39 results on '"Garagorri, J."'
Search Results
2. The geometry of catastrophic fracture during high temperature processing of silicon
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Tanner, B. K., Garagorri, J., Gorostegui-Colinas, E., Elizalde, M. R., Bytheway, R., McNally, P. J., and Danilewsky, A. N.
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- 2015
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3. Dislocation dynamics and slip band formation in silicon: In-situ study by X-ray diffraction imaging
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Danilewsky, A.N., Wittge, J., Croell, A., Allen, D., McNally, P., Vagovič, P., dos Santos Rolo, T., Li, Z., Baumbach, T., Gorostegui-Colinas, E., Garagorri, J., Elizalde, M.R., Fossati, M.C., Bowen, D.K., and Tanner, B.K.
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- 2011
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4. Serum transaminases concentrations in obese children and adolescents
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González-Gil, E. M., Bueno-Lozano, G., Bueno-Lozano, O., Moreno, L. A., Cuadrón-Andres, L., Huerta-Blas, P., Garagorri, J. M., and Bueno, M.
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- 2009
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5. Metabolic risk-factor clustering estimation in obese children
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Bueno, G., Moreno, L. A., Bueno, O., Morales, J., Pérez-Roche, T., Garagorri, J. M., and Bueno, M.
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- 2007
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6. Diversity of metabolic syndrome risk factors in obese children and adolescents
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Bueno, G., Bueno, O., Moreno, L. A., García, R., Tresaco, B., Garagorri, J. M., and Bueno, M.
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- 2006
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7. Homeostatic model assessment (HOMA) index cut-off values to identify the metabolic syndrome in children
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Tresaco, B., Bueno, G., Pineda, I., Moreno, L. A., Garagorri, J. M., and Bueno, M.
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- 2005
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8. Insulin resistance and impaired glucose tolerance in obese children and adolescents
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Tresaco, B., Bueno, G., Moreno, L. A., Garagorri, J. M., and Bueno, M.
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- 2003
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9. Psyllium fibre and the metabolic control of obese children and adolescents
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Moreno, L. A., Tresaco, B., Bueno, G., Fleta, J., Rodríguez, G., Garagorri, J. M., and Bueno, M.
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- 2003
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10. EPIGENETIC BIOMARKERS FOR WEIGHT LOSS RESPONSE AFTER A LIFESTYLE INTERVENTION IN OVERWEIGHT/OBESE SPANISH ADOLESCENTS: THE EVASYON STUDY: 644 accepted poster
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Moleres, A., Campion, J., Milagro, F., Marcos, A., Campoy, C., Garagorri, J., Martínez, A., Azcona-Sanjulián, M. C., and Marti, A.
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- 2012
11. Influence of eight obesity-related snps with body mass index and weight loss in spanish adolescents after a lifestyle intervention: T2:OS1.6
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Moreles, A, Rendo, T, Campoy, C, Zapatera, B, Moreno, L, Garagorri, J, Marcos, A, Martínez, J A, Azcona-Sanjulian, M C, and Marti, A
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- 2011
12. Body composition in adolescents: measurements and metabolic aspects
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Rodríguez, G, Moreno, L A, Blay, M G, Blay, V A, Garagorri, J M, Sarría, A, and Bueno, M
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- 2004
13. Erratum: Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents
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Nadal, I, Santacruz, A, Marcos, A, Warnberg, J, Garagorri, J M, Moreno, L A, Martin-Matillas, M, Campoy, C, Martí, A, Moleres, A, Delgado, M, Veiga, O L, García-Fuentes, M, Redondo, C G, and Sanz, Y
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- 2012
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14. Relationship between self-reported dietary intake and physical activity levels among adolescents: The HELENA study
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Ottevaere, Charlene, Huybrechts, Inge, Béghin, Laurent, Cuenca Garcia, Magdalena, De Bourdeaudhuij, Ilse, Gottrand, Frederic, Hagströmer, Maria, Kafatos, Anthony, Le Donne, Cinzia, Moreno, Luis A., Sjöström, Michael, Widhalm, Kurt, De Henauw, Stefaan, Moreno L, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús J, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Ma Garagorri J, Bueno M, Pablo Rey López J, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Ligia Díaz E, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Erhardt E, Csernus K, Török K, Bokor S, Angster M, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo Garzón MJ, Gutiérrez Sáinz Á, Ortega Porcel FB, Ruiz JR, García Artero E, España Romero V, Jiménez Pavón D, Sánchez Muñoz C, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrì L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Louisa Cook T, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Fievet N, Goumidi L, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Hurtig Wennlöf A, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Enrique Carreres J, Merino G, Sanjuán R, Lorente M, José Sánchez M, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Lilja Hallberg M, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, José Gómez Lorente J., VITAGLIONE, PAOLA, Department of Public Health, Universiteit Gent = Ghent University [Belgium] (UGENT), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Réseau Maladies Inflammatoires Chroniques de l'Intestin (RMICI), CIC 9301 CH&U et Inserm-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Department of Physiology, School of Medicine, Department of Movement and Sport Sciences, Department of Biosciences and Nutrition, Karolinska Institutet [Stockholm], University of Crete School of medicine, National Research Institute on Food and Nutrition, Growth, Exercise, Nutrition and Development (GENUD), University of Zaragoza - Universidad de Zaragoza [Zaragoza]-E.U. Ciencias de la Salud, Medizinische Universität Wien = Medical University of Vienna, The HELENA study took place with the financial support of the European Community Sixth RTD Framework Programme (Contract FOOD-CT: 2005-007034). This work was also partially supported by the European Union, in the framework of the Public Health Programme (ALPHA project, Ref: 2006120), the Swedish Council for Working Life and Social Research (FAS), the Spanish Ministry of Education (EX-2007-1124, and EX-2008-0641), and the Spanish Ministry of Health, Maternal, Child Health and Development Network (number RD08/0072) (JPRL, LAM)., Matthys, Christophe, Ottevaere, Charlene, Huybrechts, Inge, Béghin, Laurent, Cuenca Garcia, Magdalena, De Bourdeaudhuij, Ilse, Gottrand, Frederic, Hagströmer, Maria, Kafatos, Anthony, Le Donne, Cinzia, Moreno, Luis A., Sjöström, Michael, Widhalm, Kurt, De Henauw, Stefaan, Moreno, L, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, J, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Ma Garagorri, J, Bueno, M, Pablo Rey López, J, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Ligia Díaz, E, Romeo, J, Veses, A, Angeles Puertollano, M, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, M, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo Garzón, Mj, Gutiérrez Sáinz, Á, Ortega Porcel, Fb, Ruiz, Jr, García Artero, E, España Romero, V, Jiménez Pavón, D, Sánchez Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrì, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Louisa Cook, T, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Fievet, N, Goumidi, L, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Hurtig Wennlöf, A, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Enrique Carreres, J, Merino, G, Sanjuán, R, Lorente, M, José Sánchez, M, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Lilja Hallberg, M, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, José Gómez Lorente, J., BMC, Ed., Universiteit Gent = Ghent University (UGENT), and Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)
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Male ,Physiology ,030309 nutrition & dietetics ,Health Behavior ,CHILDHOOD ,Medicine (miscellaneous) ,ACTIVITY QUESTIONNAIRE ,CHILDREN ,ADULTHOOD ,Overweight ,Motor activity ,Food group ,0302 clinical medicine ,Nutrient ,Medicine and Health Sciences ,Nutrition and Dietetic ,lcsh:RC620-627 ,EUROPEAN ADOLESCENTS ,2. Zero hunger ,Sex Characteristics ,0303 health sciences ,Nutrition and Dietetics ,Medicine (all) ,lcsh:Public aspects of medicine ,Health Survey ,3. Good health ,Europe ,lcsh:Nutritional diseases. Deficiency diseases ,Health ,Cross-sectional studies ,Female ,FOOD-HABITS ,medicine.symptom ,Life Sciences & Biomedicine ,Human ,Sex characteristics ,Adolescent ,Food habits ,030209 endocrinology & metabolism ,Physical Therapy, Sports Therapy and Rehabilitation ,Clinical nutrition ,Motor Activity ,BEHAVIORS ,03 medical and health sciences ,Environmental health ,medicine ,Humans ,Dairy Product ,Life Style ,Cross-Sectional Studie ,Science & Technology ,OVERWEIGHT ,Nutrition & Dietetics ,business.industry ,Research ,lcsh:RA1-1270 ,HEALTHY LIFE-STYLE ,Feeding Behavior ,Sex Characteristic ,medicine.disease ,Health Surveys ,Obesity ,Physical activity level ,Diet ,BODY-MASS INDEX ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,Cross-Sectional Studies ,Adolescent Behavior ,Fruit ,Food Habit ,Life style ,Energy intake ,Dairy Products ,Self Report ,Energy Intake ,business ,Body mass index ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
Background Evidence suggests possible synergetic effects of multiple lifestyle behaviors on health risks like obesity and other health outcomes. Therefore it is important to investigate associations between dietary and physical activity behavior, the two most important lifestyle behaviors influencing our energy balance and body composition. The objective of the present study is to describe the relationship between energy, nutrient and food intake and the physical activity level among a large group of European adolescents. Methods The study comprised a total of 2176 adolescents (46.2% male) from ten European cities participating in the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study. Dietary intake and physical activity were assessed using validated 24-h dietary recalls and self-reported questionnaires respectively. Analyses of covariance (ANCOVA) were used to compare the energy and nutrient intake and the food consumption between groups of adolescents with different physical activity levels (1st to 3rd tertile). Results In both sexes no differences were found in energy intake between the levels of physical activity. The most active males showed a higher intake of polysaccharides, protein, water and vitamin C and a lower intake of saccharides compared to less active males. Females with the highest physical activity level consumed more polysaccharides compared to their least active peers. Male and female adolescents with the highest physical activity levels, consumed more fruit and milk products and less cheese compared to the least active adolescents. The most active males showed higher intakes of vegetables and meat, fish, eggs, meat substitutes and vegetarian products compared to the least active ones. The least active males reported the highest consumption of grain products and potatoes. Within the female group, significantly lower intakes of bread and cereal products and spreads were found for those reporting to spend most time in moderate to vigorous physical activity. The consumption of foods from the remaining food groups, did not differ between the physical activity levels in both sexes. Conclusion It can be concluded that dietary habits diverge between adolescents with different self-reported physical activity levels. For some food groups a difference in intake could be found, which were reflected in differences in some nutrient intakes. It can also be concluded that physically active adolescents are not always inclined to eat healthier diets than their less active peers., The HELENA study took place with the financial support of the European Community Sixth RTD Framework Programme (Contract FOOD-CT: 2005-007034). This work was also partially supported by the European Union, in the framework of the Public Health Programme (ALPHA project, Ref: 2006120), the Swedish Council for Working Life and Social Research (FAS), the Spanish Ministry of Education (EX-2007-1124, and EX-2008-0641), and the Spanish Ministry of Health, Maternal, Child Health and Development Network (number RD08/0072) (JPRL, LAM).
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- 2011
15. Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; The HELENA Study
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Jiménez Pavón, David, Castillo, Manuel J., Moreno, Luis A., Kafatos, Anthony, Manios, Yannis, Kondaki, Katerine, Béghin, Laurent, Zaccaria, Maria, De Henauw, Stefaan, Widhalm, Kurt, Molnár, Dénes, Sjöström, Michael, González Gross, Marcela, Ruiz, Jonatan R., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Ma Garagorri J, Bueno M, Rey López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Ligia Díaz E, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster M, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo Garzón MJ, Gutiérrez Sáinz Á, Ortega Porcel FB, Ruiz Ruiz J, García Artero E, España Romero V, Jiménez Pavón D, Sánchez Muñoz C, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrì L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Enrique Carreres J, Merino G, Sanjuán R, Lorente M, José Sánchez M, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Gómez Lorente J.J., VITAGLIONE, PAOLA, Jiménez Pavón, David, Castillo, Manuel J., Moreno, Luis A., Kafatos, Anthony, Manios, Yanni, Kondaki, Katerine, Béghin, Laurent, Zaccaria, Maria, De Henauw, Stefaan, Widhalm, Kurt, Molnár, Déne, Sjöström, Michael, González Gross, Marcela, Ruiz, Jonatan R., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Ma Garagorri, J, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Ligia Díaz, E, Romeo, J, Veses, A, Angeles Puertollano, M, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, M, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo Garzón, Mj, Gutiérrez Sáinz, Á, Ortega Porcel, Fb, Ruiz Ruiz, J, García Artero, E, España Romero, V, Jiménez Pavón, D, Sánchez Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrì, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Enrique Carreres, J, Merino, G, Sanjuán, R, Lorente, M, José Sánchez, M, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.
- Subjects
Blood Glucose ,Male ,Cross-sectional study ,medicine.medical_treatment ,Body Mass Index ,Insulin ,Age Factor ,Skinfold Thickne ,Adiposity ,Nutrition and Dietetics ,Health Policy ,Age Factors ,Health Survey ,Europe ,Skinfold Thickness ,Cardiorespiratory fitne ,Regression Analysis ,Female ,Waist Circumference ,Human ,medicine.medical_specialty ,Waist ,Adolescent ,Regression Analysi ,Insulin resistance ,Internal medicine ,medicine ,HOMA ,Humans ,Obesity ,Cardiovascular fitness ,Cross-Sectional Studie ,Analysis of Variance ,business.industry ,Body Weight ,Public Health, Environmental and Occupational Health ,nutritional and metabolic diseases ,Cardiorespiratory fitness ,medicine.disease ,Health Surveys ,Body Height ,Total and central body fat ,Endocrinology ,Cross-Sectional Studies ,Glucose ,Physical Fitness ,Pediatrics, Perinatology and Child Health ,Exercise Test ,Physical Fitne ,Insulin Resistance ,business ,Body mass index - Abstract
To examine the independent association of total and central body fat and cardiorespiratory fitness with markers of insulin resistance after controlling for several potential confounders in European adolescents participating in the HELENA-CSS (Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional) study.We conducted a cross sectional study (the HELENA-CSS) which comprised 1053 (12.5-17.5 years) adolescents from 10 European cities. Weight, height, waist circumference and skinfold thickness were measured, and body mass index (BMI) was calculated. Cardiorespiratory fitness was measured by the 20-m shuttle run test. Markers of insulin resistance were fasting insulin and glucose, and homeostasis model assessment (HOMA).HOMA and insulin were positively associated with BMI, skinfolds and waist circumference after controlling for center, age, pubertal status and cardiorespiratory fitness (all P ? 0.01). HOMA and insulin were negatively associated with cardiorespiratory fitness in adolescents with moderate to high levels of total and central body fat (all P ? 0.01).HOMA and insulin were associated with total and central body fat in European adolescents. Moreover, cardiorespiratory fitness explained a part of the HOMA and insulin variance in those adolescents with moderate to high levels of total and central body fat, and also, to some extent, in those with low to middle fat mass.
- Published
- 2011
16. X-ray asterism and the structure of cracks from indentations in silicon.
- Author
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Tanner, B. K., Garagorri, J., Gorostegui-Colinas, E., Elizalde, M. R., Allen, D., McNally, P. J., Wittge, J., Ehlers, C., and Danilewsky, A. N.
- Subjects
- *
SILICON crystallography , *ASTERISM (Crystallography) , *X-ray diffraction - Abstract
The asterism observed in white radiation X-ray diffraction images (topographs) of extended cracks in silicon is investigated and found to be associated with material that is close to breakout and surrounded by extensive cracking. It is a measure of the mechanical damage occurring when the fracture planes do not follow the low-index cleavage planes associated with the crystal structure. It is not related to a propensity for some cracked wafers to shatter during subsequent high-temperature processing. There is no correlation between crack morphology and alignment of an indenter with respect to the orientation of a silicon wafer, the cracks being generated from the apices of the indenter and having threefold symmetry for Berkovich indents and fourfold symmetry for Vickers indents. X-ray diffraction imaging (XRDI) of indents does not reveal this underlying symmetry and the images exhibit a very substantial degree of variation in their extent. This arises because the XRDI contrast is sensitive to the long-range strain field around the indent and breakout reduces the extent of this long-range strain field. Breakout is also detected in the loss of symmetry in the short-range strain field imaged by scanning micro-Raman spectroscopy. Weak fourfold symmetric features at the extremes of the images, and lying along ⟨110⟩ directions, are discussed in the context of slip generated below the room-temperature indents. Scanning electron microscopy imaging of the region around an indent during focused ion beam milling has permitted the three-dimensional reconstruction of the crack morphology. The surface-breaking Palmqvist cracks are found to be directly connected to the median subsurface cracks, and the presence of extensive lateral cracks is a prerequisite for material breakout at indenter loads above 200 mN. The overall crack shape agrees with that predicted from simulation. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
17. X-ray diffraction imaging for predictive metrology of crack propagation in 450-mm diameter silicon wafers.
- Author
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Tanner, B.K., Wittge, J., Vagovič, P., Baumbach, T., Allen, D., McNally, P.J., Bytheway, R., Jacques, D., Fossati, M.C., Bowen, D.K., Garagorri, J., Elizalde, M.R., and Danilewsky, A.N.
- Subjects
X-ray diffraction ,SILICON wafers ,SYNCHROTRON radiation sources ,SYNCHROTRON radiation ,CRACK propagation (Fracture mechanics) ,MATERIAL plasticity - Abstract
The apparatus for X-ray diffraction imaging (XRDI) of 450-mm wafers, is now placed at the ANKA synchrotron radiation source in Karlsruhe, is described in the context of the drive to inspect wafers for plastic deformation or mechanical damage. It is shown that full wafer maps at high resolution can be expected to take a few hours to record. However, we show from experiments on 200-, 300-, and 450-mm wafers that a perimeter-scan on a 450-mm wafer, to pick up edge damage and edge-originated slip sources, can be achieved in just over 10 min. Experiments at the Diamond Light Source, on wafers still in their cassettes, suggest that clean-room conditions may not be necessary for such characterization. We conclude that scaling up of the 300-mm format Jordan Valley tools, together with the existing facility at ANKA, provides satisfactory capability for future XRDI analysis of 450-mm wafers. [ABSTRACT FROM PUBLISHER]
- Published
- 2013
- Full Text
- View/download PDF
18. Influence of mechanical defects on the crystal lattice of silicon.
- Author
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Jauß, T., Danilewsky, A.N., Wittge, J., Cröll, A., Garagorri, J., Elizalde, R. M., Allen, D., and McNally, P.
- Abstract
To examine the impact of mechanical defects on the crystal lattice of silicon, controlled damage was applied to silicon wafers by a nanoindendation method. With increasing loads of 1, 5 and 50 N, the area with micro-cracks and strain around the indents increases. The damage is characterised by high resolution diffractometry using a conventional X-ray tube. Spatially resolved rocking curves were recorded across the indents and analysed with respect to full width at half maximum. From reciprocal space maps the amount of strain and tilt around the indents is separated. (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
19. Real-time X-ray diffraction imaging for semiconductor wafer metrology and high temperature in situ experiments.
- Author
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Danilewsky, A. N., Wittge, J., Hess, A., Cröll, A., Rack, A., Allen, D., McNally, P., dos Santos Rolo, T., Vagovič, P., Baumbach, T., Garagorri, J., Elizalde, M. R., and Tanner, B. K.
- Published
- 2011
- Full Text
- View/download PDF
20. Thermal slip sources at the extremity and bevel edge of silicon wafers.
- Author
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Tanner, B. K., Wittge, J., Allen, D., Fossati, M. C., Danilwesky, A. N., McNally, P., Garagorri, J., Elizalde, M. R., and Jacques, D.
- Subjects
RAPID thermal processing ,OPTICAL quality control ,X-ray diffraction ,NUCLEATION ,SEMICONDUCTOR wafers - Abstract
The article discusses a study of the thermal slip sources (TSS) at the extremity and bevel edge of a silicon wafer (SW). The authors performed rapid thermal annealing (RTA) on a 200-millimeter SW, which showed no edge defects either under optical inspection or X-ray diffraction imaging. They found that the dislocation velocity is constant during slip-band nucleation. They also observed that the majority of TSS appear at the extremity of the SW and are not suppressed by the RTA apparatus.
- Published
- 2011
- Full Text
- View/download PDF
21. X-ray diffraction imaging of dislocation generation related to microcracks in Si wafers.
- Author
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Wittge, J., Danilewsky, A., Allen, D., McNally, P., Li, Z. J., Baumbach, T., Gorostegui-Colinas, E., Garagorri, J., Elizalde, M. R., Jacques, D., Fossati, M. C., Bowen, D. K., and Tanner, B. K.
- Published
- 2010
- Full Text
- View/download PDF
22. Incidence of type I diabetes mellitus in Navarre, Spain (1975-91).
- Author
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Chueca, M, Oyarzabal, M, Reparaz, F, Garagorri, JM, Sola, A, and Garagorri, J M
- Published
- 1997
- Full Text
- View/download PDF
23. Relationship of Body Fat Distribution to Metabolic Complications in Obese Prepubertal Boys: Gender Related Differences.
- Author
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LEGIDO, A., SARRIA, A., BUENO, M., GARAGORRI, J., FLETA, J., RAMOS, F., ABOS, M. D., and PEREZ-GONZALEZ, J.
- Published
- 1989
- Full Text
- View/download PDF
24. Sclerosteosis in a Spanish male: first report in a person of Mediterranean origin.
- Author
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Bueno, M, Oliván, G, Jiménez, A, Garagorri, J M, Sarría, A, Bueno, A L, and Ramos, F J
- Abstract
We report the first observation of sclerosteosis in Spain. To the best of our knowledge, this is the first case of sclerosteosis in a person of Mediterranean origin with no known Dutch ancestors. He has the characteristic phenotype of the disease with right facial nerve palsy and syndactyly and the typical radiological features, including generalised bone sclerosis and cortical widening of the tubular bones. [ABSTRACT FROM PUBLISHER]
- Published
- 1994
25. Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents.
- Author
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Nadal, I, Santacruz, A, Marcos, A, Warnberg, J, Garagorri, J M, Moreno, L A, Martin-Matillas, M, Campoy, C, Martí, A, Moleres, A, Delgado, M, Veiga, O L, García-Fuentes, M, Redondo, C G, and Sanz, Y
- Subjects
PUBLISHED errata ,PERSONAL names ,SPELLING errors - Abstract
A correction to the article "Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents," by I. Nadal and colleagues that was published in the 2012 issue is presented.
- Published
- 2012
- Full Text
- View/download PDF
26. Prediction of the propagation probability of individual cracks in brittle single crystal materials.
- Author
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Tanner, B. K., Fossati, M. C., Garagorri, J., Elizalde, M. R., Allen, D., McNally, P. J., Jacques, D., Wittge, J., and Danilewsky, A. N.
- Subjects
SINGLE crystals ,CRACK propagation (Fracture mechanics) ,PROBABILITY theory ,X-ray diffraction ,HIGH temperatures ,SILICON wafers ,FINITE element method - Abstract
We show that x-ray diffraction imaging (topography) and finite-element modelling can determine accurately the probability of propagation of individual cracks in brittle single crystal materials. The x-ray image of the crack provides a critical parameter for crack propagation which informs a predictive model, enabling us to identify critical defects that lead to catastrophic shattering of silicon wafers during high temperature thermal processing. Wafers fracture on cooling and finite element modelling shows that, during cooling, the tangential stress at the wafer edge is tensile and results in crack propagation. The predicted fracture geometry agrees extremely well with that observed experimentally. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
27. Observation of nano-indent induced strain fields and dislocation generation in silicon wafers using micro-Raman spectroscopy and white beam X-ray topography
- Author
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Allen, D., Wittge, J., Zlotos, A., Gorostegui-Colinas, E., Garagorri, J., McNally, P.J., Danilewsky, A.N., and Elizalde, M.R.
- Subjects
- *
INDENTATION (Materials science) , *STRAINS & stresses (Mechanics) , *DISLOCATIONS in crystals , *SEMICONDUCTOR wafers , *RAMAN spectroscopy , *SEMICONDUCTOR manufacturing , *MECHANICAL loads - Abstract
Abstract: In the semiconductor manufacturing industry, wafer handling introduces micro-cracks at the wafer edge. During heat treatment these can produce larger, long range cracks in the wafer which can cause wafer breakage during manufacture. Two complimentary techniques, micro-Raman spectroscopy (μRS) and White Beam Synchrotron X-ray Topography (WBSXRT) were employed to study both the micro-cracks and the associated strain fields produced by nano-indentations in Si wafers, which were used as a means of introducing controlled strain in the wafers. It is shown that both the spatial lateral and depth distribution of these long range strain fields are relatively isotropic in nature. The Raman spectra suggest the presence of a region under tensile strain beneath the indents, which can indicate a crack beneath the indent and the data strongly suggests that there exists a minimum critical applied load below which cracking will not initiate. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
- View/download PDF
28. Hormonal Therapy of Cryptorchidism with Human Chorionic Gonadotropin (HCG)
- Author
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Job, J.-C., Canlorbe, P., Garagorri, J.-M., and Toublanc, J.-E.
- Published
- 1983
- Full Text
- View/download PDF
29. Crack propagation and fracture in silicon wafers under thermal stress.
- Author
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Danilewsky A, Wittge J, Kiefl K, Allen D, McNally P, Garagorri J, Elizalde MR, Baumbach T, and Tanner BK
- Abstract
The behaviour of microcracks in silicon during thermal annealing has been studied using in situ X-ray diffraction imaging. Initial cracks are produced with an indenter at the edge of a conventional Si wafer, which was heated under temperature gradients to produce thermal stress. At temperatures where Si is still in the brittle regime, the strain may accumulate if a microcrack is pinned. If a critical value is exceeded either a new or a longer crack will be formed, which results with high probability in wafer breakage. The strain reduces most efficiently by forming ( hhl ) or ( hkl ) crack planes of high energy instead of the expected low-energy cleavage planes like {111}. Dangerous cracks, which become active during heat treatment and may shatter the whole wafer, can be identified from diffraction images simply by measuring the geometrical dimensions of the strain-related contrast around the crack tip. Once the plastic regime at higher temperature is reached, strain is reduced by generating dislocation loops and slip bands and no wafer breakage occurs. There is only a small temperature window within which crack propagation is possible during rapid annealing.
- Published
- 2013
- Full Text
- View/download PDF
30. Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents.
- Author
-
Nadal I, Santacruz A, Marcos A, Warnberg J, Garagorri JM, Moreno LA, Martin-Matillas M, Campoy C, Martí A, Moleres A, Delgado M, Veiga OL, García-Fuentes M, Redondo CG, and Sanz Y
- Subjects
- Adolescent, Body Mass Index, Caloric Restriction, Female, Humans, Immunoglobulin A isolation & purification, Immunoglobulin G isolation & purification, Immunoglobulin M isolation & purification, Male, Motor Activity physiology, Obesity blood, Obesity therapy, Weight Loss immunology, Bacteroides isolation & purification, Clostridium isolation & purification, Feces microbiology, Immunoglobulins isolation & purification, Obesity microbiology, Weight Loss physiology
- Abstract
Objective: To evaluate the effects of a multidisciplinary obesity treatment programme on fecal microbiota composition and immunoglobulin-coating bacteria in overweight and obese adolescents and their relationship to weight loss., Design: Longitudinal intervention study based on both a calorie-restricted diet (calorie reduction=10-40%) and increased physical activity (calorie expenditure=15-23 kcal/kg body weight per week) for 10 weeks., Participants: Thirty-nine overweight and obese adolescents (BMI mean 33.1 range 23.7-50.4; age mean 14.8 range, 13.0-16.0)., Measurements: BMI, BMI z-scores and plasma biochemical parameters were measured before and after the intervention. Fecal microbiota was analyzed by fluorescent in situ hybridization. Immunoglobulin-coating bacteria were detected using fluorescent-labelled F(ab')2 antihuman IgA, IgG and IgM., Results: Reductions in Clostridium histolyticum and E. rectale-C. coccoides proportions significantly correlated with weight and BMI z-score reductions in the whole adolescent population. Proportions of C. histolyticum, C. lituseburense and E. rectale-C. coccoides dropped significantly whereas those of the Bacteroides-Prevotella group increased after the intervention in those adolescents who lost more than 4 kg. Total fecal energy was almost significantly reduced in the same group of adolescents but not in the group that lost less than 2.5 kg. IgA-coating bacterial proportions also decreased significantly in participants who lost more than 6 kg after the intervention, paralleled to reductions in C. histolyticum and E. rectale-C. coccoides populations. E. rectale-C. coccoides proportions also correlated with weight loss and BMI z-score reduction in participants whose weight loss exceeded 4 kg., Conclusions: Specific gut bacteria and an associated IgA response were related to body weight changes in adolescents under lifestyle intervention. These results suggest interactions between diet, gut microbiota and host metabolism and immunity in obesity.
- Published
- 2009
- Full Text
- View/download PDF
31. Early detection of impaired glucose tolerance in patients with cystic fibrosis and predisposition factors.
- Author
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Garagorri JM, Rodríguez G, Ros L, and Sánchez A
- Subjects
- Administration, Oral, Adolescent, Adult, Child, Child, Preschool, Cystic Fibrosis drug therapy, Female, Glucose administration & dosage, Glucose Intolerance etiology, Glucose Tolerance Test methods, Glycated Hemoglobin analysis, Humans, Infant, Insulin blood, Lipase administration & dosage, Lipase therapeutic use, Male, Cystic Fibrosis complications, Glucose Intolerance diagnosis
- Abstract
Introduction: The number of patients with glucose tolerance alterations associated with cystic fibrosis (CF) has increased, probably due to the greater survival rate among sufferers of this disease. We studied impaired glucose tolerance (IGT) in patients with CF and investigated whether its appearance has any relationship with age, sex, genetic mutation and/or the degree of clinical involvement. We assessed the parameters that might allow early detection., Patients and Methods: In 28 patients with CF (14 M, 14 F; aged 22 months to 18 years), sex, genetic mutation, nutritional status and the degree of pancreatic and pulmonary involvement were recorded. The metabolic study included glycosylated hemoglobin (HbA1c) determination, oral glucose tolerance test (OGTT) and intravenous glucose tolerance tests (IVGTT)., Results: In the patients with CF, 35.71% showed impaired glucose tolerance (IGT) and 3.57% had diabetes mellitus. The patients with IGT and CF were 3.2 years older than those with normal glucose tolerance (NGT; p<0.05), but no significant differences were found regarding sex, anthropometric measurements, percentage of pulmonary gammagraphic involvement, Shwachman-Kulczycki test or HbA1c. In the OGTT, the patients homozygous for the deltaF508 mutation had higher blood glucose values than the heterozygous group (p=0.03), but these values were not higher than those in patients with other mutations. During the OGTT, blood insulin values at 30' were reduced in patients with IGT compared to patients with NGT (p<0.02) and the insulin peak occurred at 100.9+/-24.3 min compared to 65.3+/-21.8, respectively (p<0.05). In the IVGTT, 82.14% of the patients had reduced insulin levels at 1 and 3 min (I1'+3'). No differences in the blood glucose levels during the OGTT were found between patients with normal I1'+3' values and patients with reduced values., Conclusions: A high percentage of patients with CF also present with IGT. This increases with age and is more common among patients homozygous for the deltaF508 mutation and is not related to clinical status. Alterations in the kinetics of insulin secretion play an important role in the appearance of IGT and CF. We suggest that the OGTT is a more sensitive method than IVGTT for identifying early alterations in CF-related diabetes mellitus.
- Published
- 2001
- Full Text
- View/download PDF
32. Priming with GHRH (1-29) NH2: an aid in differential diagnosis between hypothalamic and pituitary deficiencies.
- Author
-
Bueno G, Bueno M, Garagorri JM, Juste G, Rejas J, and Alvarez I
- Subjects
- Adolescent, Body Height drug effects, Bone Development drug effects, Child, Diagnosis, Differential, Female, Growth Hormone blood, Humans, Indicators and Reagents, Insulin-Like Growth Factor I metabolism, Male, Growth Hormone-Releasing Hormone, Hypopituitarism diagnosis, Hypothalamic Diseases diagnosis, Peptide Fragments
- Abstract
More than 80% of children with growth hormone deficiency (GHD) respond with a rise in growth hormone levels when given 1 microgram/kg body weight of growth hormone-releasing hormone (GHRH) in an i.v. bolus. We conducted a study to determine whether the failure of the remaining 20% to respond to GHRH is due to a pituitary deficiency or a secondary effect associated with chronically understimulated somatotrophs. We administered GHRH to "prime" 16 short-statured children (> 2 SD) presenting delayed growth (< 4 cm/year), who had not responded initially when given a single dose of GHRH. Priming consisted of administering GHRH (1-29) NH2 (5 micrograms/kg body weight, s.c.) for six consecutive days. Plasma GH response was studied again after an i.v. injection of 1 microgram/kg body weight of GHRH (1-29) NH2 on the seventh morning. On the basis of these results we were able to separate our patients into two groups: a) responders to priming (n = 8), whose GH responses to pharmacological and acute GHRH tests were < 10 ng/ml, with a 12-hour sleep secretion < 3 ng/ml/min. Priming increased the plasma GH response to acute GHRH in all the children in this group (6.0 +/- 2.1 ng/ml to 18.0 +/- 5.4 ng/ml; p < 0.001); b) non-responders to priming (n = 8), whose GH responses to pharmacological and acute GHRH tests were also < 10 ng/ml, with 12-hour sleep secretion < 3 ng/ml/min, but in whom priming with GH did not increase the plasma GH response (5.5 +/- 2.8 ng/ml to 6.2 +/- 2.9 ng/ml; p = NS).(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1994
- Full Text
- View/download PDF
33. Insulin specific binding to erythrocytes of normal and hypoglycemic infants.
- Author
-
Garagorri JM, Donnadieu M, Brijawi A, and Chaussain JL
- Subjects
- Binding Sites, Erythrocyte Count, Female, Humans, Infant, Male, Reticulocytes metabolism, Erythrocytes metabolism, Hypoglycemia blood, Insulin blood
- Published
- 1982
- Full Text
- View/download PDF
34. Insulin-specific binding to erythrocytes in 6 girls with acanthosis nigricans.
- Author
-
Chaussain JL, Donnadieu M, Garagorri JM, Dupont C, Colle M, and Leduc B
- Subjects
- Adolescent, Animals, Binding, Competitive, Child, Child, Preschool, Female, Glucose Tolerance Test, Humans, In Vitro Techniques, Rats, Acanthosis Nigricans blood, Erythrocytes metabolism, Insulin Resistance, Receptor, Insulin blood
- Abstract
6 girls, aged 4-16 years, with acanthosis nigricans and hirsutism were studied. Fasting and postglucose hyperinsulinism was present in the 5 older girls. In the youngest, a transitory diabetes with hyperinsulinism was induced by a cortisone therapy for hepatitis. Insulin resistance, suggested by the failure to significantly decrease blood glucose after insulin injection (0.1 U/kg), was demonstrated in three steps: (1) Patient plasma failed to bind 125I-insulin after a 5-day incubation followed by precipitation by antihuman globulin serum. (2) Specific 125I-insulin binding to rat liver membranes was identical in the presence of patient plasma and control plasma. (3) Specific 125I-insulin binding to the erythrocytes of the 6 patients (3.5-7.0%) was significantly lower (p less than 0.01) than in controls (4.5-19.5%). Moreover, the significant correlation present in controls between total binding and reticulocyte counts (r = 0.824, p less than 0.001) was absent in the patients. These data demonstrate further that, in the juvenile type of acanthosis nigricans, insulin resistance which may precede hyperinsulinism is not related to anti-insulin antibodies nor to antireceptor antibodies, but results from a primary defect of insulin receptors.
- Published
- 1984
- Full Text
- View/download PDF
35. Follow-up hormonal controls on a HGH secreting pituitary adenoma. Pre- and postoperative study.
- Author
-
Sarría A, Garagorri J, Ferrández A, Calatayud V, Garin P, Sanz J, and Bueno M
- Subjects
- Adenoma surgery, Child, Follow-Up Studies, Glucagon, Growth Hormone blood, Humans, Male, Pituitary Neoplasms surgery, Propranolol, Adenoma metabolism, Growth Hormone metabolism, Pituitary Neoplasms metabolism
- Abstract
The case of a 12 2/12-year-old boy with an HGH secreting eosinophilic adenoma is presented. The histologic investigation included conventional and ultrastructural techniques. The pre- and postoperative (1, 7, 11, and 20 months) hormonal controls are analyzed, indicating the persistence of HGH anteropituitary activity, even though surgical sectioning of the pituitary stalk was performed and the activities of thyroid, corticoadrenal and gonadotropin functions decreased. It is suggested that the hypothalamo-pituitary relationship may be maintained by extraportal venous circulations.
- Published
- 1980
36. Body fat distribution and hyperinsulinemia in childhood.
- Author
-
Legido A, Sarría A, Bueno M, Garagorri J, Fleta J, Abós MD, and Pérez-González J
- Subjects
- Child, Female, Humans, Male, Skinfold Thickness, Adipose Tissue pathology, Insulin blood, Obesity pathology
- Published
- 1988
- Full Text
- View/download PDF
37. Results of early treatment of cryptorchidism with human chorionic gonadotropin.
- Author
-
Garagorri JM, Job JC, Canlorbe P, and Chaussain JL
- Subjects
- Age Factors, Child, Preschool, Chorionic Gonadotropin administration & dosage, Cryptorchidism blood, Humans, Infant, Male, Testosterone blood, Chorionic Gonadotropin therapeutic use, Cryptorchidism drug therapy
- Abstract
One hundred and fifty-three children with common cryptorchidism, 109 unilateral and 44 bilateral, excluding those with associated malformations or abnormalities, were treated at age 6 to 59 months with human chorionic gonadotropin given as nine intramuscular injections on alternate days. Treatment before age 3 years resulted in complete failure in 81%. At 3 to 4 years of age treatment resulted in failure in 55%, but 19% of the patients showed complete testicular descent and 26% showed partial descent. The percent of failures was increased when the dose of human chorionic gonadotropin was lower than 1,000 IU/m2 injection and when the cryptorchid testis was very high. No correlation was found between endocrine data and the clinical results. The plasma testosterone concentration after the third injection of human chorionic gonadotropin was not significantly different in successfully and unsuccessfully treated patients. However, testosterone levels were significantly lower in patients treated at 36 to 59 months of age than in those treated at an earlier age, in contrast to the significantly better clinical results obtained in the older group. Thus human chorionic gonadotropin is not a valuable means of obtaining descent of undescended testes before age 3 years and is of limited usefulness at age 3 to 4 years.
- Published
- 1982
- Full Text
- View/download PDF
38. Hormonal therapy of cryptorchidism with human chorionic gonadotropin(HCG).
- Author
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Job JC, Canlorbe P, Garagorri JM, and Toublanc JE
- Subjects
- Adolescent, Child, Child, Preschool, Dose-Response Relationship, Drug, Evaluation Studies as Topic, Humans, Leydig Cells drug effects, Male, Stimulation, Chemical, Testosterone blood, Chorionic Gonadotropin administration & dosage, Cryptorchidism drug therapy
- Published
- 1982
39. Relationship of body fat distribution to metabolic complications in obese prepubertal girls.
- Author
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Legido A, Sarría A, Bueno M, Garagorri J, Fleta J, Abós D, and González JP
- Subjects
- Blood Glucose analysis, Child, Female, Humans, Insulin blood, Insulin Resistance, Metabolic Diseases blood, Obesity blood, Obesity pathology, Puberty metabolism, Adipose Tissue anatomy & histology, Obesity metabolism
- Abstract
The purpose of this study is to assess the relative effects of body fat distribution and obesity "per se" on serum glucose, insulin, and insulin resistance. Seventeen obese and nine nonobese control prepubertal girls were studied. Biceps, triceps, subscapular, and suprailiac skinfold thickness were measured. Percentage of body fat (% BF) and total body fat (TBF) were calculated. Body fat distribution was assessed by analyzing the central (suprailiac, subscapular)/peripheral (biceps, triceps) ratios. Oral glucose tolerance test was performed. Serum glucose and insulin were measured and insulinogenic index (insulin/glucose) was calculated. Body fat anthropometric data and body fat distribution indexes were significantly higher (p less than 0.001) in the obese group. The obese population presented significantly elevated values of glucose, insulin, and insulinogenic indexes (p less than 0.01-p less than 0.001). In the obese group, insulin showed significant positive correlations (p less than 0.05-p less than 0.001) with biceps, subscapular, and suprailiac skinfolds, % BF and TBF, whereas the insulinogenic index had positive correlations with suprailiac skinfold and TBF (p less than 0.05). Obese girls showed positive correlations between the body fat distribution indexes and insulin or insulinogenic indexes (p less than 0.05-p less than 0.001). In prepubertal girls obesity is of the centripetal (central) type. This pattern has an important role in determining the alterations in the glucose-insulin homeostasis that characterize the childhood nutritional obesity.
- Published
- 1987
- Full Text
- View/download PDF
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