Search

Your search keyword '"Douliery, Charlaine"' showing total 2 results
Start Over Author "Douliery, Charlaine" Language english
2 results on '"Douliery, Charlaine"'

1. Thrombosis and antiphospholipid antibody syndrome during acute Q fever

Author

Million, Matthieu, Bardin, Nathalie, Bessis, Simon, Nouiakh, Nadia, Douliery, Charlaine, Edouard, Sophie, Angelakis, Emmanouil, Bosseray, Annick, Epaulard, Olivier, Branger, Stéphanie, Chaudier, Bernard, Blanc-Laserre, Karine, Ferreira-Maldent, Nicole, Demonchy, Élisa, Roblot, France, Reynes, Jacques, Djossou, Félix, Protopopescu, Camelia, Carrieri, Patrizia, Camoin-Jau, Laurence, Mege, Jean-Louis, Raoult, Didier, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Vascular research center of Marseille (VRCM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), CHU Grenoble, Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Centre hospitalier de Valence, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre Hospitalier Universitaire de Nice (CHU Nice), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), ORS PACA, Laboratoire d'hématologie biologique [Hôpital de la Timone - Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Herrada, Anthony

Subjects
Adult, Male, Adolescent, Observational Study, Enzyme-Linked Immunosorbent Assay, Young Adult, Surveys and Questionnaires, Humans, Child, Q fever, thrombosis, Aged, Aged, 80 and over, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, antiphospholipid antibodies, Middle Aged, Antiphospholipid Syndrome, infection, Cross-Sectional Studies, Logistic Models, ROC Curve, Coxiella burnetii, Antibodies, Anticardiolipin, Immunoglobulin G, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, France, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article, Follow-Up Studies
Abstract

Supplemental Digital Content is available in the text, Q fever is a neglected and potentially fatal disease. During acute Q fever, antiphospholipid antibodies are very prevalent and have been associated with fever, thrombocytopenia, acquired heart valve disease, and progression to chronic endocarditis. However, thrombosis, the main clinical criterion of the 2006 updated classification of the antiphospholipid syndrome, has not been assessed in this context. To test whether thrombosis is associated with antiphospholipid antibodies and whether the criteria for antiphospholipid syndrome can be met in patients with acute Q fever, we conducted a cross-sectional study at the French National Referral Center for Q fever. Patients included were diagnosed with acute Q fever in our Center between January 2007 and December 2015. Each patient's history and clinical characteristics were recorded with a standardized questionnaire. Predictive factors associated with thrombosis were assessed using a rare events logistic regression model. IgG anticardiolipin antibodies (IgG aCL) assessed by an enzyme-linked immunosorbent assay were tested on the Q fever diagnostic serum. A dose-dependent relationship between IgG aCL levels and thrombosis was tested using a receiver operating characteristic (ROC) analysis. Of the 664 patients identified for inclusion in the study, 313 (47.1%) had positive IgG aCL and 13 (1.9%) were diagnosed with thrombosis. Three patients fulfilled the antiphospholipid syndrome criteria. After multiple adjustments, only positive IgG aCL (relative risk, 14.46 [1.85–113.14], P = .011) were independently associated with thrombosis. ROC analysis identified a dose-dependent relationship between IgG aCL levels and occurrence of thrombosis (area under curve, 0.83, 95%CI [0.73–0.93], P

Published
2017
Full Text
View/download PDF

2. Thrombosis and antiphospholipid antibody syndrome during acute Q fever: A cross-sectional study.

Author

Million M, Bardin N, Bessis S, Nouiakh N, Douliery C, Edouard S, Angelakis E, Bosseray A, Epaulard O, Branger S, Chaudier B, Blanc-Laserre K, Ferreira-Maldent N, Demonchy E, Roblot F, Reynes J, Djossou F, Protopopescu C, Carrieri P, Camoin-Jau L, Mege JL, and Raoult D

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Anticardiolipin blood, Antiphospholipid Syndrome blood, Antiphospholipid Syndrome drug therapy, Antiphospholipid Syndrome immunology, Child, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, France, Humans, Immunoglobulin G blood, Logistic Models, Male, Middle Aged, Q Fever blood, Q Fever drug therapy, Q Fever immunology, ROC Curve, Surveys and Questionnaires, Thrombosis blood, Thrombosis drug therapy, Thrombosis immunology, Young Adult, Antiphospholipid Syndrome complications, Q Fever complications, Thrombosis complications
Abstract

Q fever is a neglected and potentially fatal disease. During acute Q fever, antiphospholipid antibodies are very prevalent and have been associated with fever, thrombocytopenia, acquired heart valve disease, and progression to chronic endocarditis. However, thrombosis, the main clinical criterion of the 2006 updated classification of the antiphospholipid syndrome, has not been assessed in this context. To test whether thrombosis is associated with antiphospholipid antibodies and whether the criteria for antiphospholipid syndrome can be met in patients with acute Q fever, we conducted a cross-sectional study at the French National Referral Center for Q fever.Patients included were diagnosed with acute Q fever in our Center between January 2007 and December 2015. Each patient's history and clinical characteristics were recorded with a standardized questionnaire. Predictive factors associated with thrombosis were assessed using a rare events logistic regression model. IgG anticardiolipin antibodies (IgG aCL) assessed by an enzyme-linked immunosorbent assay were tested on the Q fever diagnostic serum. A dose-dependent relationship between IgG aCL levels and thrombosis was tested using a receiver operating characteristic (ROC) analysis.Of the 664 patients identified for inclusion in the study, 313 (47.1%) had positive IgG aCL and 13 (1.9%) were diagnosed with thrombosis. Three patients fulfilled the antiphospholipid syndrome criteria. After multiple adjustments, only positive IgG aCL (relative risk, 14.46 [1.85-113.14], P = .011) were independently associated with thrombosis. ROC analysis identified a dose-dependent relationship between IgG aCL levels and occurrence of thrombosis (area under curve, 0.83, 95%CI [0.73-0.93], P < .001).During acute Q fever, antiphospholipid antibodies are associated with thrombosis, thrombocytopenia, and acquired valvular heart disease. Antiphospholipid antibodies should be systematically assessed in acute Q fever patients. Hydroxychloroquine, which has been previously shown to antagonize IgG aCL pathogenic properties, should be tested in acute Q fever patients with anticardiolipin antibodies to prevent antiphospholipid-associated complications.Key Point: In addition to fever, thrombocytopenia and acquired valvular heart disease, antiphospholipid antibodies are associated with thrombosis during acute Q fever.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results