9 results on '"Flavio Labriola"'
Search Results
2. Serum Adalimumab Levels After Induction Are Associated With Long-Term Remission in Children With Inflammatory Bowel Disease
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Marianna Lucafò, Debora Curci, Matteo Bramuzzo, Patrizia Alvisi, Stefano Martelossi, Tania Silvestri, Veronica Guastalla, Flavio Labriola, Gabriele Stocco, and Giuliana Decorti
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inflammatory bowel disease ,children ,adalimumab ,drug levels ,anti-TNF ,therapeutic drug monitoring ,Pediatrics ,RJ1-570 - Abstract
Introduction: Adalimumab is effective in inducing and maintaining remission in children with inflammatory bowel diseases (IBD). Therapeutic drug monitoring is an important strategy to maximize the response rates, but data on the association of serum adalimumab levels are lacking. This study aimed to assess the association of adalimumab concentrations at the end of induction and early during maintenance for long-term response.Materials and Methods: Serum samples for adalimumab level measurement were collected during routine visits between adalimumab administrations and therefore not necessarily at trough, both during the induction (week 4 ± 4) and maintenance phases (week 22 ± 4, 52 ± 4, and 82 ± 4). Adalimumab and anti-adalimumab antibodies were measured retrospectively using enzyme-linked immunosorbent assays (ELISA). Disease activity was determined by Pediatric Crohn's Disease Activity Index or Pediatric Ulcerative Colitis Activity Index.Results: Thirty-two children (median age 14.9 years) were enrolled. Sixteen, 15, 14, and 12 patients were in remission at weeks 4, 22, 52, and 82, respectively. Median adalimumab concentration was higher at all time points in patients achieving sustained clinical remission. Adalimumab levels correlated with clinical and biochemical variables. Adalimumab concentration above 13.85 and 7.54 μg/ml at weeks 4 and 22 was associated with remission at weeks 52 and 82.Conclusions: Adalimumab non-trough levels are associated with long-term response in pediatric patients with IBD.
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- 2021
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- View/download PDF
3. Complementary Feeding in Italy: From Tradition to Innovation
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Patrizia Alvisi, Marco Congiu, Monica Ficara, Patrizia De Gregorio, Roberto Ghio, Enzo Spisni, Pietro Di Saverio, Flavio Labriola, Doriana Lacorte, and Paolo Lionetti
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complementary feeding ,weaning practice ,baby-led weaning ,personalized nutrition ,Italian regions ,food tastings ,Pediatrics ,RJ1-570 - Abstract
Complementary feeding (CF) is a pivotal phase of the individual’s growth, during which children develops their future dietary habits. To date, only few studies investigated and compared weaning modalities between different geographical areas. The aim of this article is to describe the current Italian practice for CF in healthy term infants among different areas (North, Center, South) of Italy. Two different multiple-choice questionnaires were produced and sent to 665 Italian primary care pediatricians (PCP) and 2023 families with children under 1 year of age. As emerged from our investigation, in Italy CF is usually started between the 5th and 6th month of life. The preferred approach (chosen by 77% of families) involves the use of home-cooked liquid or semi-liquid ailments, or industrial baby foods. A new CF modality is emerging, consisting of traditional complementary foods with adult food tastings (10% of families). Approximately 91% of pediatricians give written dietary suggestions, and 83% of families follow their advice. We found significantly divergent weaning habits among different areas of Italy. PCP have a key role in guiding parents during the introduction of new foods in their infant’s diet and should take this as an opportunity to educate the whole family to healthy dietary habits.
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- 2021
- Full Text
- View/download PDF
4. What Has Changed over Years on Complementary Feeding in Italy: An Update
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Marco Congiu, Valeria Cimador, Irene Bettini, Teresa Rongai, Flavio Labriola, Francesca Sbravati, Caterina Marcato, and Patrizia Alvisi
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Nutrition and Dietetics ,primary care pediatrician ,Italy ,baby-led weaning ,baby foods ,complementary feeding ,Food Science - Abstract
Current practice regarding complementary feeding (CF) is influenced by socio-cultural background. Our group already investigated the Italian approach to CF in the years 2015–2017. Our aim was to update those data by finding out: if the habits have changed nationwide, how the trends changed in each area, and if the differences between regions still exist. We devised and submitted to Italian primary care paediatricians (PCP) a questionnaire consisting of four items regarding the suggestions they gave to families about CF and compared the results to the ones from our previous survey. We collected 595 responses. Traditional weaning was the most recommended method, with a significant reduction compared to the period of 2015–2017 (41% vs. 60%); conversely, the proportion of PCP endorsing baby-led weaning (BLW) or traditional spoon-feeding with adult food tastings has increased, while the endorsement of commercial baby foods dropped. BLW is still more popular in the North and Centre compared to the South (24.9%, 22.3%, and 16.7%, respectively). The age to start CF and the habit of giving written information have not changed over time. Our results highlighted that Italian paediatricians encourage BLW and traditional CF with adult tastings more than in the past, at the expense of traditional spoon-feeding.
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- 2023
- Full Text
- View/download PDF
5. Epidemiological trends of pediatric IBD in Italy: A 10-year analysis of the Italian society of pediatric gastroenterology, hepatology and nutrition registry
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Patrizia Alvisi, Flavio Labriola, Luca Scarallo, Paolo Gandullia, Daniela Knafelz, Matteo Bramuzzo, Giovanna Zuin, Maria Rosa Pastore, Maria Teresa Illiceto, Erasmo Miele, Francesco Graziano, Claudio Romano, Daniela Bartoletti, Salvatore Oliva, Serena Arrigo, Fiammetta Bracci, Sara Renzo, Anna Agrusti, Marina Aloi, Paolo Lionetti, Salvatore Accomando, Claudia Banzato, Graziano Barera, Marco Brunero, Pier Luigi Calvo, Angelo Campanozzi, Mara Cananzi, Mara Corpino, Rita Cozzali, Gianluigi De Angelis, Costantino De Giacomo, Dario Dilillo, Enrico Felici, Simona Gatti, Valentina Motta, Lorenzo Norsa, Paolo Maria Pavanello, Andrea Pession, Silvia Provera, Alberto Ravelli, Antonio Maria Ricci, Silvia Salvatore, Caterina Strisciuglio, Alvisi P., Labriola F., Scarallo L., Gandullia P., Knafelz D., Bramuzzo M., Zuin G., Pastore M.R., Illiceto M.T., Miele E., Graziano F., Romano C., Bartoletti D., Oliva S., Arrigo S., Bracci F., Renzo S., Agrusti A., Aloi M., Lionetti P., Accomando S., Banzato C., Barera G., Brunero M., Calvo P.L., Campanozzi A., Cananzi M., Corpino M., Cozzali R., De Angelis G., De Giacomo C., Dilillo D., Felici E., Gatti S., Motta V., Norsa L., Pavanello P.M., Pession A., Provera S., Ravelli A., Ricci A.M., Salvatore S., Strisciuglio C., Alvisi, P., Labriola, F., Scarallo, L., Gandullia, P., Knafelz, D., Bramuzzo, M., Zuin, G., Pastore, M. R., Illiceto, M. T., Miele, E., Graziano, F., Romano, C., Bartoletti, D., Oliva, S., Arrigo, S., Bracci, F., Renzo, S., Agrusti, A., Aloi, M., Lionetti, P., Accomando, S., Banzato, C., Barera, G., Brunero, M., Calvo, P. L., Campanozzi, A., Cananzi, M., Corpino, M., Cozzali, R., De Angelis, G., De Giacomo, C., Dilillo, D., Felici, E., Gatti, S., Motta, V., Norsa, L., Pavanello, P. M., Pession, A., Provera, S., Ravelli, A., Ricci, A. M., Salvatore, S., and Strisciuglio, C.
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Registrie ,Delayed Diagnosis ,Hepatology ,Delayed Diagnosi ,Gastroenterology ,Pediatric IBD ,Epidemiological trend ,Inflammatory Bowel Diseases ,Settore MED/38 - Pediatria Generale E Specialistica ,Crohn Disease ,Italy ,Epidemiological trends ,Humans ,Colitis, Ulcerative ,Registries ,Child ,Human - Abstract
Introduction: The present study aimed at evaluating Italian epidemiological trends of pediatric inflammatory bowel diseases (IBD) over the period 2009–2018. Materials and methods: Data from 1969 patients enrolled in the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition Registry, by 49 pediatric IBD centers throughout the country, were analyzed, comparing three different time intervals (2009–2012, 2013–2015, 2016–2018). Results: The number of new IBD diagnoses ranged from 175 to 219 per year, evenly distributed over the examined period of time. From 2009 to 2018, the minimal incidence ranged from 1.59 to 2.04 /105 inhabitants aged < 18 years, with an overall slight predominance of ulcerative colitis (UC) over Crohn's disease (CD) (ratio: 1.1). Mean diagnostic delay was 6.8 months for CD and 4.1 months for UC, with a significant reduction for CD when comparing the three-time intervals (p =0.008). The most frequent disease locations according to the Paris classification were ileocolonic for CD (41.3%) and pancolitis for UC (54.6%). Conclusions: The minimal incidence rate in Italy seems to have stabilized over the last two decades, even if it has increased when compared to previous reports. UC is still slightly more prevalent than CD in our country. Diagnostic delay significantly decreased for CD, reflecting an improved diagnostic capacity.
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- 2022
6. Dietary Habits of a Group of Children with Crohn's Disease Compared to Healthy Subjects: Assessment of Risk of Nutritional Deficiencies through a Bromatological Analysis
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Flavio Labriola, Caterina Marcato, Chiara Zarbo, Ludovica Betti, Arianna Catelli, Maria Chiara Valerii, Enzo Spisni, Patrizia Alvisi, Labriola, Flavio, Marcato, Caterina, Zarbo, Chiara, Betti, Ludovica, Catelli, Arianna, Valerii, Maria Chiara, Spisni, Enzo, and Alvisi, Patrizia
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Male ,Crohn’s disease ,Nutrition and Dietetics ,Nutrition. Foods and food supply ,Malnutrition ,Feeding Behavior ,Vitamins ,dietary intake ,nutritional deficiencies ,micronutrients ,bromatology ,Healthy Volunteers ,Crohn Disease ,Humans ,micronutrient ,TX341-641 ,Child ,Food Science - Abstract
Diet is a matter of interest in the pathogenesis and management of Crohn’s Disease (CD). Little is known about CD children’s dietary habits. Our aim was assessing the quality and the amount of nutrient intake in a group of CD pediatric patients. Data were compared with those of healthy subjects (HS). In total, 20 patients (13 males) and 48 HS (24 males) aged 4–18 years were provided with a food diary to fill out for one week. Winfood software performed the bromatological analysis, providing data about intakes of proteins and amino acids, fatty acids, carbohydrates, cholesterol, fibers, minerals, vitamins, and polyphenols. Estimates of the antioxidant activity of foods and of the dietetic protein load were also calculated. The diet of CD patients was poorer in fibers, polyphenols, vitamin A, beta-carotene, and fatty acids, and richer in animal proteins, vitamin B12, and niacin. PRAL was higher in CD patients’ diets, while ORAC was higher in HS. No significant differences were observed in carbohydrate and other macro- and micronutrient consumptions. CD dietary habits seem to reflect the so-called Western diet, possibly involved in CD pathogenesis. Furthermore, analysis of dietary habits allows for prevention of nutritional deficiencies and timely correction through education and supplementation.
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- 2022
7. Complementary Feeding in Italy: From Tradition to Innovation
- Author
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Enzo Spisni, Patrizia De Gregorio, Monica Ficara, Pietro Di Saverio, Roberto Ghio, Marco Congiu, Doriana Lacorte, Flavio Labriola, Paolo Lionetti, P. Alvisi, Alvisi, Patrizia, Congiu, Marco, Ficara, Monica, De Gregorio, Patrizia, Ghio, Roberto, Spisni, Enzo, Di Saverio, Pietro, Labriola, Flavio, Lacorte, Doriana, and Lionetti, Paolo
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medicine.medical_specialty ,Primary care ,Pediatrics ,Article ,complementary feeding ,RJ1-570 ,food tastings ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Italian regions ,Weaning ,Medicine ,030212 general & internal medicine ,baby-led weaning ,personalized nutrition ,Modalities ,business.industry ,Italian region ,weaning practice ,Personalized nutrition ,Family medicine ,Pediatrics, Perinatology and Child Health ,food tasting ,business ,Baby-led weaning - Abstract
Complementary feeding (CF) is a pivotal phase of the individual’s growth, during which children develops their future dietary habits. To date, only few studies investigated and compared weaning modalities between different geographical areas. The aim of this article is to describe the current Italian practice for CF in healthy term infants among different areas (North, Center, South) of Italy. Two different multiple-choice questionnaires were produced and sent to 665 Italian primary care pediatricians (PCP) and 2023 families with children under 1 year of age. As emerged from our investigation, in Italy CF is usually started between the 5th and 6th month of life. The preferred approach (chosen by 77% of families) involves the use of home-cooked liquid or semi-liquid ailments, or industrial baby foods. A new CF modality is emerging, consisting of traditional complementary foods with adult food tastings (10% of families). Approximately 91% of pediatricians give written dietary suggestions, and 83% of families follow their advice. We found significantly divergent weaning habits among different areas of Italy. PCP have a key role in guiding parents during the introduction of new foods in their infant’s diet and should take this as an opportunity to educate the whole family to healthy dietary habits.
- Published
- 2021
8. Gluten Deprivation: What Nutritional Changes Are Found During the First Year in Newly Diagnosed Coeliac Children?
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Andrea Pession, Francesca Levi Della Vida, Maria Luisa Forchielli, Achille C. Pessina, Arianna Leone, Flavio Labriola, Nunzio Salfi, Chiara Miserocchi, Lucia Diani, Giulia Bolasco, Mario Lima, Alessandro Rocca, Laura Andreozzi, Maria Luisa, Forchielli, Lucia Diani, Flavio Labriola, Giulia Bolasco, Alessandro Rocca, Nunzio Cosimo Salfi, Arianna Leone, Chiara Miserocchi, Laura Andreozzi, Francesca, Levi della Vida, and Achille Cesare Pessina, Mario Lima, Andrea Pession
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0301 basic medicine ,Male ,Calorie ,Homocysteine ,Adolescent ,Blood sugar ,Physiology ,Nutritional Status ,lcsh:TX341-641 ,Coeliac disease ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Diet, Gluten-Free ,0302 clinical medicine ,children ,Medicine ,Humans ,Prospective Studies ,Child ,chemistry.chemical_classification ,030109 nutrition & dietetics ,Nutrition and Dietetics ,medicine.diagnostic_test ,business.industry ,Infant ,Feeding Behavior ,Anthropometry ,medicine.disease ,Gluten ,Lipids ,Celiac Disease ,chemistry ,Child, Preschool ,gluten ,030211 gastroenterology & hepatology ,Female ,business ,Lipid profile ,diet ,lcsh:Nutrition. Foods and food supply ,Food Science ,Lipoprotein - Abstract
Aim: A gluten-free diet (GFD) can expose children to excessive calories and fat intake. The study is intended to verify whether and how food intake, laboratory parameters, and growth are modified by a year of GFD. Methods: In 79 CD (coeliac disease) children (mean age 7.9 ±, 3.8 years, 52 females, 27 males) diagnosed over 24 months, 24-h food diaries, food-frequency patterns, anthropometric and laboratory parameters (mainly blood sugar, insulin, lipid profile, and homocysteine) were prospectively collected before and during the first year of GFD. Nutrient intakes were compared over time and with recommendations. They were also used as regressors to explain the levels and changes of metabolic and growth variables. p-values <, 0.05 were considered statistically significant. Results: Average macronutrient intake did not change during the year. Caloric intake remained below 90% (p &le, 0.0001) and protein intake above 200% (p &le, 0.0001) of recommendations. Lipid intake was stable at 34% of overall energy intake. Unsaturated fats increased (less omega-6 and more omega-3 with a ratio improvement from 13.3 ±, 5.5 to 8.8 ±, 3.1) and so did fibers, while folate decreased. The children who experienced a containment in their caloric intake during the year, presented a slower catch-up growth. Some differences were found across gender and age groups. In particular, adolescents consumed less calories, and females more omega-3. Fiber and simple sugar intakes emerged as implicated in lipid profile shift: fibers negatively with triglycerides (TG) (p = 0.033), simple sugars negatively with high-density lipoprotein (HDL) (p = 0.056) and positively with TG (p = 0.004). Waist-to-height ratio was positively associated with homocysteine (p = 0.018) and Homeostasis Model Assessment (p = 0.001), negatively with fibers (p = 0.004). Conclusion: In the short run, GFD is nutritionally very similar to any diet with gluten, with some improvements in unsaturated fats and fiber intake. Along with simple sugars containment, this may offer CD patients the opportunity for a fresh start. Caloric intakes may shift and should be monitored, especially in adolescents.
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- 2019
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9. An Impressive, Sudden, and Purpuric Eruption
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Iria Neri, Annalucia Virdi, Flavio Labriola, Annalisa Patrizi, Neri, Iria, Labriola, Flavio, Virdi, Annalucia, and Patrizi, Annalisa
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Male ,Vasculitis ,medicine.medical_specialty ,acute hemorrhagic edema ,Skin vasculitis ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,purpuric eruption ,skin vasculiti ,Medicine ,Edema ,Humans ,business.industry ,Infant ,medicine.disease ,Dermatology ,Purpura ,vasculiti ,030220 oncology & carcinogenesis ,Acute Disease ,purpura ,Pediatrics, Perinatology and Child Health ,medicine.symptom ,business - Published
- 2017
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