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Starting from the background of the development of Chinese and Western cultures, this paper analyzes the textual themes and interprets the ideas of the dramas created during the period of the Nanguosha. Taking into account the specificity of the era and the national perception of Nanguosha’s theatrical works, the concept of theatrical cultural interaction is put forward to analyze the basis of cultural interaction in the cultural acceptance behavior of drama. Audience interaction behavior and audience emotional intelligence are chosen as intermediary and moderating variables respectively, and a four-variable research model is constructed for the creation of Nanguosha’s dramas, the construction of national identity, audience interaction behavior and audience emotional intelligence. Introduce the causal mediation effect model based on Nanguosha theater culture, explain the symbolic variables, and discuss the estimation method for the causal mediation effect. Combine the empirical data with the descriptive analysis and correlation analysis of the variables, and carry out the main effect test, mediation effect test, moderating effect test, and moderated mediation effect test of the research hypotheses in order to verify the interaction of the variables. After introducing the mediator variable of audience interaction behavior, the regression coefficient of Nanguosha’s drama creation on national identity construction is β =0.198, P

This study establishes an analytical method for simultaneous determination of 19 Succinate dehydrogenase inhibitor fungicides pesticide residues in Green coffee by QuEChERS-Liquid chromatography tandem mass spectrometry. The Green coffee powder samples were extracted with acetonitrile by Homogenizer, the supernatant were purified by Magnesium sulfate anhydrous、PSA and C18, liquid chromatograhy - tandem mass spectrometry were used for analyzing 19 Succinate dehydrogenase inhibitor fungicides pesticide residues at positive ion mode. The results showed that the calibration curves of 19 targets showed good linearity with correlation coefficients of above 0.995 0 in the range of 1~100 ng/mL, the recoveries of 19 pesticides were 79.6%~109.4% and the relative standard deviations(RSD, n=6) were in the range of 1.4%~9.7% at spiked levels of 0.01、0.05 and 0.1 mg/kg. Limit of quantitation (LOQ) of all the tested pesticides were 0.51~4.60 μg/kg. This method has good linear relations, excellent stable and sensitive, accuracy and precision meet the requirement of quantitative analysis, it is suitable for quantitative analysis of 19 Succinate dehydrogenase inhibitor fungicides pesticide residues in Green coffee.

ObjectiveTo systematically compare the bowel cleaning ability, patient tolerance and safety of oral sodium phosphate tablets (NaPTab) and oral polyethylene glycol electrolyte lavage solution (PEGL) to inform clinical decision making.MethodsPubMed, Embase, CBM, WanFang Data, CNKI, and VIP databases were searched for studies that used randomized controlled trials (RCTs) to compare the roles of NaPTab and PEGL in bowel preparation before colonoscopy. Two reviewers independently screened the studies, extracted data, and assessed the risk of bias in the included papers. A meta-analysis was performed using RevMan 5.3 software.ResultsA total of 13 RCTs were eligible for inclusion, including 2,773 patients (1,378 and 1,395 cases in the NaPTab and PEGL groups, respectively). Meta-analysis revealed no significant difference in the cleansing quality of the NaPTab and PEGL groups [RR 1.02, 95% CI (0.96–1.08), P = 0.46]. The incidence of nausea was lower in the NaPTab group than in the PEGL group [RR 0.67, 95% CI (0.58–0.76), p < 0.00001]. Patients rated the taste of NaPTab higher than PEGL [RR 1.33, 95% CI (1.26–1.40), P < 0.00001]. Willingness to repeat the treatment was also higher in the NaPTab group than in the PEGL group [RR 1.52, 95% CI (1.28–1.80), P < 0.00001]. Both serum potassium and serum calcium decreased in both groups after the preparation; however, meta-analysis revealed that both minerals decreased more in the NaPTab group than in the PEGL group [MD = 0.38, 95% CI (0.13–0.62), P = 0.006 for serum potassium and MD = 0.41, 95% CI (0.04–0.77), P = 0.03 for serum calcium]. Meanwhile, serum phosphorus increased in both groups after the preparation; however, levels increased more in the NaPTab group than in the PEGL group [MD 4.51, (95% CI 2.9–6.11), P < 0.00001].ConclusionsWhile NaP tablets and PEGL were shown to have a similar cleaning effect before colonoscopy, NaP tablets had improved patient tolerance. However, NaP tablets had a strong effect on serum potassium, calcium, and phosphorus levels. For patients with low potassium, low calcium, and renal insufficiency, NaP tablets should be prescribed with caution. For those at high-risk for acute phosphate nephropathy, NaP tablets should be avoided. Given the low number and quality of included studies, these conclusions will require additional verification by large high-quality studies.Systematic review registration10.37766/inplasy2023.5.0013, identifier: NPLASY202350013.

To investigate the metabolic profiles of 4′-chlorodiazepam and diclazepam in vivo, the liver microsomal metabolism model was established. Firstly, the target substances were incubated in the water bath pot at 37 ℃ for about 4 h. Then the incubation buffer was terminated by ice acetonitrile. After that 10 μL of the supernatant was taken for analysing. The Agilent Eclipse plus C18 column (12.5 mm×2.1 mm×5 μm) was used and the 20 mmol/L ammonium acetate0.1% formic acid-5% acetonitrile (A) and acetonitrile (B) were served as the gradient elution. The metabolites and metabolic pathways were identified and clarified by liquid chromatography coupled with quadrupole Exactive Orbitrap mass spectrometry (LC-Q-Exactive MS) in the full scan-ddMS2 ion mode. The results showed that 4′-chlorodiazepam produced 5 phase Ⅰ and 2 phase Ⅱ metabolites in Wistar liver microsomes, and diclazepam produced 6 phase Ⅰ and 1 phase Ⅱ metabolites in Wistar liver microsomes. The differences of the metabolites might result from the substitution position of chlorine atom. And the main metabolic pathways of 4′-chlorodiazepam and diclazepam included demethylation, mono-hydroxylation, di-hydroxylation, O-glucuronidation in this work. On the basis of experimental results, phase Ⅰ metabolites M2 (demethylation), M3 (mono-hydroxylation), M4 (demethylation and mono-hydroxylation) of 4′-chlorodiazepam and M2′ (demethylation), M3′ (mono-hydroxylation), M4′ (demethylation and mono-hydroxylation) of diclazepam were proposed to be potential poisoning markers due to the high concentration level. Moreover, the metabolites and metabolic pathways of di-hydroxylation were the first reported. This study preliminarily clarified the metabolic pathways and main metabolites of 4′-chlorodiazepam and diclazepam in Wistar liver microsomes. It provided a theoretical basis for the pharmacokinetic and forensic scientific research of 4′-chlorodiazepam and diclazepam, which offered great value for the detection of related cases in laboratory.

The capacity construction project group of Changqing oilfield needs to repeatedly enter the same data into multiple different information systems of the company every day. This work mode causes many problems, such as multiple entries, heavy repetitive workload, and difficult to guarantee data quality. Through in-depth analysis of business process and data entry status of the capacity construction project group, this paper puts forward the working ideas of data collection link standardization and data collection standard standardization, explores and establishes a standardized data collection system for the whole chain of capacity construction report data, including investment plan, well information entry, investment allocation, predrilling, drilling, well log, logging, oil testing (gas testing), production and injection, and well delivery. The system guarantees the timeliness, integrity and accuracy of data. In addition, it provides an external data sharing service, build the capacity construction data sharing platform, and realize the “one-time data entry, multiple system reuse, automatic report generation” of capacity construction report data.

The morphology, ecology, and phylogenetic relationships of specimens of the family Boletaceae from subtropical and tropical China were investigated. Four species, Butyriboletus huangnianlaii, Lanmaoa macrocarpa, Neoboletus multipunctatus, and Sutorius subrufus, are new to science. Chalciporus radiatus and Caloboletus xiangtoushanensis are redescribed. Caloboletus guanyui is proposed to replace Boletus quercinus Hongo, an illegitimate later homonym. The recently described Tylopilus callainus is synonymized with the Japanese Boletus virescens, and the new combination T. virescens (Har. Takah. & Taneyama) N.K. Zeng et al. is proposed. Moreover, Neoboletus is treated as an independent genus based on evidence from morphology and molecular phylogenetic data in the present study, and many previously described taxa of Sutorius are recombined into Neoboletus: N. ferrugineus (G. Wu et al.) N.K. Zeng et al., N. flavidus (G. Wu & Zhu L. Yang) N.K. Zeng et al., N. hainanensis (T.H. Li & M. Zang) N.K. Zeng et al., N. obscureumbrinus (Hongo) N.K. Zeng et al., N. rubriporus (G. Wu & Zhu L. Yang) N.K. Zeng et al., N. sanguineoides (G. Wu & Zhu L. Yang) N.K. Zeng et al. , N. sanguineus (G. Wu & Zhu L. Yang) N.K. Zeng et al., and N. tomentulosus (M. Zang et al.) N.K. Zeng et al.

We proposed a novel temperature-compensated multi-point strain sensing system based on cascaded FBG and optical FMCW interferometry. The former is used for simultaneous sensing of temperature and strain, and the latter is used for position information reading and multiplexing. In the experiment, a narrow linewidth laser with continuous frequency-sweeping was used as the light source. After demodulating the beat-frequency signal, the link information of the 16 m fiber was obtained, and the measured result was identical to the actual position. The measurement accuracy reached 50.15 mm, and the dynamic range was up to 22.68 dB. Meanwhile, we completed the sensing experiments for temperature range from 20 °C to 90 °C and strain range from 0 με to 7000 με. The sensitivity of the sensing system to temperature was 10.21 pm/°C, the sensitivity and accuracy to strain were as high as 1.163 pm/με and 10 με, respectively. Finally, the measured strain and temperature values were obtained using the sensing matrix. The sensing system has important practical significance in the field of quasi-distributed strain measurement.

The natural ecological environment is not only the basic condition of our human existence, but also the foundation of urban construction. The natural ecological environment restricts the development of cities. However, the mountains and water bodies of mountainous cities have been damaged to varying degrees in the past urban construction. Through the analysis of the current water bodies and mountains in mountainous cities, this paper puts forward the strategies for the restoration of mountains and water bodies, so as to realize the overall restoration of urban ecology.

Abstract Nasopharyngeal carcinoma (NPC) is a complex disease caused by a combination of Epstein-Barr virus chronic infection, the environment and host genes in a multi-step process of carcinogenesis. The identity of genetic factors involved in the development of chronic Epstein-Barr virus infection and NPC remains elusive, however. Here, we describe a two-phase, population-based, case-control study of Han Chinese from Guangxi province, where the NPC incidence rate rises to a high of 25-50 per 100,000 individuals. Phase I, powered to detect single gene associations, enrolled 984 subjects to determine feasibility, to develop infrastructure and logistics and to determine error rates in sample handling. A microsatellite screen of Phase I study participants, genotyped for 319 alleles from 34 microsatellites spanning an 18-megabase region of chromosome 4 (4p15.1-q12), previously implicated by a linkage analysis of familial NPC, found 14 alleles marginally associated with developing NPC or chronic immunoglobulin A production (p = 0.001-0.03). These associations lost significance after applying a correction for multiple tests. Although the present results await confirmation, the Phase II study population has tripled patient enrolment and has included environmental covariates, offering the potential to validate this and other genomic regions that influence the onset of NPC.

Background Osteoporosis is a major global health issue, weakening bones and increasing fracture risk. Dual-energy X-ray absorptiometry (DXA) is the standard for measuring bone mineral density (BMD) and diagnosing osteoporosis, but its costliness and complexity impede widespread screening adoption. Predictive modeling using genetic and clinical data offers a cost-effective alternative for assessing osteoporosis and fracture risk. This study aims to develop BMD prediction models using data from the UK Biobank (UKBB) and test their performance across different ethnic and geographical populations. Methods and findings We developed BMD prediction models for the femoral neck (FNK) and lumbar spine (SPN) using both genetic variants and clinical factors (such as sex, age, height, and weight), within 17,964 British white individuals from UKBB. Models based on regression with least absolute shrinkage and selection operator (LASSO), selected based on the coefficient of determination (R.sup.2) from a model selection subset of 5,973 individuals from British white population. These models were tested on 5 UKBB test sets and 12 independent cohorts of diverse ancestries, totaling over 15,000 individuals. Furthermore, we assessed the correlation of predicted BMDs with fragility fractures risk in 10 years in a case-control set of 287,183 European white participants without DXA-BMDs in the UKBB. With single-nucleotide polymorphism (SNP) inclusion thresholds at 5x10.sup.-6 and 5x10.sup.-7, the prediction models for FNK-BMD and SPN-BMD achieved the highest R.sup.2 of 27.70% with a 95% confidence interval (CI) of [27.56%, 27.84%] and 48.28% (95% CI [48.23%, 48.34%]), respectively. Adding genetic factors improved predictions slightly, explaining an additional 2.3% variation for FNK-BMD and 3% for SPN-BMD over clinical factors alone. Survival analysis revealed that the predicted FNK-BMD and SPN-BMD were significantly associated with fragility fracture risk in the European white population (P < 0.001). The hazard ratios (HRs) of the predicted FNK-BMD and SPN-BMD were 0.83 (95% CI [0.79, 0.88], corresponding to a 1.44% difference in 10-year absolute risk) and 0.72 (95% CI [0.68, 0.76], corresponding to a 1.64% difference in 10-year absolute risk), respectively, indicating that for every increase of one standard deviation in BMD, the fracture risk will decrease by 17% and 28%, respectively. However, the model's performance declined in other ethnic groups and independent cohorts. The limitations of this study include differences in clinical factors distribution and the use of only SNPs as genetic factors. Conclusions In this study, we observed that combining genetic and clinical factors improves BMD prediction compared to clinical factors alone. Adjusting inclusion thresholds for genetic variants (e.g., 5x10.sup.-6 or 5x10.sup.-7) rather than solely considering genome-wide association study (GWAS)-significant variants can enhance the model's explanatory power. The study highlights the need for training models on diverse populations to improve predictive performance across various ethnic and geographical groups., Author(s): Yong Liu 1, Xiang-He Meng 2, Chong Wu 3, Kuan-Jui Su 4, Anqi Liu 4, Qing Tian 4, Lan-Juan Zhao 4, Chuan Qiu 4, Zhe Luo 4, Martha I [...]

Deng and Lynch (1, 2) proposed to characterize deleterious genomic mutations from changes in the mean and genetic variance of fitness traits upon selfing in outcrossing populations. Such observations can be readily acquired in cyclical parthenogens. Selfing and life-table experiments were performed for two such Daphnia populations. A significant inbreeding depression and an increase of genetic variance for all traits analyzed were observed. Deng and Lynch's (2) procedures were employed to estimate the genomic mutation rate (U), mean dominance coefficient ( ), mean selection coefficient ( ), and scaled genomic mutational variance ( ). On average, , , and (^ indicates an estimate) are 0.84, 0.30, 0.14 and 4.6E-4 respectively. For the true values, the and are lower bounds, and and upper bounds.

With the economic and social development, material life in the era of abundance is not only in meeting the basic needs of life, but also modern consumers become forced to pursue the spiritual and cultural needs. On the other side, clothing will not just fulfill the basic functions of beauty and suitability, thus, more consumers begin to pay closer attentions to apparel textile’s individuation expression and technological elements, or to some other deeper emotional requirements etc. Smart textiles originally belongs to the cutting-edge scientific field of fashion industry, however, with the booming development of internet industry and smart phone devices, acute apparel manufacturers must have to take a ride on advanced tech-trends and launch a wide expansion of smart textile fibres’s applications into the clothing industry. This thesis would present a basic introduction on the concept and classifications of the smart textile fibres, and then like to deploy a profound analysis of smart textiles applied in the brand fashion design.