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428 results on '"Fu, Xudong"'

36. Mitophagy defect mediates the aging‐associated hallmarks in Hutchinson–Gilford progeria syndrome.

Author

Sun, Yingying, Xu, Le, Li, Yi, Jia, Shunze, Wang, Gang, Cen, Xufeng, Xu, Yuyan, Cao, Zhongkai, Wang, Jingjing, Shen, Ning, Hu, Lidan, Zhang, Jin, Mao, Jianhua, Xia, Hongguang, Liu, Zhihong, and Fu, Xudong

Subjects
PROGERIA, PREMATURE aging (Medicine), MESENCHYMAL stem cells, PHENOTYPES
Abstract

Hutchinson–Gilford progeria syndrome (HGPS) is a rare and fatal disease manifested by premature aging and aging‐related phenotypes, making it a disease model for aging. The cellular machinery mediating age‐associated phenotypes in HGPS remains largely unknown, resulting in limited therapeutic targets for HGPS. In this study, we showed that mitophagy defects impaired mitochondrial function and contributed to cellular markers associated with aging in mesenchymal stem cells derived from HGPS patients (HGPS‐MSCs). Mechanistically, we discovered that mitophagy affected the aging‐associated phenotypes of HGPS‐MSCs by inhibiting the STING‐NF‐ĸB pathway and the downstream transcription of senescence‐associated secretory phenotypes (SASPs). Furthermore, by utilizing UMI‐77, an effective mitophagy inducer, we showed that mitophagy induction alleviated aging‐associated phenotypes in HGPS and naturally aged mice. Collectively, our results uncovered that mitophagy defects mediated the aging‐associated markers in HGPS, highlighted the function of mitochondrial homeostasis in HGPS progression, and suggested mitophagy as an intervention target for HGPS and aging. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Revisit of Polyaniline as a High-Capacity Organic Cathode Material for Li-Ion Batteries.

Author

Zhao, Ruirui, Chang, Zu, Fu, Xudong, Xu, Mingli, Ai, Xinping, and Qian, Jiangfeng

Subjects
LITHIUM-ion batteries, POLYANILINES, CATHODES, ELECTROLYTES, ELECTRODES
Abstract

Polyaniline (PANI) has long been explored as a promising organic cathode for Li-ion batteries. However, its poor electrochemical utilization and cycling instability cast doubt on its potential for practical applications. In this work, we revisit the electrochemical performance of PANI in nonaqueous electrolytes, and reveal an unprecedented reversible capacity of 197.2 mAh g−1 (244.8 F g−1) when cycled in a wide potential range of 1.5 to 4.4 V vs. Li+/Li. This ultra-high capacity derives from 70% -NH- transformed to =NH+- during deep charging/discharging process. This material also demonstrates a high average coulombic efficiency of 98%, an excellent rate performance with 73.5 mAh g−1 at 1800 mA g−1, and retains 76% of initial value after 100 cycles, which are among the best reported values for PANI electrodes in battery applications. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Metabolic remodelling during early mouse embryo development

Author

Zhao, Jing, Yao, Ke, Yu, Hua, Zhang, Ling, Xu, Yuyan, Chen, Lang, Sun, Zhen, Zhu, Yuqing, Zhang, Cheng, Qian, Yuli, Ji, Shuyan, Pan, Hongru, Zhang, Min, Chen, Jie, Correia, Cristina, Weiskittel, Taylor, Lin, Da-Wei, Zhao, Yuzheng, Chandrasekaran, Sriram, Fu, Xudong, Zhang, Dan, Fan, Heng-Yu, Xie, Wei, Li, Hu, Hu, Zeping, and Zhang, Jin

Published
2021
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47. Global Analysis of Topographic and Climatic Controls on Drainage Basin Shapes.

Author

Li, Minhui, Seybold, Hansjörg, Wu, Baosheng, Chen, Yi, Fu, Xudong, and Kirchner, James W.

Subjects
SURFACE of the earth, ARID regions, EARTHFLOWS, SURFACE morphology, CONTINENTS
Abstract

Drainage basins are fundamental units of Earth's surface, describing how flows accumulate across landscapes. They are direct expressions of how tectonics and climatic forces alter Earth's surface morphology. Here, we measure the width‐to‐length ratios (WLRs) of 386,931 drainage basins (average area ∼157 km2), covering all continents except Antarctica and Greenland. Global variations in WLRs are correlated with climatic aridity, whole‐basin slope, and local topographic roughness. Basins in arid landscapes tend to be narrower, potentially reflecting a higher prevalence of surface runoff and therefore a stronger slope‐parallel component of the transporting flow. Local topographic roughness is associated with wider basins, potentially reflecting greater dispersion of flow directions. Conversely, whole‐basin topographic gradients, potentially reflecting gradients in uplift, are associated with narrower basins. However, steeper basins are also often rougher, so revealing the effects of whole‐basin slope requires correcting for the confounding effects of roughness variations. Plain Language Summary: Drainage basins are essential features that help us understand how water accumulates and flows across Earth's landscapes. In this study, we examined the width‐to‐length ratios of 386,931 drainage basins from all continents except Antarctica and Greenland. We found that basins tend to be narrower in more arid climates. We also observed that, all else equal, basins with greater local roughness tend to be wider, and those with steeper whole‐basin slopes tend to be narrower. Our results thus indicate that on the global scale, basin shapes are strongly influenced by topographic roughness, whole‐basin slope and climatic aridity. Our findings hold across different basin scales, encompassing smaller basins with a mean area of approximately 157 km2 to larger basins with a mean area of around 1,000 km2. These results advance our understanding of global patterns of basin shapes and the tectonic and climatic drivers behind them. Key Points: Globally, basins with greater topographic roughness tend to be wider, and those with steeper whole‐basin slopes tend to be narrowerIn arid regions (aridity index <0.65), basins tend to widen as climate becomes more humidBasin shape is strongly correlated with topographic roughness, whole‐basin slope and climatic aridity on a global scale [ABSTRACT FROM AUTHOR]

Published
2024
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