Search

Coastal marine ecosystems are among the most productive ecosystems worldwide, providing essential resources both for the environment itself and for human life. This is the case of the Ligurian Sea, rich in marine biodiversity that characterizes a valuable natural capital that has, however, been damaged by the development of human activities along the coast leading to a decline of this biodiversity and health status of coastal ecosystems.This study analyzes the relationships between the distribution of natural capital and environmental flows values of Ligurian marine coastal habitats, and the natural and anthropogenic variables located along the coast. These variables may influence the capacity of the environment to generate and maintain the natural capital and affect, either directly or indirectly, positively or negatively, its spatial distribution together with that of the environmental flows. These relationships were analyzed using the Random Forest technique, subsequently compared with information from interviews administered to experts in the marine coastal field.Both methods showed that the anthropogenic variables have a greater influence on values’ distribution if compared with the natural ones, with a positive effect (namely the settlement of protection measures) showed as an increase in natural capital and environmental flows values, confirming how protection regimes (e.g., anchoring ban and establishment of Special Zones of Conservation) could be crucial for managing and conserving natural capital.This study links the status of natural capital and environmental flows along the coast to the presence of a set of variables, in order to operate on them for a better monitoring and management of the area, as well as a sustainable development.

The deep shoal of Punta del Faro (Ligurian Sea, Mediterranean Sea) is a mesophotic rocky elevation hosting complex animal forests threatened by fishing activities. To identify appropriate conservation measures and set a reference example for similar cases, we present a detailed characterization of its megabenthic communities and a quantification of the fishing pressure. The results highlight the high natural value of the area, presenting high biodiversity (111 megabenthic and demersal species) and diverse types of animal forest, predominantly dominated by cnidarians. The tridimensional seascape is among the most complex in the eastern Ligurian Sea, but the long-term evaluation of its environmental status suggested consistent affects due to the high abundance of lost fishing gear (0.65 items m−2) directly entangled with structuring cnidarians. The artisanal and recreational fishing pressure are currently moderate. However, the use of bottom-contact fishing gear causes significant modifications to the seafloor’s integrity. This study emphasizes the high conservation value and vulnerability of the shoal, highlighting the importance of its protection through its inclusion in the Portofino MPA, whose external perimeter is 200 m from the study area. A critical discussion of the advantages and disadvantages is provided with a map of the possible extension of the MPA boundaries.

Quantum key distribution, which allows two distant parties to share an unconditionally secure cryptographic key, promises to play an important role in the future of communication. For this reason such technique has attracted many theoretical and experimental efforts, thus becoming one of the most prominent quantum technologies of the last decades. The security of the key relies on quantum mechanics and therefore requires the users to be capable of performing quantum operations, such as state preparation or measurements in multiple bases. A natural question is whether and to what extent these requirements can be relaxed and the quantum capabilities of the users reduced. Here we demonstrate a novel quantum key distribution scheme, where users are fully classical. In our protocol, the quantum operations are performed by an untrusted third party acting as a server, which gives the users access to a superimposed single photon, and the key exchange is achieved via interaction-free measurements on the shared state. We also provide a full security proof of the protocol by computing the secret key rate in the realistic scenario of finite-resources, as well as practical experimental conditions of imperfect photon source and detectors. Our approach deepens the understanding of the fundamental principles underlying quantum key distribution and, at the same time, opens up new interesting possibilities for quantum cryptography networks

Cities are currently engaged through their urban policies in pushing people towards less environmentally impacting mobility modalities: therefore, cycling and walking are strongly promoted, especially by means of new and wider limited traffic and no-cars zones. In this paper, the effectiveness of the new smartphones and apps-based technologies in modifying the mobility behaviors of citizens towards more sustainable choices has been investigated. Specifically, the potential of a smartphone app, directly involving citizens by means of a game rewarding the most sustainable trips, has been tested on a university commuters' group. These latter, starting from their current mobility situation, were challenged by an enhanced scenario characterized by more restrictive and sustainable targets. Promising results have been obtained suggesting that game–based tools could be effectively used as urban policy interventions intended to obtain a more sustainable mobility.

The study of causal relations has recently been applied to the quantum realm, leading to the discovery that not all physical processes have a definite causal structure. While indefinite causal processes have previously been experimentally shown, these proofs relied on the quantum description of the experiments. Yet, the same experimental data could also be compatible with definite causal structures within different descriptions. Here, we present the first demonstration of indefinite temporal order outside of quantum formalism. We show that our experimental outcomes are incompatible with a class of generalised probabilistic theories satisfying the assumptions of locality and definite temporal order. To this end, we derive physical constraints (in the form of a Bell-like inequality) on experimental outcomes within such a class of theories. We then experimentally invalidate these theories by violating the inequality using entangled temporal order. This provides experimental evidence that there exist correlations in nature which are incompatible with the assumptions of locality and definite temporal order.

Cavity-enhanced spontaneous parametric down-conversion is capable of efficient generation of single photons with suitable spectral properties for interfacing with the atoms. However, beside the remarkable progress of this technique, multimode longitudinal emission remains a major drawback. Here, we demonstrate a bright source of single photons that overcomes this limitation by a novel mode-selection technique based on the introduction of an additional birefringent element to the cavity. This enables us to tune the double resonance condition independent of the phase matching and thus to achieve single-mode operation without mode filters. Our source emits single-frequency-mode photons at 852 nm, which is compatible to the Cs D2 line, with a bandwidth of 10.9 MHz and a detected photon-pair rate of 2.5 kHz at 10 mW of pump power, while maintaining g(2)(0) = 0.13. The efficiency of our source is further underlined by detecting a four-photon rate of 0.28 Hz at 20 mW of pump power. These detected rates correspond to a photon-pair generation rate of 47.5 Hz, and a four-photon generation rate of 37 Hz. Such photon generation rates open up a variety of new applications reaching from hybrid light-matter interactions to optical quantum information tasks based on long temporal coherence.

Topological phases play a fundamental role in a variety of physical systems, yet there is a lack of efficient tools for revealing the occurrence of associated quantum transitions. Here, Cardano et al.report that such transitions can be identified in the statistics of quantum-walk dynamics and validate this idea in a photonic experimental implementation.

Understanding the effects of environmental change on ecosystems requires the identification of baselines that may act as reference conditions. However, the continuous change of these references challenges our ability to define the true natural status of ecosystems. The so-called sliding baseline syndrome can be overcome through the analysis of quantitative time series, which are, however, extremely rare. Here we show how combining historical quantitative data with descriptive 'naturalistic' information arranged in a chronological chain allows highlighting long-term trends and can be used to inform present conservation schemes. We analysed the long-term change of a coralligenous reef, a marine habitat endemic to the Mediterranean Sea. The coralligenous assemblages of Mesco Reef (Ligurian Sea, NW Mediterranean) have been studied, although discontinuously, since 1937 thus making available both detailed descriptive information and scanty quantitative data: while the former was useful to understand the natural history of the ecosystem, the analysis of the latter was of paramount importance to provide a formal measure of change over time. Epibenthic assemblages remained comparatively stable until the 1990s, when species replacement, invasion by alien algae, and biotic homogenisation occurred within few years, leading to a new and completely different ecosystem state. The shift experienced by the coralligenous assemblages of Mesco Reef was probably induced by a combination of seawater warming and local human pressures, the latter mainly resulting in increased water turbidity; in turn, cumulative stress may have favoured the establishment of alien species. This study showed that the combined analysis of quantitative and descriptive historical data represent a precious knowledge to understand ecosystem trends over time and provide help to identify baselines for ecological management.

The effect of the Earth’s gravitational potential on a quantum wave function has only been observed for massive particles. In this paper we present a scheme to measure a gravitationally induced phase shift on a single photon traveling in a coherent superposition along different paths of an optical fiber interferometer. To create a measurable signal for the interaction between the static gravitational potential and the wave function of the photon, we propose a variant of a conventional Mach–Zehnder interferometer. We show that the predicted relative phase difference of 10 ^−5 rad is measurable even in the presence of fiber noise, provided additional stabilization techniques are implemented for each arm of a large-scale fiber interferometer. Effects arising from the rotation of the Earth and the material properties of the fibers are analysed. We conclude that optical fiber interferometry is a feasible way to measure the gravitationally induced phase shift on a single-photon wave function, and thus provides a means to corroborate the equivalence of the energy of the photon and its effective gravitational mass.

Seamounts and their influence on the surrounding environment are currently being extensively debated but, surprisingly, scant information is available for the Mediterranean area. Furthermore, although the deep Tyrrhenian Sea is characterised by a complex bottom morphology and peculiar hydrodynamic features, which would suggest a variable influence on the benthic domain, few studies have been carried out there, especially for soft-bottom macrofaunal assemblages. In order to fill this gap, the structure of the meio-and macrofaunal assemblages of the Vercelli Seamount and the surrounding deep area (northern Tyrrhenian Sea - western Mediterranean) were studied in relation to environmental features. Sediment was collected with a box-corer from the seamount summit and flanks and at two far-field sites in spring 2009, in order to analyse the metazoan communities, the sediment texture and the sedimentary organic matter. At the summit station, the heterogeneity of the habitat, the shallowness of the site and the higher trophic supply (water column phytopigments and macroalgal detritus, for instance) supported a very rich macrofaunal community, with high abundance, biomass and diversity. In fact, its trophic features resembled those observed in coastal environments next to seagrass meadows. At the flank and far-field stations, sediment heterogeneity and depth especially influenced the meiofaunal distribution. From a trophic point of view, the low content of the valuable sedimentary proteins that was found confirmed the general oligotrophy of the Tyrrhenian Sea, and exerted a limiting influence on the abundance and biomass of the assemblages. In this scenario, the rather refractory sedimentary carbohydrates became a food source for metazoans, which increased their abundance and biomass at the stations where the hydrolytic-enzyme-mediated turnover of carbohydrates was faster, highlighting high lability.

The article aims to analyze the educational function of women in the dionysiac rituals in the Greek and Roman world, concentrating on literary, epigraphic and iconographic sources. Through this investigation, the research underlines three different feminine functions inside the dionysiac practices: 1. the role in the institution or reformation of bacchic ceremonies; 2. the leadership of associations in the honour of Dionysus; 3. the transmission of dionysiac rituals and traditions.

Abstract Immune checkpoint inhibitors have revolutionized cancer treatment, but they are associated with a range of immune-related adverse events (irAEs), and emerging evidence suggests significant sex differences in the incidence, type, and severity of these toxicities, suggesting an influential factor and understanding sex-related differences in irAEs as crucial for optimizing patient care and improving clinical outcomes. In MOUSEION-07 study, we aimed to assess the association between sex and treatment-related adverse events in cancer patients treated with immunotherapy through a large up-to-date meta-analysis of available clinical trials. The present systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis. The protocol was registered with PROSPERO no. CRD42024549518. Sixteen studies encompassing a total of 4658 patients were included, and 2133 adverse effects were highlighted. The analysis observed a not statistically significant difference in terms of immune-related adverse events (irAEs) between males and females (Odds Ratio 1.19; CI 0.88–1.63) and revealed the presence of publication bias (β = −2.53; 95% CI = [−4.03; −1.04]; P = 0.006). Sex differences in immunotherapy-related adverse events are a significant factor in cancer treatment, necessitating a personalized approach to patient care. Further research is needed to fully understand the mechanisms driving these differences and to develop optimized strategies for monitoring and managing irAEs in both females and males.

Abstract The addition of metastasis-directed radiotherapy (MDRT) to immunotherapy in patients with advanced urothelial carcinoma (aUC) has shown promising results. We report the real-world data from the ARON-2 study (NCT05290038) on the impact of conventional (CRT) or stereotactic body radiotherapy (SBRT) on the outcome of aUC patients receiving pembrolizumab after platinum-based-chemotherapy. Medical records of 837 patients were reviewed from 60 institutions in 20 countries. Two hundred and sixty-two patients (31%) received radiotherapy (cohort A), of whom 193 (23%) received CRT and 69 (8%) received SBRT. Patients were assessed for overall survival (OS), progression-free survival (PFS), and overall response rate (ORR). Univariate and multivariate analyses were used to explore the association of variables of interest with OS and PFS. With a median follow-up of 22.7 months, the median OS was 10.2 months, 6.8 months and 16.0 months in no RT, CRT and SBRT subgroups (p = 0.005), with an 1y-OS rates of 47%, 34% and 61%, respectively (p

Background: The treatment of heavily pretreated patients with metastatic renal cell carcinoma (mRCC) represents an unmet medical need and is still challenging. Objectives: The primary objective was to assess the effectiveness of the lenvatinib plus everolimus combination and the secondary objective was the toxicity profile of this combination. Design: We conducted a longitudinal retrospective study examining mRCC patients pre-treated with one or more lines of therapy among different cancer centers in Italy. Methods: The study included patients who received the combination of lenvatinib plus everolimus as either a second-line treatment or beyond. We assessed progression-free survival (PFS), time to treatment failure (TTF), overall survival (OS), response rate (RR), and toxicity profile. In addition, we explored the potential relationship between treatment effectiveness and clinical and laboratory parameters. Results: In all, 33 patients were assessed, the median age was 60 years, 57% had an Eastern Cooperative Oncology Group performance status of 1–2 and. 63% received ⩾ 3 prior lines of therapy. 62% were ‘intermediate risk’ according to the International Metastatic Renal Cell Carcinoma Database Consortium and 30% were ‘poor risk’. The RR was 42% (no complete response), 18% stable disease. Median OS was 11.2 months (95% CI 6.8–19.9), median PFS was 6.7 months (95% CI 0.6–30.8), and median TTF was 6.7 months (95% CI 4.8–16.6). A shorter OS was significantly associated with lymph node metastases ( p = 0.043, 95% CI), neutrophils/ lymphocytes ratio (NLR) ⩾ 3 ( p = 0.007), hemoglobin/red cell distribution width ratio cutoff value

We present the first X-ray spectropolarimetric results for Cygnus X-1 in its soft state from a campaign of five IXPE observations conducted during 2023 May–June. Companion multiwavelength data during the campaign are likewise shown. The 2–8 keV X-rays exhibit a net polarization degree PD = 1.99% ± 0.13% (68% confidence). The polarization signal is found to increase with energy across the Imaging X-ray Polarimetry Explorer’s (IXPE) 2–8 keV bandpass. The polarized X-rays exhibit an energy-independent polarization angle of PA = −25.°7 ± 1.°8 east of north (68% confidence). This is consistent with being aligned to Cyg X-1’s au-scale compact radio jet and its parsec-scale radio lobes. In comparison to earlier hard-state observations, the soft state exhibits a factor of 2 lower polarization degree but a similar trend with energy and a similar (also energy-independent) position angle. When scaling by the natural unit of the disk temperature, we find the appearance of a consistent trend line in the polarization degree between the soft and hard states. Our favored polarimetric model indicates that Cyg X-1’s spin is likely high ( a _* ≳ 0.96). The substantial X-ray polarization in Cyg X-1's soft state is most readily explained as resulting from a large portion of X-rays emitted from the disk returning and reflecting off the disk surface, generating a high polarization degree and a polarization direction parallel to the black hole spin axis and radio jet. In IXPE’s bandpass, the polarization signal is dominated by the returning reflection emission. This constitutes polarimetric evidence for strong gravitational lensing of X-rays close to the black hole.

The Imaging X-ray Polarimetry Explorer measured with high significance the X-ray polarization of the brightest Z-source, Sco X-1, resulting in the nominal 2–8 keV energy band in a polarization degree of 1.0% ± 0.2% and a polarization angle of 8° ± 6° at a 90% confidence level. This observation was strictly simultaneous with observations performed by NICER, NuSTAR, and Insight-HXMT, which allowed for a precise characterization of its broadband spectrum from soft to hard X-rays. The source has been observed mainly in its soft state, with short periods of flaring. We also observed low-frequency quasiperiodic oscillations. From a spectropolarimetric analysis, we associate a polarization to the accretion disk at

Supernova remnants (SNRs) provide insights into cosmic-ray acceleration and magnetic field dynamics at shock fronts. Recent X-ray polarimetric measurements by the Imaging X-ray Polarimetry Explorer (IXPE) have revealed radial magnetic fields near particle acceleration sites in young SNRs, including Cassiopeia A, Tycho, and SN 1006. We present here the spatially resolved IXPE X-ray polarimetric observation of the northwestern rim of SNR RX J1713.7–3946. For the first time, our analysis shows that the magnetic field in the particle acceleration sites of this SNR is oriented tangentially with respect to the shock front. Because of the lack of precise Faraday rotation measurements in the radio band, this was not possible before. The average measured polarization degree (PD) of the synchrotron emission is 12.5% ± 3.3%, lower than the one measured by IXPE in SN 1006, comparable to the Tycho one, but notably higher than the one in Cassiopeia A. On subparsec scales, localized patches within RX J1713.7–3946 display a PD of up to 41.5% ± 9.5%. These results are compatible with a shock-compressed magnetic field. However, in order to explain the observed PD, either the presence of a radial net magnetic field upstream of the shock or partial reisotropization of the turbulence downstream by radial magnetohydrodynamical instabilities can be invoked. From comparison of PD and magnetic field distribution with γ -rays and ^12 CO data, our results provide new inputs in favor of a leptonic origin of the γ -ray emission.

How astrophysical systems translate the kinetic energy of bulk motion into the acceleration of particles to very high energies is a pressing question. SS 433 is a microquasar that emits TeV γ -rays indicating the presence of high-energy particles. A region of hard X-ray emission in the eastern lobe of SS 433 was recently identified as an acceleration site. We observed this region with the Imaging X-ray Polarimetry Explorer and measured a polarization degree in the range 38%–77%. The high polarization degree indicates the magnetic field has a well-ordered component if the X-rays are due to synchrotron emission. The polarization angle is in the range −12° to +10° (east of north), which indicates that the magnetic field is parallel to the jet. Magnetic fields parallel to the bulk flow have also been found in supernova remnants and the jets of powerful radio galaxies. This may be caused by interaction of the flow with the ambient medium.

Cir X-1 is a neutron star X-ray binary characterized by strong variations in flux during its eccentric ∼16.6 day orbit. There are also strong variations in the spectral state, and it has historically shown both atoll and Z state properties. We observed the source with the Imaging X-ray Polarimetry Explorer during two orbital segments, 6 days apart, for a total of 263 ks. We find an X-ray polarization degree in these segments of 1.6% ± 0.3% and 1.4% ± 0.3% at polarization angles of 37° ± 5° and −12° ± 7°, respectively. Thus, we observed a rotation of the polarization angle by 49° ± 8° along the orbit. Because variations of accretion flow, and then of the hardness ratio, are expected during the orbit, we also studied the polarization binned in hardness ratio and found the polarization angle differing by 67° ± 11° between the lowest and highest values of the hardness ratio. We discuss possible interpretations of this result that could indicate a possible misalignment between the symmetry axes of the accretion disk and the Comptonizing region caused by the misalignment of the neutron star’s angular momentum with respect to the orbital one.

We present multiwavelength polarization measurements of the luminous blazar Mrk 501 over a 14 month period. The 2–8 keV X-ray polarization was measured with the Imaging X-ray Polarimetry Explorer (IXPE) with six 100 ks observations spanning from 2022 March to 2023 April. Each IXPE observation was accompanied by simultaneous X-ray data from NuSTAR, Swift/XRT, and/or XMM-Newton. Complementary optical–infrared polarization measurements were also available in the B , V , R , I , and J bands, as were radio polarization measurements from 4.85 GHz to 225.5 GHz. Among the first five IXPE observations, we did not find significant variability in the X-ray polarization degree and angle with IXPE. However, the most recent sixth observation found an elevated polarization degree at >3 σ above the average of the other five observations. The optical and radio measurements show no apparent correlations with the X-ray polarization properties. Throughout the six IXPE observations, the X-ray polarization degree remained higher than, or similar to, the R -band optical polarization degree, which remained higher than the radio value. This is consistent with the energy-stratified shock scenario proposed to explain the first two IXPE observations, in which the polarized X-ray, optical, and radio emission arises from different regions.

We present Crab X-ray polarization measurements using Imaging X-Ray Polarimetry Explorer (IXPE) data with a total exposure of 300 ks, three times more than the initial 2022 discovery paper. Polarization is detected in three times more pulsar phase bins, revealing an S-shaped +40° polarization angle sweep in the main pulse and >1 σ departures from the OPTIMA optical polarization in both pulses, suggesting different radiation mechanisms or sites for the polarized emission at the two wavebands. Our polarization map of the inner nebula reveals a toroidal magnetic field, as seen in prior IXPE analyses. Along the southern jet, the magnetic field orientation relative to the jet axis changes from perpendicular to parallel and the polarization degree decreases by ∼6%. These observations may be explained by kink instabilities along the jet or a collision with a dense, jet-deflecting medium at the tip. Using spectropolarimetric analysis, we find asymmetric polarization in the four quadrants of the inner nebula, as expected for a toroidal field geometry, and a spatial correlation between polarization degree and photon index.

We present X-ray polarimetry observations from the Imaging X-ray Polarimetry Explorer (IXPE) of three low spectral peak and one intermediate spectral peak blazars, namely 3C 273, 3C 279, 3C 454.3, and S5 0716+714. For none of these objects was IXPE able to detect X-ray polarization at the 3 σ level. However, we placed upper limits on the polarization degree at ∼10%–30%. The undetected polarizations favor models where the X-ray band is dominated by unpolarized photons upscattered by relativistic electrons in the jets of blazars, although hadronic models are not completely eliminated. We discuss the X-ray polarization upper limits in the context of our contemporaneous multiwavelength polarization campaigns.

We report on an observational campaign on the bright black hole (BH) X-ray binary Swift J1727.8–1613 centered around five observations by the Imaging X-ray Polarimetry Explorer. These observations track for the first time the evolution of the X-ray polarization of a BH X-ray binary across a hard to soft state transition. The 2–8 keV polarization degree decreased from ∼4% to ∼3% across the five observations, but the polarization angle remained oriented in the north–south direction throughout. Based on observations with the Australia Telescope Compact Array, we find that the intrinsic 7.25 GHz radio polarization aligns with the X-ray polarization. Assuming the radio polarization aligns with the jet direction (which can be tested in the future with higher-spatial-resolution images of the jet), our results imply that the X-ray corona is extended in the disk plane, rather than along the jet axis, for the entire hard intermediate state. This in turn implies that the long (≳10 ms) soft lags that we measure with the Neutron star Interior Composition ExploreR are dominated by processes other than pure light-crossing delays. Moreover, we find that the evolution of the soft lag amplitude with spectral state does not follow the trend seen for other sources, implying that Swift J1727.8–1613 is a member of a hitherto undersampled subpopulation.

A large energy-dependent X-ray polarization degree is detected by the Imaging X-ray Polarimetry Explorer (IXPE) in the high-soft emission state of the black hole X-ray binary 4U 1630–47. The highly significant detection (at ≈50 σ confidence level) of an unexpectedly high polarization, rising from ∼6% at 2 keV to ∼10% at 8 keV, cannot be easily reconciled with standard models of thin accretion disks. In this work, we compare the predictions of different theoretical models with the IXPE data and conclude that the observed polarization properties are compatible with a scenario in which matter accretes onto the black hole through a thin disk covered by a partially ionized atmosphere flowing away at mildly relativistic velocities.

We present the first X-ray polarimetric study of the dipping accreting neutron star 4U 1624−49 with the Imaging X-ray Polarimetry Explorer. We report a detection of polarization in the nondip time intervals with a confidence level of 99.99%. We find an average polarization degree (PD) of 3.1% ± 0.7% and a polarization angle of 81° ± 6° east of north in the 2–8 keV band. We report an upper limit on the PD of 22% during the X-ray dips with 95% confidence. The PD increases with energy, reaching from 3.0% ± 0.9% in the 4–6 keV band to 6% ± 2% in the 6–8 keV band. This indicates the polarization likely arises from Comptonization. The high PD observed is unlikely to be produced by Comptonization in the boundary layer or spreading layer alone. It can be produced by the addition of an extended geometrically thin slab corona covering part of the accretion disk, as assumed in previous models of dippers, and/or a reflection component from the accretion disk.

Observations of linear polarization in the 2–8 keV energy range with the Imaging X-ray Polarimetry Explorer (IXPE) explore the magnetic field geometry and dynamics of the regions generating nonthermal radiation in relativistic jets of blazars. These jets, particularly in blazars whose spectral energy distribution peaks at X-ray energies, emit X-rays via synchrotron radiation from high-energy particles within the jet. IXPE observations of the X-ray-selected BL Lac–type blazar 1ES 1959+650 on 2022 May 3–4 showed a significant linear polarization degree of Π _x = 8.0% ± 2.3% at an electric-vector position angle ψ _x = 123° ± 8°. However, on 2022 June 9–12, only an upper limit of Π _x ≤ 5.1% could be derived (at the 99% confidence level). The degree of optical polarization at that time, Π _O ∼ 5%, is comparable to the X-ray measurement. We investigate possible scenarios for these findings, including temporal and geometrical depolarization effects. Unlike some other X-ray-selected BL Lac objects, there is no significant chromatic dependence of the measured polarization in 1ES 1959+650, and its low X-ray polarization may be attributed to turbulence in the jet flow with dynamical timescales shorter than 1 day.

We report on X-ray polarization measurements of the extragalactic Crab-like PSR B0540-69 and its Pulsar Wind Nebula (PWN) in the Large Magellanic Cloud, using a ∼850 ks Imaging X-ray Polarimetry Explorer (IXPE) exposure. The PWN is unresolved by IXPE. No statistically significant polarization is detected for the image-averaged data, giving a 99% confidence polarization upper limit (MDP _99 ) of 5.3% in the 2–8 keV energy range. However, a phase-resolved analysis detects polarization for both the nebula and pulsar in the 4–6 keV energy range. For the PWN defined as the off-pulse phases, the polarization degree (PD) of (24.5 ± 5.3)% and polarization angle (PA) of (78.1 ± 6.2)° is detected at 4.6 σ significance level, consistent with the PA observed in the optical band. In a single on-pulse window, a hint of polarization is measured at 3.8 σ with PD of (50.0 ± 13.1)% and PA of (6.2 ± 7.4)°. A “simultaneous” PSR/PWN analysis finds two bins at the edges of the pulse exceeding 3 σ PD significance, with PD of (68 ± 20)% and (62 ± 20)%; intervening bins at 2–3 σ significance have lower PD, hinting at additional polarization structure.

Background: High-grade neuroendocrine carcinoma (NEC) is a rare and aggressive variant of bladder cancer. Considering its rarity, its therapeutic management is challenging and not standardized. Methods: We analyzed data extracted from the Surveillance, Epidemiology, and End Results (SEER) registry to evaluate prognostic factors for high-grade NEC of the bladder. Results: We extracted data on 1134 patients: 77.6% were small cell NEC, 14.6% were NEC, 5.5% were mixed neuro-endocrine non-neuroendocrine neoplasia, and 2.3% were large cell NEC. The stage at diagnosis was localized for 45% of patients, lymph nodal disease (N+M0) for 9.2% of patients, and metastatic disease for 26.1% of patients. The median overall survival (OS) was 12 months. Multivariate analysis detected that factors associated with worse OS were age being >72 years old (HR 1.94), lymph nodal involvement (HR 2.01), metastatic disease (HR 2.04), and the size of the primary tumor being >44.5 mm (HR 1.80). In the N0M0 populations, the size of the primary tumor being Conclusions: Our SEER database analysis evidenced prognostic factors for high-grade NEC of the bladder that are of pivotal relevance to guide treatment and the decision-making process.

Urothelial carcinoma is a complex cancer with genomic immunomic drivers that have prognostic and predictive treatment implications. Identifying potential targetable alterations via next-generation sequencing and RNA sequencing may allow for elucidation of such targets and exploitation with targeted therapeutics. The role of immunotherapy in treating urothelial carcinoma has shown benefit, but it is unclear in which patients immunotherapeutics have the highest yield. Continuing efforts into better identifying which patients may benefit most from targeted therapies, immunotherapies, and combination therapies may ultimately lead to improved outcomes for patients with this disease.

Introduction: Bone metastases are the most frequent site of secondary localization of prostate cancer (PCa) and are present in about 90% of cases of advanced disease. Consequently, an adequate management of bone involvement is of pivotal importance in the therapeutic approach and skeletal-related events (SREs) need to be closely monitored and promptly assessed and treated. Bone targeting agents (BTAs), consisting in bisphosphonates and denosumab, are an essential part of the treatment of metastatic prostate cancer that accompanies systemic treatments throughout the most part of the history of the disease. Activity and safety of bone targeting agents: These treatments are correlated to better outcomes in terms of reduction of SREs and, in metastatic castration resistant setting, of increased overall survival (OS), but several important adverse events have to be managed and prevented. Of these, osteonecrosis of the jaw (ONJ) is extremely invalidating and should be managed with a special attention. Discussion: The role of BTAs in prostate cancer is pivotal throughout many stages of the disease, but several toxicities should be quickly recognized and treated. We aim at recollecting evidence on clinical benefit of BTAs, common and specific toxicities, and explore the pathophysiology and clinical aspects of osteonecrosis of the jaw. We present a review of the literature to report the role of the different types of bone targeting agents in the management of prostate cancer with bone metastases with a particular focus on common toxicities and ONJ to recollect current evidences on the activity of these compounds and the correct management of their adverse events.

Introduction In the last several years,there has been a paradigm shift in treating patients presenting with large vessel occlusion (LVO) strokes with endovascular therapy (EVT). Currently, the 24‐hour window has been incorporated in acute stroke management guidelines based on trials supporting the selection of patients with evidence of ischemic penumbra on perfusion imaging1,2. No current randomized control trials exist to support very late window EVT (beyond 24 hours) from last seen well (LSW) and its benefits are unknown. Several retrospective studies showed that EVT is safe and feasible up to 6 days from LSW in selected patients who are able preserve a favorable ischemic core to penumbra3, 4, 5. In this study we present a retrospective review of three patients with LVO strokes of the anterior circulation successfully treated between 10–14 days from LSW. We aim to explore the safety, efficiency and positive predictors of very late window EVT. Methods A single center retrospective review of stroke patients was performed. 517 patients with LVO strokes who underwent EVT between January 2018 and December 2021 were screened. 3 patients were found to have EVT performed 24 hours beyond LSW. Patient demographics, characteristics and clinical information were collected by systematic chart review. The primary outcome was functional independence as assessed by the modified Rankin Score (mRS) at 90 days. The safety outcomes included neurological deterioration and symptomatic intracranial hemorrhage, defined as an increase in National Institutes of Health Stroke Scale (NIHSS) of 4 or more). Further, a comprehensive literature review of studies describing very late window EVT cases indexed in PubMed was performed. Results We identifiedthree patients with LVO strokes, treated more than 24 hours from LSW. Patient ages ranged from 75 to 89 years. Baseline NIHSS ranged from 1 to 13. All patients had LVO or stenosis of the anterior circulation (internal carotid artery and/or M1 segment of the middle cerebral artery). All patients had fluctuation in their symptoms with worsening going from a supine position to a sitting position, evidence of ischemic penumbra on perfusion imaging and slow infarct growth on repeat brain imaging. The time from LSW to intervention ranged from 11 to 14 days. Recanalization score ranged from 2B‐3. No patients had intracranial hemorrhage or neurological decline. mRS scores were 2, 4, and 6 at 3 months. The patient who died had preservation of neurological function but died in the hospital due to heart failure. Conclusions We conclude that widening of the EVT time window presents new opportunities to treat a select population of LVO stroke patients. To our knowledge, there are no other reports of EVT in LVO patients beyond 10 days of LSW. Patients who have evidence of large ischemic penumbra, fluctuation of symptoms with change in position or blood pressure, good collateral circulation, and small infarct core that grows slowly on repeat imaging may be reasonable candidates for delayed EVT. More data are needed to inform clinical practice.

Spatially resolved observations of active galactic nuclei (AGN) host galaxies undergoing feedback processes are one of the most relevant avenues through which galactic evolution can be studied, given the long-lasting effects AGN feedback has on gas reservoirs, star formation, and AGN environments at all scales. Within this context, we report results from Very Large Telescope/MUSE integral field optical spectroscopy of TN J1049-1258, one of the most powerful radio sources known, at a redshift of 3.7. We detected extended (∼18 kpc) Ly α emission, spatially aligned with the radio axis, redshifted by 2250 ± 60 km s ^−1 with respect to the host galaxy systemic velocity, and cospatial with UV continuum emission. This Ly α emission could arise from a companion galaxy, although there are arguments against this interpretation. Alternatively, it might correspond to an outflow of ionized gas stemming from the radio galaxy. The outflow would be the highest redshift spatially resolved ionized outflow to date. The enormous amount of energy injected, however, appears to be unable to quench the host galaxy’s prodigious star formation, occurring at a rate of ∼4500 M _⊙ yr ^−1 , estimated using its far-infrared luminosity. Within the field, we also found two companion galaxies at projected distances of ∼25 and ∼60 kpc from the host, which suggests the host galaxy is harbored within a protocluster.

We report the first detection of the X-ray polarization of the bright transient Swift J1727.8−1613 with the Imaging X-ray Polarimetry Explorer. The observation was performed at the beginning of the 2023 discovery outburst, when the source resided in the bright hard state. We find a time- and energy-averaged polarization degree of 4.1% ± 0.2% and a polarization angle of 2.°2 ± 1.°3 (errors at 68% confidence level; this translates to ∼20 σ significance of the polarization detection). This finding suggests that the hot corona emitting the bulk of the detected X-rays is elongated, rather than spherical. The X-ray polarization angle is consistent with that found in submillimeter wavelengths. Since the submillimeter polarization was found to be aligned with the jet direction in other X-ray binaries, this indicates that the corona is elongated orthogonal to the jet.

The Imaging X-ray Polarimetry Explorer (IXPE) observed the black hole X-ray binary 4U 1630–47 in the steep power-law (or very high) state. The observations reveal a linear polarization degree of the 2–8 keV X-rays of 6.8% ± 0.2% at a position angle of 21.°3 ± 0.°9 east of north (all errors at 1 σ confidence level). Whereas the polarization degree increases with energy, the polarization angle stays constant within the accuracy of our measurements. We compare the polarization of the source in the steep power-law state with the previous IXPE measurement of the source in the high soft state. We find that, even though the source flux and spectral shape are significantly different between the high soft state and the steep power-law state, their polarization signatures are similar. Assuming that the polarization of both the thermal and power-law emission components are constant over time, we estimate the power-law component polarization to be 6.8%–7.0% and note that the polarization angle of the thermal and power-law components must be approximately aligned. We discuss the implications for the origin of the power-law component and the properties of the emitting plasma.

The lower-energy peak of the spectral energy distribution of blazars has commonly been ascribed to synchrotron radiation from relativistic particles in the jets. Despite the consensus regarding jet emission processes, the particle acceleration mechanism is still debated. Here, we present the first X-ray polarization observations of PG 1553+113, a high-synchrotron-peak blazar observed by the Imaging X-ray Polarimetry Explorer (IXPE). We detect an X-ray polarization degree of (10 ± 2)% along an electric-vector position angle of ψ _X = 86° ± 8°. At the same time, the radio and optical polarization degrees are lower by a factor of ∼3. During our IXPE pointing, we observed the first orphan optical polarization swing of the IXPE era, as the optical angle of PG 1553+113 underwent a smooth monotonic rotation by about 125°, with a rate of ∼17° day ^–1 . We do not find evidence of a similar rotation in either radio or X-rays, which suggests that the X-ray and optically emitting regions are separate or, at most, partially cospatial. Our spectropolarimetric results provide further evidence that the steady-state X-ray emission in blazars originates in a shock-accelerated and energy-stratified electron population.

This paper reports the first detection of polarization in the X-rays for atoll-source 4U 1820−303, obtained with the Imaging X-ray Polarimetry Explorer (IXPE) at 99.999% confidence level (CL). Simultaneous polarimetric measurements were also performed in the radio with the Australia Telescope Compact Array. The IXPE observations of 4U 1820−303 were coordinated with Swift X-ray Telescope, Neutron Star Interior Composition Explorer, and Nuclear Spectroscopic Telescope Array aiming to obtain an accurate X-ray spectral model covering a broad energy interval. The source shows a significant polarization above 4 keV, with a polarization degree of 2.0% ± 0.5% and a polarization angle of −55° ± 7° in the 4–7 keV energy range, and a polarization degree of 10% ± 2% and a polarization angle of −67° ± 7° in the 7–8 keV energy bin. This polarization also shows a clear energy trend with polarization degree increasing with energy and a hint for a position-angle change of ≃90° at 96% CL around 4 keV. The spectro-polarimetric fit indicates that the accretion disk is polarized orthogonally to the hard spectral component, which is presumably produced in the boundary/spreading layer. We do not detect linear polarization from the radio counterpart, with a 3 σ upper limit of 50% at 7.25 GHz.

We report the first >99% confidence detection of X-ray polarization in BL Lacertae. During a recent X-ray/ γ -ray outburst, a 287 ks observation (2022 November 27–30) was taken using the Imaging X-ray Polarimetry Explorer (IXPE), together with contemporaneous multiwavelength observations from the Neil Gehrels Swift observatory and XMM-Newton in soft X-rays (0.3–10 keV), NuSTAR in hard X-rays (3–70 keV), and optical polarization from the Calar Alto and Perkins Telescope observatories. Our contemporaneous X-ray data suggest that the IXPE energy band is at the crossover between the low- and high-frequency blazar emission humps. The source displays significant variability during the observation, and we measure polarization in three separate time bins. Contemporaneous X-ray spectra allow us to determine the relative contribution from each emission hump. We find >99% confidence X-ray polarization ${{\rm{\Pi }}}_{2\mbox{--}4\mathrm{keV}}={21.7}_{-7.9}^{+5.6} \% $ and electric vector polarization angle ψ _2–4keV = −28.°7 ± 8.°7 in the time bin with highest estimated synchrotron flux contribution. We discuss possible implications of our observations, including previous IXPE BL Lacertae pointings, tentatively concluding that synchrotron self-Compton emission dominates over hadronic emission processes during the observed epochs.

Magnetars are the most strongly magnetized neutron stars, and one of the most promising targets for X-ray polarimetric measurements. We present here the first Imaging X-ray Polarimetry Explorer observation of the magnetar 1RXS J170849.0-400910, jointly analyzed with a new Swift observation and archival NICER data. The total (energy- and phase-integrated) emission in the 2–8 keV energy range is linerarly polarized, at a ∼35% level. The phase-averaged polarization signal shows a marked increase with energy, ranging from ∼20% at 2–3 keV up to ∼80% at 6–8 keV, while the polarization angle remains constant. This indicates that radiation is mostly polarized in a single direction. The spectrum is well reproduced by a combination of either two thermal (blackbody) components or a blackbody and a power law. Both the polarization degree and angle also show a variation with the spin phase, and the former is almost anticorrelated with the source counts in the 2–8 and 2–4 keV bands. We discuss the possible implications and interpretations, based on a joint analysis of the spectral, polarization, and pulsation properties of the source. A scenario in which the surface temperature is not homogeneous, with a hotter cap covered by a gaseous atmosphere and a warmer region in a condensed state, provides a satisfactory description of both the phase- and energy-dependent spectro-polarimetric data. The (comparatively) small size of the two emitting regions, required to explain the observed pulsations, does not allow to reach a robust conclusion about the presence of vacuum birefringence effects.