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3,413 results on '"Deng, Chao"'

22. Meta-analysis of RCTs on the safety of non-fixation of mesh in TAPP inguinal hernia repair: an updated meta-analysis

Author

Tao Jiang, Chen Zhang, Xiao-Ling Wang, Da-Chun Yue, Xiao-Ping Yuan, and Deng-Chao Wang

Subjects
Inguinal hernia, TAPP, Mesh, Meta-analysis, Surgery, RD1-811
Abstract

Abstract Objective This meta-analysis aims to compare the clinical efficacy of mesh non-fixation and fixation in laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair, systematically evaluating the application value of the mesh non-fixation technique in clinical settings. Methods A computerized search of PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov databases was conducted to identify randomized controlled trials (RCTs) comparing mesh non-fixation and fixation in TAPP inguinal hernia repair. Meta-analysis was performed using RevMan 5.3 software, and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) evidence grading system was employed for outcome quality assessment. Publication bias analysis was performed using Begg’s test. A trial sequential analysis (TSA) was performed using TSA 0.9.5.10 Beta software. Results A total of nine RCTs involving 1,879 inguinal hernia patients were included. Meta-analysis results demonstrated that, compared to the fixation group, the non-fixation group exhibited significantly lower seroma occurrence rate [RR = 0.43, 95% CI (0.20, 0.89), P = 0.02, heterogeneity P = 0.28, I²=22%], Visual Analog Scale (VAS) pain score at 6 months postoperatively [MD=-0.21, 95% CI (-0.29, -0.12), P

Published
2024
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24. Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer

Author

Zeng, Yue, Hu, Chun-Hong, Li, Yi-Zheng, Zhou, Jian-Song, Wang, Shu-Xing, Liu, Meng-Dong, Qiu, Zhen-Hua, Deng, Chao, Ma, Fang, Xia, Chun-Fang, Liang, Fei, Peng, Yu-Rong, Liang, Ao-Xi, Shi, Sheng-Hao, Yao, Shi-Jiao, Liu, Jun-Qi, Xiao, Wen-Jie, Lin, Xiao-Qiao, Tian, Xin-Yu, Zhang, Ying-Zhe, Tian, Zhuo-Ying, Zou, Ji-An, Li, Yun-Shu, Xiao, Chao-Yue, Xu, Tian, Zhang, Xiao-Jie, Wang, Xiao-Ping, Liu, Xian-Ling, and Wu, Fang

Published
2024
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28. Prediction model construction for the occurrence of LARS after neoadjuvant therapy combined with laparoscopic total mesorectal excision in male patients with mid-low rectal cancer

Author

Deng-Chao Wang, Xue-Feng Peng, and Miao Yu

Subjects
male, neoadjuvant therapy, rectal cancer, LARS, prediction model, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

BackgroundNeoadjuvant chemoradiotherapy for rectal cancer improves surgical outcomes and reduces recurrence but can cause low anterior resection syndrome (LARS), affecting quality of life. This study aims to predict the risk of LARS in male patients with mid-low rectal cancer after laparoscopic total mesorectal excision (TME).MethodsClinical data from 203 male patients with mid-low rectal cancer who underwent neoadjuvant therapy and laparoscopic resection were collected. Patients were divided into training (n=143) and validation (n=60) cohorts. LARS risk factors were identified using logistic regression, and a predictive model was constructed and validated using ROC curve, Hosmer-Lemeshow test, calibration curve, and decision curve analysis (DCA).ResultsLARS occurred in 53.6% of the patients in this study. Multivariate logistic regression analysis revealed that BMI ≥ 25 kg/m², tumor distance from the anal margin < 5 cm, radiotherapy, and anastomotic leakage were independent risk factors for postoperative LARS in patients (P < 0.05). The areas under the ROC curves for the training cohort and validation cohort were 0.866 (95% CI: 0.807-0.925) and 0.724 (95% CI: 0.595-0.853), respectively, with both groups showing good goodness-of-fit test results (P > 0.05). The DCA curve indicated that the model had a high clinical utility.ConclusionsBMI ≥ 25 kg/m², tumor distance from the anal margin < 5 cm, radiotherapy, and anastomotic leakage are independent risk factors for the occurrence of LARS after neoadjuvant therapy combined with laparoscopic TME in male patients with mid-low rectal cancer. These factors should be emphasized in clinical practice, and corresponding preventive measures should be promptly implemented.

Published
2024
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