30 results on '"Geng, Xiu"'
Search Results
2. Evaluation of suitability of university ladder classroom environment on humans
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Liu, Xin, Geng, Xiu, Huang, Kailiang, Feng, Guohui, Zhao, He, Wang, Xiaotong, and He, Jianing
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- 2024
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3. Matrine reduced intestinal stem cell damage in eimeria necatrix-infected chicks via blocking hyperactivation of Wnt signaling
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Zan, Geng-xiu, Wang, Xiao-fan, Yan, Shao-kang, Qin, Ying-chao, Yao, Lang-qun, Gao, Chun-qi, Yan, Hui-chao, Zhou, Jia-yi, and Wang, Xiu-qi
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- 2024
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4. Heat stress disrupts intestinal stem cell migration and differentiation along the crypt–villus axis through FAK signaling
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Zan, Geng-xiu, Qin, Ying-chao, Xie, Wen-wen, Gao, Chun-qi, Yan, Hui-chao, Wang, Xiu-qi, and Zhou, Jia-yi
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- 2023
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5. L-glutamate requires β-catenin signalling through Frizzled7 to stimulate porcine intestinal stem cell expansion
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Qin, Ying-chao, Zhou, Jia-yi, Zhu, Min, Zan, Geng-xiu, Gao, Chun-qi, Yan, Hui-chao, Li, Xiang-guang, and Wang, Xiu-qi
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- 2022
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6. Effect of heavy-doping Eu3+ and charge compensation on crystalline phase and luminescence properties of K2CaP2O7 phosphors emitting orange-red light.
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Wang, Yu-Huan, Chen, Yong-Jie, Geng, Xiu-Juan, Yang, Ying, Li, Zi-Qing, and Zuo, Xiu-Yuan
- Abstract
A series of K
2 Ca1-x P2 O7 :xEu3+ phosphors were prepared by a high-temperature solid-state reaction method. The crystal structure was analyzed by X-ray diffraction (XRD). Fluorescence spectra, decay curves, and color coordinates were investigated. Under excitation at 393 nm, the strongest emission peak was located at 590 nm, corresponding to the5 D0 →7 F1 transition of Eu3+ , and the sub-strongest one was located at 612 nm which belongs to the5 D0 →7 F2 transition of Eu3+ . XRD results show that the patterns doped with a small amount of Eu3+ were fitted well with the standard card of K2 CaP2 O7 , while the pattern with the doping of high concentration Eu3+ (heavy-doping) indicated the co-existence of K2 CaP2 O7 and EuPO4 phase which leads to luminescent intensity of phosphors enhance remarkablely. The concentration quenching mechanism was explained through dipole-dipole interaction. Different doping amounts of Eu3+ and charge compensators will affect the symmetry of the host lattice, thereby affecting the emission intensity ratio of orange and red light. The color coordinates of K2 Ca0.49 P2 O7 :0.51Eu3+ and K2 Ca0.33 P2 O7 :0.67Eu3+ , 0.1Na+ phosphor were near the red region, which was close to commercial red-emitting phosphors Y2 O3 :Eu3+ and standard red light, respectively. A series of K2 CaP2 O7 phosphors emitting orange-red light with different concentrations of Eu3+ doping and alkali metal ions co-doping were synthesized via a high-temperature solid-state method, and their structure and luminescent properties were characterized. A new strategy for adjusting the light color parameters of K2 CaP2 O7 phosphors has been constructed. [ABSTRACT FROM AUTHOR]- Published
- 2024
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7. Huge fetal hepatic Hemangioma: prenatal diagnosis on ultrasound and prognosis
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Li Jiao-ling, Geng Xiu-ping, Chen Kun-shan, He Qiu-ming, Li Xiao-fen, Yang Bo-yang, and Fang Qian
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Liver tumor ,Huge hepatic hemangioma ,Prenatal diagnosis ,Ultrasound ,Magnetic resonance imaging ,Contrast-enhanced computed tomography ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Although huge fetal hepatic hemangiomas are rare, they can cause fatal complications. The purpose of this study is to describe the imaging features and prognosis of these tumors. Methods Imaging data were collected for 6 patients with huge fetal hepatic hemangiomas treated at our hospital. Imaging modalities included prenatal magnetic resonance imaging and ultrasound and postnatal color Doppler ultrasound and contrast-enhanced computed tomography (CT). Results Among the 93,562 fetuses of 92,126 pregnant women examined at our hospital, 6 had huge hepatic hemangiomas (incidence rate, 0.64/10,000), as confirmed via postnatal color Doppler imaging and contrast-enhanced CT. Five fetuses had solitary lesions, whereas 1 (fetus 2) had multiple lesions. Four fetuses had lesions in the right liver lobe and 1 had a lesion in the left liver lobe, and 1 (fetus 2) had lesions in both lobes. All lesions showed centripetal enhancement on postnatal contrast-enhanced CT, which was more intense peripherally. Following postnatal treatment with oral propranolol, with or without dexamethasone or interventional therapy with the medical sclerosant pingyangmycin, all lesions decreased in size, with calcification plaques appearing 6 months after treatment. Conclusions Huge hepatic hemangiomas have typical ultrasonographic features and can be diagnosed prenatally. Treatment with propranolol, with or without dexamethasone, may result in a favorable prognosis.
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- 2018
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8. Soil Organic Carbon Lateral Movement Processes Integrated Into a Terrestrial Ecosystem Model.
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Lu, Haibo, Wang, Xiaoyuan, Zhang, Haicheng, Xie, Xianhong, Nakhavali, Mahdi, Quine, Timothy A., Xu, Wenfang, Xia, Jiangzhou, He, Bin, Hao, Zhixin, Geng, Xiu, and Yuan, Wenping
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CARBON cycle ,DISSOLVED organic matter ,CARBON in soils ,ECOSYSTEMS ,SOIL erosion ,COLLOIDAL carbon ,WATERSHEDS - Abstract
Lateral movement of soil organic carbon (SOC) induced by soil erosion and runoff changes spatial distributions of SOC, and further changes the land‐atmosphere CO2 exchange and terrestrial carbon budget. However, current ecosystem models do not or only poorly integrate the process of SOC lateral movement and cannot simulate the impacts of soil erosion on the carbon cycle. This study integrated SOC erosion and deposition processes into a process‐based ecosystem model (i.e., Integrated BIosphere Simulator (IBIS)), and separately simulated the lateral movements of dissolved organic carbon (DOC) and particulate organic carbon (POC). The model was evaluated in three river basins in Northeast China that are dominated by cropland, forest, and grassland. The results showed that the model reproduced well the production, erosion, and deposition of DOC and POC. The annual SOC lateral movement (1.34–7.22 g C m−2 yr−1) induced by erosion in the three tested basins was 0.27%–1.45% of the annual net primary production. The model developed in this study has great implications for simulating the lateral movements of SOC in terrestrial ecosystems, which can improve model performance in projecting the terrestrial carbon budget. Plain Language Summary: Lateral movement of soil organic carbon (SOC) with soil erosion and runoff is an important process in estimating land carbon budget. However, the current ecosystem models are not or poorly integrated this process, and cannot simulate the impacts of lateral movement of SOC on carbon cycle. This study integrates SOC erosion and deposition processes into a process‐based ecosystem model (Integrated BIosphere Simulator (IBIS)), and separately simulates the lateral movements of dissolved organic carbon (DOC) and particulate organic carbon (POC). The model was evaluated at three river basins in Northeast China dominated by cropland, forest and grassland, respectively. The results showed the model can reproduce well the production, erosion, deposition of DOC and POC. The model developed in this study has great implications for simulating the lateral movements of SOC in terrestrial ecosystem, which can improve model performance on projecting terrestrial carbon budget. Key Points: Current ecosystem models inadequately depict the lateral movement of SOC, causing uncertainties in terrestrial carbon cycle modelingWe integrated SOC erosion and deposition into a process‐based ecosystem model and evaluated it in three Chinese river basinsModel simulations well represented observed data for the production, erosion, and deposition of organic carbon [ABSTRACT FROM AUTHOR]
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- 2024
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9. {(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran-3-yl}methyl 4-methylbenzenesulfonate
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Qing-Shuang Ma, Xiao-Guang Wang, Lei Xu, Sun Bin, Dao-Hong Xia, and Geng-Xiu Zheng
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crystal structure ,triazole derivative ,antifungal agent ,Crystallography ,QD901-999 - Abstract
In the title compound, C21H21F2N3O4S, the tetrahydrofuran ring adopts an envelope conformation with the β-C atom positioned at the flap. The triazole, difluorophenyl and tolyl rings of the various substituents on the tetrahydrofuran ring are inclined at 77.88 (12), 83.81 (10) and 81.00 (10)°, respectively, to the best-fit mean plane through the five atoms of the tetrahydrofuran ring. In the crystal, weak C—H...O and C—H...F hydrogen bonds link the molecules into a three-dimensional structure, with molecules stacked along the a-axis direction.
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- 2017
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10. (S)-3-[(S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyloxazolidin-2-one 0.67-hydrate
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Xiao-Guang Wang, Qing-Shuang Ma, Bin Sun, Lei Xu, Feng-Tao Zhan, and Geng-Xiu Zheng
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crystal structure ,hydrogen bonding ,oxazolidone derivative ,Crystallography ,QD901-999 - Abstract
The asymmetric unit of the title compound, 3C20H20FNO4·2H2O, consists of three (S)-3-[(S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyloxazolidin-2-one molecules and two solvent water molecules. The carbonyl groups of the oxazolidin-2-one and hydroxypentanoyl units are oriented anti to one another in each molecule. In the crystal, O—H...O, C—H...O and C—H...F hydrogen bonds link the molecules into a three-dimensional supramolecular architecture with the organic molecules linked by water molecules and stacked along the b-axis direction.
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- 2017
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11. Non-negative matrix factorization based unmixing for principal component transformed hyperspectral data
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Geng, Xiu-rui, Ji, Lu-yan, and Sun, Kang
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- 2016
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12. Recombinant Porcine R‑Spondin 1 Facilitates Intestinal Stem Cell Expansion along the Crypt–Villus Axis through Potentiating Wnt/β-Catenin Signaling in Homeostasis and Deoxynivalenol Injury.
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Zhou, Jia-yi, Zan, Geng-xiu, Zhu, Qiu-jie, Gao, Chun-qi, Yan, Hui-chao, and Wang, Xiu-qi
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- 2022
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13. Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects.
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Chen, An-Na, Luo, Yan, Yang, Yu-Han, Fu, Jian-Tao, Geng, Xiu-Mei, Shi, Jun-Ping, and Yang, Jin
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DRUG resistance in cancer cells ,POST-translational modification ,HOMEOSTASIS ,THRESHOLD energy - Abstract
Lactate is an end product of glycolysis. As a critical energy source for mitochondrial respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule. We briefly summarize emerging concepts regarding lactate metabolism, such as the lactate shuttle, lactate homeostasis, and lactate-microenvironment interaction. Accumulating evidence indicates that lactate-mediated reprogramming of immune cells and enhancement of cellular plasticity contribute to establishing disease-specific immunity status. However, the mechanisms by which changes in lactate states influence the establishment of diverse functional adaptive states are largely uncharacterized. Posttranslational histone modifications create a code that functions as a key sensor of metabolism and are responsible for transducing metabolic changes into stable gene expression patterns. In this review, we describe the recent advances in a novel lactate-induced histone modification, histone lysine lactylation. These observations support the idea that epigenetic reprogramming-linked lactate input is related to disease state outputs, such as cancer progression and drug resistance. [ABSTRACT FROM AUTHOR]
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- 2021
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14. {(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran-3-yl}methyl 4-methylbenzenesulfonate
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Sun Bin, Xiao-Guang Wang, Lei Xu, Qing-Shuang Ma, Dao-Hong Xia, and Geng-Xiu Zheng
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crystal structure ,Hydrogen bond ,Triazole ,Crystal structure ,010402 general chemistry ,010403 inorganic & nuclear chemistry ,Ring (chemistry) ,01 natural sciences ,Medicinal chemistry ,triazole derivative ,0104 chemical sciences ,Crystal ,chemistry.chemical_compound ,chemistry ,Polymer chemistry ,Triazole derivatives ,lcsh:QD901-999 ,antifungal agent ,lcsh:Crystallography ,Tetrahydrofuran - Abstract
In the title compound, C21H21F2N3O4S, the tetrahydrofuran ring adopts an envelope conformation with the β-C atom positioned at the flap. The triazole, difluorophenyl and tolyl rings of the various substituents on the tetrahydrofuran ring are inclined at 77.88 (12), 83.81 (10) and 81.00 (10)°, respectively, to the best-fit mean plane through the five atoms of the tetrahydrofuran ring. In the crystal, weak C—H...O and C—H...F hydrogen bonds link the molecules into a three-dimensional structure, with molecules stacked along thea-axis direction.
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- 2017
15. Climate Change Impacts on Winter Wheat Yield in Northern China.
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Geng, Xiu, Wang, Fang, Ren, Wei, and Hao, Zhixin
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WHEAT yields , *WINTER wheat , *CLIMATE change , *COBB-Douglas production function , *AGRICULTURAL productivity - Abstract
Exploring the impacts of climate change on agriculture is one of important topics with respect to climate change. We quantitatively examined the impacts of climate change on winter wheat yield in Northern China using the Cobb–Douglas production function. Utilizing time-series data of agricultural production and meteorological observations from 1981 to 2016, the impacts of climatic factors on wheat production were assessed. It was found that the contribution of climatic factors to winter wheat yield per unit area (WYPA) was 0.762–1.921% in absolute terms. Growing season average temperature (GSAT) had a negative impact on WYPA for the period of 1981–2016. A 1% increase in GSAT could lead to a loss of 0.109% of WYPA when the other factors were constant. While growing season precipitation (GSP) had a positive impact on WYPA, as a 1% increase in GSP could result in 0.186% increase in WYPA, other factors kept constant. Then, the impacts on WYPA for the period 2021–2050 under two different emissions scenarios RCP4.5 and RCP8.5 were forecasted. For the whole study area, GSAT is projected to increase 1.37°C under RCP4.5 and 1.54°C under RCP8.5 for the period 2021–2050, which will lower the average WYPA by 1.75% and 1.97%, respectively. GSP is tended to increase by 17.31% under RCP4.5 and 22.22% under RCP8.5 and will give a rise of 3.22% and 4.13% in WYPA. The comprehensive effect of GSAT and GSP will increase WYPA by 1.47% under RCP4.5 and 2.16% under RCP8.5. [ABSTRACT FROM AUTHOR]
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- 2019
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16. Impacts of climate change on agrometeorological indices at winter wheat overwintering stage in northern China during 2021–2050.
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Hao, Zhixin, Geng, Xiu, Wang, Fang, and Zheng, Jingyun
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AGRICULTURAL meteorology , *WINTER wheat , *CROP yields , *WHEAT farming , *VEGETATION & climate - Abstract
Climate change has a significant impact on agrometeorological conditions. We analysed the winter wheat overwintering indices for the northern winter wheat production areas of China (NWPA), which include the percentage of extreme low‐temperature (daily minimum temperature ≤−22 °C) years, the first day of the overwintering period (FDO), sowing date (SD) and precipitation before winter (PBW). Then, we compared the differences of the four indices between the forecast period 2021–2050 and the baseline period 1961–1990 under the RCP4.5 scenario, which were based on the 0.5° × 0.5° grid daily meteorological data output provided by the Inter‐Sectoral Impact Model Intercomparison Project. The results showed that the occurrence of extreme cold winters decreases the NWPA, which will result in the northern boundary of winter wheat moving north by 1–2 latitudes and in an increase in the potentially safe overwintering areas by 8.5%. The FDO will be delayed in 2021–2050 by an average of 7.7 days. Climate warming will change the meteorological conditions for winter wheat overwintering in the Huang‐Huai winter wheat area, especially near the southern boundary of the winter wheat planting area, and the areas and years with no obvious overwintering periods will experience an increase by 50% and 56%, respectively. The SD will be postponed by 8.6–9.0 days. The PBW will decrease as the accumulated temperature increases, especially in the Huang‐Huai winter wheat area. In the future, the possible northern boundary for winter wheat planting may move northward, and the northernmost tip may reach 46°N. South of the Huang‐Huai region, winter wheat planting may change from a semi‐winter to a spring variety. These findings will provide a reference for generating wheat planting and management strategies in China. Climate change has significantly influenced the winter wheat planting in northern China. In 2021–2050, climate warming would decrease the occurrence of extreme cold winters in the regions near northern planting boundary, which would result in the possible northern boundary (red and green lines) moving northward, and the northernmost tip may reach 46°N. However, south of the Huang‐Huai region (black oval areas), wheat planting may change from a semi‐winter to a spring variety due to temperature increase and precipitation reduction. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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17. Concise Synthesis of Key Intermediate of Mirabegron via a Mixed Anhydride Method.
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Zhang, Qi-Long, Zhuang, Zhi-Yuan, Liu, Qing-Dong, Zhang, Zhan-Ming, Zhan, Fu-Xu, and Zheng, Geng-Xiu
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- 2016
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18. A Three-Step Synthesis of Acotiamide for the Treatment of Patients with Functional Dyspepsia.
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Kai Fu, Liu Yang, Qiu-Fen Wang, Fu-Xu Zhan, Bin Wang, Qian Yang, Zhi-Jia Ma, and Geng-Xiu Zheng
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- 2015
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19. Nrf2 Pathway Mediates Resistance to Weaning Stress-Induced Intestinal Injury in Piglets of Different Breeds.
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Ying-chao Qin, Geng-xiu Zan, Su-juan Ding, Chun-qi Gao, Hui-chao Yan, Xiang-feng Kong, and Xiu-qi Wang
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ANIMAL weaning , *PIGLETS , *INTESTINAL injuries , *NUCLEAR factor E2 related factor , *TIGHT junctions - Abstract
The intestine is the central organ of early weaning stress in piglets; however, the response of intestinal stem cells (ISCs) that drive epithelial renewal between the different breeds of piglets is not yet known. Therefore, this investigation was to explore the sensitivity of ISCs to early weaning stress. Taoyuan Black and Duroc piglets were slaughtered at 21 days of age (on the day of weaning) and 24 days of age (3 days after weaning) with 10 pigs, respectively. And the results showed that Taoyuan Black pigs are more tolerant to early weaning stress, while the mucosal mass of jejunum was significantly decreased in 24-day-old Duroc piglets compared with the 21-day-old Duroc piglets (P < 0.05). The weaning stress damaged the jejunal structure, decreased the expression of tight junction related proteins ZO-1, Occludin, and Claudin-1, and increased intestinal permeability in Duroc piglets (P < 0.05). The ex vivo intestinal organoids (IOs) derived from the jejunal crypt of Duroc piglets after weaning exhibited lower expansion efficiency (P < 0.05). Furthermore, the levels of proliferating cell marker PCNA, terminally differentiated cell marker KRT20, absorptive cell marker Villin, goblet cell marker MUC2, and Paneth cell marker lysozyme were significantly reduced in the jejunum, crypt, and jejunal organoids of 24-day-old Duroc (P < 0.05). ROS levels in the jejunum of Duroc piglets were increased along with the inhibition of the Nrf2 pathway compared with 21-day-old Duroc piglets (P < 0.05). Collectively, the Taoyuan Black pigs had stronger tolerance to weaning stress; however early weaning suppressed the Nrf2 pathway, decreased proliferation and differentiation activity of ISCs, and disrupted intestinal homeostasis in Duroc piglets. [ABSTRACT FROM AUTHOR]
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- 2022
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20. An Improved Process for Preparation of S-Acetyl-l-glutathione.
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Kai Fu, Qiu-Fen Wang, Fu-Xu Zhan, Liu Yang, Qian Yang, and Geng-Xiu Zheng
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- 2015
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21. Application of the improved TOPSIS model for selecting team members of mathematical modeling.
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Geng, Xiu-rong
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In order to avoid the phenomenon of the disorder and facilitate the decision-making, the traditional TOPSIS model should be improved. First, set the virtual program corresponding to the virtual positive and negative ideal point. The minimum or the maximum of the property value of alternative programs constitute the virtual program. Virtual programs are only related to the property value of alternative programs, but not connected with the number of alternative programs. Thus the virtual positive and negative ideal points have nothing to do with the number of alternative programs. Second, generate the improved decision-making matrix including virtual programs and original programs. Empirical results show that the improved TOPSIS model can sort the existing candidates after deleting the virtual team members and it does not produce the opposite sequence. Then it can be proved that the improved TOPSIS model can preserve the order. [ABSTRACT FROM PUBLISHER]
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- 2012
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22. The interactive new algorithm improving the consistency of the judgment matrix in the AHP.
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Geng, Xiu-rong
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In order to get the satisfactory consistency of the judgment matrix A in AHP, an existing algorithm was modified and an interactive new algorithm was got. Through the introduction of binary variable δij, a new non-linear programming model was created. And then the data αij was obtained using the model. The former is used to correct its deviation in the matrix A. The analysis shows that the interactive algorithm incorporates the mechanical and subjective thoughts, keeping the advantages and avoiding the shortcomings. It can not only realize the satisfactory consistency of the judgment matrix, but also have humanities, meeting the subjective will of the decision-maker. The algorithm can improve the consistency of the judgment matrix; at the same time, it is the promotion of algorithm provided by the paper of [2], having a universal nature. [ABSTRACT FROM PUBLISHER]
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- 2012
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23. Export Performance Assessment : A Jiangsu Case.
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Geng Xiu-.lin
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INTERNATIONAL trade ,EXPORT & import trade of commercial products ,EXPORT marketing ,MULTIVARIATE analysis ,ECONOMICS - Abstract
Foreign trade export provides power to the growth of national economy. In this study, findings of related researches are examined, with a special consideration of Jiangsu cases, so that an export performance evaluation system may be constructed. Based on this evaluating system, a multivariate analysis is made to weigh the foreign trade export performance in Jiangsu Province. It proves that this system works well. From the data studied, it is clear that gaps in foreign trade export performance in regions over Jiangsu are big, and there is no sign of improvement. Therefore, in the new adjustment of foreign trade strategy, it is important for Jiangsu to see a balanced development in all regions and efficiency and effectiveness of foreign trade as well. [ABSTRACT FROM AUTHOR]
- Published
- 2008
24. Study on Physical Distribution of B2C E-commerce Model.
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Gu Yu and Geng Xiu-yan
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- 2010
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25. Changes in Climate Extremes in Central Asia under 1.5 and 2 °C Global Warming and their Impacts on Agricultural Productions.
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Liu, Yang, Geng, Xiu, Hao, Zhixin, and Zheng, Jingyun
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CLIMATE change , *AGRICULTURAL productivity , *GLOBAL warming , *GROWING season , *FOOD security - Abstract
Changes in climate extremes under 1.5 °C and 2 °C global warming may impact agricultural production across Central Asia. We used the simulated daily data of average temperature, maximum temperature, minimum temperature, and precipitation provided by the Inter-Sectoral Impact Model Intercomparison Project and analyzed the current climate status and future projected changes of a set of climate extreme indices related to agricultural production under 1.5 °C and 2 °C global warming. In addition, the possible impacts of climate change on agricultural production in Central Asia were discussed. The results show that the annual mean temperature in Central Asia will increase by 1.48 °C and 2.34 °C at 1.5 °C and 2 °C warming levels, respectively, compared to the base period (1986–2005), and the increasing trends are significant at the α = 0.01 level for all grids. The number of warm days and growing season length will increase. Under the 1.5 °C scenario, the mean annual total precipitation (PRCPTOT) and heavy precipitation (R95P) will experience increases of 7.68% and 26.55%, respectively, and the consecutive dry days (CDD) will be reduced by 1.1 days. However, the standardized precipitation evapotranspiration index (SPEI) shows significant drought conditions in most of Central Asia (more than 60%). Under the 2 °C scenario, there will be a 3.89% increase in PRCPTOT and a 24.78% increase in R95P. Nevertheless, accompanying the increase in CDD (0.8 day) and the decrease in SPEI, drought conditions will be further exacerbated. These results indicate that Central Asia is likely to face more severe ecological problems in the future, which will threaten the regional agricultural production and the food security. Therefore, adaptation strategies should be implemented immediately to mitigate the negative impacts of climate change on Central Asia's agriculture. [ABSTRACT FROM AUTHOR]
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- 2020
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26. Lauric acid alleviates deoxynivalenol-induced intestinal stem cell damage by potentiating the Akt/mTORC1/S6K1 signaling axis.
- Author
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Liu, Zhen-hua, Xie, Wen-wen, Zan, Geng-xiu, Gao, Chun-qi, Yan, Hui-chao, Zhou, Jia-yi, and Wang, Xiu-qi
- Subjects
- *
LAURIC acid , *INTESTINES , *STEM cells , *LABORATORY mice , *CELL differentiation - Abstract
Intestinal stem cell (ISC)-driven intestinal homeostasis is subjected to dual regulation by dietary nutrients and toxins. Our study investigated the use of lauric acid (LA) to alleviate deoxynivalenol (DON)-induced intestinal epithelial damage. C57BL/6 mice in the control, LA, DON, and LA + DON groups were orally administered PBS, 10 mg/kg BW LA, 2 mg/kg BW DON, and 10 mg/kg BW LA + 2 mg/kg BW DON for 10 days. The results showed that LA increased the average daily gain and average daily feed intake of the mice exposed to DON. Moreover, the DON-triggered impairment of jejunal morphology and barrier function was significantly improved after LA supplementation. Moreover, LA rescued ISC proliferation, inhibited intestinal cell apoptosis, and promoted ISC differentiation into absorptive cells, goblet cells, and Paneth cells. The jejunum crypt cells from the mice in the LA group expanded into enteroids, resulting in a significantly greater enteroid area than that in the DON group. Furthermore, LA reversed the DON-mediated inhibition of the Akt/mTORC1/S6K1 signaling axis in the jejunum. Our results indicated that LA accelerates ISC regeneration to repair intestinal epithelial damage after DON insult by reactivating the Akt/mTORC1/S6K1 signaling pathway, which provides new implications for the function of LA in ISCs. • Lauric acid promotes intestinal renewal and regeneration. • Lauric acid improves intestinal stem cell proliferation and differentiation. • Lauric acid activates Akt/mTORC1/S6K1 signaling axis to resist deoxynivalenol-induced decrease in intestinal stem cell activity. [ABSTRACT FROM AUTHOR]
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- 2021
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27. Whole-transcriptome sequencing with ceRNA regulation network construction and verification in glioblastoma.
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Zeng ZM, Chen YY, Wen XC, Geng XC, Zhu YX, Hao LC, Dong ZS, Yang JF, Wang TT, Zhang RB, Sun ZW, Zhang YH, and Zheng KB
- Abstract
Objectives: To explore the key genes involved in the occurrence and development of glioblastoma (GBM) by analyzing whole-transcriptome sequencing and biologic data from GBM and normal cerebral cortex tissues and to search for important noncoding RNA (ncRNA) molecular markers based on the competitive endogenous RNA (ceRNA) network., Methods: Ten GBM and normal cerebral cortex tissues were collected for full transcriptome sequencing, screened for differentially expressed (DE) mRNAs, miRNAs, lncRNAs, and circRNAs, and subjected to bioinformatic analysis. We constructed a Protein-Protein Interaction (PPI) network and a circRNA/lncRNA-miRNA-mRNA regulatory network and identified them using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Finally, The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases were used to validate and conduct a survival analysis of the target genes., Results: A total of 5341 DEmRNAs, 259 DEmiRNAs, 3122 DElncRNAs, and 2135 DEcircRNAs were identified. Enrichment analysis showed that target genes regulated by DEmiRNA, DElncRNA, and DEcircRNA were closely related to chemical synaptic transmission and ion transmembrane transport. A PPI network analysis screened 10 hub genes that directly participate in tumor cell mitosis regulation. In addition, the ceRNA composite network showed that hsa-miR-296-5p and hsa-miR-874-5p were the central nodes of the network, and the reliability of relevant key molecules was successfully verified through RT-qPCR identification and the TCGA database. The CGGA database survival analysis produced 8 DEmRNAs closely related to GBM patient survival prognosis., Conclusions: This study revealed the important regulatory functions and molecular mechanisms of ncRNA molecules and identified hsa-miR-296-5p and hsa-miR-874-5p as key molecules in the ceRNA network. They may play an important role in GBM pathogenesis, treatment, and prognosis., Competing Interests: None., (AJTR Copyright © 2023.)
- Published
- 2023
28. Gastric foregut cystic developmental malformation: case series and literature review.
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Geng YH, Wang CX, Li JT, Chen QY, Li XZ, and Pan H
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- Biopsy, Cysts classification, Cysts diagnosis, Cysts therapy, Gastrectomy, Humans, Lymph Node Excision, Male, Middle Aged, Predictive Value of Tests, Stomach Diseases classification, Stomach Diseases diagnosis, Stomach Diseases surgery, Terminology as Topic, Tomography, X-Ray Computed, Treatment Outcome, Cysts congenital, Gastric Mucosa abnormalities, Stomach Diseases congenital
- Abstract
Foregut cystic developmental malformation (FCDM) is a very rare lesion of the alimentary tract, especially in the stomach. We discuss the concepts of gastric duplication cyst, bronchogenic cysts, and FCDM. Nomenclature has been inconsistent and confusing, but, by some definitions, gastric duplication cysts involve gastric mucosa and submucosal glands, bronchogenic cysts involve respiratory mucosa with underlying cartilage and glands, and FCDM lacks gastric mucosa or underlying glands or cartilage but has pseudostratified ciliated columnar epithelium (PCCE). We searched our departmental case files from the past 15 years and identified 12 cases of FCDM in the alimentary tract. We summarize the features of these 12 cases including a report in detail on a 52-year-old man with a submucosal cyst lined with simple PCCE and irregular and stratified circular muscle layers that merged with gastric smooth muscle bundles near the lesser curvature of the gastric cardia. A literature review of cases with this histology yielded 25 cases. We propose the term gastric-FCDM for such cases. Our own series of 12 cases confirms that preoperative recognition of the entity is infrequent and problematic. The rarity of this developmental disorder, as well as a lack of understanding of its embryologic origins, may contribute to missing the diagnosis. Not appreciating the diagnosis preoperatively can lead to an inappropriate surgical approach. In contrast, presurgical recognition of the entity will contribute to a good outcome and reduced risk of complications.
- Published
- 2015
- Full Text
- View/download PDF
29. Near-infrared luminescence from Y2O3:Eu3+, Yb3+ prepared by sol-gel method.
- Author
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Xie Y, Xiao LJ, Yan FQ, Chen YJ, Li WZ, and Geng XJ
- Subjects
- Crystallization methods, Infrared Rays, Materials Testing, Molecular Conformation, Particle Size, Phase Transition, Surface Properties, Europium chemistry, Luminescent Measurements methods, Nanostructures chemistry, Nanostructures ultrastructure, Ytterbium chemistry, Yttrium chemistry
- Abstract
Eu3+ and Yb3+ codoped Y2O3 phosphors were synthesized by the sol-gel method. The phosphors possess absorption in the region of 300-550 nm, exhibiting an intense NIR emission of Yb3+ around 1000 nm, which is suitable for matching the maximum spectral response of c-Si solar cells. The optimum composition of Eu3+ and Yb3+ codoped Y2O3 was (Y1.94Yb0.04Eu0.02)2O3. It is observed that two-step energy transfer occurs from the 5D2 level of Eu3+ situated around (466 nm) exciting two neighboring Yb3+ ions to the 2F5/2 level (1000 nm). The down-conversion material based on Eu(3+)- Yb3+ couple may have great potential applications in c-Si solar cells to enhance their photovoltaic conversion efficiency via spectral modification.
- Published
- 2014
- Full Text
- View/download PDF
30. Luminescent properties of BaAl12O19:Tb, Dy phosphors prepared by sol-gel method.
- Author
-
Xiao LJ, Xie Y, He MR, Chen YJ, Geng XJ, and Li WZ
- Subjects
- Macromolecular Substances chemistry, Materials Testing, Molecular Conformation, Particle Size, Phase Transition, Surface Properties, Barium Compounds chemistry, Crystallization methods, Luminescent Measurements methods, Nanostructures chemistry, Nanostructures ultrastructure
- Abstract
BaAl12O19:Tb, Dy phosphor was prepared by the sol-gel technique using citric acid as a complextant. XRD was used to characterize the relevant crystallization behavior of the phosphor. The luminescence properties and energy transfer between Tb3+ and Dy3+ were investigated. The results revealed that energy transfer exists between Dy3+ and Tb3+ at appropriate Tb3+ concentrations. The emission intensity of Tb3+ increases and energy transfer happens from Dy3+ to Tb3+ ions at the higher content of Tb3+ when Tb3+ and Dy3+ ions were co-doped. BaAl12O19 phosphors doped with Tb3+ or Dy3+ ions only were studied to compared with BaAl12O19:Tb, Dy phosphors. The results showed that the maximum excitation peak of BaAl12O19:Tb is 240 nm and the emission spectrum consists of four peaks at 490, 545, 590, and 625 nm, originating from 5D4 --> 7FJ (J = 6, 5, 4, 3) transitions of Tb3+ ion, respectively. The excitation peaks of BaAl12O19:Dy are at 291, 324 nm and the emissions of Dy3+ are at 370, 447 and 578 nm, originating from 4F9/2 --> 6P5/2, 4F9/2 --> 6H15/2 and 4F9/2 --> 6H13/2 transitions of Dy3+ ion, respectively.
- Published
- 2014
- Full Text
- View/download PDF
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