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Support Vector Regression (SVR) and its variants are widely used regression algorithms, and they have demonstrated high generalization ability. This research proposes a new SVR-based regressor: v-minimum absolute deviation distribution regression (v-MADR) machine. Instead of merely minimizing structural risk, as with v-SVR, v-MADR aims to achieve better generalization performance by minimizing both the absolute regression deviation mean and the absolute regression deviation variance, which takes into account the positive and negative values of the regression deviation of sample points. For optimization, we propose a dual coordinate descent (DCD) algorithm for small sample problems, and we also propose an averaged stochastic gradient descent (ASGD) algorithm for large-scale problems. Furthermore, we study the statistical property of v-MADR that leads to a bound on the expectation of error. The experimental results on both artificial and real datasets indicate that our v-MADR has significant improvement in generalization performance with less training time compared to the widely used v-SVR, LS-SVR, ε-TSVR, and linear ε-SVR. Finally, we open source the code of v-MADR at https://github.com/AsunaYY/v-MADR for wider dissemination.

Big data offer a great opportunity for nature-based recreation (NbR) mapping and evaluation. However, it is important to determine when and how it is appropriate to use this resource. We used Scotland as a case study to validate the use of data from Flickr as an indicator of NbR on a national scale and at several regional spatial and temporal resolutions. We compared Flickr photographs to visitor statistics in the Cairngorms National Park (CNP) and determined whether temporal variability in photo counts could be explained by known annual estimates of CNP visitor numbers. We then used a unique recent national survey of nature recreation in Scotland to determine whether the spatial distribution of Flickr photos could be explained by known spatial variability in nature use. Following this validation work, we used Flickr data to identify hotspots of wildlife watching in Scotland and investigated how they changed between 2005 and 2015.We found that spatial and temporal patterns in Flickr count are explained by measures of visitation obtained through surveys and that this relationship is reliable down to a 10 Km scale resolution. Our findings have implications for planning and management of NbR as they suggest that photographs uploaded on Flickr reflect patterns of NbR at spatial and temporal scales that are relevant for ecosystem management.

Background The yeast Saccharomyces cerevisiae responds to amino acid starvation by inducing the transcription factor Gcn4. This is mainly mediated via a translational control mechanism dependent upon the translation initiation eIF2·GTP·Met-tRNAi Met ternary complex, and the four short upstream open reading frames (uORFs) in its 5' mRNA leader. These uORFs act to attenuate GCN4 mRNA translation under normal conditions. During amino acid starvation, levels of ternary complex are reduced. This overcomes the GCN4 translation attenuation effect via a scanning/reinitiation control mechanism dependent upon uORF spacing. Results Using published experimental data, we have developed and validated a probabilistic formulation of GCN4 translation using the Chemical Master Equation (Model 1). Model 1 explains GCN4 translation's nonlinear dependency upon uORF placements, and predicts that an as yet unidentified factor, which was proposed to regulate GCN4 translation under some conditions, only has pronounced effects upon GCN4 translation when intercistronic distances are unnaturally short. A simpler Model 2 that does not include this unidentified factor could well represent the regulation of a natural GCN4 mRNA. Using parameter values optimised for this algebraic Model 2, we performed stochastic simulations by Gillespie algorithm to investigate the distribution of ribosomes in different sections of GCN4 mRNA under distinct conditions. Our simulations demonstrated that ribosomal loading in the 5'-untranslated region is mainly determined by the ratio between the rates of 5'-initiation and ribosome scanning, but was not significantly affected by rate of ternary complex binding. Importantly, the translation rate for codons starved of cognate tRNAs is predicted to be the most significant contributor to the changes in ribosomal loading in the coding region under repressing and derepressing conditions. Conclusions Our integrated probabilistic Models 1 and 2 explained GCN4 translation and helped to elucidate the role of a yet unidentified factor. The ensuing stochastic simulations evaluated different factors that may impact on the translation of GCN4 mRNA, and integrated translation status with ribosomal density.

This paper reviews the state of the art in model-based systems and qualitative reasoning, and considers where the field will be in 20 years time. It highlights six areas where developments in model-based systems in general, and in qualitative reasoning in particular, have the potential to provide significant computer-based help. The paper also examines where further technological developments might be needed in order to achieve these qualitative futures.

This paper proposes a qualitative representation for robot kinematics in order to close the gap, raised by the perception–action problem, with a focus on intelligent connection of qualitative states to their corresponding numeric data in a robotic system. First, qualitative geometric primitives are introduced by combining a qualitative orientation component and qualitative translation component using normalisation techniques. A position in Cartesian space can be mathematically described by the scalable primitives. Secondly, qualitative robot kinematics of an n-link planar robot is derived in terms of the qualitative geometry primitives. Finally, it shows how to connect quantitativeness and qualitativeness of a robotic system. On the one hand, the integration of normalisation and domain knowledge generates normalised labels to introduce the meaningful parameters into the proposed representation. On the other hand, the normalised labels of this representation can be converted to a quantitative description using aggregation operators, whose numeric outputs can be used to generate desired trajectories based on mature interpolation techniques.

Cells are capable of accommodating the environmental changes by reprogramming gene expression. In the yeast Saccharomyces cerevisiae, under the amino acid deprivation condition, the translational barrier primarily exerted on GCN4 mRNA is alleviated to enhance the production of Gcn4p, which subsequently induces the expression of nearly all genes involved in amino acid biosyntheses. Our Systems Biology project's goal is to construct a dynamic mathematical model that accurately predicts the kinetic behaviour of the GCN Response in S. cerevisiae. Here, we report the mathematical formulations to describe the translational control exerted on the GCN4 mRNA. More importantly, the kinetic parameter estimation for this model indicates differential scanning rates of the 40S ribosomal subunit on the GCN4 mRNA 5' leader sequence under the amino acid replete and starvation conditions. This discovery is speculated to be attributable to the change in relative helicase activities under the two conditions.