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419 results on '"Fiocca, R."'

2. P301 Non-familial small bowel carcinomas in Crohnʼs disease: clinico-pathological, molecular and prognostic features

Author

Di Sabatino, A., Vanoli, A., Furlan, D., Giuffrida, P., Klersy, C., Grillo, F., Fiocca, R., Mescoli, C., Rugge, M., Nesi, G., Fociani, P., Sampietro, G., Ardizzone, S., Luinetti, O., Calabrò, A., Tonelli, F., Volta, U., Santini, D., Caio, G., Elli, L., Ferrero, S., Latella, G., Ciardi, A., Solina, G., Rizzo, A., Ciacci, C., DʼArmiento, F.P., Salemme, M., Villanacci, V., Cannizzaro, R., Canzonieri, V., Reggiani Bonetti, L., Biancone, L., Monteleone, G., Orlandi, A., Santeusanio, G., Macciomei, M.C., DʼIncà, R., Perfetti, V., Sandri, G., Silano, M., Florena, A.M., Giannone, A.G., Papi, C., Coppola, L., Usai, P., Maccioni, A., Astegiano, M., Migliora, P., Manca, R., Martino, M., Trapani, D., Cerutti, R., Alberizzi, P., Riboni, R., Sessa, F., Paulli, M., Solcia, E., and Corazza, G.R.

Published
2017
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6. OLGA staging for gastritis: A tutorial

Author

Rugge, M., Correa, P., Di Mario, F., El-Omar, E., Fiocca, R., Geboes, K., Genta, R.M., Graham, D.Y., Hattori, T., Malfertheiner, P., Nakajima, S., Sipponen, P., Sung, J., Weinstein, W., and Vieth, M.

Published
2008
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9. Gastro-oesophageal reflux symptoms, oesophagitis and Barrett's oesophagus in the general population: the Loiano-Monghidoro study

Author

Zagari, R.M., Fuccio, L., Wallander, M.-A., Johansson, S., Fiocca, R., Casanova, S., Farahmand, B.Y., Winchester, C.C., Roda, E., and Bazzoli, F.

Subjects
Esophageal diseases -- Distribution, Esophageal diseases -- Risk factors, Esophageal diseases -- Complications and side effects, Esophageal diseases -- Research, Company distribution practices, Health
Published
2008

10. Comparing laparoscopic antireflux surgery with esomeprazole in the management of patients with chronic gastro-oesophageal reflux disease: a 3-year interim analysis of the LOTUS trial

Author

Lundell, L., Attwood, S., Ell, C., Fiocca, R., Galmiche, J.-P., Hatlebakk, J., Lind, T., and Junghard, O.

Subjects
Laparoscopic surgery -- Patient outcomes, Laparoscopic surgery -- Research, Gastroesophageal reflux -- Care and treatment, Gastroesophageal reflux -- Patient outcomes, Gastroesophageal reflux -- Research, Health
Published
2008

11. Correction: PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability (Modern Pathology, (2020), 33, 7, (1398-1409), 10.1038/s41379-020-0497-0)

Author

Giuffrida, P., Arpa, G., Grillo, F., Klersy, C., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., D'Errico, A., Malvi, D., Mescoli, C., Rugge, M., Nesi, G., Ferrero, S., Furlan, D., Poggioli, G., Rizzello, F., Macciomei, M. C., Santini, D., Volta, U., De Giorgio, R., Caio, G., Calabro, A., Ciacci, C., D'Armiento, M., Rizzo, A., Solina, G., Martino, M., Tonelli, F., Villanacci, V., Cannizzaro, R., Canzonieri, V., Florena, A. M., Biancone, L., Monteleone, G., Caronna, R., Ciardi, A., Elli, L., Caprioli, F., Vecchi, M., D'Inca, R., Zingone, F., D'Odorico, A., Lenti, M. V., Oreggia, B., Bonetti, L. R., Astegiano, M., Biletta, E., Cantoro, L., Giannone, A. G., Orlandi, A., Papi, C., Perfetti, V., Quaquarini, E., Sandri, G., Silano, M., Usai, P., Barresi, V., Ciccocioppo, R., Luinetti, O., Pedrazzoli, P., Pietrabissa, A., Viglio, A., Paulli, M., Corazza, G. R., Solcia, E., Vanoli, A., and Di Sabatino, A.

Published
2020

23. Abstract form for the Irish Journal of Medical Science v workshop on gastroduodenal pathology and Helicobacter pylori July 5th — 7th 1992 — Dublin, Ireland

Author

Logan, R. P. H., Gummett, P. A., Walker, M. M., Karim, Q. N., Baron, J. H., Misiewicz, J. J., Trieber, G., Walker, S., Klotz, U., Lozniewski, A., Weber, M., de Korwin, J. D., Floquet, J., Conroy, M. C., Burdin, J. C., Mannes, G. A., Bayerdörffer, E., Höchter, W., Weingart, J., Heldwein, W., Sommer, A., Müller-Lissner, S., Bomschein, W., Miehlke, S., Weinzierl, M., Ruckdeschel, G., von Wulffen, H., Köpcke, W., Stolte, M., Rune, S. J., Justesen, T., Hansen, J. M., Jensen, T. G., Eriksen, J., Thomsen, O. ø., Scheibel, J., Bonnevie, O., Bremmelgaard, A., Vilien, M., Knuhtsen, S., Elsborg, L., Hansen, J., Lauritsen, K., Wulff, H. R., Boixeda, D., Ballestero, S., Cantón, R., De Rafael, L., Martinm de Argila, C., Pozuelo, M. J., Sampedro, J., Baquero, F., Grigoriev, P. Ya., Isakov, V. A., Iakovenko, E. P., Hirschl, A. M., Brandstätter, G., Dragosics, B., Hentschel, E., Kundi, M., Rotter, M. L., Schütze, K., Taufer, M., Neri M, Susi D, Bovani I, Pindo R, Cuccurullo F., Coelho, L. G. V., Passos, M. C. F., Chausson, Y., Vieira, W. L. S., Castro, F. J., Franco, J. M. M., Fernandes, M. L. M., Castro, L. P., Jonas, C., De Koster, E., Van Gossum, M., Depierreux, M., Cheval, M., Deltenre, M., Schütz, E., Bethke, B., Lee, A., Hegedus, E., O’Rourke, J., Larsson, H., Sjöstedt, S., Veress, B., Nord, C. E., Sobala, G. M., George, R., Tompkins, D., Finlay, J., Manning, A., Sant, S., Xia, H. X., Daw, M., Gilvarry, J., Keane, C. T., O’Morain, C., Rubio, M. A., Hegarty, B., Blum, A. L., Sulser, E., Stadelmann, O., Munoz, N., Buiatti, E., Vivas, J., Oliver, W., Cano, E., Peraza, S., Castro, D., Sanchez, V., Andrade, O., Benz, M., Mendz, G. L., Hazell, S. L., Salmela, K. S., Roire, R. P., Hook-Nikanne, J., Kosunen, T. U., Salaspur, M., Luke, C. J., Reynolds, D. D. J., Penn, C. W., Bode, G., Mauch, F., Ditschuneit, H., Malfertheiner, P., Ferrero, Richard L., Agnes Labigne, Eaton, K. A., Krakowka, S., Mobley, H. L. T., Hu, Li-Tai, Foxall, P. A., Moran, A. P., Helander, I. M., Altman, C., Sobhani, I., Vissugaire, C., Migrant, M., Etienne, J. P., Sommi, P., Ricci, V., Fiocca, R., Cova, E., Figura, N., Romano, M., Ivey, K. J., Solcia, E., Ventura, U., Nilius, M., Schieffer, S., Hengels, K. J., Jablonowski, H., Strohmeyer, G., Cabrai, M. D., Barbosa, A. J. A., Lima Hr., G. F., Oliveira, C. A., Polak, J. M., Oderda, G., Villani, L., Altare, F., Morra, I., Miserendino, L., Ansaldi, N., Dixon, M. F., Wyatt, J. I., Axon, A. T. R., Beattie, S., Hamilton, H., Shabib, S., Cutz, E., Drumm, B., Sherman, P., Noach, L. A., Rolf, T., Bosma, N. B., Schwartz, M. P., Oosting, J., Rauws, E. A. J., Tytgat, G. N. J., Andrew, A., Nardone, G., d’Ormiento, F., Pontillo, M., Lobo, A. J., Uff, J. S., McNulty, C. N. M., Wilkinson, S. P., Suriani, R., Pallante, C., Ravizza, M., Galliano, D., Sallio, D., Malandrino, M., Oneglio, R., Colozza, M., Mazzucco, D., Gaia, E., Eidt, S., Vincent, P., Gottrand, F., Turck, D., Lecomte-Houcke, M., Leclerc, H., Bonvicini, F., Pretolani, S., Baraldini, M., Cilla, D., Baldinelli, S., Bazocchi, E., Acampora, P., Careddu, N., Brocchi, E., Gasbarrini, G., Joubert, M., Bazin, N., Thiaucourt, D., Protte, E., Gissler, C., Duprez, A., Merlin, P., Forestier, S., Labenz, J., Gyenes, E., Rühl, G. H., Börsch, G., Daskalopoulos, G., Carrick, J., Lian, R., Wagner, S., Bleck, J., Gebel, M., Bär, W., Manns, M., Lamouliatte, H., Bernard, P. H., Cayla, R., Vialette, G., Quinton, A., Mégraud, F., Lemaire, M., Quinten, A., De Mascarel, A., Webb, P., Forman, D., Knight, T., Wilson, A., Graves, S., Newell, D., Elder, J., Tonelli, E., Gatte, M. R. A., Ghironzi, G. C., Giulianelli, G., Bamford, K. B., Collins, J. S. A., Bickley, J., Johnston, B. T., Potts, S., Boston, V., Owen, R. J., Sloan, J., Basso, L., Lawlor, S., Clune, J., Szelényi, H., Stohmeyer, G., Macedo, G., Iglésias, I., Chaves, A. P., Loureiro, A., Katelaris, P. H., Seow, F., Lin, B., Napoli, J., Hones, D. B., Ngu, M. C., Akopyantz, Natalia S., Bukanov, Nikolay O., Westblom, T. Ulf, Berg, Douglas E., Nyst, J. F., Denis, P., Buset, M., De Reuck, M., Nielsen, H., Andersen, L. P., Birkholz, Sabine, Knipp, Ulrich, Nietzki, Claudia, Opferkuch, Wolfgang, Crabtree, J. E., Peichl, P., Lindly, I. J. D., Deusch, K., Seifirth, C., Funk, A., Dahie, I., Reut, K., Classen, M., Gionchetti, P., Vaira, D., Campieri, M., Bertinelli, E., Menegatti, M., Belluzzi, A., Briognola, C., Miglioli, M., Barbara, L., Tommaso, A. Di, Magistris, M. T. De, Bugnoli, M., Petracca, R., Covacci, A., Censini, S., Rappuoli, R., Abrignani, S., Territo, M. C., Smela, K. L., Reeve, J. R., Lee, T. D., Walsh, J. H., Armellini, D., Crabtree, J. E., Xiang, Z. Y., Mitchell, H. M., Hu, P. J., Li, Y. Y., Wang, Z. J., Zhao, S. M., Liu, Q., Chen, M., Du, G. G., Filipe, M. I., Reed, P. I., Craanen, M. E., Blok, P., Dekker, W., Colombo, E., Redaelli, D., Santangelo, M., Spinelli, M., Farinati, F., Valiante, F., Delia Libera, G., Germanà, B., Baffa, R., Rugge, M., Vianelo, F., Di Mario, F., Sipponen, Pentti, Rokkas, T., Popotheodorou, G., Kaldgeropoulos, N., Deprez, C., Galand, P., Fox, J. G., Wishnok, P., Murphy, J. C., Tannenbaum, S., Correa, P., Parsonnet, Julie, Macor, C., Da Broi, G. L., Avellinio, C., Reifen, R., Rasooly, I., Millson, M. E., Murphy, K., Thomas, J. E., Eastham, E. J., Malorgio, E., Dell’Olio, D., Kemmer, T. P., Dominguez-Munoz, J. E., Klingel, H., Gatto, M. R. A., Olivieri, R., Bayeli, R. F., Abate, L., De Gregorio, L., Aziz, J., Esposito, E., Basagni, C., Guilluy, R., Rousseau-Tsangaris, M., Brazier, J. L., Wadstiöm, Torkel, Tyszkiewicz, Tadeusz, Bergenzaun, Per, Olsson, Karin, Birac, C., Tall, F., Albenque, M., Labigne, A., Megraud, F., Feldman, R. A., Deeks, J., Glupczynski, Y., Burette, A., Goossens, H., Van den Boore, C., Butzler, J. P., Veldhuyzen van Zanten, S., Best, L., Benzanson, G., Haldane, D., Hazell, S., Mapstone, N. P., Lynch, D. A. F., Quirke, P., Taylor, D. E., Chang, N., Eaton, M., Stockdale, E., Salama, S. M., Thompson, L., Cockayne, A., Spiller, R. C., Leen, E., Sweeney, E., Klann, H., Hatz, R., Bornschein, W., Simon, T., Eimiller, A., Bolle, F., Schweikert, C., Köpeke, W., Moss, S. F., Bishop, A. E., Calam, J., Cahill, R. J., Xia, H., Solnick, J., and Tompkins, L.

Published
1992
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24. Treatment

Author

Goodwin, C. S., Worsley, B., Pillai, E., Willems, V., Janisch, H. D., Langmaack, H., Sanchez, P., Alcalde, M., Lancho, A., Carpintero, P., Garcia, R., Pajares, J. M., Grigoriev, P. Ya., Isakov, V. A., Iakovenko, E. P., Iakovenko, A. V., Vogt, K., Hahn, H., Rehmann, I. H., Hedding-Eckerich, M., Blessing, J., Sobala, G. M., Lynch, D. A. F., Gallacher, B., Dixon, M. F., Axon, A. T. R., Bayerdörffer, E., Mannes, G., Sommer, A., Höchter, W., Weingart, J., Hatz, R., Miehlke, S., Lehn, N., Ruckdeschel, G., Dirschedl, P., Stolte, M., Adamek, R. J., Wegener, M., Birkholz, S., Opferkuch, W., Rühl, G. H., Wedmann, B., Labenz, J., Gyenes, E., R’hl, G. H., Börsch, G., Maieron, R., Rizzi, C., Zoratti, L., Andreoli, S., Da Broi, G. L., Beltrami, C. A., Chengyl, Zhuya, Yangiong, Mou, Jiesong, Hua, Zhenhua, Zhang, Bierti, L., Bolis, E. G., Di Battista, R., de Franchis, R., McAvinchey, D. J., Laurence, M., O’Riordan, J., Fantazi, M., Khawaja, M., Bologna, E, Stroppiana, M., Peyre, S., Pulitano’, R., Sategna-Guidetti, C., Martin, E., Alarcön, T., Sanz, J. C., Jimonez, M. I., López-Brea, M., Burette, A., Glupczynski, Y., Deprez, C., Di Mario, F., Ferrana, M., Battaglia, G., Dotto, P., Vianello, F., Grasso, G. A., Fiocca, R., Villiani, L., Luinetti, O., Gianatti, A., Boldorini, R., Lazzaroni, M., Bianchi Porro, G., Trespi, E., Perego, M., Alvisi, C., Cesana, B., Solcia, E., Logan, R. P. H., Greaves, R. R., Gummett, P. A., Walker, M. M., Karim, Q. N., Duggan, A. E., Baron, J. H., Misiewicz, J. J., Lohmarm, J., Porst, L. H. H., Schönlebe, J., Riedel, H., Catalano, F., Rizzo, G., Ayoubi Khajekini, M. T., Branciforte, G., Inserra, G., Liberti, A., Suriani, R., Pallante, C., Ravizza, M., Mazzucco, D., Galliano, D., Malandrino, M., Oneglio, R., Colozza, M., Gaia, E., Sallio, F., Colozza, D., Grandis, C., Forte, G. B., Bottiglieri, M. E., Durasco, R., Grimaldi, E., Rocco, P., Xia, H. X., Daw, M. A., Sant, S., Beattie, S., Keane, C. T., O’Morain, C. A., Larsson, H., Berglund, M. L., Tessaro, P., Schiavon, R., Contini, M. G., Ton, T., Norberto, L., Cassaro, M., Rugge, M., Guido, M., Baffa, R., Gloriosa, S., Turatello, F., Naccarato, R., Collins, R., O’Moram, C., Kemmer, T. P., Dominguez-Munoz, J. E., Klingel, H., Malfertheiner, P., McCarthy, C. J., McDermott, M., Hourihane, D., O’Morain, C., Droy-Lefiax, M. T., Forestier, B., Guillomain, D., Plique, O., Brugmann, D., Mégraud, F., Lamouliatte, H., Bernard, P. H., Cayla, R., Mégraud, M., de Mascarel, A., Quintonl, A., McLaren, A., McDowell, S. R., McColm, A. A., O’Malley, C., Bagshaw, J., Bouffant, F., Marelli, P., Cellini, L., Campa, M., Dainelli, B., Soldani, G., del Tacca, M., Ferrini, G., Larcinese, G., Semperlotti, N., Molnar, Gy., Fzentmihalyi, A., Takats, A., Gero, G., Penyige, J., Mark, Gy., Martínez-Gómez, J., García-Novo, D., Acuña-Quinõs, D., Gimeno, M., Vigneri, S., Termini, R., Scialabba, A., Pisciotta, G., Gusmaroli, R., Milesi, F., Mule, P., Menegatti, M., Reale, C., Holten, J., and Vaira, D.

Published
1992
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25. Gastric cancer

Author

Xu, S. G., Zotz, R. B., Recklinghausen, G. von, Meusers, P., Goebell, H., Khandekar, M. A. K., Lesseis, A. M., Eastwood, M. A., Palmer, K. R., Rizzi, C., Avellini, C., Scott, C. A., Floretti, G., Desinan, L., Beltrami, C. A., Igarashi, H., Takahashi, S., Ishiyama, N., Nakamura, K., Masubuchi, N., Saito, S., Aoyagi, T., Itoh, T., Hirata, I., Miglio, F., Miglioli, M., Mazzeo, V., Holton, J., Mulè, P., Menegatti, M., Maiolo, P., Grazia, E., Bini, A., Gusmaroli, R., Casadei, A., Valpiani, D., Gaudio, M., Bazzocchi, R., Barbara, L., Webb, P., Forman, D., Ierardi, E., Monno, R. A., Ingrosso, M., Panza, P., Lorenzis, A. De, Rizzi, S., Pisani, A., Valenza, M., Francavilla, A., Fukuda, Y., Inoue, H., Yamamoto, I., Tonokatsu, Y., Tamura, T., Hori, S., Shimoyama, T., Little, C. L., Corbett-Feeney, G., O’Callaghan, J., McCarthy, C. F., Testoni, P. A., Colombo, E., Bagnolo, F., Jonghi-Lavarini, E., Scelsi, R., Fiocca, R., Farinati, F., Valiante, F., Delia Libera, G., Germanà, B., Baffa, R., Rugge, M., Vianello, F., Mario, F. Di, Fox, J. G., Blanco, M., Murphy, J. C., Kabok, Z., and Pappo, J.

Published
1992
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35. Programmed Cell Death Ligand-1 (PD-L1) Expression is Coupled with Microsatellite Instability in Non-Familial Small Bowel Carcinomas Associated or not with Coeliac Disease or Crohn's Disease: Results from the Small Bowel Cancer Italian Consortium

Author

Vanoli, A., Giuffrida, P., Martino, M., Persichella, A., Viglio, A., Furlan, D., Klersy, C., Grillo, F., Fiocca, R., Mescoli, C., Rugge, M., Nesi, G., Fociani, P., Sampietro, G., Ardizzone, S., Luinetti, O., Calabro, A., Tonelli, F., Volta, U., Santini, D., Giacomo Caio, Elli, L., Ferrero, S., Latella, G., Ciardi, A., Caronna, R., Solina, G., Rizzo, A. G., Ciacci, C., D Armiento, F. P., Salemme, M., Villanacci, V., Cannizzaro, R., Canzonieri, V., Bonetti, L. Reggiani, Biancone, L., Monteleone, G., Orlandi, A., Santeusanio, G., Macciomei, M., D Inca, R., Perfetti, V., Sandri, G., Silano, M., Florena, A., Giannone, A., Papi, C., Coppola, L., Usai, P., Maccioni, A., Astegiano, M., Migliora, P., Sessa, F., Solcia, E., Corazza, G. R., Paulli, M., and Di Sabatino, A.

Subjects
NO
Published
2018

37. Interobserver reproducibility in pathologist interpretation of columnar-lined esophagus

Author

Interobserver reproducibility in pathologist interpretation of columnar lined e.s.o.p.h.a.g.u.s. Mastracci L1, 2, Piol N3, 4, Molinaro L5, Pitto F3, Tinelli C6, De Silvestri A6, Fiocca R3, Grillo F3, ABRAM Study G.r.o.u.p. Collaborators Alò P, Al Omoush TM, Asioli S, Buffelli F, Conforti F, Cornaggia M, Cossu S, De Marco L, Fiocca R, Foscolo AM, Fraternali Orcioni G, Ingravallo G, Locatelli F, Luinetti O, Marchio C, Montinari E, Melchiorri L, Messerini L, Migliora P, Pizzi M, Rugge M, Saragoni L, Tamponi E, Tomezzoli A, Trisolini MP, Trombatore M, Vanoli A, Vellone VG, Villanacci V., D'ARMIENTO, FRANCESCO PAOLO, Mastracci L1, Interobserver reproducibility in pathologist interpretation of columnar lined e. s. o. p. h. a. g. u. s., Piol, N3, Molinaro, L5, Pitto, F3, Tinelli, C6, De Silvestri, A6, Fiocca, R3, Grillo, F3, Collaborators Alò P, ABRAM Study G. r. o. u. p., Al Omoush, Tm, Asioli, S, Buffelli, F, Conforti, F, Cornaggia, M, Cossu, S, D'Armiento, FRANCESCO PAOLO, De Marco, L, Fiocca, R, Foscolo, Am, Fraternali Orcioni, G, Ingravallo, G, Locatelli, F, Luinetti, O, Marchio, C, Montinari, E, Melchiorri, L, Messerini, L, Migliora, P, Pizzi, M, Rugge, M, Saragoni, L, Tamponi, E, Tomezzoli, A, Trisolini, Mp, Trombatore, M, Vanoli, A, Vellone, Vg, and Villanacci, V.

Subjects
Adult, medicine.medical_specialty, Barrett’s esophagu, Esophageal Neoplasms, Concordance, Biopsy, Epithelium, Pathology and Forensic Medicine, 03 medical and health sciences, Barrett Esophagus, 0302 clinical medicine, Esophagus, Metaplasia, Histological diagnosi, Interobserver variation, Medicine, Barrett’s esophagus, Humans, Molecular Biology, Aged, medicine.diagnostic_test, business.industry, Medicine (all), Columnar-lined esophagus, Histological diagnosis, Middle Aged, Reproducibility of Results, Intestinal metaplasia, General Medicine, Anatomy, Cell Biology, medicine.disease, Endoscopy, medicine.anatomical_structure, 2734, 030220 oncology & carcinogenesis, Barrett's esophagus, 030211 gastroenterology & hepatology, Radiology, medicine.symptom, business, Kappa, Columnar-lined esophagu
Abstract

Confirmation of endoscopically suspected esophageal metaplasia (ESEM) requires histology, but confusion in the histological definition of columnar-lined esophagus (CLE) is a longstanding problem. The aim of this study is to evaluate interpathologist variability in the interpretation of CLE. Thirty pathologists were invited to review three ten-case sets of CLE biopsies. In the first set, the cases were provided with descriptive endoscopy only; in the second and the third sets, ESEM extent using Prague criteria was provided. Moreover, participants were required to refer to a diagnostic chart for evaluation of the third set. Agreement was statistically assessed using Randolph's free-marginal multirater kappa. While substantial agreement in recognizing columnar epithelium (K = 0.76) was recorded, the overall concordance in clinico-pathological diagnosis was low (K = 0.38). The overall concordance rate improved from the first (K = 0.27) to the second (K = 0.40) and third step (K = 0.46). Agreement was substantial when diagnosing Barrett's esophagus (BE) with intestinal metaplasia or inlet patch (K = 0.65 and K = 0.89), respectively, in the third step, while major problems in interpretation of CLE were observed when only cardia/cardia-oxyntic atrophic-type epithelium was present (K = 0.05-0.29). In conclusion, precise endoscopic description and the use of a diagnostic chart increased consistency in CLE interpretation of esophageal biopsies. Agreement was substantial for some diagnostic categories (BE with intestinal metaplasia and inlet patch) with a well-defined clinical profile. Interpretation of cases with cardia/cardia-oxyntic atrophic-type epithelium, with or without ESEM, was least consistent, which reflects lack of clarity of definition and results in variable management of this entity.

Published
2016

38. Small bowel carcinomas in celiac or Crohn's disease: Distinctive histophenotypic, molecular and histogenetic patterns

Author

Vanoli, A., Di Sabatino, A., Martino, M., Klersy, C., Grillo, F., Mescoli, C., Nesi, G., Volta, U., Fornino, D., Luinetti, O., Fociani, P., Villanacci, V., D'Armiento, F. P., Cannizzaro, R., Latella, G., Ciacci, C., Biancone, L., Paulli, M., Sessa, F., Rugge, M., Fiocca, R., Corazza, G. R., Solcia, E., Ardizzone, S., Astegiano, M., Caio, G., Calabro, A., Canzonieri, V., Cerutti, R., Ciardi, A., Coppola, L., D'Inca, R., Elli, L., Ferrero, S., Florena, A. M., Furlan, D., Giannone, A. G., Giuffrida, P., Macciomei, M. C., Maccioni, A., Monteleone, G., Migliora, P., Orlandi, A., Papi, C., Perfetti, V., Bonetti, L. R., Rizzo, A., Salemme, M., Sandri, G., Sampietro, G., Santeusanio, G., Santini, D., Silano, M., Solina, G., Tonelli, F., Trapani, D., Usai, P., Vanoli, Alessandro, Di Sabatino, Antonio, Martino, Michele, Klersy, Catherine, Grillo, Federica, Mescoli, Claudia, Nesi, Gabriella, Volta, Umberto, Fornino, Daniele, Luinetti, Ombretta, Fociani, Paolo, Villanacci, Vincenzo, D'Armiento, Francesco P., Cannizzaro, Renato, Latella, Giovanni, Ciacci, Carolina, Biancone, Livia, Paulli, Marco, Sessa, Fausto, Rugge, Massimo, Fiocca, Roberto, Corazza, Gino R., Solcia, Enrico, D'Armiento, Francesco P, and Corazza, Gino R

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Pathology, small bowel carcinoma, celiac disease, immunology, gastrointestinal cancer, Kaplan-Meier Estimate, Histogenesis, Biology, Small, Gastroenterology, Pathology and Forensic Medicine, NO, Surgical pathology, immunology, inflammatory bowel disease, 03 medical and health sciences, small bowel carcinoma, 0302 clinical medicine, Crohn Disease, Internal medicine, Intestine, Small, Intestinal Neoplasms, medicine, Carcinoma, Humans, 2734 small bowel carcinoma, coeliac disease, Crohn's disease, Proportional Hazards Models, Retrospective Studies, Crohn's disease, Settore MED/12 - Gastroenterologia, Celiac Disease, Female, Middle Aged, Microsatellite instability, Anatomical pathology, medicine.disease, digestive system diseases, Intestine, 030104 developmental biology, Dysplasia, 030220 oncology & carcinogenesis, Hematopathology, celiac disease
Abstract

Non-familial small bowel carcinomas are relatively rare and have a poor prognosis. Two small bowel carcinoma subsets may arise in distinct immune-inflammatory diseases (celiac disease and Crohn's disease) and have been recently suggested to differ in prognosis, celiac disease-associated carcinoma cases showing a better outcome, possibly due to their higher DNA microsatellite instability and tumor-infiltrating T lymphocytes. In this study, we investigated the histological structure (glandular vs diffuse/poorly cohesive, mixed or solid), cell phenotype (intestinal vs gastric/pancreatobiliary duct type) and Wnt signaling activation (beta-catenin and/or SOX-9 nuclear expression) in a series of 26 celiac disease-associated small bowel carcinoma, 25 Crohn's disease-associated small bowel carcinoma and 25 sporadic small bowel carcinoma cases, searching for new prognostic parameters. In addition, non-tumor mucosa of celiac and Crohn's disease patients was investigated for epithelial precursor changes (hyperplastic, metaplastic or dysplastic) to help clarify carcinoma histogenesis. When compared with non-glandular structure and non-intestinal phenotype, both glandular structure and intestinal phenotype were associated with a more favorable outcome at univariable or stage-and microsatellite instability/tumor-infiltrating lymphocyte-inclusive multivariable analysis. The prognostic power of histological structure was independent of the clinical groups while the non-intestinal phenotype, associated with poor outcome, was dominant among Crohn's disease-associated carcinoma. Both nuclear beta-catenin and SOX-9 were preferably expressed among celiac disease-associated carcinomas; however, they were devoid, per se, of prognostic value. We obtained findings supporting an origin of celiac disease-associated carcinoma in SOX-9-positive immature hyperplastic crypts, partly through flat beta-catenin-positive dysplasia, and of Crohn's disease-associated carcinoma in a metaplastic (gastric and/or pancreatobiliary-type) mucosa, often through dysplastic polypoid growths of metaplastic phenotype. In conclusion, despite their common origin in a chronically inflamed mucosa, celiac disease-associated and Crohn's disease-associated small bowel carcinomas differ substantially in histological structure, phenotype, microsatellite instability/tumor-infiltrating lymphocyte status, Wnt pathway activation, mucosal precursor lesions and prognosis.

Published
2017

41. Crohn’s disease-associated small bowel carcinomas show distinctive histology and phenotype in comparison to sporadic cases: an italian multicentre study

Author

Vanoli, A., Grillo, F., Mescoli, C., Nesi, G., Giuffrida, P., Papi, C., Luinetti, O., Sampietro, G., Latella, Giovanni, Fociani, P., Tonelli, F., Cannizzaro, R., Coppola, L., D’Incà, R., Monteleone, G., Biancone, L., Solina, G., Villanacci, V., Martino, M., Orlandi, A., Rizzo, A., Salemme, M., Astegiano, M., Migliora, P., Rugge, M., Fiocca, R., Corazza, G. R., Solcia, E., and Di Sabatino, A.

Published
2016

42. Crohn’s disease-associated small bowel carcinomas show distinctive histologic and phenotypic features: an Italian multicentric study

Author

Di Sabatino, A. Vanoli, Grillo, Francesco, Mescoli, C., Nesi, G., Giuffrida, P., Papi, C., Luinetti, O., Sampietro, G., Latella, Giovanni, Fociani, P., Tonelli, F., Cannizzaro, R., Coppola, L., D’Incà, R., Monteleone, G., Biancone, L., Solina, G., Villanacci, V., Martino, M., Orlandi, A., Rizzo, A., Salemme, M., Astegiano, M., Migliora, P., Rugge, M., Fiocca, R., and Corazza, G. R.

Published
2016

43. V workshop on gastroduodenal pathology and helicobacter pylori: Proceedings of meeting held in Dublin on 5th – 7th July, 1992

Author

Cammarota, G., Cannizzaro, O., Forti, G., Certo, M., Abagnale, R., Fedeli, G., Bonamico, M., Magliocca, F. M., Mariani, P., Benedetti, I., Monti, S., Luzzi, I., de Giacomo, C., Gianatti, A., C’Acobone, E., Fiocca, R., Perotti, P., Bawa, P., De Giacomo, C., Negrini, R., Grasso, G., Gerosa, C., Biancardi, M., Bonfardeci, G., and Tavani, E.

Published
1993
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44. Diagnosis and management of non-erosive reflux disease--the Vevey NERD Consensus Group

Author

Modlin IM, Hunt RH, Malfertheiner P, Moayyedi P, Quigley EM, Tytgat GN, Tack J, Heading RC, Holtman G, Moss SF, Vevey NERD Consensus Group: Armstrong D, Aziz Q, Cicala M, El Serag H, Falk G, Fiocca R, Fock KM, Fried M, Goh KL, Heading R, Holtmann G, Hungin P, Hunt R, Ivashkin V, Kahrilas P, Katelaris P, McColl K, Modlin I, Moss S, Orlando R, Piche T, Pinto des Moraes Filho JP, Quigley E, Rubin G, Shaker R, Sifrim D, Smout A, Sollano J, Sung J, Trukhmanov A, Tytgat G, Vieth M., STANGHELLINI, VINCENZO, Modlin IM, Hunt RH, Malfertheiner P, Moayyedi P, Quigley EM, Tytgat GN, Tack J, Heading RC, Holtman G, Moss SF, Vevey NERD Consensus Group: Armstrong D, Aziz Q, Cicala M, El-Serag H, Falk G, Fiocca R, Fock KM, Fried M, Goh KL, Heading R, Holtmann G, Hungin P, Hunt R, Ivashkin V, Kahrilas P, Katelaris P, McColl K, Modlin I, Moss S, Orlando R, Piche T, Pinto des Moraes-Filho JP, Quigley E, Rubin G, Shaker R, Sifrim D, Smout A, Sollano J, Stanghellini V, Sung J, Trukhmanov A, Tytgat G, and Vieth M.

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Nerd, business.industry, Definitive Therapy, Mucosal lesions, Gastroenterology, Reflux, Review, Disease, Severity of Illness Index, Endoscopy, Quality of life, Internal medicine, Practice Guidelines as Topic, Severity of illness, Gastroesophageal Reflux, Quality of Life, medicine, Humans, business
Abstract

Background/Aims: Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world. Methods: An expert international group using the modified Delphi technique examined the quality of evidence and established levels of agreement relating to different aspects of NERD. Discussion focused on clinical presentation, assessment of clinical outcome, pathobiological mechanisms, and clinical strategies for diagnosis and management. Results: Consensus was reached on 85 specific statements. NERD was defined as a condition with reflux symptoms in the absence of mucosal lesions or breaks detected by conventional endoscopy, and without prior effective acid-suppressive therapy. Evidence supporting this diagnosis included: responsiveness to acid suppression therapy, abnormal reflux monitoring or the identification of specific novel endoscopic and histological findings. Functional heartburn was considered a separate entity not related to acid reflux. Proton pump inhibitors are the definitive therapy for NERD, with efficacy best evaluated by validated quality-of-life instruments. Adjunctive antacids or H2 receptor antagonists are ineffective, surgery seldom indicated. Conclusions: Little is known of the pathobiology of NERD. Further elucidation of the mechanisms of mucosal and visceral hypersensitivity is required to improve NERD management.

Published
2009

45. Helicobacter pylori infection and chronic corpus gastritis related in gastro-esofageal reflux disease

Author

ZAGARI, ROCCO MAURIZIO, RICCIARDIELLO, LUIGI, BAZZOLI, FRANCO, Casanova S, Martuzzi C, Fuccio L, Di Marco M, Maltoni S, D'ERRICO, ANTONIETTA, Grigioni W, Fiocca R, Roda E, Zagari R, Casanova S, Martuzzi C, Fuccio L, Di Marco M, Maltoni S, Ricciardiello L, D'Errico A, Grigioni W, Fiocca R, Roda E, and Bazzoli F.

Subjects
GASTRO-ESOPHAGEAL REFLUX DISEASE, HELICOBACTER PYLORI, GASTRITIS
Published
2004

48. OC.11.1 PROGRAMMED CELL DEATH LIGAND-1 (PD-L1) EXPRESSION IS COUPLED WITH MICROSATELLITE INSTABILITY IN NON-FAMILIAL SMALL BOWEL CARCINOMAS ASSOCIATED OR NOT WITH COELIAC DISEASE OR CROHN'S DISEASE: RESULTS FROM THE SMALL BOWEL CANCER ITALIAN CONSORTIUM

Author

Vanoli, A., Giuffrida, P., Martino, M., Persichella, A., Viglio, A., Furlan, D., Klersy, C., Grillo, F., Fiocca, R., Mescoli, C., Rugge, M., Nesi, G., Fociani, P., Sampietro, G., Ardizzone, S., Luinetti, O., Calabrò, A., Tonelli, F., Volta, U., Santini, D., Caio, G., Elli, L., Ferrero, S., Latella, G., Ciardi, A., Caronna, R., Solina, G., Rizzo, A.G., Ciacci, C., D'Armiento, F.P., Salemme, M., Villanacci, V., Cannizzaro, R., Canzonieri, V., Bonetti, L. Reggiani, Biancone, L., Monteleone, G., Orlandi, A., Santeusanio, G., Macciomei, M., D'Incà, R., Perfetti, V., Sandri, G., Silano, M., Florena, A., Giannone, A., Papi, C., Coppola, L., Usai, P., Maccioni, A., Astegiano, M., Migliora, P., Sessa, F., Solcia, E., Corazza, G.R., Paulli, M., and Di Sabatino, A.

Published
2018
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