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3 results on '"Fabíola Silva Garcia Praça"'

1. A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids in Solanum lycocarpum and Its Extracts

Author

Renata Fabiane Jorge Tiossi, Mariza Abreu Miranda, João Paulo Barreto de Sousa, Fabíola Silva Garcia Praça, Maria Vitória Lopes Badra Bentley, James Dewey McChesney, and Jairo Kenupp Bastos

Subjects
Analytical chemistry, QD71-142
Abstract

Solanum lycocarpum (Solanaceae) is native to the Brazilian Cerrado. Fruits of this species contain the glycoalkaloids solasonine (SN) and solamargine (SM), which display antiparasitic and anticancer properties. A method has been developed for the extraction and HPLC-UV analysis of the SN and SM in different parts of S. lycocarpum, mainly comprising ripe and unripe fruits, leaf, and stem. This analytical method was validated and gave good detection response with linearity over a dynamic range of 0.77–1000.00 μg mL−1 and recovery in the range of 80.92–91.71%, allowing a reliable quantitation of the target compounds. Unripe fruits displayed higher concentrations of glycoalkaloids (1.04% ± 0.01 of SN and 0.69% ± 0.00 of SM) than the ripe fruits (0.83% ± 0.02 of SN and 0.60% ± 0.01 of SM). Quantitation of glycoalkaloids in the alkaloidic extract gave 45.09% ± 1.14 of SN and 44.37% ± 0.60 of SM, respectively.

Published
2012
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2. Nanotechnology approaches in the current therapy of skin cancer

Author

Angelo Luis Caron, Ana Vitoria Pupo Silvestrini, Maria Vitória Lopes Badra Bentley, Marcelo Kravicz, Fabíola Silva Garcia Praça, Lívia Neves Borgheti-Cardoso, Juliana Santos Rosa Viegas, Borgheti-Cardoso, L, Viegas, J, Silvestrini, A, Caron, A, Praça, F, Kravicz, M, and Bentley, M

Subjects
Skin Neoplasms, Surface Properties, Skin Absorption, Bioactive molecules, medicine.medical_treatment, Drug delivery system, Cancer therapy, Metal Nanoparticles, Pharmaceutical Science, Antineoplastic Agents, Nanotechnology, Context (language use), 02 engineering and technology, Disease, Administration, Cutaneous, Nanocarrier design, 03 medical and health sciences, Gene therapy, Multifunctional delivery system, Nonmelanoma skin cancer, Skin Physiological Phenomena, Humans, Medicine, Skin cancer, Particle Size, Melanoma, Càncer de pell, 030304 developmental biology, Drug Carriers, 0303 health sciences, business.industry, Nanotecnologia, Melanoma skin cancer, Immunotherapy, 021001 nanoscience & nanotechnology, medicine.disease, Dacarbazine, Drug Resistance, Neoplasm, IMUNOTERAPIA, Nanoparticles, Fluorouracil, Gold, 0210 nano-technology, business
Abstract

Skin cancer is a high burden disease with a high impact on global health. Conventional therapies have several drawbacks; thus, the development of effective therapies is required. In this context, nanotechnology approaches are an attractive strategy for cancer therapy because they enable the efficient delivery of drugs and other bioactive molecules to target tissues with low toxic effects. In this review, nanotechnological tools for skin cancer will be summarized and discussed. First, pathology and conventional therapies will be presented, followed by the challenges of skin cancer therapy. Then, the main features of developing efficient nanosystems will be discussed, and next, the most commonly used nanoparticles (NPs) described in the literature for skin cancer therapy will be presented. Subsequently, the use of NPs to deliver chemotherapeutics, immune and vaccine molecules and nucleic acids will be reviewed and discussed as will the combination of physical methods and NPs. Finally, multifunctional delivery systems to codeliver anticancer therapeutic agents containing or not surface functionalization will be summarized.

Published
2020

3. Lycopene from tomatoes: vesicular nanocarrier formulations for dermal delivery

Author

Conceição Santos, Olga Silva, Fabíola Silva Garcia Praça, Sónia Pinho, Sandra Simões, Maria Vitória Lopes Badra Bentley, Helena Oliveira, Carla Eleutério, and Andreia Ascenso

Subjects
Keratinocytes, Transfersomes, Ear swelling, Chemistry, Pharmaceutical, Cytotoxicity, Anti-Inflammatory Agents, Positive control, Iycopene, Administration, Cutaneous, Antioxidants, Mice, chemistry.chemical_compound, Drug Delivery Systems, Lycopene, Solanum lycopersicum, In vivo, Cell Line, Tumor, Cellular uptake, Animals, Humans, Experimental work, Inflammation, Drug Carriers, Chromatography, Anthralin-induced dermatitis, Plant Extracts, Chemistry, Extraction (chemistry), Ethosomes, General Chemistry, Extraction method, Carotenoids, DERMATITE, Biochemistry, Female, Extraction methods, Nanocarriers, General Agricultural and Biological Sciences
Abstract

Submitted by Patrícia Correia (patriciacorreia@ua.pt) on 2018-10-09T14:46:08Z No. of bitstreams: 1 Ascenso et al. - 2013 - Lycopene from Tomatoes Vesicular Nanocarrier Form.pdf: 1101334 bytes, checksum: c4285248f72fd6ee71283a8015c6cbce (MD5) Approved for entry into archive by Patrícia Correia (patriciacorreia@ua.pt) on 2018-10-09T14:51:09Z (GMT) No. of bitstreams: 1 Ascenso et al. - 2013 - Lycopene from Tomatoes Vesicular Nanocarrier Form.pdf: 1101334 bytes, checksum: c4285248f72fd6ee71283a8015c6cbce (MD5) Made available in DSpace on 2018-10-09T14:51:10Z (GMT). No. of bitstreams: 1 Ascenso et al. - 2013 - Lycopene from Tomatoes Vesicular Nanocarrier Form.pdf: 1101334 bytes, checksum: c4285248f72fd6ee71283a8015c6cbce (MD5) Previous issue date: 2013 We acknowledge Dr. Joana Tavares and Dr. Daniela Ribeiro from Universidade de Aveiro for technical support with confocal microscopy, Dr. Manuela Gaspar for supporting animal experiments included in this work, Dr. João Pedro Ferreira for the technical support with mass spectrometry experiments, and Prof. Dr. Maria Rosário Bronze for the discussion of the data obtained. published

Published
2013

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