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118 results on '"Ewing, William R."'

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1. Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer

2. Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities

7. Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability

12. Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor.

14. Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency

16. meta‐Selective C−H Arylation of Fluoroarenes and Simple Arenes.

17. PdII‐Catalyzed Enantioselective C(sp3)–H Arylation of Cyclobutyl Ketones Using a Chiral Transient Directing Group.

26. β‐Selective C−H Arylation of Electron‐Deficient Thiophenes, Pyrroles, and Furans.

29. Selective C−H Halogenation with a Highly Fluorinated Manganese Porphyrin.

34. Design and synthesis of tetrazole-based growth hormone secretagogue: The SAR studies of the O-benzyl serine side chain

35. Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series

43. Cannabinoid CB1 receptor ligand binding and function examined through mutagenesis studies of F200 and S383

44. Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.

45. Ligand Enabled Pd(II)-Catalyzed γ-C(sp 3 )-H Lactamization of Native Amides.

46. Site-Selective Functionalization of Methionine Residues via Photoredox Catalysis.

47. meta-Selective C-H Arylation of Fluoroarenes and Simple Arenes.

48. Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.

49. Pd II -Catalyzed Enantioselective C(sp 3 )-H Arylation of Cyclobutyl Ketones Using a Chiral Transient Directing Group.

50. Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis.

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