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Your search keyword '"De Ridder, R.J."' showing total 4 results
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4 results on '"De Ridder, R.J."'

2. Review article: Non-alcoholic fatty liver disease in morbidly obese patients and the effect of bariatric surgery

Author

De Ridder, R.J., Schoon, E.J., Smulders, J.F., van Hout, G.C., Stockbrugger, R.W., Koek, G.H., Interne Geneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, and RS: NUTRIM - R2 - Gut-liver homeostasis

Abstract

BACKGROUND: Morbid obesity is strongly associated with non-alcoholic fatty liver disease. The effects of bariatric surgery on liver tests an histological abnormalities after weight loss are controversial. AIM: To review the literature on the prevalence of non-alcoholic fatty liver disease in patients with morbid obesity with respect to laboratory and histopathological parameters and the effect of weight loss on these parameters after bariatric surgery. RESULTS: Standard liver tests do not seem to be a sensitive tool for the assessment and follow-up of non-alcoholic fatty liver disease in obesity. In nearly all patients with morbid obesity, histological abnormalities reflecting non-alcoholic fatty liver disease are present. Bariatric surgery in these patients will decrease the grade of steatosis. However, there are some concerns about the effect of bariatric surgery on hepatic inflammation and fibrosis. In particular, older follow-up studies reported negative results as opposed to more recent studies, which also showed improvement in hepatic inflammation and fibrosis. Unfortunately, most studies had limitations because of the selection of patients. CONCLUSION: Despite limitations in many studies, bariatric surgery seems to be a promising treatment in patients with obesity presenting with non-alcoholic fatty liver disease.

Published
2007

3. Opportunistic Screening of Hospital Staff Using Primary Colonoscopy: Participation, Discomfort and Willingness to Repeat the Procedure.

Author

Khalid-de Bakker, C.A., Jonkers, D.M., Hameeteman, W., de Ridder, R.J., Masclee, A.A., and Stockbrügger, R.W.

Subjects
COLON cancer diagnosis, COLONOSCOPY, SYMPTOMS, MEDICAL screening, HOSPITAL personnel
Abstract

Background: Participation in and tolerability of primary colonoscopy screening are presumed to be relatively low. The present study aimed to test its feasibility in a well-informed population of hospital staff using an intensive information campaign, and to identify factors associated with screening colonoscopy rated as uncomfortable. Methods: Data were collected using standardized forms. Results: Out of 1,090 invited employees (50-65 years), 447 (41.0%) participated. Bowel preparation and colonoscopy were rated as 'somewhat to very uncomfortable' by 79.5 and 21.9%, respectively. 96.3% of participants were willing to repeat colonoscopy in the future. Participants rating colonoscopy as uncomfortable were more likely unwilling to repeat the procedure (OR 8.026, CI 2.667-24.154). Multivariate analysis (age- and gender-adjusted) showed an association of colonoscopy rated as uncomfortable with: abdominal pain during colonoscopy (OR 3.185, CI 1.642-6.178), other pain (OR 2.428, CI 1.335-4.416), flatulence (OR 2.175, CI 1.219-3.881), embarrassment (OR 2.843, CI 1.350-5.989), abdominal pain after colonoscopy (OR 1.976, CI 1.041-3.751), and a prolonged procedure time (OR 1.000, CI 1.000-1.001). Conclusions: Acceptance of primary colonoscopy screening for colorectal neoplasia was high, although participants with symptoms during and after colonoscopy were more likely to rate colonoscopy as uncomfortable. This type of opportunistic screening procedure is suitable for the introduction of screening programs and may be useful in areas that have no access to population-based screening. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2011
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