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7. Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials

Author

Cole, Abosede O, Gerstenblith, Adam T, Kotagiri, Ajay, Edwards, Albert O, Zambrano, Alberto D, Eaton, Alexander M, Rubowitz, Alexander, Lyon, Alice T, Chiang, Allen, Ho, Allen, Hu, Allen Y, Guerami, Amir H, Dessouki, Amr L, de Carvalho, André Corrêa Maia, Emanuelli, Andrés, Chang, Andrew A, Antoszyk, Andrew N, Francone, Anibal Andrés, Prasad, Anita, Wolf, Armin, Khanani, Arshad M, Abbey, Ashkan Michael, Moulana, Asma, Wihelm, Barbara, Sikorski, Bartosz L, Kuppermann, Baruch D, Wolff, Benjamin, Jewart, Brian H, Do, Brian K, Chan-Kai, Brian T, Mein, Calvin, Hoyng, Carel B, Awh, Carl C, Regillio, Carl, Zeolite, Carlos, Baumal, Caroline R, Creuzot-Garcher, Catherine, Maury, Catherine Français, Wykoff, Charles C, Newell, Charles K, Jhaveri, Chirag, Lohmann, Chris P, Dinah, Christiana B, Ma, Colin, Crawford, Courtney, Parke, D Wilkin, Lavinsky, Daniel, Roth, Daniel, Pieramici, Dante J, Moshfeghi, Darius M, Levin, Darrin, Saperstein, David A, Brown, David, Gaucher, David, Lally, David R, Liao, David S, Brown, David Warren, Goldstein, Debra, Marcus, Dennis, Chan, Derek G, Dhoot, Dilsher, Tacite, Domingo, Zalewski, Dominik, Espana, Edgar M, Lad, Eleonora M, Souied, Eric H, Suan, Eric P, Eting, Eva, Sola, Federico Furno, de Bats, Flore, Bandello, Francesco, Gómez-Ulla, Francisco, Devin, François, Holz, Frank G, Chen, Fred K, Makkouk, Fuad, Dyer, Gawain, Spital, George, Staurenghi, Giovanni, Stoller, Glenn, Cousins, Gwen, Salehi-Had, Hani, Agostini, Hansjürgen, Eleftheriadis, Haralabos, Weiss, Harold, Sultan, Harris C, Massé, Hélène, Pearce, Ian, Dias, Indra, Barbazetto, Irene, Rosenblatt, Irit, Suñer, Ivan J, Kovach, Jaclyn L, Kaluzny, Jakub, Borthwick, James, Howard, James G, Wong, James, Ernest, Jan, Němčanský, Jan, Ysasaga, Jason Edward, Handza, Jason M, Moreno, Javier Antonio Montero, Korobelnik, Jean-François, Heier, Jeffrey S, Arnold, Jennifer J, Brown, Jeremiah, Bafalluy, Joaquin, Pearlman, Joel, Pitcher, John D, Kitchens, John, Carlson, John P, Gilhotra, Jolly, Fein, Jordana, Monés, Jordi M, Luna, José Domingo, Moreno, José María Ruiz, Coney, Joseph M, Sallum, Juliana Maria Ferraz, Olsen, Karl R, Blobner, Katharina, Macoul, Katherine A, Oh, Kean T, Malik, Khurram Javed, Hattenbach, Lars-Olof, Kodjikian, Laurent, Neto, Laurentino Biccas, Singerman, Lawrence J, Altay, Lebriz, Sheck, Leo-H, Feiner, Leonard, Harris, Lindsey D, Chishold, Lionel D, Rao, Llewelyn J, Nehemy, Márcio Bittar, Elizalde, Maria Jose Capella, Gamulescu, Maria-Andreea, Saravia, Mario J, Johnson, Mark W, McKibbin, Martin, Maccumber, Mathew, Vidosevich, Matko, Ohr, Matthew P, Samuel, Michael A, Singer, Michael A, Cassell, Michael, Dollin, Michael, Elman, Michael J, Ip, Michael S, Goldstein, Michaella, Busquets, Miguel, Mititelu, Mihai, Shah, Milan, Veith, Miroslav, Fineman, Mitchell, Varano, Monica, Christmas, Nancy, Steinle, Nathan C, Chaudhry, Nauman, Chinskey, Nicholas D, Eter, Nicole, London, Nikolas J S, Mathalone, Nurit, Schlottmann, Patricio G, Coady, Patrick, Higgins, Patrick M, Raskauskas, Paul A, Yates, Paul A, Bernstein, Paul, Mitchell, Paul, Monsour, Paul, Raphaelian, Paul V, Stanga, Paulo E, Stodulka, Pavel, Issa, Peter Charbel, Pavan, Peter, Ferrone, Phil J, Oleksy, Piotr, Abraham, Prema, Mruthyunjaya, Prithvi, Nguyen, Quan Dong, Reddy, Rahul K, Khurana, Rahul N, Tuli, Raman, Tadayoni, Ramin, Katz, Randy Steven, Arora, Rashi, Schlingemann, Reinier O, Rosen, Richard B, Gale, Richard, Scartozzi, Richard, Isernharge, Ricky, Singh, Rishi P, Stoltz, Robert A, Avery, Robert L, Wirthlin, Robert S, Guymer, Robyn, Goldberg, Roger A, Frenkel, Ronald, Belfort, Rubens Jr, Mohand-Said, Saddek, Grisanti, Salvatore, Razavi, Sam, Fraser-Bell, Samantha, Shah, Sandeep N, Wickremasinghe, Sanjeewa, Haug, Sara Joy, Adrean, Sean D, Priglinger, Siegfried G, Esposti, Simona Degli, Guest, Stephen, Huddleston, Stephen, Itty, Sujit, Moon, Suk Jin, Bhatia, Sumit P, Gupta, Sunil, Patel, Sunil S, Garg, Sunir J, Joshi, Sunir, Nghiem-Buffet, Sylvia, Johnson, T Mark, Jaouni, Tareq, Ach, Thomas, Williams, Thomas R, Sheidow, Thomas, Cleland, Timothy P, You, Timothy T, Peto, Tunde, Konidaris, Vasileios, Gonzalez, Victor H, Korda, Vladimir, Freeman, William R, Bridges, William Z, Barak, Yoreh, Zagorski, Zbigniew, Yehoshua, Zohar, Dubska, Zora, Rosenfeld, Philip J, Guymer, Robyn H, Boyer, David, Grossi, Federico, Korobelnik, Jean-Francois, Slakter, Jason S, Waheed, Nadia K, Metlapally, Ravi, Steinle, Nathan, Francone, Anibal A, Hu, Allen, Deschatelets, Pascal, Francois, Cedric, Bliss, Caleb, Monés, Jordi, and Ribeiro, Ramiro

Published
2023
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8. A Randomized Controlled Trial of OPT-302, a VEGF-C/D Inhibitor for Neovascular Age-Related Macular Degeneration

Author

Kousal, Bohdan, Studnicka, Jan, Veith, Michal, Creuzot-Garcher, Catherine, De Bats, Flore, Gaucher, David, Mauget-Faysse, Martine, Souied, Eric, Tadayoni, Ramin, Facsko, Andrea, Kerénvi, Agnes, Papp, Andras, Tsorbatzoglou, Alexis, Vogt, Gabor, Barak, Yoreh, Chowers, Itay, Goldstein, Michaella, Hanhart, Joel, Morori-Katz, Haya, Rosenblatt, Irit, Rubowitz, Alexander, Netzer, Oren Tomkins, Bandello, Francesco, Ciardella, Antonio, Ricci, Federico, Staurenghi, Giovanni, Virgili, Gianni, Baumane, Kristine, Laganovska, Guna, Ozolina, Signe, Strautmane, Ilze, Kaluzny, Bartlomiej, Mackiewicz, Jerzy, Misiuk-Hoilo, Marta, Mrukwa-Kominek, Ewa, Oleksy, Piotr, Raczynska, Krystyna, Zarnowski, Tomasz, Adan, Alfredo, Araiz, Javier, Boixadera, Anna, Fernández-Vega, Alvaro, Layana, Alfredo Garcia, Gomez-Ulla, Francisco, Montero, Javier, Ruiz Moreno, Jose Maria, Gilmour, David, Jackson, Timothy, Liyanage, Sidath, Membrey, Luke, Menon, Geeta, Narendran, Niro, Sivaprasad, Sobha, Alfaro, Daniel, Antoszyk, Andrew, Baker, Carl, Batille, Ivan, Berger, Brian, Boyer, David, Bridges, William, Brooks, Harold, Brown, David, Chang, Margaret, Chao, Daniel, Chen, Sanford, Crawford, Courtney, Dugel, Pravin, Eaton, Alexander, Eichenbaum, David, Fein, Jordana, Feiner, Leonard, Flaxel, Christina, Garber, Frank, Gordon, Alan, Gupta, Sunil, Haegedorn, Curtis, Hampton, George, Hanscom, Thomas, Hershberger, Vrinda, Kaiser, Peter, Katz, Randy, Khanani, Arshad, Kruger, Erik, Marcus, Denis, Ohr, Matthew, Patel, Sunil, Pearlman, Joel, Pesavento, Richard, Pieramici, Dante, Pitcher, John, Prensky, Jay, Randolf, John, Regillo, Carl, Rose, Steven, Samuel, Michael, Schneiderman, Todd, Shah, Sumit, Singer, Michael, Steinle, Nathan, Stoller, Glenn, Thach, Alan, Thompson, John, Varenhorst, Michael, Wagner, Alan, Walker, Joseph, Wells, John, Williams, Jonathan, Wong, Robert, Wykoff, Charles, Jackson, Timothy L., Slakter, Jason, Buyse, Marc, Wang, Kun, Dugel, Pravin U., Wykoff, Charles C., Boyer, David S., Gerometta, Michael, Baldwin, Megan E., and Price, Clare F.

Published
2023
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13. TELANGIECTATIC CAPILLARIES CAUSING PERSISTENT DIABETIC MACULAR EDEMA SUCCESSFULLY TREATED BY PHOTODYNAMIC THERAPY.

Author

Schaeffer, Marion, Dormegny, Léa, Speeg-Schatz, Claude, Sauer, Arnaud, Bourcier, Tristan, and Gaucher, David

Abstract

Purpose: To report two cases of persistent macular edema caused by the exudation of diabetic telangiectatic capillaries (TelCaps), which have been successfully treated with photodynamic therapy (PDT). Methods: Review of data from two patients suffering from persistent macular edema caused by parafoveolar TelCaps. In both cases, conventional laser was impossible because TelCaps were to close from foveal center. Results: The use of focal PDT on perifoveolar TelCaps permitted to reduce persistent macular edema and to avoid inefficient intravitreal anti-vascular epithelial growth factor or steroid injections. In both cases, visual acuity was fully restored four to six months after PDT. Central macular thickness was also normalized in the first case and significantly reduced in the second case. In both cases, visual gain was sustained throughout the whole follow-up period (2 and 1 year, respectively). Conclusion: Photodynamic therapy can be helpful to treat diabetic macular edema caused by TelCaps nonresponding to approved intravitreal therapy or for which conventional laser is contraindicated. [ABSTRACT FROM AUTHOR]

Published
2024
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18. No association of endothelial lipase and aldose reductase polymorphisms with proliferative diabetic retinopathy: Results of the French prospective multicenter REDIAGEN study

Author

HENRY, Adrien, BOIGELOT, Tiffany, MOURA, Thomas FERREIRA DE, LECLERCQ, Isabelle, BARBE, Coralie, THIERY, Aurore, DJERADA, Zoubir, NAZEYROLLAS, Pierre, CLAVEL, Christine, CORNILLET-LEFEBVRE, Pascale, BERROD, Jean-Paul, CREUZOT-GARCHER, Catherine, MEYER, Laurent, GAUCHER, David, GUERCI, Bruno, LENOBLE, Patrick, MILAZZO, Solange, PERONE, Jean-Marc, ARNDT, Carl, and DURLACH, Vincent

Published
2024
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19. ADVERSE EVENTS OF THE ARGUS II RETINAL PROSTHESIS: Incidence, Causes, and Best Practices for Managing and Preventing Conjunctival Erosion

Author

Rizzo, Stanislao, Barale, Pierre-Olivier, Ayello-Scheer, Sarah, Devenyi, Robert G., Delyfer, Marie-Noëlle, Korobelnik, Jean-François, Rachitskaya, Aleksandra, Yuan, Alex, Jayasundera, K. Thiran, Zacks, David N., Handa, James T., Montezuma, Sandra R., Koozekanani, Dara, Stanga, Paulo E., da Cruz, Lyndon, Walter, Peter, Augustin, Albert J., Chizzolini, Marzio, Olmos de Koo, Lisa C., Ho, Allen C., Kirchhof, Bernd, Hahn, Paul, Vajzovic, Lejla, Iezzi, Raymond, Jr, Gaucher, David, Arevalo, J. Fernando, Gregori, Ninel Z., Grisanti, Salvatore, Özmert, Emin, Yoon, Young Hee, Kokame, Gregg T., Lim, Jennifer I., Szurman, Peter, de Juan, Eugene, Jr, Rezende, Flavio A., Salzmann, Joël, Richard, Gisbert, Huang, Suber S., Merlini, Francesco, Patel, Uday, Cruz, Cynthia, Greenberg, Robert J., Justus, Sally, Cinelli, Laura, and Humayun, Mark S.

Published
2020
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20. ADVERSE EVENTS OF THE ARGUS II RETINAL PROSTHESIS: Incidence, Causes, and Best Practices for Managing and Preventing Conjunctival Erosion

Author

Rizzo, Stanislao, Barale, Pierre-Olivier, Ayello-Scheer, Sarah, Devenyi, Robert G., Delyfer, Marie-Noëlle, Korobelnik, Jean-François, Rachitskaya, Aleksandra, Yuan, Alex, Jayasundera, K. Thiran, Zacks, David N., Handa, James T., Montezuma, Sandra R., Koozekanani, Dara, Stanga, Paulo E., da Cruz, Lyndon, Walter, Peter, Augustin, Albert J., Chizzolini, Marzio, Olmos de Koo, Lisa C., Ho, Allen C., Kirchhof, Bernd, Hahn, Paul, Vajzovic, Lejla, Iezzi, Raymond, Jr, Gaucher, David, Arevalo, J. Fernando, Gregori, Ninel Z., Grisanti, Salvatore, Özmert, Emin, Yoon, Young Hee, Kokame, Gregg T., Lim, Jennifer I., Szurman, Peter, de Juan, Eugene, Jr, Rezende, Flavio A., Salzmann, Joël, Richard, Gisbert, Huang, Suber S., Merlini, Francesco, Patel, Uday, Cruz, Cynthia, Greenberg, Robert J., Justus, Sally, Cinelli, Laura, and Humayun, Mark S.

Published
2018
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22. Endophthalmitis After Intravitreal Injections: Incidence, Presentation, Management, and Visual Outcome

Author

Berthon, Laurent, Maftouhi, Quaranta-El, Bakhti, Amina, Conrath, John, Le Mer, Yannick, Ramahefasolo, Christiane Besse, Coscas, Florence, Français, Catherine, Grenet, Typhaine, Cohen, Salomon Yves, Uzzan, Joël, Razavi, Sam, Saleh, Maher, Delbosc, Bernard, Chaine, Gilles, Fajnkuchen, Franck, Giocanti, Audrey, Delyfer, Marie-Noëlle, Korobelnik, Jean-François, Querques, Giuseppe, Chevreaud, Olivier, Souied, Eric, Musson, Cécile, Chiquet, Christophe, Fortoul, Vincent, Kodjikian, Laurent, Straub, Morgane, Burillon, Carole, Berrod, Jean-Paul, Baillif, Stéphanie, Girmens, Jean-François, Pérol, Julien, Leveziel, Nicolas, Boissonnot, Michèle, Muraine, Marc, Gaucher, David, Le Lez, Marie-Laure, Pisella, Pierre-Jean, Dossarps, Denis, Bron, Alain M., Koehrer, Philippe, Aho-Glélé, Ludwig S., and Creuzot-Garcher, Catherine

Published
2015
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25. Binocular visual function improvement after pars plana vitrectomy for epiretinal membrane.

Author

Dormegny, Lea, Foch, Maxime, Messerlin, Arnaud, Bourcier, Tristan, Sauer, Arnaud, and Gaucher, David

Subjects
VISION, VITRECTOMY, PARS plana, CONTRAST sensitivity (Vision), VISUAL acuity, OPTICAL coherence tomography
Abstract

Purpose: To report binocular visual function changes after pars plana vitrectomy for epiretinal membrane (ERM) and the related outcomes. Methods: Twenty‐three eyes of 23 patients operated on for ERM were included in a retrospective study. Clinical data, best‐corrected visual acuity (BCVA), contrast sensitivity and binocular visual function were assessed pre‐ and 1 and 3 months post‐operatively. Binocular visual function assessment included the evaluation of fusional amplitudes (i.e., vergences) by the synoptophore, far distance stereopsis using polarized glasses and near stereopsis using Randot and TNO tests. Central macular thickness (CMT) was measured on Spectral Domain – Optical Coherence Tomography. Results: Mean age of the patients was 67 years. Mean BCVA and contrast sensitivity significantly improved post‐operatively at one (p = 0.0006 and p = 0.0022, respectively) and 3 months (p < 0.0001 and p < 0.0001, respectively), while CMT significantly decreased after 1–3 months (p < 0.0001 and p < 0.0001, respectively). Fusional amplitudes improved after 3 months (p < 0.0001). Far distance and near stereopsis significantly improved after 3 months (p < 0.0001 and p = 0.0007 for Randot test, and p < 0.0001 for TNO test, respectively). Conclusions: Pars plana vitrectomy for ERM surgery leads to an improvement of monocular and binocular visual functions (i.e., binocular fusion, near and far distance stereopsis), within 3 months post‐operatively. [ABSTRACT FROM AUTHOR]

Published
2023
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26. The Use of Dog Guides for Orientation and Mobility by Individuals With the Argus II Retinal Prosthesis: A Case Series.

Author

Flourence, Marine, Merlini, Francesco, Leffel, Ana, Fossati, Marco, Meddouri, Sophia, Carbone, Valentina, Benninghofen, Matthias, Studer, Fouzia, Dollfus, Hélène, Gaucher, David, Kirchhof, Bernd, Mura, Marco, and Fisher, Andy

Subjects
BLINDNESS, REHABILITATION of blind people, MENTAL orientation, CONFIDENCE, LOW vision, TRAVEL, RETINITIS pigmentosa, PHYSICAL mobility, ARTIFICIAL eyes, EMOTIONS, SERVICE animals, DOGS, DISEASE complications
Published
2023
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30. Management of postoperative inflammation after cataract and complex ocular surgeries: a systematic review and Delphi survey

Author

Aptel, Florent, Colin, Cyrille, Kaderli, Sema, Deloche, Catherine, Bron, Alain M, Stewart, Michael W, Chiquet, Christophe, Baillif, Stephanie, Berrocal, Mariah, Berrod, Jean-paul, Bron, Alain M, Chiquet, Christophe, Devin, François, Delyfer, Marie-noelle, Denis, Philippe, De smet, Marc D, Fogagnolo, Paolo, Gaucher, David, Germain, Philippe, Bernard, Agnès Glacet, Kodjikian, Laurent, Labbè, Antoine, Labetoulle, Marc, Mansouri, Kaweh, Meyer, Carsten H, Murray, Timothy G, Myers, Jonathan S, Pournaras, Constantin J, Rouberol, Frédéric, Saleh, Maher, Singer, Michael A, Stewart, Michael W, Tatham, Andrew J, and Wolfensberger, Thomas

Published
2017
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31. The effect of strabismus surgery on the learning abilities of school‐aged children.

Author

Feuillade, Vincent, Bourcier, Tristan, Gaucher, David, Speeg, Claude, and Sauer, Arnaud

Subjects
SCHOOL children, LEARNING ability, STRABISMUS, VERBAL behavior testing, SURGICAL indications, CONVERGENT strabismus
Abstract

Purpose: To evaluate whether strabismus surgery improves the learning performance – calculation, reading and drawing – of school‐aged children. Methods: In a case–control study, patients between the ages of 7 and 10 years with horizontal strabismus, recommended for surgical correction, were prospectively included. Reading, calculating and drawing abilities were evaluated before and 3 months after corrective strabismus surgery using standardized tests. Cases were compared to control patients: patients with a surgical indication postponed due to the COVID lockdown. Results: Forty‐two operated patients and 42 controls between the ages of 7 and 10 years with horizontal strabismus were included. The average reading speed was 65.8 words per minute pre‐operatively compared to 80.6 words per minute post‐operatively (p = 0.0038). The average drawing score was 71.1 pre‐operatively compared to 84.3 post‐operatively (p = 0.012). The average calculation score was 3.2 pre‐operatively compared to 3.4 post‐operatively (p = 0.363). Improvement given by strabismus surgery was confirmed avoiding the learning effect by comparison with the control group. The improvements observed were more significant in the youngest patients and esotropia. Conclusions: This study highlights that strabismus surgery significantly improved the children's reading fluency and drawing task execution. These encouraging data should be taken into account when considering the indications for strabismus surgery. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Optical Coherence Tomography Angiography in Diabetic Macular Edema Treated with Intravitreal Aflibercept: A 48-Week Observational Study (the DOCTA Study).

Author

Korobelnik, Jean-François, Gaucher, David, Baillif, Stéphanie, Creuzot-Garcher, Catherine, Kodjikian, Laurent, and Weber, Michel

Subjects
*OPTICAL coherence tomography, *MACULAR edema, *DIABETIC retinopathy, *ANGIOGRAPHY, *AFLIBERCEPT, *RETINAL vein occlusion, *INTRAVITREAL injections
Abstract

Introduction: Central vision loss due to diabetic macular edema (DME) is related to the macular edema itself but also, in some cases, to alterations of the foveal avascular zone (FAZ). The aim of this trial was to study changes in macular vessels in eyes with DME treated with aflibercept using optical coherence tomography angiography (OCTA). Methods: This was a longitudinal, prospective, noncontrolled, single-arm study. The primary objective was the quantitative assessment of macular vessels over time in patients with DME treated with intravitreal aflibercept during a 48-week follow-up using OCTA. Results: Twenty-six DME eyes from 26 patients were included (mean age, 64.6 years; women, 53.8%; prior anti-VEGF treatment, 46.1%). Each eye received a mean (SD) of 7.2 (2.2) injections. The following parameters of the FAZ did not change during the 48-week follow-up: the mean (SD) FAZ area varied from 0.19 (0.19) mm2 at baseline (n = 22) to 0.23 (0.20) mm2 at week 48 (n = 15), boundary from 1.54 (1.21) to 2.04 (1.20) mm, and circularity from 0.45 (0.33)% to 0.57 (0.20)%. There was no change in perfusion density and vessel density of the macula in the 3-mm circle. As expected, mean central retinal thickness, macular volume, and visual acuity improved during follow-up. Conclusion: No change in macular perfusion was observed in eyes with DME during a 48-week follow-up after intravitreal injections of aflibercept. Randomized controlled trials using OCT angiography in large populations with extended observation periods are needed to assess changes in macular vessels after intravitreal anti-VEGF treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Choroidal thickness and vessel pattern in myopic eyes with dome-shaped macula.

Author

Negrier, Pierre, Couturier, Aude, Gaucher, David, Touhami, Sara, Guern, Guillaume Le, Tadayoni, Ramin, Gaudric, Alain, and Philippakis, Elise

Abstract

Aim To analyse the choroidal thickness (CT) and vessel pattern of myopic patients with dome-shaped macula (DSM) and their association with the DSM axis and serous retinal detachment (SRD). Methods Retrospective study. The CT and vessel pattern were assessed on optical coherence tomography (OCT), OCT-angiography and ultra-wide-field photography. Results 27 eyes of 18 subjects (mean age: 65 years) were included. Compared with the 11 eyes (41%) with horizontal DSM, the 16 eyes (59%) with vertical DSM had a shorter axial length (25.8±2 mm vs 28.3±2.5 mm; p=0.01), a higher mean macular bulge height (624.4±207 µm vs 255.4±160.3 µm; p=0.0001) and a thicker CT (183.1±91.1 µm vs 72±38.3 µm; p<0.001). Large choroidal vessels crossed the macular area in 75% of eyes with vertical DSM vs 27% of eyes with horizontal DSM (p=0.02), whereas a watershed zone framing the macula was more often seen in horizontal DSM (72% vs 25%, p=0.02). Thirteen eyes (48%) had an SRD that was not associated with the DSM axis, the mean bulge height, the CT or the vessel pattern. Conclusion The presence of an SRD did not correlate with the DSM axis, the CT or the vessel pattern. However, the rate of large choroidal vessels crossing the macula was higher in vertical DSM than in horizontal DSM. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Efficacy and Safety of 0.1% Cyclosporine versus 2% Cyclosporine in the Treatment of Severe Vernal Keratoconjunctivitis in Children.

Author

Bourcier, Tristan, Dory, Anne, Dormegny, Lea, Alcazar, Joffrey, Gaucher, David, and Sauer, Arnaud

Subjects
ALLERGIC conjunctivitis, CYCLOSPORINE, KERATOCONJUNCTIVITIS, DRUG dosage, AGE of onset, THERAPEUTICS
Abstract

Introduction: Vernal keratoconjunctivitis (VKC) is an inflammatory condition in children that can cause severe eye complications. Treatment is based on corticosteroid therapy during flare-ups, then antihistamines and cyclosporine in calmer periods. The dosage and posology of cyclosporine are subject to debate. Methods: The aim of the study is to compare the evolution in symptomatic and clinical scores, and need for topical corticosteroid treatment in a population of children with severe VKC treated with two dosages of cyclosporine treatment (0.1% and 2%). Data were compiled on inclusion then every three months from March, with a total follow-up duration of 12 months. Data concerning patient evolutions and complications were collected for the two treatment groups. Results: The mean age of the 46 children was 8.8 ± 2.4 years with age at onset of symptoms of 5.1 ± 0.9 years. The cohort was predominantly (65%) male. Corticosteroid dependence on inclusion was present in 52% of the children included. A significant improvement in the various symptomatic and clinical scores was observed following treatment with cyclosporine (0.1% and 2%). Use of topical corticosteroid treatment reduced from 19 drops per month on inclusion to 4 drops per month at 12 months. Safety was comparable for the two groups. Conclusion: Treatments with cyclosporine 0.1% and 2% lead to a favourable evolution in clinical and symptomatic scores and reduced corticosteroid use. Cyclosporine 0.1% is an interesting alternative to the 2% dosage, particularly due to its availability and ease of handling. [ABSTRACT FROM AUTHOR]

Published
2022
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50. OCT-Angiography for Detection of Choroidal Neovascularization: A Retrospective Real-Life Study.

Author

Bernard, Myriam, Messerlin, Arnaud, Sauer, Arnaud, Speeg-Schatz, Claude, and Gaucher, David

Subjects
FLUORESCENCE angiography, NEOVASCULARIZATION, POLYPOIDAL choroidal vasculopathy, INDOCYANINE green, ANGIOGRAPHY, UNIVERSITY hospitals
Abstract

Purpose: The purpose of the study was to assess OCT-angiography (OCT-A) contribution for choroidal neovascularization (CNV) detection, with respect to multimodal imaging (MMI) modality (including OCT, fluorescein angiography (FFA), and indocyanine green angiography [ICG]), in a real-life consultation practice. Methods: Data of all consecutive patients undergoing OCT-A examination for CNV suspicion were collected between September 2017 and September 2019 at Strasbourg University Hospital, France. Only eyes which had anti-VEGF injection in the last 3 months were excluded. All types of neovascularization were included. For all patients, data from OCT, OCT-A, FFA, and ICG were interpreted by residents and retinal specialists, independently. Final diagnosis of CNV was based on decision to treat. Sensibility, specificity, and predictive values were computed for OCT-A alone and for MMI (OCT combined to angiography). They were computed for each group. OCT-A was also assessed as "contributory" (i.e., assessing without doubt the presence or absence of CNV) or not, with respect to MMI. Results: In total, 161 eyes of 145 patients were included. MMI sensibility was better than OCT-A sensibility (93.8 vs. 65.6%). OCT-A specificity was better than MMI specificity (96.9 vs. 89.5%). OCT-A was essential for diagnosis in 16.9% of cases. Sensibility and specificity values for all exams were better when interpreted by retinal specialists than residents. OCT-A was judged "contributory" in 57.4% of eyes. OCT-A was significantly less contributory when artefacts were present (32.9% of eyes with artefacts vs. 63.5% without, p < 0.001). Conclusion: OCT-A showed to be essential in diagnosing CNV in >16% of cases. However, it often failed to conclude for the absence of CNV, which obliged to perform more exams such as angiography. OCT-A must be part of diagnostic procedure for CNV detection but does not discard angiography in everyday life practice. [ABSTRACT FROM AUTHOR]

Published
2022
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