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2. Colonization and infection due to carbapenemase-producing Enterobacteriaceae in liver and lung transplant recipients and donor-derived transmission: a prospective cohort study conducted in Italy

Author

Farina, C., Vailati, F., Gesu, G., Vismara, C., Arghittu, M., Colombo, R., Torresani, E., Rossi, L., Conaldi, P.G., Gona, F., Cambieri, P., Marone, P., Venditti, C., Fernandez, A. Garcia, Mancini, C., Cusi, M., De Angelis, L. Henrici, Fossati, L., Finarelli, A.C., De Cillia, C., Sangiorgi, G., Pinna, A.D., Stella, F., Viale, P., Colledan, M., Platto, M., Bonizzoli, M., Peris, A., Torelli, R., Vesconi, S., Cibelli, E., De Carlis, L., De Gasperi, A., Ravini, M., Carrinola, R., Coluccio, E., Dondossola, D., Rossi, G., Santambrogio, L., Tosi, D., Feltrin, G., Rago, C., Cillo, U., Da Riva, A., Rea, F., Sparacino, V., Bertani, A., Canzonieri, M., Gridelli, B., Mularoni, A., Spada, M., Carrara, E., D’Armini, A. Maria, Paladini, P., Adorno, D., Valeri, M., Caprio, M., Di Ciaccio, P., Puoti, F., Berloco, P., D’Auria, B., Maldarelli, F., Paglialunga, G., Pugliese, F., Rossi, M., Venuta, F., Amoroso, A., Giacometti, R., Rinaldi, M., Salizzoni, M., Errico, G., Gagliotti, C., Monaco, M., Masiero, L., Gaibani, P., Ambretti, S., Landini, M.P., D’Arezzo, S., Di Caro, A., Parisi, S.G., Palù, G., Vespasiano, F., Morsillo, F., Moro, M.L., Procaccio, F., Ricci, A., Grossi, P.A., Pantosti, A., and Nanni Costa, A.

Published
2019
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19. Infections in liver and lung transplant recipients. A national prospective cohort

Author

Gagliotti, Carlo, Morsillo, Filomena, Moro, Maria Luisa, Masiero, Lucia, Procaccio, Francesco, Vespasiano, Francesca, Pantosti, Annalisa, Monaco, Monica, Errico, Giulia, Ricci, Andrea, Grossi, Paolo, Nanni Costa, Alessandro, Adorno, D., Ambretti, S., Amoroso, A., Arghittu, M., Berloco, P., Bertani, A., Bonizzoli, M., Cambieri, P., Canzonieri, M., Caprio, M., Carrara, E., Carrinola, R., Cibelli, E., Cillo, U., Colledan, M., Colombo, R., Coluccio, E., Conaldi, P. G., Cusi, M., D’Armini, A. M., da Riva, A., D’Auria, B., de Carlis, L., de Cillia, C., de Gasperi, A., Di Caro, A., Di Ciaccio, P., Dondossola, D., Farina, C., Feltrin, G., Finarelli, A. C., Fossati, L., Gaibani, P., Garcia Fernandez, A., Gesu, G., Giacometti, R., Gona, F., Gridelli, B., Henrici de Angelis, L., Landini, M. P., Maldarelli, F., Mancini, C., Marone, P., Mularoni, A., Paglialunga, G., Paladini, P., Palù, G., Parisi, S., Peris, A., Pinna, A. D., Platto, M., Pugliese, F., Puoti, F., Rago, C., Ravini, M., Rea, F., Rinaldi, M., Rossi, G., Rossi, L., Rossi, M., Salizzoni, M., Sangiorgi, G., Santambrogio, L., Spada, M., Sparacino, V., Stella, F., Torelli, R., Torresani, E., Tosi, D., Vailati, F., Valeri, M., Venuta, F., Vesconi, S., Viale, P., Vismara, C., Gagliotti, C, Morsillo, F, Moro, M, Masiero, L, Procaccio, F, Vespasiano, F, Pantosti, A, Monaco, M, Errico, G, Ricci, A, Grossi, P, Nanni Costa, A, Adorno, D, Ambretti, S, Amoroso, A, Arghittu, M, Berloco, P, Bertani, A, Bonizzoli, M, Cambieri, P, Canzonieri, M, Caprio, M, Carrara, E, Carrinola, R, Cibelli, E, Cillo, U, Colledan, M, Colombo, R, Coluccio, E, Conaldi, P, Cusi, M, D’Armini, A, da Riva, A, D’Auria, B, de Carlis, L, de Cillia, C, de Gasperi, A, Di Caro, A, Di Ciaccio, P, Dondossola, D, Farina, C, Feltrin, G, Finarelli, A, Fossati, L, Gaibani, P, Garcia Fernandez, A, Gesu, G, Giacometti, R, Gona, F, Gridelli, B, Henrici de Angelis, L, Landini, M, Maldarelli, F, Mancini, C, Marone, P, Mularoni, A, Paglialunga, G, Paladini, P, Palù, G, Parisi, S, Peris, A, Pinna, A, Platto, M, Pugliese, F, Puoti, F, Rago, C, Ravini, M, Rea, F, Rinaldi, M, Rossi, G, Rossi, L, Rossi, M, Salizzoni, M, Sangiorgi, G, Santambrogio, L, Spada, M, Sparacino, V, Stella, F, Torelli, R, Torresani, E, Tosi, D, Vailati, F, Valeri, M, Venuta, F, Vesconi, S, Viale, P, Vismara, C, Gagliotti, Carlo, Morsillo, Filomena, Moro, Maria Luisa, Masiero, Lucia, Procaccio, Francesco, Vespasiano, Francesca, Pantosti, Annalisa, Monaco, Monica, Errico, Giulia, Ricci, Andrea, Grossi, Paolo, Costa, Alessandro Nanni, Adorno, Domenico, Ambretti, Simone, Amoroso, Antonio, Arghittu, Milena, Berloco, Pasquale, Bertani, Alessandro, Bonizzoli, Manuela, Cambieri, Patrizia, Canzonieri, Marco, Caprio, Mario, Carrara, Elena, Carrinola, Rosaria, Cibelli, Eva, Cillo, Umberto, Colledan, Michele, Colombo, Rosaria, Coluccio, Elena, Conaldi, Pier Giulio, Cusi, Mariagrazia, D’Armini, Andrea Maria, Da Riva, Adelaide, D'Auria, Bianca, De Carlis, Luciano, De Cillia, Carlo, De Gasperi, Andrea, Di Caro, Antonino, Di Ciaccio, Paola, Dondossola, Daniele, Farina, Claudio, Feltrin, Giuseppe, Finarelli, Alba Carola, Fossati, Lucina, Gaibani, Paolo, Fernandez, Aurora Garcia, Gesu, Giovanni, Giacometti, Raffaella, Gona, Floriana, Gridelli, Bruno, De Angelis, Lucia Henrici, Landini, Maria Paola, Maldarelli, Federica, Mancini, Carlo, Marone, Piero, Mularoni, Alessandra, Paglialunga, Giulia, Paladini, Piero, Palù, Giorgio, Parisi, Saverio, Peris, Adriano, Pinna, Antonio Daniele, Platto, Marco, Pugliese, Francesco, Puoti, Francesca, Rago, Claudio, Ravini, Mario, Rea, Federico, Rinaldi, Mauro, Rossi, Giorgio, Rossi, Lucia, Rossi, Massimo, Salizzoni, Mauro, Sangiorgi, Gabriela, Santambrogio, Luigi, Spada, Marco, Sparacino, Vito, Stella, Franco, Torelli, Rosanna, Torresani, Erminio, Tosi, Davide, Vailati, Francesca, Valeri, Maurizio, Venuta, Federico, Vesconi, Sergio, Viale, Pierluigi, and Vismara, Chiara

Subjects
Microbiology (medical), Infectious Diseases, Male, 0301 basic medicine, medicine.medical_treatment, Drug Resistance, Transplant Recipient, 030230 surgery, Liver transplantation, Postoperative Complications, 0302 clinical medicine, Drug Resistance, Multiple, Bacterial, Medicine, Cumulative incidence, Prospective Studies, Prospective cohort study, Incidence, Incidence (epidemiology), Mortality rate, Bacterial, Bacterial Infections, General Medicine, Middle Aged, lung transplant, Anti-Bacterial Agents, infectious, Italy, Female, Multiple, Adult, Bacteria, Humans, Transplant Recipients, Liver Transplantation, Lung Transplantation, Human, medicine.medical_specialty, 030106 microbiology, Bacterial Infection, Infectious Diseases, transplantation, 03 medical and health sciences, Internal medicine, Anti-Bacterial Agent, Lung transplantation, business.industry, lung transplant, liver transplant, infectious, Transplantation, Prospective Studie, liver transplant, Etiology, Postoperative Complication, business, transplantation
Abstract

Infections are a major complication of solid organ transplants (SOTs). This study aimed to describe recipients’ characteristics, and the frequency and etiology of infections and transplant outcome in liver and lung SOTs, and to investigate exposures associated to infection and death in liver transplant recipients. The study population included recipients of SOTs performed in Italy during a 1-year period in ten Italian lung transplant units and eight liver transplant units. Data on comorbidities, infections, retransplantation, and death were prospectively collected using a web-based system, with a 6-month follow-up. The cumulative incidence of infection was 31.7% and 47.8% in liver and lung transplants, respectively, with most infections occurring within the first month after transplantation. Gram-negatives, which were primarily multidrug-resistant, were the most frequent cause of infection. Death rates were 0.42 per 1000 recipient-days in liver transplants and 1.41 per 1000 recipient-days in lung transplants. Infection after SOT in adult liver recipients is associated to an increased risk of death (OR = 13.25; p-value < 0.001). Given the frequency of infection caused by multidrug-resistant microorganisms in SOT recipients in Italy and the heavy impact of infections on the transplant outcome, the reinforcement of surveillance and control activities to prevent the transmission of multidrug-resistant microorganisms in SOT recipients represents a priority. The implementation of the study protocol in liver and lung transplant units and the sharing of results have increased the awareness about the threat due to antimicrobial resistance in the country.

Published
2018

24. Gunshot wounds covered by different textiles: determination of GSR through micro-CT analysis

Author

Cecchetto, G, Amagliani, A, Viel, G, Fais, Paolo, Giraudo, C, Feltrin, G, Ferrara, Sd, Montisci, M., Cecchetto G, Amagliani A, Viel G, Fais P, Giraudo C, Feltrin G, Ferrara SD, and Montisci M

Subjects
firearm wounds, textiles, GSR, Gunshot residue, gunshot wound, Terminal ballistics, micro-CT, firing range, forensic pathology, Forensic Pathology, Gunshot Wounds, Firing Range
Abstract

After attending this presentation, attendees will have novel information on the role of Micro-CT analysis of gunshot wounds for estimating the firing range. This presentation will impact the forensic science community by adding new data on the estimation of the firing distance of intermediate-range gunshot wounds in clothed victims, through a micro-CT analysis of the gunshot residue. Estimation of the firing range is often critical for reconstructing gunshot fatalities, where the main measurable evidence consists of the gunshot residue (GSR). Several techniques and methods have already been used for characterizing GSR, such as Atomic Absorption Spectroscopy, Neutron Activation Analysis, Autoradiography, Routine- CT, Scanning Electron Microscopy, and Histochemistry. Recently, a novel approach, based on the use of Micro-CT, proved to be an objective, reliable, rapid, and inexpensive tool for estimating the firing range in intermediate-range shots. Aim of the Study: It is well known that the presence of clothes covering the body heavily affects the distribution of GSR on the entrance wound, hindering the estimation of the firing range on the basis of the sole macroscopic inspection. The goal of the present study was to evaluate the differential distribution of GSR, with regard to the different kinds of textiles covering the skin, by means of micro-CT analysis, with the final purpose of reconstructing the firing distance. Materials and methods: Human legs, surgically amputated, were cleaned of dried blood and any other contaminants, and cut into sections of approximately 6 cm in length. A total of 60 sections were selected; each section was covered with a single type of textile, chosen among cotton fabric (n = 15), jeans (n = 15), leather (n = 15), and waterproof synthetic fabric (n = 15). Bare skin sections were used as controls (n = 15). Firing was carried out perpendicularly at distances of 5, 15, and 30 cm, using a .32 pistol loaded with full-jacketed bullets. A total of 75 shots were performed (five replicates for each distance). After each firing test, the gunshot wounds were photographed and formalin fixed. The skin specimens, comprising the epidermis, dermis, and subcutaneous fat, were cut into parallelepipeds (height 1 cm, side 1 cm) with a lancet. Samples were scanned following standard processing procedures, using a high resolution scanner. The acquired raw data were reconstructed with reconciliation software, which uses the back-projection algorithm to reconstruct axial subsequent images saved as bitmap format. The bitmap images were analyzed by a CT analysis software: the selected volume of interest. (VOI side of 1 cm and height of 3.8 mm) was focused in the centre of the specimen in order to have the entire entry wound positioned in the middle, All the samples were binarized using the same parameters. The percentage of GSR deposit was calculated analyzing all particles with a density higher than 1000 Hu (particles with a density lower than 1000 Hu were excluded to reduce iron artefacts). The 3D images were reconstructed through a Ct-Vox Software. Results: The visual inspection of the skin did not allow the estimation of the firing distance for the covered gunshot-wounds; the morphological features of the entrance wounds (blackening and tattooing) were, indeed, not discernible. The micro-CT analysis revealed that: - GSR particles were less represented in cases compared to controls; - In cases GSR particles were distributed inside the cavity and the fatty tissue of the entrance wound, while in controls they were present mainly on the skin around the hole; and, - Increasing the firing range, the radiological detection of GSR progressively decreased in both cases and controls, allowing a good discrimination of the firing distances tested in the present study. Conclusions: Micro-CT analysis might be useful for the forensic assessment of the firing range, particularly when the morphological features of intermediate-range wounds are not visually discernible (i.e., black people or clothed victims).

Published
2011

37. Adrenal vein sampling for identification of surgically curable primary aldosteronism: impact of accessory hepatic veins on the selectivity index

Author

Rossi, Gianpaolo, Pitter, G, Seccia, TERESA MARIA, Cavasin, N, DE TONI, R, Vincenzi, M, Pessina, ACHILLE CESARE, Feltrin, G. P., and Miotto, Diego

Subjects
adrenal gland, vasoactive intestinal polypeptide (VIP), aldosterone secretion, pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), PACAP/VIP receptors, adrenal gland, aldosterone secretion, catecholamine secretion, PACAP/VIP receptors, catecholamine secretion
Published
2008

38. The influence of the inflow cannula length in rotary blood pumps on the neurological adverse event rate - Results from a multi-center analysis

Author

Schmid, C, Jurmann, M, Birnbaum, D, Colombo, T, Falk, V, Feltrin, G, Garatti, A, Genoni, M, Gerosa, Gino, Gottel, P, Gummert, J, Halfmann, R, Hammel, D, Hennig, E, Kaufmann, F, Lanfranconi, M, Meyns, B, Mohr, F, Muller, J, Nikolov, D, Rucinskas, K, Scheld, Hh, Schmid, Fx, Schneider, M, Sirvydis, V, Tandler, R, Vitali, E, Vlasselaers, D, Weyand, M, Wilhelm, M, and Hetzer, R.

Published
2008

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