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Copyright of Polimery is the property of Industrial Chemistry Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Polimery is the property of Industrial Chemistry Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction. Failure to perform surgical repair of varicocele before puberty is among the common causes of male infertility. The purpose of this study was to evaluate the testicular volume and fertility potential in men after laparoscopic varicocelectomy conducted in adolescence due to varicocele and concomitant testicular hypotrophy. Material and methods. From 1996 through 2011, eighty-two adolescents were operated on for unilateral primary varicocele with testicular hypotrophy. Sixty-eight patients were subject to the current analysis. The age of the patients was 13 to 17 years (mean 15.3 years). Clinical diagnosis was established on the basis of andrologic examination and ultrasonography with an assessment of testicular size and varicocele severity. Laparoscopic surgical repair was performed by a transperitoneal approach with division of testicular vein only. Results. An increase in left testicular volume when compared with the contralateral testis was found in 25 (78.1%) young men with clinical grade 2 varicocele (p = 0.02) and in 32 (88.8%) subjects with grade 3 abnormality (p = 0.04). An increase in left testicular volume was found in 46 (85.1%) of 54 patients with unilateral varicocele and in 12 (85.7%) of 14 subjects operated on for bilateral disease. A left testicular volume increase was comparable independent of the use of uni- or bilateral repair. Fifty-eight (85.2%) of our 68 patients had normozoospermia. Conclusions. Laparoscopic varicocele repair resulted in a significant increase of hypotrophic testicular volume in 83.8% of our subjects. [ABSTRACT FROM AUTHOR]

Introduction. The clinical significance of biochemical recurrence (BCR) after radical prostatectomy (RP) due to prostate cancer (PCa) is not unambiguous, sometimes being independent from the real progression. BCR is followed by a greater risk of adverse events and almost always results with the necessity for implementation of adjuvant therapy (AT). The aim of the following study was to examine the impact of AT in patients with BCR together with PCa progression and mortality 5-years after RP. Material and methods. Two hundred forty-seven patients after RP, who were treated in the period from 1995 to 2009, underwent the retrospective analysis. They were divided into three groups according to the applied AT after prior BCR diagnosis. The first group (n - 39) included patients treated with radiotherapy, along with hormonotherapy. The second group (n - 63) covers patients receiving hormonotherapy only. The third group (n - 145) consists of patients without BCR. Five-year general and disease-specific survival was evaluated and choice prognostic factors were compared. Results. Five-year overall survival was 74.2% in group I, 88.3% in group II, and 98.7% in group III. Diseasespecific survival was: 76.9%, 90.5%, and 100% (p = 0.001), respectively. BCR was diagnosed in 102 (41.5%) patients; while in another 24 (23.5%) of them progression was diagnosed after the AT was applied. Conclusions. The risk of BCR 5-years after RP is greater in patients with high initial concentration of PSA, higher Gleason score, and clinical advancement. Five-year overall and disease-specific survivals are higher among patients after hormonotherapy alone compared to those after both radio- and hormonotherapy. [ABSTRACT FROM AUTHOR]

Introduction. An evaluation of prostate cancer progression in group 1 (n - 30) with simultaneous prostate cancer (PCa) and premalignant lesions (PL) in comparison with group 2 (n - 159) with prostate cancer alone was carried out. Materials and methods. All patients underwent radical prostatectomy (RP). The assessment consisted of PSA levels, Gleason score (Gs), clinical staging, percentage of multifocal tumors, and tumor volume in both groups. Postoperative follow-up was evaluated: including clinical recurrence and biochemical recurrence (BCR) rate, metastases, and cancer specific deaths. Results. Sixty percent of patients in group 1 had clinically insignificant prostate cancer. Although in this group PSA levels, Gs, and tumor staging were statistically lower. Tumor progression was similar to group 2. A considerably prevalent presence of multifocal tumors in group 1 did not result in their greater volume. [ABSTRACT FROM AUTHOR]

Introduction. The increasing number of benign and non-cancerous tumors has resulted in the common use of NSS for the treatment of pT1 tumors. However, this kind of treatment did not reduce the number of unnecessary operations. Material and methods. Two-hundred nineteen patients with pT1 tumors treated with NSS were analyzed retrospectively. The mean time of observation was 77.9 months. The patients were divided into groups depending on tumor size and the degree of cellular differentiation of the tumor - DCTD (according to Fuhrman). Results. Statistical analysis revealed that an increase in tumor diameter accompanied a decrease in the percentage of patients with tumors staged pT1 as well as those graded G1 and G0 (according to Fuhrmann). Mean survival time also decreases. While the percentage of tumors graded G3, those staged pT3, unconventional varieties of renal cell carcinoma (RCC), local recurrence, as well as renal insufficiency all increase together with increases in tumor diameter. Conclusions. In patients with tumors up to 3 cm, the risk of surgical overtreatment increases. In patients with pT1 increases: the risk of unconventional varieties of RCC, cancerous progression, and death along with the increase in the size of the tumor and DCTD. Along with the size of pT1 tumors, a decrease in the number of benign and non-cancerous tumors as well as 5-years survival after NSS is observed. The dynamics of cancerous changes in the tumors up to 2 cm is similar to the dynamics observed in the tumors up to 3 cm, whereas those of 4 cm act similarly as the tumors of 5 cm diameter. [ABSTRACT FROM AUTHOR]

Introduction. Lower testosterone (T) and higher estrogen (E) concentrations in obese men associated with aggravation, delay of detection, and adequate treatment of prostate carcinoma (PCa) make BMI an independent factor influencing the outcomes of its treatment. The aim of this study was the clinical assessment of the influence of BMI depending on preoperative PSA concentration on PCa progression, continence, and erectile dysfunction in 214 patients after radical retropubic prostatectomy. Material and methods. The group of 214 patients after radical suprapubic prostatectomy was divided into 3 subgroups depending on increasing PSA concentration and into 2 subgroups depending on nerve sparing surgery. The group of 168 patients was divided into 3 subgroups depending on BMI and progression continence and erectile dysfunction were also assessed. Results. Preoperative PSA concentration significantly influences the postoperative Gleason score and PCa progression. BMI does not influence PCa progression. Neither BMI nor preoperative PSA concentration influenced continence and erectile dysfunction in patients after radical suprapubic prostatectomy. Conclusions. 1. Preoperative PSA concentration affects postoperative Gleason score, biochemical recurrence, and metastases, but does not influence continence or erectile function. 2. BMI does not correlate with preoperative PSA concentration, postoperative Gleason score, progression, continence, or erectile function. 3. Radical retropubic prostatectomy with nerve sparing impacts on decreased percentage of continence and erectile dysfunction, but it is not proportional improvement. [ABSTRACT FROM AUTHOR]

The hydrophobisation of cellulose can be achieved by the treatment of wood fibers with aluminum sulfate and sodium salts of fatty acids. The purpose of the study was to determine the effect of various factors on the resultant hydrophobicity. The investigated variables were fatty acid chemistry and reaction conditions. The hydrophobic property was assessed indirectly by quantifying the wettability of cellulosic material (contact angle) and water retention value (WRV). [ABSTRACT FROM AUTHOR]

Copyright of Fibres & Textiles in Eastern Europe is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Fibres & Textiles in Eastern Europe is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: This study aimed to demonstrate the clinical equivalence of biosimilar QL1205 and reference ranibizumab, Lucentis, in patients with neovascular age-related macular degeneration (nAMD)., Design: This was a multicenter, double-masked, randomized, controlled phase III trial., Participants: Treatment-naive patients with active nAMD were randomly assigned to receive QL1205 or reference ranibizumab., Methods: Patients received intravitreal injection of QL1205 or reference ranibizumab at a dose of 0.5 mg in the study eye once every 4 weeks for 48 weeks., Main Outcome Measures: The primary end point was change in best-corrected visual acuity (BCVA) by ETDRS letters at week 8 compared with baseline level. Biosimilarity of QL1205 to reference ranibizumab was assessed with an equivalence range for the difference in BCVA letters between -3.49 and +3.49., Results: Between June 27, 2019 and June 8, 2021, 616 patients were randomized to the QL1205 group (n = 308) and the reference ranibizumab group (n = 308). The mean improvement of BCVA was +6.3 ± 9.13 ETDRS letters in the QL1205 group and +7.3 ± 8.82 ETDRS letters in the reference ranibizumab group at week 8. Both the 90% confidence interval (CI, -2.23 to 0.13) and 95% CI (-2.46 to 0.36) of the difference between the 2 treatment groups (P = 0.1434) were within the predefined equivalence range. Safety profiles were manageable in both groups., Conclusions: QL1205 was biosimilar to reference ranibizumab regarding clinical efficacy, ocular and systemic safety, as well as immunogenicity and pharmacokinetics profiles in the treatment of patients with nAMD., Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article., (Copyright © 2024. Published by Elsevier Inc.)