Search

Your search keyword '"Facultad de Ciencias de la Salud [Salta]"' showing total 3 results
Start Over Author "Facultad de Ciencias de la Salud [Salta]" Language english
3 results on '"Facultad de Ciencias de la Salud [Salta]"'

1. WAO-ARIA consensus on chronic cough – Part III

Author

Philip W. Rouadi, Samar A. Idriss, Jean Bousquet, Tanya M. Laidlaw, Cecilio R. Azar, Mona S. Al-Ahmad, Anahi Yañez, Maryam Ali Y. Al-Nesf, Talal M. Nsouli, Sami L. Bahna, Eliane Abou-Jaoude, Fares H. Zaitoun, Usamah M. Hadi, Peter W. Hellings, Glenis K. Scadding, Peter K. Smith, Mario Morais-Almeida, René Maximiliano Gómez, Sandra N. Gonzalez Diaz, Ludger Klimek, Georges S. Juvelekian, Moussa A. Riachy, Giorgio Walter Canonica, David Peden, Gary W.K. Wong, James Sublett, Jonathan A. Bernstein, Lianglu Wang, Luciana K. Tanno, Manana Chikhladze, Michael Levin, Yoon-Seok Chang, Bryan L. Martin, Luis Caraballo, Adnan Custovic, Jose Antonio Ortego-Martell, Olivia J.Ly Lesslar, Erika Jensen-Jarolim, Motohiro Ebisawa, Alessandro Fiocchi, Ignacio J. Ansotegui, Beirut Eye & ENT Specialist Hospital (BESH), Eye & Ear Hospital [Beirut], Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Berlin Institute of Health (BIH), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Brigham and Women’s Hospital [Boston, MA], Harvard Medical School [Boston] (HMS), American University of Beirut Faculty of Medicine and Medical Center (AUB), Middle East Institute of Health, Clemenceau Medical Center (CMC), Kuwait University, Investigaciones en Alergia y Enfermedades Respiratorias (InAER), Hamad Medical Corporation [Doha, Qatar], International Cough Institute (ICI), Louisiana State University (LSU), LAU Medical Center-Rizk Hospital, University Hospitals Leuven [Leuven], Department of Microbiology, Immunology and Transplantation [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Ghent University Hospital, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), The Royal National Throat, Nose and Ear Hospital, Griffith University [Brisbane], Hospital CUF Descobertas, Facultad de Ciencias de la Salud [Salta], Universidad Nacional de Salta (UNSA), Universidad Autonoma de Nuevo Leon [Mexique] (UANL), Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, Saint George Hospital University Medical Center [UOB LIBAN], University of Balamand [Liban] (UOB), Hôtel-Dieu de France (HDF), Université Saint-Joseph de Beyrouth (USJ), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], UNC School of Medicine, The Chinese University of Hong Kong [Hong Kong], University of Louisville School of Medicine, University of Cincinnati College of Medicine, Peking Union Medical College Hospital [Beijing] (PUMCH), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), World Health Organisation (WHO), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Akaki Tsereteli State University, University of Cape Town, Seoul National University Bundang Hospital (SNUBH), The Ohio State University Wexner Medical Center., University of Cartagena, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Universidad Autónoma del Estado de Hidalgo (UAEH), LifeSpan medicine, Medizinische Universität Wien = Medical University of Vienna, Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University of Vienna [Vienna]-University of Vienna [Vienna]-Medical University Vienna, University of Vienna [Vienna]-University of Vienna [Vienna], Sagamihara National Hospital [Kanagawa, Japan], Bambino Gesù Children’s Hospital [Rome, Italy], Hospital Quirónsalud Bizkaia [Bilbao], and Salvy-Córdoba, Nathalie

Subjects
EXHALED NITRIC-OXIDE, Pulmonary and Respiratory Medicine, Cough specialty care, Chronic cough management, Allergy, AIRWAY INFLAMMATION, Upper airway cough syndrome, Immunology, MUCOSAL EOSINOPHILIC INFLAMMATION, GASTROESOPHAGEAL-REFLUX DISEASE, INHALED CORTICOSTEROIDS, Lower airway disease, Speech therapy, QUALITY-OF-LIFE, CHEST GUIDELINE, Immunology and Allergy, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, Neuromodulators, VARIANT ASTHMA, Cough primary care, Science & Technology, CLINICAL-PRACTICE GUIDELINE, Reflux cough, REFRACTORY CHRONIC COUGH, Life Sciences & Biomedicine, [SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology
Abstract

BACKGROUND: Chronic cough management necessitates a clear integrated care pathway approach. Primary care physicians initially encounter the majority of chronic cough patients, yet their role in proper management can prove challenging due to limited access to advanced diagnostic testing. A multidisciplinary approach involving otolaryngologists and chest physicians, allergists, and gastroenterologists, among others, is central to the optimal diagnosis and treatment of conditions which underly or worsen cough. These include infectious and inflammatory, upper and lower airway pathologies, or gastro-esophageal reflux. Despite the wide armamentarium of ancillary testing conducted in cough multidisciplinary care, such management can improve cough but seldom resolves it completely. This can be due partly to the limited data on the role of tests (eg, spirometry, exhaled nitric oxide), as well as classical pharmacotherapy conducted in multidisciplinary specialties for chronic cough. Other important factors include presence of multiple concomitant cough trigger mechanisms and the central neuronal complexity of chronic cough. Subsequent management conducted by cough specialists aims at control of cough refractory to prior interventions and includes cough-specific behavioral counseling and pharmacotherapy with neuromodulators, among others. Preliminary data on the role of neuromodulators in a proof-of-concept manner are encouraging but lack strong evidence on efficacy and safety. OBJECTIVES: The World Allergy Organization (WAO)/Allergic Rhinitis and its Impact on Asthma (ARIA) Joint Committee on Chronic Cough reviewed the recent literature on management of chronic cough in primary, multidisciplinary, and cough-specialty care. Knowledge gaps in diagnostic testing, classical and neuromodulator pharmacotherapy, in addition to behavioral therapy of chronic cough were also analyzed. OUTCOMES: This third part of the WAO/ARIA consensus on chronic cough suggests a management algorithm of chronic cough in an integrated care pathway approach. Insights into the inherent limitations of multidisciplinary cough diagnostic testing, efficacy and safety of currently available antitussive pharmacotherapy, or the recently recognized behavioral therapy, can significantly improve the standards of care in patients with chronic cough. ispartof: WORLD ALLERGY ORGANIZATION JOURNAL vol:15 issue:5 ispartof: location:United States status: published

Published
2022

2. Tooth crown tissue proportions and enamel thickness in Early Pleistocene Homo antecessor molars (Atapuerca, Spain)

Author

Laura Martín-Francés, Laura Rodríguez, Marina Martínez de Pinillos, José María Bermúdez de Castro, Mario Modesto-Mata, María Martinón-Torres, Cecilia García-Campos, Clément Zanolli, Centro Nacional de Investigación sobre la Evolución Humana (CENIEH), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Facultad de Ciencias de la Salud [Salta], and Universidad Nacional de Salta (UNSA)

Subjects
Teeth, Hominids, Early Pleistocene, Neanderthal, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Social Sciences, lcsh:Medicine, 01 natural sciences, Geographical Locations, Pleistocene Epoch, Medicine and Health Sciences, Dentin, 0601 history and archaeology, lcsh:Science, Phylogeny, Neanderthals, Quaternary Period, Multidisciplinary, Crowns, Enamel paint, biology, Fossils, Geology, 06 humanities and the arts, Biological Evolution, Europe, medicine.anatomical_structure, visual_art, visual_art.visual_art_medium, Physical Anthropology, France, Anatomy, [SDU.STU.PG]Sciences of the Universe [physics]/Earth Sciences/Paleontology, Research Article, 010506 paleontology, Pleistocene, Molars, stomatognathic system, Paleoanthropology, biology.animal, medicine, Hominins, Animals, Humans, European Union, Dental Enamel, 0105 earth and related environmental sciences, Paleodontology, Tooth Crown, 060101 anthropology, lcsh:R, Biology and Life Sciences, Paleontology, Geologic Time, Homo antecessor, biology.organism_classification, Molar, stomatognathic diseases, Jaw, Spain, Evolutionary biology, Anthropology, People and Places, Earth Sciences, Cenozoic Era, lcsh:Q, Digestive System, Head
Abstract

International audience; Tooth crown tissue proportions and enamel thickness distribution are considered reliable characters for inferring taxonomic identity, phylogenetic relationships, dietary and behavioural adaptations in fossil and extant hominids. While most Pleistocene hominins display variations from thick to hyper-thick enamel, Neanderthals exhibit relatively thinner. However, the chronological and geographical origin for the appearance of this typical Neanderthal condition is still unknown. The European late Early Pleistocene species Homo antecessor (Gran Dolina-TD6 site, Sierra de Atapuerca) represents an opportunity to investigate the appearance of the thin condition in the fossil record. In this study, we aim to test the hypothesis if H. antecessor molars approximates the Neanderthal condition for tissue proportions and enamel thickness. To do so, for the first time we characterised the molar inner structural organization in this Early Pleistocene hominin taxon (n = 17) and compared it to extinct and extant populations of the genus Homo from African, Asian and European origin (n = 355). The comparative sample includes maxillary and mandibular molars belonging to H. erectus, East and North African Homo, European Middle Pleistocene Homo, Neanderthals, and fossil and extant H. sapiens. We used high-resolution images to investigate the endostructural configuration of TD6 molars (tissue proportions, enamel thickness and distribution). TD6 permanent molars tend to exhibit on average thick absolute and relative enamel in 2D and 3D estimates, both in the complete crown and the lateral enamel. This condition is shared with the majority of extinct and extant hominin sample, except for Neanderthals and some isolated specimens. However, while the total crown percentage of dentine in TD6 globally resembles the low modern values, the lateral crown percentage of dentine tends to be much higher, closer to the Neanderthal signal. Similarly, the H. antecessor molar enamel distribution maps reveal a relative distribution pattern that is more similar to the Neanderthal condition (with the thickest enamel more spread at the periphery of the occlusal basin) rather than that of other fossil specimens and modern humans (with thicker cuspal enamel). Future studies on European Middle Pleistocene populations will provide more insights into the evolutionary trajectory of the typical Neanderthal dental structural organization.

Published
2018

3. International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patients

Author

Janis Ladzins, Gladys Crisante, Ana M. Mejia Jaramillo, Maria I. Jercic, Tatiana Tellez, Alexandre J. DaSilva, Stijn Deborggraeve, Alejandro O. Luquetti, Debbie Nolder, Pilar Zorrilla, Patricio Diosque, Maria Mercedes Monje Rumi, Lúcia Maria da Cunha Galvão, Sergio Sosa Estani, Carlos Robello, Omar Triana Chávez, Faustino Torrico, María Flores, Alejandro G. Schijman, Juan David Ramírez, Néstor Añez, Pedro Yachelini, Mariela Sued, Azzedine Assal, Raul Horacio Lucero, Constança Britto, Inés Zulantay, Gisely Hijar, Christine Aznar, Vincent Veron, Margarita Bisio, Carolina Cura, Ana Maria de Castro, Philippe Büscher, Elsa F. Velazquez, Tomás Duffy, Clara Isabel González, José Eduardo Levi, Frederic Auter, Felipe Guhl, Karla Y. Acosta Viana, Yvonne Qvarnstrom, Graciela Russomando, Liliana Orellana, Zunilda Sanchez Leon, Laboratorio de Biologia Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Instituto de Cálculo [Buenos Aires], Facultad de Ciencias Exactas y Naturales [Buenos Aires] (FCEyN), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA), Grupo Chagas, Universidad de Antioquia = University of Antioquia [Medellín, Colombia], French Blood Services, Coordination Régionale de la Lutte contre le VIH, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Department of parasitic diseases, Centers for Disease Control, Institute of Tropical Medicine [Antwerp] (ITM), Instituto nacional de Salud, Facultad de Medicina, Universidad Nacional del Nordeste [Corrientes] (UNNE), Instituto Nacional de Chagas, Instituto Nacional de Parasitología 'Dr. Mario Fatala Chaben' (INP), Centro universitario de Medicina Tropical, Facultad de Medicina-Universidad Mayor de San Simón [Cochabamba, Bolivie] (UMSS), Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción [Paraguay] (UNA), Faculdade de Farmacia, Faculdade de Farmácia, Department of Clinical Parasitology, Hospital for Tropical Diseases-London School of Hygiene and Tropical Medicine (LSHTM), Instituto de Patología Experimental [Salta], Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias de la Salud [Salta], Universidad Nacional de Salta (UNSA)-Universidad Nacional de Salta (UNSA), Blood Bank, Hospital Sirio Libanes, Centro de Investigaciones en Microbiologia y Parasitologia Tropical, Universidad de los Andes [Bogota] (UNIANDES), Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP), Centro de Mahahonda, Instituto de Salud Carlos III [Madrid] (ISC)-Centro Nacional de Microbiologia, Seccion Parasitologia, Centro de Investigaciones Parasitologicas 'J.F Torrealba', Instituto de Patologia Tropical e Saúde Pública (IPTSP), Universidade Federal de Goiás [Goiânia] (UFG), Grupo de Inmunologia y Epidemiologia Molecular, Universidad Industrial de Santander [Bucaramanga] (UIS)-Facultad de Salud, Departamento de Biomedicina de Enfermedades Infecciosas y Parasitarias, Laboratorio de Biologia Celular, Centro de Investigaciones Regionales 'Dr Hideyo Noguchi'-Universidad Autónoma de Yucatán, Instituto de Biomedicina, Universidad Catolica de Santiago del Estero, Centro Nacional de Diagnostico e Investigacion de Endemoepidemias, Laboratory of Molecular Biology and Diagnosis of Infectious Diseases / Laboratório de Biologia Molecular e Doenças Endêmicas [Rio de Janeiro], Instituto Oswaldo Cruz / Oswaldo Cruz Institute [Rio de Janeiro] (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Laboratorio de pesquisa de Doença de Chagas, Special Programme for Research and Training in Tropical Diseases, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Funding was provided by World Health Organization-Tropical Diseases Research, Panamerican Health Organization (WHO-TDR-PAHO), Universidad de las Naciones Unidas/Biotecnologia para America Latina y el Caribe (UNU-BIOLAC), Consejo Nacional de Ciencias y Tecnologia (CONICET) PIP 112-200801-09215, National Agency of Science and Technology, PICT 33955, Buenos Aires, Argentina., World Health Organization (WHO/OMS), Organización Panamericana de la Salud, United Nations University, and Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina)

Subjects
lcsh:Arctic medicine. Tropical medicine, Enfermedad de chagas, Satellite DNA, lcsh:RC955-962, International Cooperation, Trypanosoma cruzi, 030231 tropical medicine, Consensus PCR, MESH: DNA, Protozoan, MESH: Parasitology, Sensitivity and Specificity, Polymerase Chain Reaction, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, TaqMan, Humans, Chagas Disease, MESH: Chagas Disease, Microbiology/Parasitology, Molecular Biology, Polymerase chain reaction, 0303 health sciences, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, biology, 030306 microbiology, lcsh:Public aspects of medicine, Infectious Diseases/Protozoal Infections, Public Health, Environmental and Occupational Health, MESH: Polymerase Chain Reaction, lcsh:RA1-1270, DNA, Protozoan, biology.organism_classification, DNA extraction, Molecular biology, MESH: Sensitivity and Specificity, 3. Good health, MESH: International Cooperation, Infectious Diseases, Real-time polymerase chain reaction, Infectious Diseases/Neglected Tropical Diseases, Reacción en Cadena de la Polimerasa, Parasitology, Low copy number, MESH: Trypanosoma cruzi, Research Article
Abstract

Background A century after its discovery, Chagas disease still represents a major neglected tropical threat. Accurate diagnostics tools as well as surrogate markers of parasitological response to treatment are research priorities in the field. The purpose of this study was to evaluate the performance of PCR methods in detection of Trypanosoma cruzi DNA by an external quality evaluation. Methodology/Findings An international collaborative study was launched by expert PCR laboratories from 16 countries. Currently used strategies were challenged against serial dilutions of purified DNA from stocks representing T. cruzi discrete typing units (DTU) I, IV and VI (set A), human blood spiked with parasite cells (set B) and Guanidine Hidrochloride-EDTA blood samples from 32 seropositive and 10 seronegative patients from Southern Cone countries (set C). Forty eight PCR tests were reported for set A and 44 for sets B and C; 28 targeted minicircle DNA (kDNA), 13 satellite DNA (Sat-DNA) and the remainder low copy number sequences. In set A, commercial master mixes and Sat-DNA Real Time PCR showed better specificity, but kDNA-PCR was more sensitive to detect DTU I DNA. In set B, commercial DNA extraction kits presented better specificity than solvent extraction protocols. Sat-DNA PCR tests had higher specificity, with sensitivities of 0.05–0.5 parasites/mL whereas specific kDNA tests detected 5.10−3 par/mL. Sixteen specific and coherent methods had a Good Performance in both sets A and B (10 fg/µl of DNA from all stocks, 5 par/mL spiked blood). The median values of sensitivities, specificities and accuracies obtained in testing the Set C samples with the 16 tests determined to be good performing by analyzing Sets A and B samples varied considerably. Out of them, four methods depicted the best performing parameters in all three sets of samples, detecting at least 10 fg/µl for each DNA stock, 0.5 par/mL and a sensitivity between 83.3–94.4%, specificity of 85–95%, accuracy of 86.8–89.5% and kappa index of 0.7–0.8 compared to consensus PCR reports of the 16 good performing tests and 63–69%, 100%, 71.4–76.2% and 0.4–0.5, respectively compared to serodiagnosis. Method LbD2 used solvent extraction followed by Sybr-Green based Real time PCR targeted to Sat-DNA; method LbD3 used solvent DNA extraction followed by conventional PCR targeted to Sat-DNA. The third method (LbF1) used glass fiber column based DNA extraction followed by TaqMan Real Time PCR targeted to Sat-DNA (cruzi 1/cruzi 2 and cruzi 3 TaqMan probe) and the fourth method (LbQ) used solvent DNA extraction followed by conventional hot-start PCR targeted to kDNA (primer pairs 121/122). These four methods were further evaluated at the coordinating laboratory in a subset of human blood samples, confirming the performance obtained by the participating laboratories. Conclusion/Significance This study represents a first crucial step towards international validation of PCR procedures for detection of T. cruzi in human blood samples., Author Summary A century after its discovery, Chagas disease, caused by the parasite Trypanosoma cruzi, still represents a major neglected tropical threat. Accurate diagnostics tools as well as surrogate markers of parasitological response to treatment are research priorities in the field. The polymerase chain reaction (PCR) has been proposed as a sensitive laboratory tool for detection of T. cruzi infection and monitoring of parasitological treatment outcome. However, high variation in accuracy and lack of international quality controls has precluded reliable applications in the clinical practice and comparisons of data among cohorts and geographical regions. In an effort towards harmonization of PCR strategies, 26 expert laboratories from 16 countries evaluated their current PCR procedures against sets of control samples, composed by serial dilutions of T.cruzi DNA from culture stocks belonging to different lineages, human blood spiked with parasite cells and blood samples from Chagas disease patients. A high variability in sensitivities and specificities was found among the 48 reported PCR tests. Out of them, four tests with best performance were selected and further evaluated. This study represents a crucial first step towards device of a standardized operative procedure for T. cruzi PCR.

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results