Search

Background: The cutaneous features of acute cutaneous lupus erythematosus (ACLE) can be confused with other dermatoses. The dermoscopic features of ACLE have rarely been reported. Aims: We aimed to study the dermoscopic features of ACLE, malar rash, and generalized ACLE. Materials and Methods: The dermoscopic features of all biopsy and direct immunofluorescence confirmed ACLE cases were analysed retrospectively between May 2019 and May 2020. Results: A total of 21 patients with skin phototypes III, IV, or V were included in the analysis. A pinkish‐white to reddish‐white homogenous area (94.1%), brown dots, globules and peppering (76.4%), and keratotic follicular plugging (64.7%) were the common dermoscopic features observed in the case of generalized ACLE. Similarly, in the case of malar rash, a pinkish‐white to reddish‐white homogenous area (77.8%) was the most common dermoscopic feature, followed by keratotic follicular plugging (66.7%), scales (44.5%), and brown dots, globules, and peppering (44.5%). In both variants, vascular structures were dominated by linear vessels with or without branching. Conclusions: A multicomponent pattern comprising white scales, homogenous pinkish‐white to the reddish‐white area, brown dots/globules/peppering, keratotic follicular plugging, and linear vessels with or without branching were the common dermoscopic features observed in our study and may indicate the diagnosis of both localized and generalized ACLE. In addition, a paucity of dotted vessels may serve as an additional clue. [ABSTRACT FROM AUTHOR]

Livedoid vasculopathy (LV) associated with sticky platelets syndrome type 3 (SPS type 3) and enhanced activity of plasminogen activator inhibitor (PAI-1) anomalies. A 14-year-old girl presented with a six-month history of multiple painful ulcers on both ankles, preceded by erythema in the affected areas. In this patient, the ulcers healed spontaneously without any recurrence.6 We describe a rare case of LV in an adolescent girl. [Extracted from the article]

Background: Atypical antipsychotics, widely used in many psychiatric diseases, are known to cause metabolic syndrome (MetS). But, there is sparse of prospective study to see the effect of atypical antipsychotics causing MetS in drug naïve or drug free patients among the Indian population. This study aimed to determine the incidence of MetS and change in individual risk factor for MetS in schizophrenia and mood disorder patients after three months of receiving atypical antipsychotics. Method: Sixty patients of schizophrenia (n=40) and mood disorders (n=20) were screened at the baseline and all of them were prospectively followed up for the occurrence of MetS after three months. Results: By applying the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP/ATP III) modified criteria for Asian, the incidence of MetS was found to be 11.66%. When analysing the individual risk factor for MetS, the mean value from baseline to follow-up was weight (in kg) 58.55±10.03 to 59.80±10.24 (p<0.001), waist circumference (cm) 80.52±6.33 to 81.43±6.42 (p<0.001), systolic blood pressure (mm/Hg) 113.93±8.28 to 117.53±10.89 (p<0.001), diastolic blood pressure (mm/Hg) 74.80±7.31 to 78.32±6.79 (p<0.001), fasting blood glucose (mg/dl) 86.23±12.02 to 91.35±13.04 (p<0.001), triglyceride (mg/dl) 97.32±31.41 to 101.25±34.38 (p<0.001), high-density lipoproteins (HDL) (mg/dl) 48.07±4.98 to 48.05±4.57 (p=0.951). Conclusion: Our study suggests that incidence of MetS in Indian population was 11.66% after three months of using atypical antipsychotic drugs in patients with schizophrenia or mood disorder. The change in mean value in the individual risk factor for MetS was statistically significant. Long-term follow-up studies are required to identify the real burden of MetS after using atypical antipsychotic drugs. [ABSTRACT FROM AUTHOR]

Dermoscopy (Dermlite, DL4, 10x magnification) under polarized mode showed patchy to diffuse white scales, white structureless area, white shiny structures (white shiny structureless area, clods, and lines), focal multicolored (not rainbow) pattern, brown to blue-gray peppering, follicular plugging, and linear, linear curved (comma), and focal dotted vessels [Figure 1]b, [Figure 1]c, [Figure 1]d, [Figure 1]e, [Figure 1]f, [Figure 1]g. Histology showed hyperkeratotic atrophic epidermis, basal vacuolar degeneration, cytoid bodies, dermal melanophages, melanin incontinence, and upper dermal dilated blood vessels [Figure 2]a, [Figure 2]b. [Extracted from the article]

Differential diagnoses of Crohn's disease, Wegner's granulomatosis, deep fungal and tubercular infections were considered. Observation Letter Indian Journal of Dermatology, Venereology and Leprology | Volume 87 | Issue 1 | January-February 2021 106 Focal ulcero-proliferative gingivitis: A rare presentation of mucosal tuberculosis Sir, A 35-year-old woman presented with a 10-month-old history of a painful non-healing ulcer on the anterior aspect of the lower gum towards the left side. Tuberculosis of the oral cavity is relatively rare, accounting for 0.1-5% of extrapulmonary tuberculosis. [Extracted from the article]