7 results on '"Frunzio, S"'
Search Results
2. P 166 ArF 193nm excimer laser corneal surgery and photo-oxidative stress in aqueous humor and lens of rabbit: One-month follow-up
- Author
-
Costagliola, C., Balestrieri, P., Fioretti, F., Frunzio, S., Rinaldi, M., and Scibelli, G.
- Published
- 1995
- Full Text
- View/download PDF
3. ArF 193nm excimer laser corneal surgery and photo-oxidative stress in aqueous humor and lens of rabbit: one month follow-up
- Author
-
Ciro Costagliola, G. Scibelli, Michele Rinaldi, Felice Fioretti, Stefano Frunzio, Paola Balestrieri, Costagliola, Ciro, Balestrieri, P, Fioretti, F, Frunzio, S, Rinaldi, M, Scibelli, G., Costagliola, C, and Rinaldi, Michele
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Aqueous humor ,Ascorbic Acid ,medicine.disease_cause ,Photorefractive Keratectomy ,Cataract ,Aqueous Humor ,Cornea ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Malondialdehyde ,Ophthalmology ,Lens, Crystalline ,medicine ,Animals ,Hydrogen peroxide ,Glutathione Disulfide ,Excimer laser ,Hydrogen Peroxide ,Ascorbic acid ,Glutathione ,Photobiology ,eye diseases ,Sensory Systems ,Photorefractive keratectomy ,Surgery ,Oxidative Stress ,medicine.anatomical_structure ,chemistry ,Lens (anatomy) ,Lasers, Excimer ,Rabbits ,Oxidative stress - Abstract
Twenty male albino rabbits were studied. Four animals served as controls; the remaining 16 animals represented the treated group. All the treated animals were exposed to the same amount of energy delivered by the excimer laser (pulse rate: 20 Hz, fluence 250mJ/cm2; number of pulses: 6032; cumulative UV dose 1508 J/cm2) and were divided into eight groups of 2 animals each (four eyes). Samples of aqueous humor and lens were obtained at the following intervals: 5, 10, 20 and 40 min and 1, 2, 3 and 4 weeks after photorefractive keratectomy (PRK). The levels of reduced and oxidized glutathione, hydrogen peroxide, ascorbic acid and malondialdehyde were determined. Aqueous humor analyses, twenty min after PRK, showed no significant differences with pre-treatment values, while the observed variations in lens were constantly present over the entire follow-up period (one month). These findings suggest that the biochemical lens alterations induced by PRK may represent the earliest events relevant to cataractogenesis in the rabbit. Twenty male albino rabbits were studied. Four animals served as controls; the remaining 16 animals represented the treated group. All the treated animals were exposed to the same amount of energy delivered by the excimer laser (pulse rate: 20 Hz, fluence 250mJ/cm(2); number of pulses: 6032; cumulative UV dose 1508 J/cm(2)) and were divided into eight groups of 2 animals each (four eyes). Samples of aqueous humor and lens were obtained at the following intervals: 5, 10, 20 and 40 min and 1, 2, 3 and 4 weeks after photorefractive keratectomy (PRK). The levels of reduced and oxidized glutathione, hydrogen peroxide, ascorbic acid and malondialdehyde were determined.Aqueous humor analyses, twenty min after PRK, showed no significant differences with pre-treatment values, while the observed variations in lens were constantly present over the entire follow-up period (one month).These findings suggest that the biochemical lens alterations induced by PRK may represent the earliest events relevant to cataractogenesis in the rabbit.
- Published
- 1995
4. ArF 193 nm excimer laser corneal surgery as a possible risk factor in cataractogenesis
- Author
-
G. Scibelli, Ciro Costagliola, Ernesto Rinaldi, Felice Fioretti, Michele Rinaldi, Stefano Frunzio, Paola Balestrieri, Adolfo Sebastiani, Costagliola, C, Balestrieri, P, Fioretti, F, Frunzio, S, Rinaldi, Michele, Scibelli, G, Sebastiani, A, Rinaldi, E., Costagliola, Ciro, and Rinaldi, M
- Subjects
Male ,malondialdehyde ,medicine.medical_specialty ,cataractogenesis ,Ultraviolet Rays ,medicine.medical_treatment ,ultraviolet light ,hydrogen peroxide ,photostress ,Photochemistry ,Excimer ,Radiation Dosage ,Aqueous Humor ,Cornea ,ascorbic acid ,cataract ,excimer laser ,oxidized glutathione ,reduced glutathione ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Risk Factors ,Internal medicine ,Lens, Crystalline ,medicine ,Ultraviolet light ,Animals ,cataractogenesi ,Excimer laser ,Chemistry ,Aqueous humour ,Glutathione ,photostre ,Ascorbic acid ,eye diseases ,Sensory Systems ,Photorefractive keratectomy ,Refractive Surgical Procedures ,Ophthalmology ,Endocrinology ,medicine.anatomical_structure ,Laser Therapy ,Rabbits ,Oxidation-Reduction - Abstract
It was evaluated whether ArF 193 nm excimer laser corneal surgery represents a risk factor in cataractogenesis. For this purpose, 20 male albino rabbits underwent a photorefractive keratectomy and biochemical analyses on aqueous humour (hydrogen peroxide, ascorbic acid, and reduced and oxidized glutathione) and on lens (malondialdehyde, reduced and oxidized glutathione) were performed. In the aqueous humour of all treated animals a significant increase in hydrogen peroxide and in oxidized glutathione and a concomitant decrease in ascorbic acid and reduced glutathione concentration were observed. Moreover, all these variations were significantly correlated with the cumulative UV dose used. In the lens, after excimer laser corneal surgery, there was a dramatic loss of reduced glutathione and a parallel increase in oxidized glutathione levels. Malondialdehyde concentration was also increased, but only at the highest UV exposure. Moreover, all these variations were significantly correlated with the cumulative UV dose used. These findings demonstrate that the exposure of aqueous humour and lens to the secondary radiation generated after ArF 193 nm excimer laser corneal photoablative keratectomy induces biochemical modifications which are known to be markers of cataractogenesis. © 1994 Academic Press. All rights reserved.
- Published
- 1994
5. Arf 193nm excimer laser corneal surgery and photo-oxidation stress in aqueous humor and lens of rabbit: one-month follow-up.
- Author
-
Costagliola C, Balestrieri P, Fioretti F, Frunzio S, Rinaldi M, and Scibelli G
- Subjects
- Animals, Aqueous Humor metabolism, Aqueous Humor radiation effects, Ascorbic Acid metabolism, Cataract etiology, Glutathione analogs & derivatives, Glutathione metabolism, Glutathione Disulfide, Hydrogen Peroxide metabolism, Lasers, Excimer, Lens, Crystalline metabolism, Lens, Crystalline radiation effects, Male, Malondialdehyde metabolism, Oxidative Stress, Photobiology, Rabbits, Time Factors, Cornea surgery, Photorefractive Keratectomy adverse effects
- Abstract
Twenty male albino rabbits were studied. Four animals served as controls; the remaining 16 animals represented the treated group. All the treated animals were exposed to the same amount of energy delivered by the excimer laser (pulse rate: 20 Hz, fluence 250mJ/cm2; number of pulses: 6032; cumulative UV dose 1508 J/cm2) and were divided into eight groups of 2 animals each (four eyes). Samples of aqueous humor and lens were obtained at the following intervals: 5, 10, 20 and 40 min and 1, 2, 3 and 4 weeks after photorefractive keratectomy (PRK). The levels of reduced and oxidized glutathione, hydrogen peroxide, ascorbic acid and malondialdehyde were determined. Aqueous humor analyses, twenty min after PRK, showed no significant differences with pre-treatment values, while the observed variations in lens were constantly present over the entire follow-up period (one month). These findings suggest that the biochemical lens alterations induced by PRK may represent the earliest events relevant to cataractogenesis in the rabbit.
- Published
- 1996
- Full Text
- View/download PDF
6. ArF 193 nm excimer laser corneal surgery as a possible risk factor in cataractogenesis.
- Author
-
Costagliola C, Balestrieri P, Fioretti F, Frunzio S, Rinaldi M, Scibelli G, Sebastiani A, and Rinaldi E
- Subjects
- Animals, Aqueous Humor chemistry, Aqueous Humor radiation effects, Ascorbic Acid radiation effects, Glutathione radiation effects, Hydrogen Peroxide radiation effects, Lens, Crystalline chemistry, Lens, Crystalline radiation effects, Male, Malondialdehyde radiation effects, Oxidation-Reduction, Rabbits, Radiation Dosage, Risk Factors, Ultraviolet Rays, Cataract etiology, Cornea surgery, Laser Therapy adverse effects, Refractive Surgical Procedures
- Abstract
It was evaluated whether ArF 193 nm excimer laser corneal surgery represents a risk factor in cataractogenesis. For this purpose, 20 male albino rabbits underwent a photorefractive keratectomy and biochemical analyses on aqueous humour (hydrogen peroxide, ascorbic acid, and reduced and oxidized glutathione) and on lens (malondialdehyde, reduced and oxidized glutathione) were performed. In the aqueous humour of all treated animals a significant increase in hydrogen peroxide and in oxidized glutathione and a concomitant decrease in ascorbic acid and reduced glutathione concentration were observed. Moreover, all these variations were significantly correlated with the cumulative UV dose used. In the lens, after excimer laser corneal surgery, there was a dramatic loss of reduced glutathione and a parallel increase in oxidized glutathione levels. Malondialdehyde concentration was also increased, but only at the highest UV exposure. Moreover, all these variations were significantly correlated with the cumulative UV dose used. These findings demonstrate that the exposure of aqueous humour and lens to the secondary radiation generated after ArF 193 nm excimer laser corneal photoablative keratectomy induces biochemical modifications which are known to be markers of cataractogenesis.
- Published
- 1994
- Full Text
- View/download PDF
7. Galactokinase activity in patients with idiopathic presenile and senile cataract.
- Author
-
Simonelli F, Giovane A, Frunzio S, Balestrieri P, Amicone A, Rinaldi M, Cotticelli L, and Rinaldi E
- Subjects
- Adult, Aged, Aging, Female, Galactokinase deficiency, Humans, Male, Middle Aged, Cataract enzymology, Erythrocytes enzymology, Galactokinase metabolism
- Abstract
The activity of galactokinase in red blood cells of 30 patients affected by idiophatic presenile and senile cataract, and of 20 age-matched controls with perfectly transparent lenses, was investigated. The results obtained show a partial deficiency of the galactokinase activity in the patients affected by presenile idiopathic cataract. There is, moreover, a significant relationship between the cortical form of cataract and enzymatic reduction.
- Published
- 1992
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.