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2 results on '"Enrico R. Fantoni"'

1. Infrequent false positive [18F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques

Author

Milos D. Ikonomovic, Enrico R. Fantoni, Gill Farrar, and Stephen Salloway

Subjects
Flutemetamol, Amyloid, PET, Diffuse plaques, Neuritic plaques, Alzheimer’s disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background The performance of [18F]flutemetamol amyloid PET against histopathological standards of truth was the subject of our recent article in Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (2017;9:25–34). Main body This viewpoint article addresses infrequently observed discordance between visual [18F]flutemetamol PET image readings and histopathology based solely on neuritic plaque assessment by CERAD criteria, which is resolved by assessing both neuritic and diffuse plaques and/or brain atrophy. Conclusion [18F]flutemetamol PET signal corresponds predominantly to neuritic plaque pathology but is also influenced by the presence of diffuse plaques. This could allow for detection of diffuse amyloid deposits in the early stages of AD dementia, particularly in the striatum where diffuse amyloid is most commonly observed.

Published
2018
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2. What outcomes are important to patients with mild cognitive impairment or Alzheimer's disease, their caregivers, and health-care professionals?

Author

Christophe Bintener, Michael Sharwood Smith, Michele Potashman, Amanda Ly, Alex McKeown, Christoph Jindra, Anders Gustavsson, Emilse Roncancio-Diaz, Cathie Sudlow, Olin Janssen, Anna Ponjoan, Claire Tochel, Stephanie J.B. Vos, Isabella Friis Jørgensen, Buket Öztürk, Catherine Reed, Josep Garre-Olmo, Mia Nelson, Christin Bexelius, Helen Baldwin, Enrico R. Fantoni, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Promovendi MHN, and Ondersteunend personeel MHN

Subjects
Gerontology, Quality of life, Activities of daily living, Patients, media_common.quotation_subject, Disease, Outcomes, Burden, lcsh:Geriatrics, Alzheimer's Disease, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Mild Cognitive Impairment (MCI), Memory, Healthcare professionals, Health care, medicine, Mild cognitive impairment (MCI), Autonomy, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, media_common, Diagnostic Assessment & Prognosis, 0303 health sciences, business.industry, Mild cognitive impairment, medicine.disease, Mental health, 3. Good health, Clinical trial, Psychiatry and Mental health, lcsh:RC952-954.6, Caregivers, Alzheimer's disease (AD), Systematic review, Neurology (clinical), business, Qualitative, 030217 neurology & neurosurgery, Quantitative
Abstract

Introduction: Clinical trials involving patients with Alzheimer’s disease (AD) continue to try to identify disease-modifying treatments. Although trials are designed to meet regulatory and registration requirements, many do not measure outcomes of the disease most relevant to key stakeholders. Methods: A systematic review sought research that elicited information from people with AD, their caregivers, and health-care professionals on which outcomes of the disease were important. Studies published in any language between 2008 and 2017 were included. Results: Participants in 34 studies described 32 outcomes of AD. These included clinical (memory, mental health), practical (ability to undertake activities of daily living, access to health information), and personal (desire for patient autonomy, maintenance of identity) outcomes of the disease. Discussion: Evidence elicited directly from the people most affected by AD reveals a range of disease outcomes that are relevant to them but are not commonly captured in clinical trials of new treatments.

Published
2019

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