A., Louhaichi, Mounir, Lövei, Gabor L., Lucas-Borja, Manuel Esteban, Luja, Victor H., Maeto, Kaoru, Magura, Tibor, Mallari, Neil Aldrin, Marin-Spiotta, Erika, Marhall, E. J. P., Martínez, Eliana, Mayfield, Margaret M., Mikusinski, Gregorz, Milder, Jeffery C., Miller, James R., Morales, Carolina L., Muchane, Mary N., Muchane, Muchai, Naidoo, Robin, Nakamura, Akihiro, Naoe, Shoji, Nates-Parra, Guiomar, Navarerete Gutierrez, Dario A., Neuschulz, Eike L., Noreika, Norbertas, Norfolk, Olivia, Noriega, Jorge Ari, Nöske, Nicole M., O'Dea, Niall, Oduro, William, Ofori-Boateng, Caleb, Oke, Chris O., Osgathorpe, Lynne M., Paritsis, Juan, Parrah, Alejandro, Pelegrin, Nicolás, Peres, Carlos A., Persson, Anna S., Petanidou, Theodora, Phalan, Ben, Philips, T. Keith, Poveda, Katja, Power, Eileen F., Presley, Steven J., Proença, Vânia, Quaranta, Marino, Quintero, Carolina, Redpath-Downing, Nicola A., Reid, J. Leighton, Reis, Yana T., Ribeiro, Danilo B., Richardson, Barbara A., Richardson, Michael J., Robles, Carolina A., Römbke, Jörg, Romero-Duque, Luz Piedad, Rosselli, Loreta, Rossiter, Stephen J., Roulston, T'ai H., Rousseau, Laurent, Sadler, Jonathan P., Sáfián, Szbolcs, Saldaña-Vásquez, Romeo A., Samnegård, Ulrika, Schüepp, Christof, Schweiger, Oliver, Sedlock, Jodi L., Shahabuddin, Ghazala, Sheil, Douglas, Silva, Fernando A. B., Slade, Eleanor, Smith-Pardo, Allan H., Sodhi, Navjot S., Somarriba, Eduardo J., Sosa, Ramón A., Stout, Jane C., Struebig, Matthew J., Sung, Yik-Hei, Threlfall, Caragh G., Tonietto, Rebecca, Tóthmérész, Béla, Tscharntke, Teja, Turner, Edgar C., Tylianakis, Jason M., Vanbergen, Adam J., Vassilev, Kiril, Verboven, Hans A. F., Vergara, Carlos H., Vergara, Pablo M., Verhulst, Jort, Walker, Tony R., Wang, Yanping, Watling, James I., Wells, Konstans, Williams, Christopher D., Willig, Michael R., Woinarski, John C. Z., Wolf, Jan H. D., Woodcock, Ben A., Yu, Douglas W., Zailsev, Andreys, Collen, Ben, Ewers, Rob M., Mace, Georgina M., Purves, Drew W., Scharlemann, Jörn P. W., Pervis, Andy, Environmental Sciences, Biosciences, Spatial Foodweb Ecology Group, Lawrence N., Hudson, Tim, Newbold, Sara, Contu, Samantha L. L., Hill, Igor, Lysenko, Adriana De, Palma, Helen R. P., Phillip, Rebecca A., Senior, Dominic J., Bennett, Hollie, Booth, Argyrios, Choime, David L. P., Correia, Julie, Day, Susy Echeverrıa, London, Morgan, Garon, Michelle L. K., Harrison, Daniel J., Ingram, Martin, Jung, Victoria, Kemp, Lucinda, Kirkpatrick, Callum D., Martin, Yuan, Pan, Hannah J., White, Job, Aben, Stefan, Abrahamczyk, Gilbert B., Adum, Virginia Aguilar, Barquero, Marcelo A., Aizen, Marc, Ancrenaz, Enrique Arbelaez, Corte, Inge, Armbrecht, Badrul, Azhar, Adrian B., Azpiroz, Lander, Baeten, Andras, Baldi, John E., Bank, Jos, Barlow, Peter, Batary, Adam J., Bate, Erin M., Bayne, Pedro, Beja, Ake, Berg, Nicholas J., Berry, Jake E., Bicknell, Jochen H., Bihn, Katrin B€ohning, Gaese, Teun, Boekhout, Celine, Boutin, Jeremy, Bouyer, Francis Q., Brearley, Isabel, Brito, J€org, Brunet, Grzegorz, Buczkowski, Erika, Buscardo, Tiago F., Carrijo, Anelena L., Carvalho, Helena, Castro, Alejandro A., Castro Luna, Rolando, Cerda, Alexis, Cerezo, Matthieu, Chauvat, Frank M., Clarke, Daniel F. R., Cleary, Stuart P., Connop, D'Aniello, Biagio, Pedro Giovani da, Silva, Ben, Darvill, Jens, Dauber, Alain, Dejean, Tim, Diekotter, Yamileth Dominguez, Haydar, Carsten F., Dormann, Bertrand, Dumont, Simon G., Dure, Mats, Dynesiu, Lars, Edeniu, Zoltan, Elek, Martin H., Entling, Nina, Farwig, Tom M., Fayle, Antonio, Felicioli, Annika M., Felton, Gentile F., Ficetola, Bruno K. C., Filgueira, Steven J., Fonte, Lauchlan H., Fraser, Daisuke, Fukuda, Dario, Furlani, Jeorg U., Ganzhorn, Jenni G., Garden, Carla Gheler, Costa, Paolo, Giordani, Giordano, Simonetta, Marco S., Gottschalk, Dave, Goulson, Aaron D., Gove, James, Grogan, Mick E., Hanley, Thor, Hanson, Nor R., Hashim, Joseph E., Hawe, Christian, Hebert, Alvin J., Helden, John Andre, Henden, Lionel, Hernandez, Felix, Herzog, Diego Higuera, Diaz, Branko, Hilje, Finbarr G., Horgan, Roland, Horvath, Kristoffer, Hylander, Paola Isaacs, Cubide, Masahiro, Ishitani, Carmen T., Jacob, Vıctor J., Jaramillo, Birgit, Jauker, Mats, Jonsell, Thomas S., Jung, Vena, Kapoor, Vassiliki, Kati, Eric, Katovai, Michael, Kessler, Eva, Knop, Annette, Kolb, Adam, Koreosi, Thibault, Lachat, Victoria, Lantschner, Violette Le, Feon, Gretchen, Lebuhn, Jean Philippe, Legare, Susan G., Letcher, Nick A., Littlewood, Carlos A., Lopez Quintero, Mounir, Louhaichi, Gabor L., Leovei, Manuel Esteban Lucas, Borja, Victor H., Luja, Kaoru, Maeto, Tibor, Magura, Neil Aldrin, Mallari, Erika Marin, Spiotta, E. J. P., Marshall, Eliana, Martınez, Margaret M., Mayfield, Grzegorz, Mikusinski, Jeffrey C., Milder, James R., Miller, Carolina L., Morale, Mary N., Muchane, Muchai, Muchane, Robin, Naidoo, Akihiro, Nakamura, Shoji, Naoe, Guiomar Nates, Parra, Dario A., Navarrete Gutierrez, Eike L., Neuschulz, Norbertas, Noreika, Olivia, Norfolk, Jorge Ari, Noriega, Nicole M., Neoske, Niall, O’Dea, William, Oduro, Caleb Ofori, Boateng, Chris O., Oke, Lynne M., Osgathorpe, Juan, Paritsi, Alejandro Parra, H, Nicolas, Pelegrin, Carlos A., Pere, Anna S., Persson, Theodora, Petanidou, Ben, Phalan, T., Keith Philip, Katja, Poveda, Eileen F., Power, Steven J., Presley, Vania, Proenca, Marino, Quaranta, Carolina, Quintero, Nicola A., Redpath Downing, J., Leighton Reid, Yana T., Rei, Danilo B., Ribeiro, Barbara A., Richardson, Michael J., Richardson, Carolina A., Roble, Jeorg, Reombke, Luz Piedad Romero, Duque, Loreta, Rosselli, Stephen J., Rossiter, T’ai H., Roulston, Laurent, Rousseau, Jonathan P., Sadler, Szabolcs, Safian, Romeo A., Saldana Vazquez, Ulrika, Samnegard, Christof, Scheuepp, Oliver, Schweiger, Jodi L., Sedlock, Ghazala, Shahabuddin, Douglas, Sheil, Fernando A. B., Silva, Eleanor M., Slade, Allan H., Smith Pardo, Navjot S., Sodhi, Eduardo J., Somarriba, Ramon A., Sosa, Jane C., Stout, Matthew J., Struebig, Yik Hei, Sung, Caragh G., Threlfall, Rebecca, Tonietto, Bela, Tothmeresz, Teja, Tscharntke, Edgar C., Turner, Jason M., Tylianaki, Adam J., Vanbergen, Kiril, Vassilev, Hans A. F., Verboven, Carlos H., Vergara, Pablo M., Vergara, Jort, Verhulst, Tony R., Walker, Yanping, Wang, James I., Watling, Konstans, Well, Christopher D., William, Michael R., Willig, John C. Z., Woinarski, Jan H. D., Wolf, Ben A., Woodcock, Douglas W., Yu, Andrey S., Zaitsev, Ben, Collen, Rob M., Ewer, Georgina M., Mace, Drew W., Purve, Jeorn P. W., Scharlemann, Andy, Purvis, Pan, Yuan [0000-0003-2729-6377], Littlewood, Nick [0000-0002-6672-0639], Phalan, Benjamin [0000-0001-7876-7226], Turner, Edgar [0000-0003-2715-2234], and Apollo - University of Cambridge Repository

Subjects
BOMBUS SPP. HYMENOPTERA, VDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecology: 488, Data sharing, Global change, Habitat destruction, Land use, Ecology, Evolution, Behavior and Systematics, Ecology, Nature and Landscape Conservation, Reptilia, Evolution, global change, habitat destruction, land use, education, INTENSIVELY MANAGED FARMLAND, Biológiai tudományok, NORTHEASTERN COSTA-RICA, BIRD SPECIES RICHNESS, Ecology and Environment, Magnoliophyta, MEXICAN COFFEE PLANTATIONS, Amphibia, VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økologi: 488, BUMBLEBEE NEST DENSITY, Behavior and Systematics, Természettudományok, ddc:570, Biology, DUNG BEETLE COLEOPTERA, 1172 Environmental sciences, SDG 15 - Life on Land, Original Research, QL, QH0075, QH, PLANT COMMUNITY COMPOSITION, Biology and Life Sciences, LAND-USE CHANGE, Hymenoptera, Coleoptera, Lepidoptera, Chemistry, URBAN-RURAL GRADIENT, Mammalia, Gymnospermae, Aves
Abstract

Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project - and avert - future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups - including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems - www.predicts.org.uk). We make site-level summary data available alongside this article. The full database will be publicly available in 2015. The collation of biodiversity datasets with broad taxonomic and biogeographic extents is necessary to understand historical declines and to project - and hopefully avert - future declines. We describe a newly collated database of more than 1.6 million biodiversity measurements from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. © 2014 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd.

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