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Your search keyword '"GRECCO, F. B."' showing total 2 results
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2 results on '"GRECCO, F. B."'

1. Eugenia uniflora fruit (red type) standardized extract: a potential pharmacological tool to diet-induced metabolic syndrome damage management

Author

OLIVEIRA, P. S., CHAVES, V. C., BONA, N. P., SOARES, M. S. P., CARDOSO, J. de S., VASCONCELLOS, F. A., TAVARES, R. G., VIZZOTTO, M., SILVA, L. M. C. da, GRECCO, F. B., GAMARO, G. D., SPANEVELLI, R. M., LENCINA, C. L., REGINATTO, F. H., STEFANELLO, F. M., Pathise Souto Oliveira, Vitor Clasen Chaves, Natália Pontes Bona, Mayara Sandrielly Pereira Soares, Juliane de Souza Cardoso, Flávia Aleixo Vasconcellos, Rejane Giacomelli Tavares, MARCIA VIZZOTTO, CPACT, Luísa Mariano Cerqueira da Silva, Fabiane Borelli Grecco, Giovana Duzzo Gamaro, Roselia Maria Spanevello, Claiton Leoneti Lencina, Flávio Henrique Reginatto, and Francieli Moro Stefanello.

Subjects
Eugenia Uniflora, Pharmacological management, phenolic compounds, metabolic syndrome
Published
2017

2. Ketoprofen-loaded rose hip oil nanocapsules attenuate chronic inflammatory response in a pre-clinical trial in mice.

Author

Ramos PT, Pedra NS, Soares MSP, da Silveira EF, Oliveira PS, Grecco FB, da Silva LMC, Ferreira LM, Ribas DA, Gehrcke M, Felix AOC, Stefanello FM, Spanevello RM, Cruz L, and Braganhol E

Subjects
Animals, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics, Cell Line, Chronic Disease, Disease Models, Animal, Drug Liberation, Drug Stability, Edema drug therapy, Humans, Keratinocytes drug effects, Ketoprofen administration & dosage, Ketoprofen pharmacokinetics, Male, Mice, Inbred C57BL, Nanocapsules therapeutic use, Oxidative Stress drug effects, Rosa chemistry, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Inflammation drug therapy, Ketoprofen pharmacology, Nanocapsules chemistry, Plant Oils chemistry
Abstract

This study aimed to develop nanocapsules containing ketoprofen using rose hip oil (Keto-NC) as oil core, and to evaluate their anti-inflammatory activity in acute and chronic ear edema models in mice. Physicochemical characterization, drug release, photostability and cytotoxicity assays were performed for the developed Keto-NC formulations and compared to ketoprofen-loaded nanocapsules using medium chain triglycerides as oil core (Keto-MCT-NC). Anti-inflammatory activity of orally delivered KP (Ketoprofen-free; 10 mg.kg -1 ) or Keto-NC (2.5; 5; 10 mg.kg -1 ) was assessed in mouse acute and chronic ear edema induced by croton oil (CO). Edema histological characteristics were determined by H&E stain, and redox parameters were analyzed in blood plasma and erythrocytes. Keto-MCT-NC and Keto-NC did not exhibit differences regarding physicochemical parameters, including size diameters, polydispersity index, pH, Ketoprofen content, and encapsulation efficiency. However, Keto-NC, which contains rose hip oil as lipid core, decreased drug photodegradation under UVC radiation when compared to Keto-MCT-NC. KP or Keto-NC were not cytotoxic to keratinocyte cultures and produced equal edema inhibition in the acute protocol. Conversely, in the chronic protocol, Keto-NC was more effective in reducing edema (~60-70% on 7-9th days of treatment) when compared to KP (~40% on 8-9th days of treatment). This result was confirmed by histological analysis, which indicated reduction of edema and inflammatory infiltrate. A sub-therapeutic dose of Keto-NC (5 mg.kg -1 ) significantly reduced edema when compared to control. Finally, KP and Keto-NC exhibited similar effects on redox parameters, suggesting that the advantages associated with Ketoprofen nanoencapsulation did not involve oxidative stress pathways. The results showed that Keto-NC was more efficient than KP in reducing chronic inflammation. These data may be important for the development of strategies aiming treatment of chronic inflammatory diseases with fewer adverse effects., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Published
2019
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