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219 results on '"Gardin, Claude"'

1. Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia

Author

Pardieu, Bryann, Pasanisi, Justine, Ling, Frank, Dal Bello, Reinaldo, Penneroux, Justine, Su, Angela, Joudinaud, Romane, Chat, Laureen, Wu, Hsin Chieh, Duchmann, Matthieu, Sodaro, Gaetano, Chauvel, Clémentine, Castelli, Florence A., Vasseur, Loic, Pacchiardi, Kim, Belloucif, Yannis, Laiguillon, Marie-Charlotte, Meduri, Eshwar, Vaganay, Camille, Alexe, Gabriela, Berrou, Jeannig, Benaksas, Chaima, Forget, Antoine, Braun, Thorsten, Gardin, Claude, Raffoux, Emmanuel, Clappier, Emmanuelle, Adès, Lionel, de Thé, Hugues, Fenaille, François, Huntly, Brian J., Stegmaier, Kimberly, Dombret, Hervé, Fenouille, Nina, Lobry, Camille, Puissant, Alexandre, and Itzykson, Raphael

Published
2022
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2. Prognostic impact of DDX41 germline mutations in intensively treated acute myeloid leukemia patients: an ALFA-FILO study

Author

Duployez, Nicolas, Largeaud, Laëtitia, Duchmann, Matthieu, Kim, Rathana, Rieunier, Julie, Lambert, Juliette, Bidet, Audrey, Larcher, Lise, Lemoine, Jean, Delhommeau, François, Hirsch, Pierre, Fenwarth, Laurène, Kosmider, Olivier, Decroocq, Justine, Bouvier, Anne, Le Bris, Yannick, Ochmann, Marlène, Santagostino, Alberto, Adès, Lionel, Fenaux, Pierre, Thomas, Xavier, Micol, Jean-Baptiste, Gardin, Claude, Itzykson, Raphael, Soulier, Jean, Clappier, Emmanuelle, Recher, Christian, Preudhomme, Claude, Pigneux, Arnaud, Dombret, Hervé, Delabesse, Eric, and Sébert, Marie

Published
2022
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3. Machine learning identifies the independent role of dysplasia in the prediction of response to chemotherapy in AML

Author

Duchmann, Matthieu, Wagner-Ballon, Orianne, Boyer, Thomas, Cheok, Meyling, Fournier, Elise, Guerin, Estelle, Fenwarth, Laurène, Badaoui, Bouchra, Freynet, Nicolas, Benayoun, Emmanuel, Lusina, Daniel, Garcia, Isabel, Gardin, Claude, Fenaux, Pierre, Pautas, Cécile, Quesnel, Bruno, Turlure, Pascal, Terré, Christine, Thomas, Xavier, Lambert, Juliette, Renneville, Aline, Preudhomme, Claude, Dombret, Hervé, Itzykson, Raphael, and Cluzeau, Thomas

Published
2022
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4. A personalized approach to guide allogeneic stem cell transplantation in younger adults with acute myeloid leukemia

Author

Fenwarth, Laurène, Thomas, Xavier, de Botton, Stéphane, Duployez, Nicolas, Bourhis, Jean-Henri, Lesieur, Auriane, Fortin, Gael, Meslin, Paul-Arthur, Yakoub-Agha, Ibrahim, Sujobert, Pierre, Dumas, Pierre-Yves, Récher, Christian, Lebon, Delphine, Berthon, Céline, Michallet, Mauricette, Pigneux, Arnaud, Nguyen, Stéphanie, Chantepie, Sylvain, Vey, Norbert, Raffoux, Emmanuel, Celli-Lebras, Karine, Gardin, Claude, Lambert, Juliette, Malfuson, Jean-Valère, Caillot, Denis, Maury, Sébastien, Ducourneau, Benoît, Turlure, Pascal, Lemasle, Emilie, Pautas, Cécile, Chevret, Sylvie, Terré, Christine, Boissel, Nicolas, Socié, Gérard, Dombret, Hervé, Preudhomme, Claude, and Itzykson, Raphael

Published
2021
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6. Added prognostic value of secondary AML-like gene mutations in ELN intermediate-risk older AML: ALFA-1200 study results

Author

Gardin, Claude, Pautas, Cécile, Fournier, Elise, Itzykson, Raphaël, Lemasle, Emilie, Bourhis, Jean-Henri, Adès, Lionel, Marolleau, Jean-Pierre, Malfuson, Jean-Valère, Gastaud, Lauris, Raffoux, Emmanuel, Lambert, Juliette, Braun, Thorsten, Thomas, Xavier, Chantepie, Sylvain, Cluzeau, Thomas, de Botton, Stéphane, Berthon, Céline, Boissel, Nicolas, Duployez, Nicolas, Terré, Christine, Peffault de Latour, Régis, Michallet, Mauricette, Celli-Lebras, Karine, Preudhomme, Claude, and Dombret, Hervé

Published
2020
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7. Autoimmune and inflammatory diseases associated with chronic myelomonocytic leukemia: A series of 26 cases and literature review

Author

Grignano, Eric, Mekinian, Arsene, Braun, Thorsten, Liozon, Eric, Hamidou, Mohamed, Decaux, Olivier, Puéchal, Xavier, Kahn, Jean Emmanuel, Schoindre, Yoland, Rossignol, Julien, Lortholary, Olivier, Lioger, Bertrand, Hermine, Olivier, Park, Sophie, Ades, Lionel, Montestruc, François, Ricard, Laure, Gardin, Claude, Fenaux, Pierre, and Fain, Olivier

Published
2016
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11. Azacitidine for the treatment of relapsed and refractory AML in older patients

Author

Itzykson, Raphael, Thépot, Sylvain, Berthon, Céline, Delaunay, Jacques, Bouscary, Didier, Cluzeau, Thomas, Turlure, Pascal, Prébet, Thomas, Dartigeas, Caroline, Marolleau, Jean-Pierre, Recher, Christian, Plantier, Isabelle, Stamatoullas, Aspasia, Devidas, Alain, Taksin, Anne-Laure, Guièze, Romain, Caillot, Denis, Vey, Norbert, Adès, Lionel, Ifrah, Norbert, Dombret, Hervé, Fenaux, Pierre, and Gardin, Claude

Published
2015
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13. Fractionated Inotuzumab Ozogamicin Combined with Low-Intensity Chemotherapy in Older Patients with Newly Diagnosed CD22+ Philadelphia Chromosome (Ph)-Negative B-Cell Precursor (BCP) Acute Lymphoblastic Leukemia (ALL): Results of the EWALL-INO Study

Author

Chevallier, Patrice, Leguay, Thibault, KIM, Rathana, Delord, Marc, Doubek, Michael, Huguet, Francoise, Cabannes-Hamy, Aurelie, Wartiovaara-Kautto, Ulla, Saillard, Colombe, Raffoux, Emmanuel, Cluzeau, Thomas, Lepretre, Stephane, Balsat, Marie, Berceanu, Anna, Boissel, Nicolas, Gardin, Claude, Clappier, Emmanuelle, Dombret, Herve, and Rousselot, Philippe

Published
2022
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14. Outcome of treatment after first relapse in younger adults with acute myeloid leukemia initially treated by the ALFA-9802 trial

Author

Thomas, Xavier, Raffoux, Emmanuel, Renneville, Aline, Pautas, Cécile, de Botton, Stéphane, de Revel, Thierry, Reman, Oumedaly, Terré, Christine, Gardin, Claude, Chelghoum, Youcef, Boissel, Nicolas, Quesnel, Bruno, Cordonnier, Catherine, Bourhis, Jean-Henri, Elhamri, Mohamed, Fenaux, Pierre, Preudhomme, Claude, Socié, Gérard, Michallet, Mauricette, Castaigne, Sylvie, and Dombret, Hervé

Published
2012
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16. Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial

Author

Braun, Thorsten, Itzykson, Raphael, Renneville, Aline, de Renzis, Benoit, Dreyfus, François, Laribi, Kamel, Bouabdallah, Krimo, Vey, Norbert, Toma, Andrea, Recher, Christian, Royer, Bruno, Joly, Bertrand, Vekhoff, Anne, Lafon, Ingrid, Sanhes, Laurence, Meurice, Guillaume, Oréar, Cédric, Preudhomme, Claude, Gardin, Claude, Ades, Lionel, Fontenay, Michaela, Fenaux, Pierre, Droin, Nathalie, and Solary, Eric

Published
2011
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17. Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine

Author

Itzykson, Raphael, Thépot, Sylvain, Quesnel, Bruno, Dreyfus, Francois, Beyne-Rauzy, Odile, Turlure, Pascal, Vey, Norbert, Recher, Christian, Dartigeas, Caroline, Legros, Laurence, Delaunay, Jacques, Salanoubat, Célia, Visanica, Sorin, Stamatoullas, Aspasia, Isnard, Francoise, Marfaing-Koka, Anne, de Botton, Stephane, Chelghoum, Youcef, Taksin, Anne-Laure, Plantier, Isabelle, Ame, Shanti, Boehrer, Simone, Gardin, Claude, Beach, C.L., Adès, Lionel, and Fenaux, Pierre

Published
2011
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18. Systemic inflammatory and autoimmune manifestations associated with myelodysplastic syndromes and chronic myelomonocytic leukaemia: a French multicentre retrospective study

Author

Mekinian, Arsène, Grignano, Eric, Braun, Thorsten, Decaux, Olivier, Liozon, Eric, Costedoat-Chalumeau, Nathalie, Kahn, Jean-Emmanuel, Hamidou, Mohammed, Park, Sophie, Puéchal, Xavier, Toussirot, Eric, Falgarone, Géraldine, Launay, David, Morel, Nathalie, Trouiller, Sébastien, Mathian, Alexis, Gombert, Bruno, Schoindre, Yoland, Lioger, Bertrand, De Wazieres, Benoit, Amoura, Zahir, Buchdaul, Anne-Laure, Georgin-Lavialle, Sophie, Dion, Jérémie, Madaule, Serge, Raffray, Loïc, Cathebras, Pascal, Piette, Jean Charles, Rose, Christian, Ziza, Jean Marc, Lortholary, Olivier, Montestruc, Francois, Omouri, Mohammed, Denis, Guillaume, Rossignol, Julien, Nimubona, Stanislas, Adès, Lionel, Gardin, Claude, Fenaux, Pierre, and Fain, Olivier

Published
2016
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19. Preclinical Evaluation of a Novel Small Molecule Inhibitor of LIM Kinases (LIMK) CEL_Amide in Philadelphia-Chromosome Positive (BCR::ABL+) Acute Lymphoblastic Leukemia (ALL).

Author

Berrou, Jeannig, Dupont, Mélanie, Djamai, Hanane, Adicéam, Emilie, Parietti, Véronique, Kaci, Anna, Clappier, Emmanuelle, Cayuela, Jean-Michel, Baruchel, André, Paublant, Fabrice, Prudent, Renaud, Ghysdael, Jacques, Gardin, Claude, Dombret, Hervé, and Braun, Thorsten

Subjects
NILOTINIB, LYMPHOBLASTIC leukemia, SMALL molecules, ACUTE leukemia, KINASES, CELL cycle
Abstract

Ph+ (BCR::ABL+) B-ALL was considered to be high risk, but recent advances in BCR::ABL-targeting TKIs has shown improved outcomes in combination with backbone chemotherapy. Nevertheless, new treatment strategies are needed, including approaches without chemotherapy for elderly patients. LIMK1/2 acts downstream from various signaling pathways, which modifies cytoskeleton dynamics via phosphorylation of cofilin. Upstream of LIMK1/2, ROCK is constitutively activated by BCR::ABL, and upon activation, ROCK leads to the phosphorylation of LIMK1/2, resulting in the inactivation of cofilin by its phosphorylation and subsequently abrogating its apoptosis-promoting activity. Here, we demonstrate the anti-leukemic effects of a novel LIMK1/2 inhibitor (LIMKi) CEL_Amide in vitro and in vivo for BCR::ABL-driven B-ALL. The IC50 value of CEL_Amide was ≤1000 nM in BCR::ABL+ TOM-1 and BV-173 cells and induced dose-dependent apoptosis and cell cycle arrest in these cell lines. LIMK1/2 were expressed in BCR::ABL+ cell lines and patient cells and LIMKi treatment decreased LIMK1 protein expression, whereas LIMK2 expression was unaffected. As expected, CEL_Amide exposure caused specific activating downstream dephosphorylation of cofilin in cell lines and primary cells. Combination experiments with CEL_Amide and BCR::ABL TKIs imatinib, dasatinib, nilotinib, and ponatinib were synergistic for the treatment of both TOM-1 and BV-173 cells. CDKN2Ako/BCR::ABL1+ B-ALL cells were transplanted in mice, which were treated with combinations of CEL_Amide and nilotinib or ponatinib, which significantly prolonged their survival. Altogether, the LIMKi CEL_Amide yields activity in Ph+ ALL models when combined with BCR::ABL-targeting TKIs, showing promising synergy that warrants further investigation. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: the European APL Group experience

Author

Adès, Lionel, Guerci, Agnes, Raffoux, Emmanuel, Sanz, Miguel, Chevallier, Patrice, Lapusan, Simona, Recher, Christian, Thomas, Xavier, Rayon, Consuelo, Castaigne, Sylvie, Tournilhac, Olivier, de Botton, Stephane, Ifrah, Norbert, Cahn, Jean-Yves, Solary, Eric, Gardin, Claude, Fegeux, Nathalie, Bordessoule, Dominique, Ferrant, Augustin, Meyer-Monard, Sandrine, Vey, Norbert, Dombret, Herve, Degos, Laurent, Chevret, Sylvie, Fenaux, Pierre, and for the European APL Group

Published
2010
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21. Incidence of ATRX mutations in myelodysplastic syndromes, the value of microcytosis

Author

Herbaux, Charles, Duployez, Nicolas, Badens, Catherine, Poret, Nicolas, Gardin, Claude, Decamp, Mathieu, Eclache, Virginie, Daliphard, Sylvie, Murati, Anne, Cony-Makhoul, Pascale, Cheze, Stéphane, Beve, Blandine, Lacoste, Caroline, Prebet, Thomas, Hunault-Berger, Mathilde, Maloisel, Frédéric, Renneville, Aline, Figeac, Martin, Stamatoullas-Bastard, Aspasia, Bastard, Christian, Fenaux, Pierre, Preudhomme, Claude, and Rose, Christian

Published
2015
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23. The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis: a report on 241 cases

Author

Kiladjian, Jean-Jacques, Cervantes, Francisco, Leebeek, Franck W.G., Marzac, Christophe, Cassinat, Bruno, Chevret, Sylvie, Cazals-Hatem, Dominique, Plessier, Aurélie, Garcia-Pagan, Juan-Carlos, Murad, Sarwa Darwish, Raffa, Sebastian, Janssen, Harry L.A., Gardin, Claude, Cereja, Sophie, Tonetti, Carole, Giraudier, Stéphane, Condat, Bertrand, Casadevall, Nicole, Fenaux, Pierre, and Valla, Dominique C.

Published
2008
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25. Azacitidine in untreated acute myeloid leukemia: A report on 149 patients

Author

Thépot, Sylvain, Itzykson, Raphael, Seegers, Valerie, Recher, Christian, Raffoux, Emmanuel, Quesnel, Bruno, Delaunay, Jacques, Cluzeau, Thomas, Marfaing Koka, Anne, Stamatoullas, Aspasia, Chaury, Marie-Pierre, Dartigeas, Caroline, Cheze, Stéphane, Banos, Anne, Morel, Pierre, Plantier, Isabelle, Taksin, Anne-Laure, Marolleau, Jean Pierre, Pautas, Cecile, Thomas, Xavier, Isnard, Francoise, Beve, Blandine, Chait, Yasmine, Guerci, Agnes, Vey, Norbert, Dreyfus, Francois, Ades, Lionel, Ifrah, Norbert, Dombret, Herve, Fenaux, Pierre, and Gardin, Claude

Published
2014
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26. BET inhibitors impair leukemic stem cell function only in defined oncogenic subgroups of acute myeloid leukaemias

Author

Massé, Aline, Roulin, Louise, Pasanisi, Justine, Penneroux, Justine, Gachet, Stéphanie, Delord, Marc, Ali, Ashfaq, Alberdi, Antonio, Berrou, Jeannig, Passet, Marie, Hernandez, Lucie, Quentin, Samuel, Gardin, Claude, Raffoux, Emmanuel, Adès, Lionel, Braun, Thorsten, Soulier, Jean, Clappier, Emmanuelle, Dombret, Hervé, Puissant, Alexandre, and Itzykson, Raphael

Published
2019
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27. Outcome of older patients with acute myeloid leukemia in first relapse

Author

Sarkozy, Clémentine, Gardin, Claude, Gachard, Nathalie, Merabet, Fathia, Turlure, Pascal, Malfuson, Jean-Valère, Pautas, Cécile, Micol, Jean-Baptiste, Thomas, Xavier, Quesnel, Bruno, Celli-Lebras, Karine, Preudhomme, Claude, Terré, Christine, Fenaux, Pierre, Chevret, Sylvie, Castaigne, Sylvie, and Dombret, Hervé

Published
2013
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35. Prognostic Impact of Monoallelic Versus Biallelic TP53 Alterations in Intensively-Treated Adults AML Patients: A Retrospective Study from the ALFA Group

Author

Fenwarth, Laurène, Vasseur, Loïc, Duployez, Nicolas, Gardin, Claude, Terré, Christine, Lambert, Juliette, de Botton, Stéphane, Celli-Lebras, Karine, Turlure, Pascal, Cluzeau, Thomas, Braun, Thorsten, Thomas, Xavier, Recher, Christian, Chantepie, Sylvain, Pautas, Cécile, Dombret, Hervé, Preudhomme, Claude, and Itzykson, Raphael

Published
2022
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38. Additional chromosomal abnormalities in patients with acute promyelocytic leukaemia (APL) do not confer poor prognosis: results of APL 93 trial

Author

de Botton, Stéphane, Chevret, Sylvie, Sanz, Miguel, Dombret, Hervé, Thomas, Xavier, Guerci, Agnès, Fey, Martin, Rayon, Consuelo, Huguet, Françoise, Sotto, Jean-Jacques, Gardin, Claude, Cony Makhoul, Pascale, Travade, Philippe, Solary, Eric, Fegueux, Nathalie, Bordessoule, Dominique, San Miguel, Jesus, Link, Harmut, Desablens, Bernard, Stamatoullas, Aspasia, Deconinck, Eric, Geiser, K, Hess, U, Maloisel, Fréderic, Castaigne, Sylvie, Preudhomme, Claude, Chomienne, Christine, Degos, Laurent, and Fenaux, Pierre

Published
2000

40. Efficacy of Azacitidine in autoimmune and inflammatory disorders associated with myelodysplastic syndromes and chronic myelomonocytic leukemia

Author

Fraison, Jean-Baptiste, Mekinian, Arsène, Grignano, Eric, Kahn, Jean-Emmanuel, Arlet, Jean-Benoit, Decaux, Olivier, Denis, Guillaume, Buchdahl, Anne-Laure, Omouri, Mohamed, Maigne, Gwenola, Aouba, Achille, Leon, Nathalie, Berthier, Sabine, Liozon, Eric, Park, Sophie, Gardin, Claude, Lortholary, Olivier, Rossignol, Julien, Fenaux, Pierre, Fain, Olivier, and Braun, Thorsten

Published
2016
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41. Insights into the cellular pharmacological properties of the BET-inhibitor OTX015/MK-8628 (birabresib), alone and in combination, in leukemia models.

Author

Astorgues-Xerri, Lucile, Vázquez, Ramiro, Odore, Elodie, Rezai, Keyvan, Kahatt, Carmen, Mackenzie, Sarah, Bekradda, Mohamed, Coudé, Marie-Magdelaine, Dombret, Herve, Gardin, Claude, Lokiec, Francois, Raymond, Eric, Noel, Kay, Cvitkovic, Esteban, Herait, Patrice, Bertoni, Francesco, and Riveiro, María E.

Subjects
AZACITIDINE, LEUKEMIA
Abstract

The bromodomain and extra-C-terminal domain (BET) protein family is a class of epigenetic readers that recognize acetyl-lysine residues of histones, and their targeting with small molecules is a novel therapeutic approach [[1]]. Cell cycle and apoptosis induction were evaluated in a subset of cell lines, including two resistant models (NALM1, K562) after 48-h treatments with 500 nM OTX015 (Figure 1(A)). Similarly, OTX015 significantly down-regulated I MTHFD1L i and I BCL2 i in all leukemic cell lines after 4 or 24 h of treatment, in a similar manner as I MYC i , although the effect on I BCL2 i appeared reversible in three nonresistant cell lines (Figure S2). We then evaluated the downstream effects of OTX015 (500 nM) combined with azacitidine (3 µM) or panobinostat (20 nM) in sensitive and resistant OTX015 cell lines. [Extracted from the article]

Published
2019
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42. Comparison of a Combination of Vosaroxin (VOS) and Intermediate-Dose Cytarabine (IDAC) with Idac for the Consolidation Therapy of Younger Patients with Favorable- and Intermediate-Risk Acute Myeloid Leukemia (AML) in First Complete Remission (CR): Preliminary Results of a Randomized Phase 2 R4-VOS Study of the French ALFA-Filo AML Intergroup

Author

Vey, Norbert, Orvain, Corentin, Recher, Christian, Pigneux, Arnaud, Bernard, Marc, Banos, Anne, Peterlin, Pierre, Chantepie, Sylvain, Thomas, Xavier, Pautas, Cecile, Gardin, Claude, Lemasle, Emilie, Raffoux, Emmanuel, Guieze, Romain, Himberlin, Chantal, Loiseau, Clémence, Belhabri, Amine, Luquet, Isabelle, Terré, Christine, Carre, Martin, Preudhomme, Claude, Delabesse, Eric, Celli-Lebras, Karine, Mineur, Ariane C, Brasme, Jean-Francois, Hamel, Jean Francois, Dombret, Hervé, and Hunault, Mathilde

Published
2020
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43. Very Long Term Follow up a Phase II Study of Post-Remission Subcutaneous (SC) Azacitidine (AZA) in Patients with AML Post-MDS or Higher-Risk (HR) MDS

Author

Cherait, Amina, Braun, Thorsten, Bouabdallah, Krimo, Caillot, Denis, Guerci, Agnès, Raffoux, Emmanuel, Marolleau, Jean Pierre, Pautas, Cecile, Banos, Anne, Himberlin, Chantal, Taksin, Anne Laure, Pigneux, Arnaud, Thomas, Xavier, Vey, Norbert, Chevret, Sylvie, Dombret, Herve, Chermat, Fatiha, Ades, Lionel, Gardin, Claude, and Fenaux, Pierre

Published
2020
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44. A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

Author

Fenaux, Pierre, Chastang, Claude, Chevret, Sylvie, Sanz, Miguel, Dombret, Hervé, Archimbaud, Eric, Fey, Martin, Rayon, Consuelo, Huguet, Françoise, Sotto, Jean-Jacques, Gardin, Claude, Makhoul, Pascale Cony, Travade, Philippe, Solary, Eric, Fegueux, Nathalie, Bordessoule, Dominique, Miguel, Jesus San, Link, Harmut, Desablens, Bernard, Stamatoullas, Aspasia, Deconinck, E., Maloisel, Fréderic, Castaigne, Sylvie, Preudhomme, Claude, and Degos, Laurent

Published
1999
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48. Real life experience with frontline azacitidine in a large series of older adults with acute myeloid leukemia stratified by MRC/LRF score: results from the expanded international E-ALMA series (E-ALMA+).

Author

for the European ALMA + Investigators, Falantes, José, Itzykson, Raphael, Fenaux, Pierre, Pinto, Ricardo, Bargay, Joan, Burgstaller, Sonja, Martínez, María Pilar, Seegers, Valerie, Gardin, Claude, Cortesão, Emilia, Foncillas, María Ángeles, Montesinos, Pau, Sanz, Miguel Angel, Musto, Pellegrino, Pleyer, Lisa, Greil, Richard, Thépot, Sylvain, Almeida, António M., and Maurillo, Luca

Subjects
HEALTH of older people, MYELOID leukemia, AZACITIDINE, CANCER chemotherapy, HEMATOLOGIC malignancies
Abstract

Azacitidine (AZA) prolonged overall survival (OS) in the AZA-AML-001 trial. However, few subjects were randomized to AZA or intensive chemotherapy (IC). The Medical Research Council (MRC) and the Leukemia Research Foundation (LRF) developed a score for older AML patients receiving IC or non-intensive regimens, whereas the E-ALMA study validated a score for survival and response in elderly patients receiving AZA in daily practice. Both identified three groups with different risk estimates. This analysis evaluates the efficacy of frontline AZA in older AML patients (N = 710) unfit for IC from different national registries (E-ALMA + series) stratified by the MRC/LRF risk score. Median OS of patients categorized as good, standard and poor-risk groups by the MRC/LRF score was 13.4 (95% CI, 10.8-16), 12.4 (95% CI, 9.9-14.8), and 8.1 months (95% CI, 7-9.1), respectively (p = .0001). In conclusion, this is the largest retrospective cohort of older AML patients treated with AZA. [ABSTRACT FROM AUTHOR]

Published
2018
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49. Randomized Phase 2 Trial of Lirilumab (anti-KIR monoclonal antibody, mAb) As Maintenance Treatment in Elderly Patients (pts) with Acute Myeloid Leukemia (AML): Results of the Effikir Trial

Author

Vey, Norbert, Dumas, Pierre-Yves, Recher, Christian, Gastaud, Lauris, Lioure, Bruno, Bulabois, Claude-Eric, Pautas, Cecile, Marolleau, Jean-Pierre, Leprêtre, Stéphane, Raffoux, Emmanuel, Thomas, Xavier, Hicheri, Yosr, Bonmati, Caroline, Quesnel, Bruno, Rousselot, Philippe, Castaigne, Sylvie, Jourdan, Eric, Malfuson, Jean Valère, Guillerm, Gaelle, Bouhris, Jean Henri, Ojeda, Mario, Hunault, Mathilde, Ifrah, Norbert, Gardin, Claude, Delannoy, Andre, Beautier, Lucile, Paturel, Carine, Andre, Pascale, Zerbib, Robert, Preudhomme, Claude, Toubert, Antoine, Dulphy, Nicolas, Olive, Daniel, Pigneux, Arnaud, and Dombret, Herve

Published
2017
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50. Role of Allogeneic Reduced Intensity Conditioning Stem Cell Transplantation (RIC-SCT) in Older Patients with Acute Myeloid Leukemia (AML): Analysis of the ALFA-1200 Study

Author

Gardin, Claude, Pautas, Cécile, Lemasle, Emilie, Bourhis, Jean-Henri, Ades, Lionel, Marolleau, Jean-Pierre, Malfuson, Jean Valère, Gastaud, Lauris, Raffoux, Emmanuel, Cano, Isabel, Braun, Thorsten, Thomas, Xavier, Chantepie, Sylvain, Cluzeau, Thomas, De Botton, Stephane, Berthon, Céline, Papoular, Benjamin, Boissel, Nicolas, Preudhomme, Claude, Terré, Christine, Socié, Gérard, Michallet, Mauricette, Yakoub-Agha, Ibrahim, Celli-Lebras, Karine, and Dombret, Herve

Published
2017
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