202 results on '"Errazuriz A"'
Search Results
2. M1-derived extracellular vesicles polarize recipient macrophages into M2-like macrophages and alter skeletal muscle homeostasis in a hyper-glucose environment
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Stefano Tacconi, Francesco Vari, Carolina Sbarigia, Diana Vardanyan, Serena Longo, Francesco Mura, Federica Angilè, Audrey Jalabert, Ferninand Blangero, Assia Eljaafari, Laurence Canaple, Daniele Vergara, Francesco Paolo Fanizzi, Marco Rossi, Claire Crola Da Silva, Elizabeth Errazuriz-Cerda, Christel Cassin, Rienk Nieuwland, Anna Maria Giudetti, Sophie Rome, and Luciana Dini
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Extracellular vesicles ,Hyperglycemia ,Macrophage ,Lipid metabolism ,Skeletal muscle ,Oxidative phosphorylation ,Medicine ,Cytology ,QH573-671 - Abstract
Abstract Background Macrophages release not only cytokines but also extracellular vesicles (EVs). which are small membrane-derived nanovesicles with virus-like properties transferring cellular material between cells. Until now, the consequences of macrophage plasticity on the release and the composition of EVs have been poorly explored. In this study, we determined the impact of high-glucose (HG) concentrations on macrophage metabolism, and characterized their derived-EV subpopulations. Finally, we determined whether HG-treated macrophage-derived EVs participate in immune responses and in metabolic alterations of skeletal muscle cells. Methods THP1-macrophages were treated with 15mM (MG15) or 30mM (MG30) glucose. Then, M1/M2 canonical markers, pro- and anti-inflammatory cytokines, activities of proteins involved in glycolysis or oxidative phosphorylation were evaluated. Macrophage-derived EVs were characterized by TEM, NTA, MRSP, and 1H-Nuclear magnetic resonance spectroscopy for lipid composition. Macrophages or C2C12 muscle cells were used as recipients of MG15 and MG30-derived EVs. The lipid profiles of recipient cells were determined, as well as proteins and mRNA levels of relevant genes for macrophage polarization or muscle metabolism. Results Untreated macrophages released small and large EVs (sEVs, lEVs) with different lipid distributions. Proportionally to the glucose concentration, glycolysis was induced in macrophages, associated to mitochondrial dysfunction, triacylglycerol and cholesterol accumulation. In addition, MG15 and MG30 macrophages had increased level of CD86 and increase release of pro-inflammatory cytokines. HG also affected macrophage sphingolipid and phospholipid compositions. The differences in the lipid profiles between sEVs and lEVs were abolished and reflected the lipid alterations in MG15 and MG30 macrophages. Interestingly, MG15 and MG30 macrophages EVs induced the expression of CD163, Il-10 and increased the contents of triacylglycerol and cholesterol in recipient macrophages. MG15 lEVs and sEVs induced insulin-induced AKT hyper-phosphorylation and accumulation of triacylglycerol in myotubes, a state observed in pre-diabetes. Conversely, MG30 lEVs and sEVs induced insulin-resistance in myotubes. Conclusions As inflammation involves first M1 macrophages, then the activation of M2 macrophages to resolve inflammation, this study demonstrates that the dialog between macrophages through the EV route is an intrinsic part of the inflammatory response. In a hyperglycemic context, EV macrophages could participate in the development of muscle insulin-resistance and chronic inflammation.
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- 2024
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3. Exploring the impact of Agaricus bisporus on mitigating lead reproductive toxicity using the Caenorhabditis elegans model
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Caetano, Erika Leão Ajala, Novoa San Miguel, Francisco Javier, Errázuriz León, Rocío, Grotto, Denise, and Hornos Carneiro, Maria Fernanda
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- 2024
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4. Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses
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Solmi, Marco, Thompson, Trevor, Cortese, Samuele, Estradé, Andrés, Agorastos, Agorastos, Radua, Joaquim, Dragioti, Elena, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schlögelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Cuénod, Kim Q. Do, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pál, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V., Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Cáceres, Antonia San José, Arango, Celso, Díaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Peñas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Andrlíková, Eva, Janků, Karolina, Millan, Mark J., Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Łoniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Łukasz, Marlicz, Maria, Sowa, Paweł, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Machado, Ana Inés, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Carvalho, Andre F., Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winkel, Ruud, Ng, Bernardo, Peña de León, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sheybani, Farshad, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, López-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aïcha, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Jamei, Yasser Abu, Weiser, Mark, and Correll, Christoph U
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- 2025
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5. Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases
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Sandrine Vadon-Le Goff, Agnès Tessier, Manon Napoli, Cindy Dieryckx, Julien Bauer, Mélissa Dussoyer, Priscillia Lagoutte, Célian Peyronnel, Lucie Essayan, Svenja Kleiser, Nicole Tueni, Emmanuel Bettler, Natacha Mariano, Elisabeth Errazuriz-Cerda, Carole Fruchart Gaillard, Florence Ruggiero, Christoph Becker-Pauly, Jean-Marc Allain, Leena Bruckner-Tuderman, Alexander Nyström, and Catherine Moali
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Science - Abstract
Abstract BMP-1/tolloid-like proteinases (BTPs) are major players in tissue morphogenesis, growth and repair. They act by promoting the deposition of structural extracellular matrix proteins and by controlling the activity of matricellular proteins and TGF-β superfamily growth factors. They have also been implicated in several pathological conditions such as fibrosis, cancer, metabolic disorders and bone diseases. Despite this broad range of pathophysiological functions, the putative existence of a specific endogenous inhibitor capable of controlling their activities could never be confirmed. Here, we show that procollagen C-proteinase enhancer-2 (PCPE-2), a protein previously reported to bind fibrillar collagens and to promote their BTP-dependent maturation, is primarily a potent and specific inhibitor of BTPs which can counteract their proteolytic activities through direct binding. PCPE-2 therefore differs from the cognate PCPE-1 protein and extends the possibilities to fine-tune BTP activities, both in physiological conditions and in therapeutic settings.
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- 2023
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6. Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study
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Solmi, Marco, Thompson, Trevor, Estradé, Andrés, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schlögelhofer, Monika, Aschauer, Elena, Schneeberger, Andres, Huber, Christian G., Hasler, Gregor, Conus, Philippe, Cuénod, Kim Q. Do, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai G., Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pál, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios P., Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre R., Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana V., Valvassori, Samira S., Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Cáceres, Antonia San José, Arango, Celso, Díaz-Caneja, Covadonga M., Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Peñas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel A., Verdolini, Norma, Andrlíková, Eva, Janků, Karolina, Millan, Mark J., Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Łoniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Łukasz, Marlicz, Maria, Sowa, Paweł, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Machado, Ana Inés, Estrade, Natalia, De Leo, Diego, Curtis, Jackie, Berk, Michael, Carvalho, Andre F., Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien H., Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winkel, Ruud, Ng, Bernardo, Peña de León, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sheybani, Farshad, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, López-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Daskalakis, Jeff, Yatham, Lakshmi N., Yang, Lin, Okasha, Tarek, Dahdouh, Aïcha, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Jamei, Yasser Abu, Weiser, Mark, and Correll, Christoph U.
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- 2024
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7. Tuning viscoelasticity and stiffness in bioprinted hydrogels for enhanced 3D cell culture: A multi-scale mechanical analysis
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Pragnere, Sarah, Courtial, Edwin-Joffrey, Dubreuil, Frédéric, Errazuriz-Cerda, Elisabeth, Marquette, Christophe, Petiot, Emma, and Pailler-Mattei, Cyril
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- 2024
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8. Nonaneurysmal perimesencephalic subarachnoid hemorrhage on noncontrast head CT: An accuracy, inter-rater, and intra-rater reliability study
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Benomar, Anass, Diestro, Jose Danilo B., Darabid, Houssam, Saydy, Karim, Tzaneva, Lora, Li, Jimmy, Zarour, Eleyine, Tanguay, William, El Sayed, Nohad, Padilha, Igor Gomes, Létourneau-Guillon, Laurent, Bard, Céline, Nelson, Kristoff, Weill, Alain, Roy, Daniel, Eneling, Johanna, Boisseau, William, Nguyen, Thanh N., Abdalkader, Mohamad, Najjar, Ahmed A., Nehme, Ahmad, Lemoine, Émile, Jacquin, Gregory, Bergeron, David, Brunette-Clément, Tristan, Chaalala, Chiraz, Bojanowski, Michel W., Labidi, Moujahed, Jabre, Roland, Ignacio, Katrina H.D., Omar, Abdelsimar T., II, Volders, David, Dmytriw, Adam A., Hak, Jean-François, Forestier, Géraud, Holay, Quentin, Olatunji, Richard, Alhabli, Ibrahim, Nico, Lorena, Shankar, Jai J.S., Guenego, Adrien, Pascual, Jose L.R., Marotta, Thomas R., Errázuriz, Juan I., Lin, Amy W., Alves, Aderaldo Costa, Jr, Fahed, Robert, Hawkes, Christine, Lee, Hubert, Magro, Elsa, Sheikhi, Lila, Darsaut, Tim E., and Raymond, Jean
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- 2024
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9. Photoaged polystyrene nanoplastics exposure results in reproductive toxicity due to oxidative damage in Caenorhabditis elegans
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Errázuriz León, Rocío, Araya Salcedo, Vicente André, Novoa San Miguel, Francisco Javier, Llanquinao Tardio, Cynthia Rosa Andrea, Tobar Briceño, Adolfo Andrés, Cherubini Fouilloux, Stefano Francesco, de Matos Barbosa, Marcela, Saldías Barros, Cesar Antonio, Waldman, Walter Ruggeri, Espinosa-Bustos, Christian, and Hornos Carneiro, Maria Fernanda
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- 2024
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10. Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases
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Vadon-Le Goff, Sandrine, Tessier, Agnès, Napoli, Manon, Dieryckx, Cindy, Bauer, Julien, Dussoyer, Mélissa, Lagoutte, Priscillia, Peyronnel, Célian, Essayan, Lucie, Kleiser, Svenja, Tueni, Nicole, Bettler, Emmanuel, Mariano, Natacha, Errazuriz-Cerda, Elisabeth, Fruchart Gaillard, Carole, Ruggiero, Florence, Becker-Pauly, Christoph, Allain, Jean-Marc, Bruckner-Tuderman, Leena, Nyström, Alexander, and Moali, Catherine
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- 2023
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11. Common mental disorders in Peruvian immigrant in Chile: a comparison with the host population
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Errazuriz, Antonia, Schmidt, Kristin, Valenzuela, Paulina, Pino, Rodolfo, and Jones, Peter B.
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- 2023
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12. Common mental disorders in Peruvian immigrant in Chile: a comparison with the host population
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Antonia Errazuriz, Kristin Schmidt, Paulina Valenzuela, Rodolfo Pino, and Peter B. Jones
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Common mental disorders ,Depression ,Anxiety ,Immigrant mental health ,Healthy immigrant effect ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The Inner Santiago Health Study (ISHS) aimed to (i) estimate the prevalence of common mental disorders (CMD; i.e. depressive and anxiety disorders) among immigrants of Peruvian origin in Chile; (ii) determine whether such immigrants are at higher risk of CMD when compared with the native-born geographically matched population (i.e. non-immigrants); and (iii) identify factors associated with higher risk of any CMD among this immigrant group. A secondary aim was to describe access to mental health services by Peruvian immigrants meeting criteria for any CMD. Methods Findings are based on a population-based cross-sectional household mental health survey of 608 immigrant and 656 non-immigrant adults (18-64 years) residing in Santiago de Chile. Diagnoses of ICD-10 depressive and anxiety disorders and of any CMD were obtained using the Revised Clinical Interview Schedule. The relationships between demographic, economic, psychosocial, and migration-specific predictor variables, and risk of any CMD were analyzed with a series of stepwise multivariate logistic regression models. Results The one-week prevalence of any CMD was 29.1% (95% CI: 25.2-33.1) among immigrants and 34.7% (95% CI: 30.7-38.7) among non-immigrants. Depending on the statistical model used in the pooled sample, we found the prevalence of any CMD among non-immigrants to be higher (OR=1.53; 95% CI: 1.05-2.25) or similar (OR=1.34; 95% CI: 0.94-19.2) when compared with immigrants. In the multivariate stepwise regression of any CMD in immigrants only, the prevalence was higher for females, those with primary compared to higher education, in debt and exposed to discrimination. Conversely, higher levels of functional social support, sense of comprehensibility, and manageability were associated with a lower risk of any CMD in immigrants. In addition, no differences were observed between immigrants and non-immigrants reporting any CMD in mental health service utilization. Conclusion Our results evidence high levels of current CMD in this immigrant group, particularly amongst women. However, lower adjusted prevalence of any CMD in immigrants compared to non-immigrants was limited to preliminary statistical models, thus failing to provide clear support for a “healthy immigrant effect”. The study sheds new light on differences in CMD prevalence by immigrant status in Latin America by examining differential exposure to risk factors in immigrant versus non-immigrant groups.
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- 2023
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13. Prevalence of depressive disorder in the adult population of Latin America: a systematic review and meta-analysisResearch in context
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Antonia Errazuriz, Dalia Avello-Vega, Juan P. Ramirez-Mahaluf, Rafael Torres, Nicolas A. Crossley, Eduardo A. Undurraga, and Peter B. Jones
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Depression ,Depressive disorder ,Prevalence ,Latin America ,Systematic review ,Meta-analysis ,Public aspects of medicine ,RA1-1270 - Abstract
Summary: Background: Depressive disorder is one of the leading causes of disability worldwide; however its prevalence and association with inequality and crime is poorly characterised in Latin America. This study aimed to: i. systematically review population-based studies of prevalence of ICD/DSM depressive disorder in Latin America, ii. report pooled regional, country, and sex-specific prevalence estimates, and iii. test its association with four country-level development indicators: human development (HDI), income (Gini) and gender inequality (GII), and intentional homicide rate (IHR). Methods: We conducted a systematic review and meta-analysis of population-based studies reporting primary data on the prevalence of ICD/DSM depressive disorder in Latin America from 1990 to 2023, irrespective of language. We searched PubMed, PsycINFO, Cochrane Library, SciELO (regional database), LILAC (regional database), and available grey literature. Study quality was assessed using JBI's critical appraisal tools. We generated pooled estimates using random-effects meta-analysis; heterogeneity was assessed using the I2 statistic. Meta-regression analyses were used to test associations of depression prevalence with indicators of inequality and human development. The study was registered with PROSPERO (CRD42019143054). Findings: Using data from 40 studies in Latin America, lifetime, 12-month, and current prevalence of ICD/DSM depressive disorder were calculated at 12.58% (95% CI 11.00%–14.16%); 5.30% (4.55–6.06%), and 3.12% (2.22–4.03), respectively. Heterogeneity was high across lifetime, 12-month, and current prevalence, sex, and countries. 12-month and current prevalence was associated with higher Gini and GII, 12-month prevalence with lower HDI, and current prevalence with higher IHR. Interpretation: We found a high prevalence of ICD/DSM depressive disorders in Latin America, and a statistically significant association with inequality and development indicators. The high heterogeneity found across prevalence periods and the major gaps in country representation underscore the need to escalate efforts to improve mental health access and research capabilities in Latin America. Systematic, comparable prevalence estimates would inform more effective decision-making in the region. Funding: Pfizer Independent Medical Education Grant.
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- 2023
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14. Climate-driven compositional modifications of arc volcanoes along the East Equatorial Pacific Margin — The magmatic response to a cooling planet
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Errázuriz-Henao, Carlos, Gómez-Tuena, Arturo, Parolari, Mattia, and Weber, Marion
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- 2022
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15. First wave of SARS-CoV-2 in Santiago Chile: Seroprevalence, asymptomatic infection and infection fatality rate
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Vial, Pablo A., González, Claudia, Apablaza, Mauricio, Vial, Cecilia, Lavín, M.Estela, Araos, Rafael, Rubilar, Paola, Icaza, Gloria, Florea, Andrei, Pérez, Claudia, Concha, Paula, Bastías, Diego, Errázuriz, María Paz, Pérez, Ruth, Guzmán, Francisco, Olea, Andrea, Guzmán, Eugenio, Correa, Juan, Munita, José Manuel, and Aguilera, Ximena
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- 2022
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16. Follow-up of gallbladder polyps in a high-risk population of gallbladder cancer: a cohort study and multivariate survival competing risk analysis
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Candia, Roberto, Viñuela, Macarena, Chahuan, Javier, Diaz, Luis A., Gándara, Vicente, Errázuriz, Pedro, Bustamante, Luis, Villalon, Alejandro, Huete, Álvaro, Crovari, Fernando, and Briceño, Eduardo
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- 2022
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17. The Amazing Story of How 'Women' Conquered It All: The Production of Gender Scripts in the Chilean Curricular Documents of History and Social Studies
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Errazuriz, Valentina
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This article explores the construction of the category "Woman" in the official history and social studies curricular documents distributed by the Chilean Ministry of Education to all public and charter schools in 2014. It answers two major questions: what are the characteristics and acceptable gender performances of the category "Woman" in these Chilean curricular documents? Are there differences in the expected/acceptable performances of "Woman" according to her categories of ethnicity/race or social class? I will argue that these curricular documents construct a historical narrative where two archetypal categories represent possible, oppressive gendered citizens. Students that wish to be identified as "Woman" will be able to read these categories as scripts for gender performance. The objective of this paper is to disrupt untroubled "inclusive" historical narratives. A bibliography is included.
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- 2016
18. Zinc Uptake by HIV-1 Viral Particles: An Isotopic Study
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Olivia Guillin, Emmanuelle Albalat, Caroline Vindry, Elisabeth Errazuriz-Cerda, Théophile Ohlmann, Vincent Balter, and Laurent Chavatte
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zinc ,MC-ICP-MS ,isotope fractionation ,isotope labeling ,viral particles ,HIV-1 ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Zinc, an essential trace element that serves as a cofactor for numerous cellular and viral proteins, plays a central role in the dynamics of HIV-1 infection. Among the viral proteins, the nucleocapsid NCp7, which contains two zinc finger motifs, is abundantly present viral particles and plays a crucial role in coating HIV-1 genomic RNA, thus concentrating zinc within virions. In this study, we investigated whether HIV-1 virus production impacts cellular zinc homeostasis and whether isotopic fractionation occurs between the growth medium, the producing cells, and the viral particles. We found that HIV-1 captures a significant proportion of cellular zinc in the neo-produced particles. Furthermore, as cells grow, they accumulate lighter zinc isotopes from the medium, resulting in a concentration of heavier isotopes in the media, and the viruses exhibit a similar isotopic fractionation to the producing cells. Moreover, we generated HIV-1 particles in HEK293T cells enriched with each of the five zinc isotopes to assess the potential effects on the structure and infectivity of the viruses. As no strong difference was observed between the HIV-1 particles produced in the various conditions, we have demonstrated that enriched isotopes can be accurately used in future studies to trace the fate of zinc in cells infected by HIV-1 particles. Comprehending the mechanisms underlying zinc absorption by HIV-1 viral particles offers the potential to provide insights for developing future treatments aimed at addressing this specific facet of the virus’s life cycle.
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- 2023
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19. Effects of mindfulness-based stress reduction on psychological distress in health workers: A three-arm parallel randomized controlled trial
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Errazuriz, Antonia, Schmidt, Kristin, Undurraga, Eduardo A., Medeiros, Sebastián, Baudrand, Rene, Cussen, Diego, Henriquez, Marcela, Celhay, Pablo, and Figueroa, Rodrigo A.
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- 2022
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20. Profiling of ob/ob mice skeletal muscle exosome-like vesicles demonstrates combined action of miRNAs, proteins and lipids to modulate lipid homeostasis in recipient cells
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Audrey Jalabert, Laura Reininger, Emmanuelle Berger, Yohann Coute, Emmanuelle Meugnier, Alexis Forterre, Elizabeth Errazuriz-Cerda, Alain Geloen, Myriam Aouadi, Karim Bouzakri, Jennifer Rieusset, and Sophie Rome
- Subjects
Medicine ,Science - Abstract
Abstract We have determined the lipid, protein and miRNA composition of skeletal muscle (SkM)-released extracellular vesicles (ELVs) from Ob/ob (OB) vs wild-type (WT) mice. The results showed that atrophic insulin-resistant OB-SkM released less ELVs than WT-SkM, highlighted by a RAB35 decrease and an increase in intramuscular cholesterol content. Proteomic analyses of OB-ELVs revealed a group of 37 proteins functionally connected, involved in lipid oxidation and with catalytic activities. OB-ELVs had modified contents for phosphatidylcholine (PC 34-4, PC 40-3 and PC 34-0), sphingomyelin (Sm d18:1/18:1) and ceramides (Cer d18:1/18:0) and were enriched in cholesterol, likely to alleviated intracellular accumulation. Surprisingly many ELV miRNAs had a nuclear addressing sequence, and targeted genes encoding proteins with nuclear activities. Interestingly, SkM-ELV miRNA did not target mitochondria. The most significant function targeted by the 7 miRNAs altered in OB-ELVs was lipid metabolism. In agreement, OB-ELVs induced lipid storage in recipient adipocytes and increased lipid up-take and fatty acid oxidation in recipient muscle cells. In addition, OB-ELVs altered insulin-sensitivity and induced atrophy in muscle cells, reproducing the phenotype of the releasing OB muscles. These data suggest for the first time, a cross-talk between muscle cells and adipocytes, through the SkM-ELV route, in favor of adipose tissue expansion.
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- 2021
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21. Similar optimal distalization and lateralization angles can be achieved with different reverse shoulder arthroplasty implant designs
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Marsalli, Michael, Errázuriz, Juan De Dios, Cartaya, Marco A., De La Paz, Joaquín, Fritis, Diego N., Alsúa, Pedro I., Morán, Nicolas I., and Rojas, José T.
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- 2021
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22. Immune-Mediated Rippling Muscle Disease Associated With Thymoma and Anti-MURC/Cavin-4 Autoantibodies
- Author
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Svahn, Juliette, Coudert, Laurent, Streichenberger, Nathalie, Kraut, Alexandra, Gravier-Dumonceau-Mazelier, Alice, Rotard, Ludivine, Calemard-Michel, Laurence, Menassa, Rita, Errazuriz-Cerda, Elisabeth, Chalabreysse, Lara, Osseni, Alexis, Vial, Christophe, Jomir, Laurentiu, Tronc, François, Le Duy, Do, Bernard, Emilien, Gache, Vincent, Couté, Yohann, Jacquemond, Vincent, Schaeffer, Laurent, and Leblanc, Pascal
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- 2023
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23. Orogenic andesites and their link to the continental rock cycle
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Parolari, Mattia, Gómez-Tuena, Arturo, Errázuriz-Henao, Carlos, and Cavazos-Tovar, José G.
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- 2021
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24. The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis.
- Author
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Zibold, Julia, Lessard, Lola E R, Picard, Flavien, Silva, Lara Gruijs da, Zadorozhna, Yelyzaveta, Streichenberger, Nathalie, Belotti, Edwige, Osseni, Alexis, Emerit, Andréa, Errazuriz-Cerda, Elisabeth, Michel-Calemard, Laurence, Menassa, Rita, Coudert, Laurent, Wiessner, Manuela, Stucka, Rolf, Klopstock, Thomas, Simonetti, Francesca, Hutten, Saskia, Nonaka, Takashi, and Hasegawa, Masato
- Subjects
AMYOTROPHIC lateral sclerosis ,MISSENSE mutation ,DNA-binding proteins ,MUSCLE diseases ,NEMALINE myopathy ,GENETIC testing ,FRONTOTEMPORAL lobar degeneration - Abstract
TAR DNA binding protein of 43 kDa (TDP-43)-positive inclusions in neurons are a hallmark of several neurodegenerative diseases including familial amyotrophic lateral sclerosis (fALS) caused by pathogenic TARDBP variants as well as more common non-Mendelian sporadic ALS (sALS). Here we report a G376V-TDP-43 missense variant in the C-terminal prion-like domain of the protein in two French families affected by an autosomal dominant myopathy but not fulfilling diagnostic criteria for ALS. Patients from both families presented with progressive weakness and atrophy of distal muscles, starting in their fifth to seventh decade. Muscle biopsies revealed a degenerative myopathy characterized by accumulation of rimmed (autophagic) vacuoles, disruption of sarcomere integrity and severe myofibrillar disorganization. The G376V variant altered a highly conserved amino acid residue and was absent in databases on human genome variation. Variant pathogenicity was supported by in silico analyses and functional studies. The G376V mutant increased the formation of cytoplasmic TDP-43 condensates in cell culture models, promoted assembly into high molecular weight oligomers and aggregates in vitro , and altered morphology of TDP-43 condensates arising from phase separation. Moreover, the variant led to the formation of cytoplasmic TDP-43 condensates in patient-derived myoblasts and induced abnormal mRNA splicing in patient muscle tissue. The identification of individuals with TDP-43-related myopathy, but not ALS, implies that TARDBP missense variants may have more pleiotropic effects than previously anticipated and support a primary role for TDP-43 in skeletal muscle pathophysiology. We propose to include TARDBP screening in the genetic work-up of patients with late-onset distal myopathy. Further research is warranted to examine the precise pathogenic mechanisms of TARDBP variants causing either a neurodegenerative or myopathic phenotype. [ABSTRACT FROM AUTHOR]
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- 2024
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25. ArchDaily and Representations of Domestic Architecture in the era of Digital Platforms
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Bruno Cruz Petit and Tomás Errazuriz Infante
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digital era ,digital platform ,project diffusion ,residential architecture ,space representation ,Ethnology. Social and cultural anthropology ,GN301-674 - Abstract
At present, ArchDaily.com is the most visited virtual architecture platform in the world. Aware of the importance acquired in the architectural practice, the site declares itself to be the main source from which architects feed on tools, information and inspiration to develop their projects. However, it is clear that its importance is not limited to its status as reference bank for professional practice. The accumulation of visual and textual representations contributes to the idea of “good architecture”, in turn transforming this platform into an institution validating and legitimizing the understanding of the discipline, its scope and limitations, its protagonists and predominant methods applied. The following pages propose an analysis of the platform’s content in its residential architecture section, an analysis that supports a critical reflection on its wider cultural effects.
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- 2020
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26. Profiling of ob/ob mice skeletal muscle exosome-like vesicles demonstrates combined action of miRNAs, proteins and lipids to modulate lipid homeostasis in recipient cells
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Jalabert, Audrey, Reininger, Laura, Berger, Emmanuelle, Coute, Yohann, Meugnier, Emmanuelle, Forterre, Alexis, Errazuriz-Cerda, Elizabeth, Geloen, Alain, Aouadi, Myriam, Bouzakri, Karim, Rieusset, Jennifer, and Rome, Sophie
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- 2021
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27. The role of subducted sediments in the formation of intermediate mantle-derived magmas from the Northern Colombian Andes
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Errázuriz-Henao, Carlos, Gómez-Tuena, Arturo, Duque-Trujillo, Jose, and Weber, Marion
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- 2019
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28. The role of progesterone elevation in IVF
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Drakopoulos, Panagiotis, Racca, Annalisa, Errázuriz, Joaquín, De Vos, Michel, Tournaye, Herman, Blockeel, Christophe, Pluchino, Nicola, and Santos-Ribeiro, Samuel
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- 2019
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29. Dermal stiffness governs the topography of the epidermis and the underlying basement membrane in young and old human skin.
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Roig‐Rosello, Eva, Dayan, Guila, Bovio, Simone, Manissier, Patricia, Errazuriz, Elisabeth, and Rousselle, Patricia
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BASAL lamina ,KRUPPEL-like factors ,SKIN aging ,EPIDERMIS ,TISSUE mechanics ,ATOMIC force microscopy - Abstract
The epidermis is a stratified epithelium that forms the outer layer of the skin. It is composed primarily of keratinocytes and is constantly renewed by the proliferation of stem cells and their progeny that undergo terminal differentiation as they leave the basal layer and migrate to the skin surface. Basal keratinocytes rest on a basement membrane composed of an extracellular matrix that controls their fate via integrin‐mediated focal adhesions and hemidesmosomes which are critical elements of the epidermal barrier and promote its regenerative capabilities. The distribution of basal cells with optimal activity provides the basement membrane with its characteristic undulating shape; this configuration disappears with age, leading to epidermal weakness. In this study, we present an in‐depth imaging analysis of basal keratinocyte anchorage in samples of human skin from participants across the age spectrum. Our findings reveal that skin aging is associated with the depletion of hemidesmosomes that provide crucial support for stem cell maintenance; their depletion correlates with the loss of the characteristic basement membrane structure. Atomic force microscopy studies of skin and in vitro experiments revealed that the increase in tissue stiffness observed with aging triggers mechanical signals that alter the basement membrane structure and reduce the extent of basal keratinocyte anchorage, forcing them to differentiate. Genomic analysis revealed that epidermal aging was associated with mechanical induction of the transcription factor Krüppel‐like factor 4. The altered mechanical properties of tissue being a new hallmark of aging, our work opens new avenues for the development of skin rejuvenation strategies. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Validation of the collaborative outcomes study on health and functioning during infection times (COH-FIT) questionnaire for adults
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Marco Solmi, Trevor Thompson, Andrés Estradé, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schlögelhofer, Elena Aschauer, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuénod, Roland von Känel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Żydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kamiński, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Manková, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pál Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana V. Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San José Cáceres, Celso Arango, Covadonga M. Díaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Peñas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Andrlíková, Karolina Janků, Mark John Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Łoniewski, Jerzy Samochowiec, Łukasz Kiszkiel, Maria Marlicz, Paweł Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Inés Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winkel, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Farshad Sheybani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos López-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aïcha Dahdouh, Björn Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll, MUMC+: MA Med Staf Spec Psychiatrie (9), RS: MHeNs - R2 - Mental Health, and Psychiatry 3
- Subjects
Survey: P-factor: well-being: mental health: psychiatry: psychometric ,Pandemic ,psychometric ,COH-FIT ,Covid-19 ,P-factor ,psychiatry ,Psychiatry and Mental health ,Clinical Psychology ,P-factor: well-being: mental health: psychiatry: psychometric [COH-FIT ,Survey] ,well-being ,P-factor: well-being: mental health: psychiatry: psychometric [Survey] ,Survey ,mental health - Abstract
BACKGROUND: The Collaborative Outcome study on Health and Functioning during Infection Times (COH-FIT; www.coh-fit.com) is an anonymous and global online survey measuring health and functioning during the COVID-19 pandemic. The aim of this study was to test concurrently the validity of COH-FIT items and the internal validity of the co-primary outcome, a composite psychopathology "P-score". METHODS: The COH-FIT survey has been translated into 30 languages (two blind forward-translations, consensus, one independent English back-translation, final harmonization). To measure mental health, 1-4 items ("COH-FIT items") were extracted from validated questionnaires (e.g. Patient Health Questionnaire 9). COH-FIT items measured anxiety, depressive, post-traumatic, obsessive-compulsive, bipolar and psychotic symptoms, as well as stress, sleep and concentration. COH-FIT Items which correlated r ≥ 0.5 with validated companion questionnaires, were initially retained. A P-score factor structure was then identified from these items using exploratory factor analysis (EFA) and confirmatory factor analyses (CFA) on data split into training and validation sets. Consistency of results across languages, gender and age was assessed. RESULTS: From >150,000 adult responses by May 6th, 2022, a subset of 22,456 completed both COH-FIT items and validated questionnaires. Concurrent validity was consistently demonstrated across different languages for COH-FIT items. CFA confirmed EFA results of five first-order factors (anxiety, depression, post-traumatic, psychotic, psychophysiologic symptoms) and revealed a single second-order factor P-score, with high internal reliability (ω = 0.95). Factor structure was consistent across age and sex. CONCLUSIONS: COH-FIT is a valid instrument to globally measure mental health during infection times. The P-score is a valid measure of multidimensional mental health. ispartof: JOURNAL OF AFFECTIVE DISORDERS vol:326 pages:249-261 ispartof: location:Netherlands status: published
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- 2023
31. Adverse childhood experiences and suicidal ideation among immigrants in Santiago, Chile
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A. Errazuriz, D. Avello, S. Morales, and R. Pino
- Subjects
immigrant ,healthy immigrant effect ,adverse childhood experiences ,Suicidal ideation ,Psychiatry ,RC435-571 - Abstract
Introduction Understanding suicidal ideation and its association with childhood adversity is crucial for preventing suicide. Although the “healthy immigrant effect”, whereby immigrants are healthier than the native-born population, has been well documented across studies, little research has examined the presence of such effect on lifetime suicidal ideation (LSI) and its association to early adversity. Objectives The aim of this study was to compare the prevalence of LSI between the immigrant and native-born population in Chile and explore the association between childhood adversity and suicidal ideation in immigrants. Methods Data from two cross-sectional health surveys: the Santiago Immigrant Wellbeing Study (STRING, n=1,091; 2019) and the Chilean National Health Survey (ENS2016, n=3,432) were used. Each study used multistage probability sampling and estimates were weighted to approximate the distribution of demographic variables in each population. Outcomes included LSI measured by WHO-CIDI and an adapted version of the Adverse Childhood Experience Questionnaire. Multivariate logistic regression was employed. Results indicated that immigrants were less likely to report LSI compared with the native-born population. Moreover, male and female immigrants had lower risk of having SI than native-born counterparts. After controlling for socioeconomic status, social support, and health conditions, childhood adversities predicted an increased risk of LSI in immigrants. No gender differences were found in the effects of childhood adversity on suicidal thoughts. Conclusions Findings confirm the presence of a healthy immigrant effect in LSI and support a life course perspective, highlighting the importance of assessing early life disadvantages to understand suicidal ideation among immigrants.
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- 2021
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32. '¡Tenga Ud. cuidado!' El peligro como fundamento para la normalización del uso de las calles en Santiago (1900-1930)
- Author
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Tomas Errazuriz
- Subjects
Accidentes de tránsito ,automotores ,tránsito moderno ,Santiago ,History (General) ,D1-2009 - Abstract
La incorporación de los nuevos vehículos motorizados a la vida urbana durante las décadas iniciales del siglo XX fue un proceso conflictivo que supuso una transformación material y simbólica de la experiencia de los viajes en la ciudad. Haciendo foco en el caso de Santiago, este artículo analiza el lugar que tuvo el accidente de tránsito en este proceso. Específicamente, se busca comprender distintas formas en que el accidente impactó en la cultura urbana y en las nociones del tránsito de la época, diferenciando entre los alcances del evento particular y aquellos producidos por la imagen cada vez más arraigada de la eventualidad del accidente. El análisis sugiere que fue la cotidianeidad adquirida por el accidente, como evento y eventualidad, la que posibilitó la implementación y legitimación del nuevo sistema de circulación que permitió incorporar a los vehículos motorizados como elementos ordenadores del tránsito.
- Published
- 2020
33. Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia
- Author
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Andrés Pizzorno, Blandine Padey, Thomas Julien, Sophie Trouillet-Assant, Aurélien Traversier, Elisabeth Errazuriz-Cerda, Julien Fouret, Julia Dubois, Alexandre Gaymard, François-Xavier Lescure, Victoria Dulière, Pauline Brun, Samuel Constant, Julien Poissy, Bruno Lina, Yazdan Yazdanpanah, Olivier Terrier, and Manuel Rosa-Calatrava
- Subjects
COVID-19 ,cell ultrastructure remodeling ,innate immune response ,remdesivir ,diltiazem ,repurposing ,Medicine (General) ,R5-920 - Abstract
Summary: In the current COVID-19 pandemic context, proposing and validating effective treatments represents a major challenge. However, the scarcity of biologically relevant pre-clinical models of SARS-CoV-2 infection imposes a significant barrier for scientific and medical progress, including the rapid transition of potentially effective treatments to the clinical setting. We use reconstituted human airway epithelia to isolate and then characterize the viral infection kinetics, tissue-level remodeling of the cellular ultrastructure, and transcriptional early immune signatures induced by SARS-CoV-2 in a physiologically relevant model. Our results emphasize distinctive transcriptional immune signatures between nasal and bronchial HAE, both in terms of kinetics and intensity, hence suggesting putative intrinsic differences in the early response to SARS-CoV-2 infection. Most important, we provide evidence in human-derived tissues on the antiviral efficacy of remdesivir monotherapy and explore the potential of the remdesivir-diltiazem combination as an option worthy of further investigation to respond to the still-unmet COVID-19 medical need.
- Published
- 2020
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34. The Notion Of The Enemy In The Discourse Of Philosophes: Towards A Taxonomy of The Concept
- Author
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Jose Antonio Errazuriz
- Subjects
enemy ,conflict ,crime ,philosophy of war ,carl schmitt ,Political science (General) ,JA1-92 - Abstract
This study reviews and classifies the most common uses of the terms “enemy” and “enmity” within the context of traditional philosophical discourse. In order to contribute to a structured understanding of these concepts, we proceed in two steps. We first explore the auxiliary (or non-technical) uses of the terms, which we distinguish from each other according to their axiological connotations. In a second part, we review the technical uses of the concepts known to philosophy of law. Here, we distinguish between two different approaches to the concept, one of which defines it through qualitative criteria, and a second approach that uses the term as a quantifier (of intensity, strength, etc.).
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- 2020
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35. Heterogeneity Among Poor Ovarian Responders According to Bologna Criteria Results in Diverging Cumulative Live Birth Rates
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Alessia Romito, Erlisa Bardhi, Joaquin Errazuriz, Christophe Blockeel, Samuel Santos-Ribeiro, Michel De Vos, Annalisa Racca, Shari Mackens, Annelore Van Der Kelen, Pierluigi Benedetti Panici, Alberto Vaiarelli, Herman Tournaye, and Panagiotis Drakopoulos
- Subjects
Bologna criteria ,poor ovarian response ,poor responders ,cumulative live birth rate ,ICSI ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Research Question: Does reproductive outcome differ among the various subgroups of poor ovarian responders according to the Bologna criteria?Design: This was a retrospective, cohort study including poor ovarian responders according to Bologna criteria, undergoing an ICSI cycle from January 2011 until December 2017. Patients were divided into four groups: (1) age ≥ 40 years and abnormal ovarian response test, (2) age ≥ 40 years, abnormal ovarian reserve test and one previous poor response to stimulation, (3) age ≥ 40 years and one previous poor response, (4) abnormal ovarian reserve test and one previous poor response.Result(s): Overall, 846 cycles in 706 Bologna poor ovarian responders were included: 310 cycles in group 1, 169 in group 2, 52 in group 3, and 315 in group 4. There were significant differences in age, antral follicle count, antimüllerian hormone, cycle cancellation rates, and number of retrieved oocytes between the four groups. Live birth and cumulative live birth rate differed significantly between groups and were highest in Group 4 [Live birth rate: 7.4% (1) vs. 4.1% (2) vs. 5.8% (3) vs. 13.4% (4), p = 0.001 and Cumulative live birth rate: 8.3% (1) vs. 4.1 % (2) vs. 9.6% (3) vs. 16.8% (4) p < 0.001]. The multivariate GEE analysis revealed that the number of MIIs and the Bologna criteria pattern were the variables which were significantly associated with cumulative live birth rate.Conclusion(s): Poor ovarian responders represent a heterogeneous population. The young subpopulation has a better clinical prognosis in terms of fresh and cumulative live birth rate.
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- 2020
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36. Prevalence of depression in Latin America and the Caribbean: protocol for a systematic review and meta-analysis
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Errazuriz, Antonia and Crisostomo, Natalia
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- 2021
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37. LipoParticles: a lipid membrane coating onto polymer particles to enhance the internalization in osteoblast cells.
- Author
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Vanneste, Florian, Faure, Allison, Varache, Mathieu, Menendez-Miranda, Mario, Dyon-Tafani, Virginie, Dussurgey, Sébastien, Errazuriz-Cerda, Elisabeth, La Padula, Veronica, Alcouffe, Pierre, Carriεave;re, Marie, Gref, Ruxandra, Laurent, Frédéric, Josse, Jérôme, and Ladaviεave;re, Catherine
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- 2023
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38. Four essays on reputation and self regulation
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Nunez Errazuriz, Javier I.
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658 ,Fraud ,Employee ,Public - Published
- 1999
39. Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections
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Tcherniuk, Sergey, Cenac, Nicolas, Comte, Marjorie, Frouard, Julie, Errazuriz-Cerda, Elisabeth, Galabov, Angel, Morange, Pierre-Emmanuel, Vergnolle, Nathalie, Si-Tahar, Mustapha, Alessi, Marie-Christine, and Riteau, Béatrice
- Published
- 2016
40. The Ambiguities of Progress: Cultural appropriation of electric trams in the Southern Cone, 1890-1950 (Chile, Argentina, Uruguay and Brazil)
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Errázuriz, Tomás and Giucci, Guillermo
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- 2016
41. Zinc Uptake by HIV-1 Viral Particles: An Isotopic Study.
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Guillin, Olivia, Albalat, Emmanuelle, Vindry, Caroline, Errazuriz-Cerda, Elisabeth, Ohlmann, Théophile, Balter, Vincent, and Chavatte, Laurent
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ZINC ,HIV ,ZINC-finger proteins ,LIFE cycles (Biology) ,CELL fractionation ,ISOTOPIC fractionation ,VIRAL proteins - Abstract
Zinc, an essential trace element that serves as a cofactor for numerous cellular and viral proteins, plays a central role in the dynamics of HIV-1 infection. Among the viral proteins, the nucleocapsid NCp7, which contains two zinc finger motifs, is abundantly present viral particles and plays a crucial role in coating HIV-1 genomic RNA, thus concentrating zinc within virions. In this study, we investigated whether HIV-1 virus production impacts cellular zinc homeostasis and whether isotopic fractionation occurs between the growth medium, the producing cells, and the viral particles. We found that HIV-1 captures a significant proportion of cellular zinc in the neo-produced particles. Furthermore, as cells grow, they accumulate lighter zinc isotopes from the medium, resulting in a concentration of heavier isotopes in the media, and the viruses exhibit a similar isotopic fractionation to the producing cells. Moreover, we generated HIV-1 particles in HEK293T cells enriched with each of the five zinc isotopes to assess the potential effects on the structure and infectivity of the viruses. As no strong difference was observed between the HIV-1 particles produced in the various conditions, we have demonstrated that enriched isotopes can be accurately used in future studies to trace the fate of zinc in cells infected by HIV-1 particles. Comprehending the mechanisms underlying zinc absorption by HIV-1 viral particles offers the potential to provide insights for developing future treatments aimed at addressing this specific facet of the virus's life cycle. [ABSTRACT FROM AUTHOR]
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- 2023
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42. The Activation of the RIG-I/MDA5 Signaling Pathway upon Influenza D Virus Infection Impairs the Pulmonary Proinflammatory Response Triggered by Mycoplasma bovis Superinfection
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Maria Gaudino, Adrien Lion, Eveline Sagné, Brandy Nagamine, Justine Oliva, Olivier Terrier, Elisabeth Errazuriz-Cerda, Anaëlle Scribe, Fatima-Zohra Sikht, Elisa Simon, Charlotte Foret-Lucas, Blandine Gausserès, Julie Lion, Ana Moreno, Emilie Dordet-Frisoni, Eric Baranowski, Romain Volmer, Mariette F. Ducatez, Gilles Meyer, Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Virology and human respiratory Pathologies - Virology and human respiratory Pathologies (VirPath), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna 'Bruno Ubertini' (IZSLER), Innovations Thérapeutiques et Résistances (InTheRes), This study was funded by the by the Ecole Nationale Veterinaire de Toulouse (ENVT), project BQR-2020-ANIMEX, and the ICRAD-ERA NET cofund ANR-21-ICRD-0007, 'Deciphering the role of influenza D virus in bovine and human respiratory diseases in Europe.' Maria Gaudino was supported by a Ph.D. scholarship funded by the Departement Sante Animale (INRAE Toulouse) and the Region Occitanie. Maria Gaudino, Adrien Lion, Justine Oliva, Olivier Terrier, Fatima-Zohra Sikht, Romain Volmer, Gilles Meyer, and Mariette F. Ducatez are members of the French research network on influenza viruses (ResaFlu, GDR2073) financed by the CNRS., and ANR-21-ICRD-0007,PREVENTER,Deciphering the role of influenza D virus in bovine and human respiratory diseases in Europe(2021)
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coinfections ,[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health ,PCLS ,cattle ,Virology ,Insect Science ,respiratory viruses ,Immunology ,ex vivo ,precision-cut lung slices ,mycoplasma ,influenza ,Microbiology - Abstract
International audience; Concurrent infections with multiple pathogens are often described in cattle with respiratory illness. However, how the host-pathogen interactions influence the clinical outcome has been only partially explored in this species. Influenza D virus (IDV) was discovered in 2011. Since then, IDV has been detected worldwide in different hosts. A significant association between IDV and bacterial pathogens in sick cattle was shown in epidemiological studies, especially with Mycoplasma bovis. In an experimental challenge, IDV aggravated M. bovis-induced pneumonia. However, the mechanisms through which IDV drives an increased susceptibility to bacterial superinfections remain unknown. Here, we used the organotypic lung model precision-cut lung slices to study the interplay between IDV and M. bovis coinfection. Our results show that a primary IDV infection promotes M. bovis superinfection by increasing the bacterial replication and the ultrastructural damages in lung pneumocytes. In our model, IDV impaired the innate immune response triggered by M. bovis by decreasing the expression of several proinflammatory cytokines and chemokines that are important for immune cell recruitment and the bacterial clearance. Stimulations with agonists of cytosolic helicases and Toll-like receptors (TLRs) revealed that a primary activation of RIG-I/MDA5 desensitizes the TLR2 activation, similar to what was observed with IDV infection. The cross talk between these two pattern recognition receptors leads to a nonadditive response, which alters the TLR2-mediated cascade that controls the bacterial infection. These results highlight innate immune mechanisms that were not described for cattle so far and improve our understanding of the bovine host-microbe interactions and IDV pathogenesis.IMPORTANCE: Since the spread of the respiratory influenza D virus (IDV) infection to the cattle population, the question about the impact of this virus on bovine respiratory disease (BRD) remains still unanswered. Animals affected by BRD are often coinfected with multiple pathogens, especially viruses and bacteria. In particular, viruses are suspected to enhance secondary bacterial superinfections. Here, we use an ex vivo model of lung tissue to study the effects of IDV infection on bacterial superinfections. Our results show that IDV increases the susceptibility to the respiratory pathogen Mycoplasma bovis. In particular, IDV seems to activate immune pathways that inhibit the innate immune response against the bacteria. This may allow M. bovis to increase its proliferation and to delay its clearance from lung tissue. These results suggest that IDV could have a negative impact on the respiratory pathology of cattle.
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- 2023
43. The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic
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Solmi, Marco, Estradé, Andrés, Thompson, Trevor, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schloegelhofer, Monika, Akimova, Elena, Schneeberger, Andres, Huber, Christian, Hasler, Gregor, Conus, Philippe, Cuénod, Kim, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai, Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pal, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios, Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre, Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana, Valvassori, Samira, Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Cáceres, Antonia San José, Arango, Celso, Díaz-Caneja, Covadonga, Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Peñas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel, Verdolini, Norma, Fárková, Eva, Janků, Karolina, Millan, Mark, Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Łoniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Łukasz, Marlicz, Maria, Sowa, Paweł, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Machado, Ana Inés, Estrade, Natalia, de Leo, Diego, Curtis, Jackie, Berk, Michael, Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien, Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-Wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winke, Ruud, Ng, Bernardo, Pena, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, López-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Carvalho, Andre, Daskalakis, Jeff, Yatham, Lakshmi, Yang, Lin, Okasha, Tarek, Dahdouh, Aïcha, Gerdle, Björn, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Jamei, Yasser Abu, Weiser, Mark, Correll, Christoph, Thygesen, Lau, Kwon, Jun, Lee, Tae, Costardi, Carlos, Schuch, Felipe, Luiz, Jhoanne, Hoffmann, Sofie, Cáceres, Antonia, Darcin, Asli, Machado, Ana, Horodnic, Adrian, Ristic, Dragana, Kallivayalil, Roy, Afridi, Muhammad, Seb-Akahomen, Omonefe, Shin, Jae, Jamei, Yasser, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Movement Disorder (MD), Clinique des maladies mentales et de l'encéphale (CMME - Service de psychiatrie), Hôpital Sainte-Anne-Université Paris Cité (UPCité), GHU Paris Psychiatrie et Neurosciences, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Clermont-Ferrand, Pathologies et épithéliums : prévention, innovation, traitements, évaluation (UR 4267) (PEPITE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Martinez Rico, Clara, Solmi, M., Estradé, A., Thompson, T., Agorastos, A., Radua, J., Cortese, S., Dragioti, E., Leisch, F., Vancampfort, D., Thygesen, L.C., Aschauer, H., Schloegelhofer, M., Akimova, E., Schneeberger, A., Huber, C.G., Hasler, G., Conus, P., Cuénod, K.Q.D., von Känel, R., Arrondo, G., Fusar-Poli, P., Gorwood, P., Llorca, P.-M., Krebs, M.-O., Scanferla, E., Kishimoto, T., Rabbani, G., Skonieczna-Żydecka, K., Brambilla, P., Favaro, A., Takamiya, A., Zoccante, L., Colizzi, M., Bourgin, J., Kamiński, K., Moghadasin, M., Seedat, S., Matthews, E., Wells, J., Vassilopoulou, E., Gadelha, A., Su, K.-P., Kwon, J.S., Kim, M., Lee, T.Y., Papsuev, O., Manková, D., Boscutti, A., Gerunda, C., Saccon, D., Righi, E., Monaco, F., Croatto, G., Cereda, G., Demurtas, J., Brondino, N., Veronese, N., Enrico, P., Politi, P., Ciappolino, V., Pfennig, A., Bechdolf, A., Meyer-Lindenberg, A., Kahl, K.G., Domschke, K., Bauer, M., Koutsouleris, N., Winter, S., Borgwardt, S., Bitter, I., Balazs, J., Czobor, P., Unoka, Z., Mavridis, D., Tsamakis, K., Bozikas, V.P., Tunvirachaisakul, C., Maes, M., Rungnirundorn, T., Supasitthumrong, T., Haque, A., Brunoni, A.R., Costardi, C.G., Schuch, F.B., Polanczyk, G., Luiz, J.M., Fonseca, L., Aparicio, L.V., Valvassori, S.S., Nordentoft, M., Vendsborg, P., Hoffmann, S.H., Sehli, J., Sartorius, N., Heuss, S., Guinart, D., Hamilton, J., Kane, J., Rubio, J., Sand, M., Koyanagi, A., Solanes, A., Andreu-Bernabeu, A., Cáceres, A.S.J., Arango, C., Díaz-Caneja, C.M., Hidalgo-Mazzei, D., Vieta, E., Gonzalez-Peñas, J., Fortea, L., Parellada, M., Fullana, M.A., Verdolini, N., Fárková, E., Janků, K., Millan, M., Honciuc, M., Moniuszko-Malinowska, A., Łoniewski, I., Samochowiec, J., Kiszkiel, Ł., Marlicz, M., Sowa, P., Marlicz, W., Spies, G., Stubbs, B., Firth, J., Sullivan, S., Darcin, A.E., Aksu, H., Dilbaz, N., Noyan, O., Kitazawa, M., Kurokawa, S., Tazawa, Y., Anselmi, A., Cracco, C., Machado, A.I., Estrade, N., De Leo, D., Curtis, J., Berk, M., Ward, P., Teasdale, S., Rosenbaum, S., Marx, W., Horodnic, A.V., Oprea, L., Alexinschi, O., Ifteni, P., Turliuc, S., Ciuhodaru, T., Bolos, A., Matei, V., Nieman, D.H., Sommer, I., van Os, J., van Amelsvoort, T., Sun, C.-F., Guu, T.-W., Jiao, C., Zhang, J., Fan, J., Zou, L., Yu, X., Chi, X., de Timary, P., van Winke, R., Ng, B., Pena, E., Arellano, R., Roman, R., Sanchez, T., Movina, L., Morgado, P., Brissos, S., Aizberg, O., Mosina, A., Krinitski, D., Mugisha, J., Sadeghi-Bahmani, D., Sadeghi, M., Hadi, S., Brand, S., Errazuriz, A., Crossley, N., Ristic, D.I., López-Jaramillo, C., Efthymiou, D., Kuttichira, P., Kallivayalil, R.A., Javed, A., Afridi, M.I., James, B., Seb-Akahomen, O.J., Fiedorowicz, J., Carvalho, A.F., Daskalakis, J., Yatham, L.N., Yang, L., Okasha, T., Dahdouh, A., Gerdle, B., Tiihonen, J., Shin, J.I., Lee, J., Mhalla, A., Gaha, L., Brahim, T., Altynbekov, K., Negay, N., Nurmagambetova, S., Jamei, Y.A., Weiser, M., Correll, C.U., Adult Psychiatry, APH - Mental Health, ANS - Compulsivity, Impulsivity & Attention, and ANS - Mood, Anxiety, Psychosis, Stress & Sleep
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Gerontology ,DISORDER ,STRESS ,Outcome Assessment ,IMPACT ,[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,RA0421 ,well-being ,Pandemic ,Health care ,Outcome Assessment, Health Care ,adults ,Medicine ,ANXIETY ,COVID-19 ,mental health ,functioning ,physical health ,representative ,resilience ,survey ,international ,psychiatry ,depression ,anxiety ,post-traumatic ,COH-FIT ,children ,adolescents ,mental health, functioning, physical health, representative, well-being, resilience, survey, international, psychiatry, depression, anxiety, post-traumatic, COH-FIT, children, adolescents, adult ,Child ,SCALE ,Psychiatry ,education.field_of_study ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Public Health, Global Health, Social Medicine and Epidemiology ,Psychiatry and Mental health ,Clinical Psychology ,Professional association ,Life Sciences & Biomedicine ,Psychopathology ,Research Paper ,Adult ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,Population ,Clinical Neurology ,BF ,Anxiety ,Cross-Sectional Studies ,Depression ,Humans ,Mental Health ,SARS-CoV-2 ,Pandemics ,Intervention (counseling) ,MANAGEMENT ,VALIDITY ,education ,Science & Technology ,business.industry ,MORTALITY ,CARE ,Mental health ,Health Care ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Neurosciences & Neurology ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
BACKGROUND: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed. METHODS: . The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/regions, endorsed by national/international professional associations. COH-FIT is a multi-wave, on-line anonymous, cross-sectional survey [wave 1: 04/2020 until the end of the pandemic, 12 months waves 2/3 starting 6/24 months threreafter] for adults, adolescents (14-17), and children (6-13), utilizing non-probability/snowball and representative sampling. COH-FIT aims to identify non-modifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to improve social/health outcomes in the general population/vulnerable subgrous during/after COVID-19. In adults, co-primary outcomes are change from pre-COVID-19 to intra-COVID-19 in well-being (WHO-5) and a composite psychopathology P-Score. Key secondary outcomes are a P-extended score, global mental and physical health. Secondary outcomes include health-service utilization/functioning, treatment adherence, functioning, symptoms/behaviors/emotions, substance use, violence, among others. RESULTS: . Starting 04/26/2020, up to 14/07/2021 >151,000 people from 155 countries/territories/regions and six continents have participated. Representative samples of ≥1,000 adults have been collected in 15 countries. Overall, 43.0% had prior physical disorders, 16.3% had prior mental disorders, 26.5% were health care workers, 8.2% were aged ≥65 years, 19.3% were exposed to someone infected with COVID-19, 76.1% had been in quarantine, and 2.1% had been COVID 19-positive. LIMITATIONS: . Cross-sectional survey, preponderance of non-representative participants. CONCLUSIONS: . Results from COH-FIT will comprehensively quantify the impact of COVID-19, seeking to identify high-risk groups in need for acute and long-term intervention, and inform evidence-based health policies/strategies during this/future pandemics. ispartof: JOURNAL OF AFFECTIVE DISORDERS vol:299 pages:393-407 ispartof: location:Netherlands status: published
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- 2022
44. Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times-Children and Adolescents (COH-FIT-C&A)
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Solmi, Marco, Estradé, Andrés, Thompson, Trevor, Agorastos, Agorastos, Radua, Joaquim, Cortese, Samuele, Dragioti, Elena, Leisch, Friedrich, Vancampfort, Davy, Thygesen, Lau Caspar, Aschauer, Harald, Schloegelhofer, Monika, Akimova, Elena, Schneeberger, Andres, Huber, Christian, Hasler, Gregor, Conus, Philippe, Cuénod, Kim, von Känel, Roland, Arrondo, Gonzalo, Fusar-Poli, Paolo, Gorwood, Philip, Llorca, Pierre-Michel, Krebs, Marie-Odile, Scanferla, Elisabetta, Kishimoto, Taishiro, Rabbani, Golam, Skonieczna-Żydecka, Karolina, Brambilla, Paolo, Favaro, Angela, Takamiya, Akihiro, Zoccante, Leonardo, Colizzi, Marco, Bourgin, Julie, Kamiński, Karol, Moghadasin, Maryam, Seedat, Soraya, Matthews, Evan, Wells, John, Vassilopoulou, Emilia, Gadelha, Ary, Su, Kuan-Pin, Kwon, Jun Soo, Kim, Minah, Lee, Tae Young, Papsuev, Oleg, Manková, Denisa, Boscutti, Andrea, Gerunda, Cristiano, Saccon, Diego, Righi, Elena, Monaco, Francesco, Croatto, Giovanni, Cereda, Guido, Demurtas, Jacopo, Brondino, Natascia, Veronese, Nicola, Enrico, Paolo, Politi, Pierluigi, Ciappolino, Valentina, Pfennig, Andrea, Bechdolf, Andreas, Meyer-Lindenberg, Andreas, Kahl, Kai, Domschke, Katharina, Bauer, Michael, Koutsouleris, Nikolaos, Winter, Sibylle, Borgwardt, Stefan, Bitter, Istvan, Balazs, Judit, Czobor, Pal, Unoka, Zsolt, Mavridis, Dimitris, Tsamakis, Konstantinos, Bozikas, Vasilios, Tunvirachaisakul, Chavit, Maes, Michael, Rungnirundorn, Teerayuth, Supasitthumrong, Thitiporn, Haque, Ariful, Brunoni, Andre, Costardi, Carlos Gustavo, Schuch, Felipe Barreto, Polanczyk, Guilherme, Luiz, Jhoanne Merlyn, Fonseca, Lais, Aparicio, Luana, Valvassori, Samira, Nordentoft, Merete, Vendsborg, Per, Hoffmann, Sofie Have, Sehli, Jihed, Sartorius, Norman, Heuss, Sabina, Guinart, Daniel, Hamilton, Jane, Kane, John, Rubio, Jose, Sand, Michael, Koyanagi, Ai, Solanes, Aleix, Andreu-Bernabeu, Alvaro, Cáceres, Antonia San José, Arango, Celso, Díaz-Caneja, Covadonga, Hidalgo-Mazzei, Diego, Vieta, Eduard, Gonzalez-Peñas, Javier, Fortea, Lydia, Parellada, Mara, Fullana, Miquel, Verdolini, Norma, Fárková, Eva, Janků, Karolina, Millan, Mark, Honciuc, Mihaela, Moniuszko-Malinowska, Anna, Łoniewski, Igor, Samochowiec, Jerzy, Kiszkiel, Łukasz, Marlicz, Maria, Sowa, Paweł, Marlicz, Wojciech, Spies, Georgina, Stubbs, Brendon, Firth, Joseph, Sullivan, Sarah, Darcin, Asli Enez, Aksu, Hatice, Dilbaz, Nesrin, Noyan, Onur, Kitazawa, Momoko, Kurokawa, Shunya, Tazawa, Yuki, Anselmi, Alejandro, Cracco, Cecilia, Machado, Ana Inés, Estrade, Natalia, de Leo, Diego, Curtis, Jackie, Berk, Michael, Ward, Philip, Teasdale, Scott, Rosenbaum, Simon, Marx, Wolfgang, Horodnic, Adrian Vasile, Oprea, Liviu, Alexinschi, Ovidiu, Ifteni, Petru, Turliuc, Serban, Ciuhodaru, Tudor, Bolos, Alexandra, Matei, Valentin, Nieman, Dorien, Sommer, Iris, van Os, Jim, van Amelsvoort, Therese, Sun, Ching-Fang, Guu, Ta-Wei, Jiao, Can, Zhang, Jieting, Fan, Jialin, Zou, Liye, Yu, Xin, Chi, Xinli, de Timary, Philippe, van Winke, Ruud, Ng, Bernardo, Pena, Edilberto, Arellano, Ramon, Roman, Raquel, Sanchez, Thelma, Movina, Larisa, Morgado, Pedro, Brissos, Sofia, Aizberg, Oleg, Mosina, Anna, Krinitski, Damir, Mugisha, James, Sadeghi-Bahmani, Dena, Sadeghi, Masoud, Hadi, Samira, Brand, Serge, Errazuriz, Antonia, Crossley, Nicolas, Ristic, Dragana Ignjatovic, López-Jaramillo, Carlos, Efthymiou, Dimitris, Kuttichira, Praveenlal, Kallivayalil, Roy Abraham, Javed, Afzal, Afridi, Muhammad Iqbal, James, Bawo, Seb-Akahomen, Omonefe Joy, Fiedorowicz, Jess, Carvalho, Andre, Daskalakis, Jeff, Yatham, Lakshmi, Yang, Lin, Okasha, Tarek, Dahdouh, Aïcha, Gerdle, Björn, Tiihonen, Jari, Shin, Jae Il, Lee, Jinhee, Mhalla, Ahmed, Gaha, Lotfi, Brahim, Takoua, Altynbekov, Kuanysh, Negay, Nikolay, Nurmagambetova, Saltanat, Jamei, Yasser Abu, Weiser, Mark, Correll, Christoph, Thygesen, Lau, Kwon, Jun, Lee, Tae, Costardi, Carlos, Schuch, Felipe, Luiz, Jhoanne, Hoffmann, Sofie, Cáceres, Antonia, Darcin, Asli, Machado, Ana, Horodnic, Adrian, Ristic, Dragana, Kallivayalil, Roy, Afridi, Muhammad, Seb-Akahomen, Omonefe, Shin, Jae, Jamei, Yasser, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Movement Disorder (MD), Solmi, M., Estradé, A., Thompson, T., Agorastos, A., Radua, J., Cortese, S., Dragioti, E., Leisch, F., Vancampfort, D., Thygesen, L.C., Aschauer, H., Schloegelhofer, M., Akimova, E., Schneeberger, A., Huber, C.G., Hasler, G., Conus, P., Cuénod, K.Q.D., von Känel, R., Arrondo, G., Fusar-Poli, P., Gorwood, P., Llorca, P.-M., Krebs, M.-O., Scanferla, E., Kishimoto, T., Rabbani, G., Skonieczna-Żydecka, K., Brambilla, P., Favaro, A., Takamiya, A., Zoccante, L., Colizzi, M., Bourgin, J., Kamiński, K., Moghadasin, M., Seedat, S., Matthews, E., Wells, J., Vassilopoulou, E., Gadelha, A., Su, K.-P., Kwon, J.S., Kim, M., Lee, T.Y., Papsuev, O., Manková, D., Boscutti, A., Gerunda, C., Saccon, D., Righi, E., Monaco, F., Croatto, G., Cereda, G., Demurtas, J., Brondino, N., Veronese, N., Enrico, P., Politi, P., Ciappolino, V., Pfennig, A., Bechdolf, A., Meyer-Lindenberg, A., Kahl, K.G., Domschke, K., Bauer, M., Koutsouleris, N., Winter, S., Borgwardt, S., Bitter, I., Balazs, J., Czobor, P., Unoka, Z., Mavridis, D., Tsamakis, K., Bozikas, V.P., Tunvirachaisakul, C., Maes, M., Rungnirundorn, T., Supasitthumrong, T., Haque, A., Brunoni, A.R., Costardi, C.G., Schuch, F.B., Polanczyk, G., Luiz, J.M., Fonseca, L., Aparicio, L.V., Valvassori, S.S., Nordentoft, M., Vendsborg, P., Hoffmann, S.H., Sehli, J., Sartorius, N., Heuss, S., Guinart, D., Hamilton, J., Kane, J., Rubio, J., Sand, M., Koyanagi, A., Solanes, A., Andreu-Bernabeu, A., Cáceres, A.S.J., Arango, C., Díaz-Caneja, C.M., Hidalgo-Mazzei, D., Vieta, E., Gonzalez-Peñas, J., Fortea, L., Parellada, M., Fullana, M.A., Verdolini, N., Fárková, E., Janků, K., Millan, M., Honciuc, M., Moniuszko-Malinowska, A., Łoniewski, I., Samochowiec, J., Kiszkiel, Ł., Marlicz, M., Sowa, P., Marlicz, W., Spies, G., Stubbs, B., Firth, J., Sullivan, S., Darcin, A.E., Aksu, H., Dilbaz, N., Noyan, O., Kitazawa, M., Kurokawa, S., Tazawa, Y., Anselmi, A., Cracco, C., Machado, A.I., Estrade, N., De Leo, D., Curtis, J., Berk, M., Ward, P., Teasdale, S., Rosenbaum, S., Marx, W., Horodnic, A.V., Oprea, L., Alexinschi, O., Ifteni, P., Turliuc, S., Ciuhodaru, T., Bolos, A., Matei, V., Nieman, D.H., Sommer, I., van Os, J., van Amelsvoort, T., Sun, C.-F., Guu, T.-W., Jiao, C., Zhang, J., Fan, J., Zou, L., Yu, X., Chi, X., de Timary, P., van Winke, R., Ng, B., Pena, E., Arellano, R., Roman, R., Sanchez, T., Movina, L., Morgado, P., Brissos, S., Aizberg, O., Mosina, A., Krinitski, D., Mugisha, J., Sadeghi-Bahmani, D., Sadeghi, M., Hadi, S., Brand, S., Errazuriz, A., Crossley, N., Ristic, D.I., López-Jaramillo, C., Efthymiou, D., Kuttichira, P., Kallivayalil, R.A., Javed, A., Afridi, M.I., James, B., Seb-Akahomen, O.J., Fiedorowicz, J., Carvalho, A.F., Daskalakis, J., Yatham, L.N., Yang, L., Okasha, T., Dahdouh, A., Gerdle, B., Tiihonen, J., Shin, J.I., Lee, J., Mhalla, A., Gaha, L., Brahim, T., Altynbekov, K., Negay, N., Nurmagambetova, S., Jamei, Y.A., Weiser, M., Correll, C.U., Adult Psychiatry, APH - Mental Health, ANS - Compulsivity, Impulsivity & Attention, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Martinez Rico, Clara, Clinique des maladies mentales et de l'encéphale (CMME - Service de psychiatrie), Hôpital Sainte-Anne-Université Paris Cité (UPCité), GHU Paris Psychiatrie et Neurosciences, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Clermont-Ferrand, Pathologies et épithéliums : prévention, innovation, traitements, évaluation (UR 4267) (PEPITE), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
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Gerontology ,DISORDER ,[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Psychological intervention ,Physical health ,Adolescents ,HV ,Children ,Covid-19 ,Mental health ,Pandemic ,Resilience ,RA0421 ,Medicine ,Adolescent ,Adult ,Child ,Cross-Sectional Studies ,Health Promotion ,Humans ,Mental Health ,Pandemics ,Quality of Life ,SARS-CoV-2 ,COVID-19 ,SCALE ,media_common ,Psychiatry ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Public Health, Global Health, Social Medicine and Epidemiology ,Psychiatry and Mental health ,Clinical Psychology ,Professional association ,Psychological resilience ,Life Sciences & Biomedicine ,Psychopathology ,Covid-19, Pandemic, Mental health, Physical health, Resilience, Children, Adolescents ,media_common.quotation_subject ,Clinical Neurology ,BF ,Article ,Quality of life (healthcare) ,Intervention (counseling) ,VALIDITY ,Science & Technology ,business.industry ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Neurosciences & Neurology ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
BACKGROUND: The COVID-19 pandemic has altered daily routines and family functioning, led to closing schools, and dramatically limited social interactions worldwide. Measuring its impact on mental health of vulnerable children and adolescents is crucial. METHODS: The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT - www.coh-fit.com) is an on-line anonymous survey, available in 30 languages, involving >230 investigators from 49 countries supported by national/international professional associations. COH-FIT has thee waves (until the pandemic is declared over by the WHO, and 6-18 months plus 24-36 months after its end). In addition to adults, COH-FIT also includes adolescents (age 14-17 years), and children (age 6-13 years), recruited via non-probability/snowball and representative sampling and assessed via self-rating and parental rating. Non-modifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to promote health and prevent mental and physical illness in children and adolescents will be generated by COH-FIT. Co-primary outcomes are changes in well-being (WHO-5) and a composite psychopathology P-Score. Multiple behavioral, family, coping strategy and service utilization factors are also assessed, including functioning and quality of life. RESULTS: Up to June 2021, over 13,000 children and adolescents from 59 countries have participated in the COH-FIT project, with representative samples from eleven countries. LIMITATIONS: Cross-sectional and anonymous design. CONCLUSIONS: Evidence generated by COH-FIT will provide an international estimate of the COVID-19 effect on children's, adolescents' and families', mental and physical health, well-being, functioning and quality of life, informing the formulation of present and future evidence-based interventions and policies to minimize adverse effects of the present and future pandemics on youth. ispartof: JOURNAL OF AFFECTIVE DISORDERS vol:299 pages:367-376 ispartof: location:Netherlands status: published
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- 2022
45. The Validity and Reliability of the PHQ-9 and PHQ-2 on Screening for Major Depression in Spanish Speaking Immigrants in Chile: A Cross-Sectional Study
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Antonia Errazuriz, Rodrigo Beltrán, Rafael Torres, and Alvaro Passi-Solar
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Adult ,Depressive Disorder, Major ,Psychometrics ,Depression ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Reproducibility of Results ,Emigrants and Immigrants ,Patient Health Questionnaire ,Cross-Sectional Studies ,Surveys and Questionnaires ,Humans ,Mass Screening ,depression ,patient health questionnaire ,Composite International Diagnostic Interview ,population-based sample ,immigrant mental health ,Chile ,Child - Abstract
Background: The study aimed to explore the psychometric properties of two versions of the Patient Health Questionnaires (PHQ-9 and PHQ-2) on screening for Major Depressive Disorder (MDD) among Spanish-speaking Latin American adult immigrants in Santiago, and to explore factors associated with a higher risk of occurrence of MDD among them. Methods: A representative sample of 897 Spanish-speaking immigrants completed the PHQ-9. The Composite International Diagnostic Interview (CIDI) was employed to evaluate MDD. Internal consistency and structural validity were evaluated using Cronbach’s α coefficient and confirmatory factor analysis (CFA). Convergent validity with the 7-item General Anxiety Disorder Scale (GAD-7) was assessed using Spearman’s correlations. Sensitivity, specificity, positive predictive values, and area under the receiver operating characteristic (ROC) curve were calculated for different cut-off points. Logistic regression analysis was used to identify factors associated with the risk of MDD. Results: Cronbach’s α coefficient of the PHQ-9 was 0.90; item-total correlation coefficients ranged from 0.61 to 0.76 and correlation with the GAD-7 was moderate (r = 0.625; p < 0.001). CFA on three alternative models suggests a plausible fit in the overall sample and among two of the subsamples: Peruvians and Venezuelans. Taking the results of CIDI as the gold standard for MDD, the area under the ROC curve was 0.91 (95% confidence interval (CI): 0.83~1.0). When the cut-off score was equal to 5, values of sensitivity, specificity, and Youden’s index were 0.85, 0.90, and 0.75, respectively. Multivariate logistic regression analyses showed that the influence of having three or more children (OR = 3.91, 95% CI: 1.20~12.81; p < 0.05), residency in Chile of up to three years (OR = 1.79, 95% CI: 1.07~3.00; p < 0.05), active debt (OR = 2.74, 95% CI: 1.60~4.70; p < 0.001), a one (OR = 2.01, 95% CI: 1.03~3.94; p < 0.05) and two or more events of adversity during childhood (OR = 5.25, 95% CI: 1.93~14.3; p < 0.01) on the occurrence of MDD was statistically significant. Reliability (α = 0.62), convergent (r = 0.534; p < 0.01) and criterion (AUC = 0.85, 95% CI: 0.67~1.00) validity coefficients of the PHQ-2 were weaker than for the PHQ-9. Conclusions: The PHQ-2 and the PHQ-9 are reliable and valid instruments for use as screeners for MDD among Spanish-speaking populations of Latin America.
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- 2022
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46. Incidental venous thromboembolism detected by PET-CT in patients with cancer: Prevalence and impact on survival rate
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Callejas, Matías F., Errázuriz, Juan I., Castillo, Felipe, Otárola, Claudia, Riquelme, Carlos, Ortega, Claudia, Huete, Álvaro, and Bächler, Pablo
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- 2014
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47. Scapular balance angle reference values in a healthy population
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Contreras, J., Gil, D., de Dios Errázuriz, J., Ruiz, P., Díaz, C., Águila, P., Rosselot, A., Espinoza, R., Beltrán, M., Liendo, R., and Soza, F.
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- 2014
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48. THE PERFORMATIVE CONTRADICTION AS AN ARGUMENTATIVE DEVICE: AN ANALYSIS OF ITS REACH AND SCOPE
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Errázuriz, José Antonio
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- 2014
49. A Longitudinal Study of the Relation between Depressive Symptomatology and Parenting Practices
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Arellano, Paula A. Errazuriz, Harvey, Elizabeth A., and Thakar, Dhara A.
- Abstract
This longitudinal study examined whether mothers' depressive symptomatology predicted parenting practices in a sample of 199 mothers of 3-year-old children with behavior problems who were assessed yearly until age 6. Higher maternal depressive symptoms were associated with higher overreactivity and laxness and lower warmth when children were 6 years old. Higher maternal depressive symptoms were also related to increases in overreactivity across the preschool years. Moreover, depression and parenting practices (overreactivity and laxness) covaried over time within mothers. These results provide evidence of a strong link between maternal depression and parenting during the preschool years.
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- 2012
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50. Predicting Attention-Deficit/Hyperactivity Disorder and Oppositional Defiant Disorder from Preschool Diagnostic Assessments
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Harvey, Elizabeth A., Youngwirth, Sara D., Thakar, Dhara A., and Errazuriz, Paula A.
- Abstract
The present study examined the power of measures of early preschool behavior to predict later diagnoses of attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD)/conduct disorder (CD). Participants were 168 children with behavior problems at age 3 who underwent a multimethod assessment of ADHD and ODD symptoms and were followed annually for 3 years. Fifty-eight percent of 3-year-old children with behavior problems met criteria for ADHD and/or ODD/CD 3 years later. Using a diagnostic interview and rating scales at age 3, the authors could accurately predict later diagnostic status for 3/4 of children for ADHD and for 2/3 of children for ODD/CD. Predictive power of the best models did not increase significantly at age 4 and age 5 compared with age 3. Results provide support for the validity of early diagnoses of ADHD, although caution is needed in making diagnoses because a significant minority of children with early hyperactivity and inattention do outgrow their problems. (Contains 3 footnotes and 3 tables.)
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- 2009
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