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245 results on '"Gien, Jason"'

6. Synergistic association of fluid overload and acute kidney injury on outcomes in pediatric cardiac ECMO: a retrospective analysis of the KIDMO database

Author

Pettit, Kevin A., Selewski, David T., Askenazi, David J., Basu, Rajit K., Bridges, Brian C., Cooper, David S., Fleming, Geoffrey M., Gien, Jason, Gorga, Stephen M., Jetton, Jennifer G., King, Eileen C., Steflik, Heidi J., Paden, Matthew L., Sahay, Rashmi D., Zappitelli, Michael, and Gist, Katja M.

Published
2023
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11. Predicting treatment of pulmonary hypertension at discharge in infants with congenital diaphragmatic hernia

Author

Mahmood, Burhan, Murthy, Karna, Rintoul, Natalie, Weems, Mark, Keene, Sarah, Brozanski, Beverly, DiGeronimo, Robert, Haberman, Beth, Hedrick, Holly, Gien, Jason, Seabrook, Ruth, Ali, Noorjahan, Chapman, Rachel, Daniel, John, Harrison, Allen, Johnson, Yvette, Porta, Nicolas F. M., Uhing, Michael, Zaniletti, Isabella, and Grover, Theresa R.

Published
2022
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16. Treatment of pulmonary hypertension during initial hospitalization in a multicenter cohort of infants with congenital diaphragmatic hernia (CDH)

Author

Seabrook, Ruth B., Grover, Theresa R., Rintoul, Natalie, Weems, Mark, Keene, Sarah, Brozanski, Beverly, DiGeronimo, Robert, Haberman, Beth, Hedrick, Holly, Gien, Jason, Ali, Noorjahan, Chapman, Rachel, Daniel, John, Harrison, H. Allen, Johnson, Yvette, Porta, Nicolas F. M., Uhing, Michael, Zaniletti, Isabella, and Murthy, Karna

Published
2021
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21. Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy: a multicenter retrospective cohort study

Author

Gorga, Stephen M., Sahay, Rashmi D., Askenazi, David J., Bridges, Brian C., Cooper, David S., Paden, Matthew L., Zappitelli, Michael, Gist, Katja M., Gien, Jason, Basu, Rajit K., Jetton, Jennifer G., Murphy, Heidi J., King, Eileen, Fleming, Geoffrey M., and Selewski, David T.

Published
2020
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23. Maternal Hypertension Disorders and Neonatal Acute Kidney Injury: Results from the AWAKEN Study.

Author

DeFreitas, Marissa J., Griffin, Russell, Sanderson, Keia, Nada, Arwa, Charlton, Jennifer R., Jetton, Jennifer G., Kent, Alison L., Guillet, Ronnie, Askenazi, David, Abitbol, Carolyn L., Ambalavanan, Namasivayam, Goldstein, Stuart, Nathan, Amy, Greenberg, James, KentAlisonMD, Kent, Alison, Fletcher, Jeffrey, Sethna, Farah, Soranno, Danielle, and Gien, Jason

Subjects
RISK assessment, RESEARCH funding, NEONATAL intensive care units, LOGISTIC regression analysis, ACUTE kidney failure, NEONATAL intensive care, RETROSPECTIVE studies, CHI-squared test, HYPERTENSION in pregnancy, LONGITUDINAL method, ODDS ratio, MEDICAL records, ACQUISITION of data, PREECLAMPSIA, ANALYSIS of variance, PREGNANCY complications, ECLAMPSIA, DISEASE risk factors, DISEASE complications, CHILDREN
Abstract

Objective This study aimed to examine the association between maternal hypertension (HTN) exposure and neonatal acute kidney injury (AKI). Study Design Retrospective cohort study of 2,162 neonates admitted to 24 neonatal intensive care units (NICUs). Neonates were classified into the following exposure groups: any maternal HTN, chronic maternal HTN, preeclampsia/eclampsia, both, or neither. Demographics, clinical characteristics, and AKI status were compared using Chi-square and analysis of variance. General estimating logistic regression was used to estimate adjusted odds ratios and included a stratified analysis for site of delivery. Result Neonates exposed to any maternal HTN disorder had a tendency toward less overall and early AKI. When stratified by inborn versus outborn, exposure to both maternal HTN disorders was associated with a significantly reduced odds of early AKI only in the inborn neonates. Conclusion Exposure to maternal HTN, especially preeclampsia/eclampsia superimposed on chronic HTN, was associated with less likelihood of early AKI in the inborn group. Key Points Maternal HTN is associated with less neonatal AKI. Maternal HTN category is variably associated with AKI. Inborn status is an important contributor to this association. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Predicting Risk of Infection in Infants with Congenital Diaphragmatic Hernia

Author

Asselin, Jeanette, Durand, David, Dykes, Francine, Evans, Jacquelyn, Murthy, Karna, Padula, Michael, Pallotto, Eugenia, Grover, Theresa, Brozanski, Beverly, Piazza, Anthony, Reber, Kristina, Short, Billie, Porta, Nicolas F.M., Pallotto, Eugenia K., Rintoul, Natalie, Keene, Sarah, Chicoine, Louis, Gien, Jason, Brozanski, Beverly S., Johnson, Yvette R., Haberman, Beth, DiGeronimo, Robert, Zaniletti, Isabella, and Grover, Theresa R.

Published
2018
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27. Extracorporeal membrane oxygenation and bloodstream infection in congenital diaphragmatic hernia

Author

Keene, Sarah, Grover, Theresa R., Murthy, Karna, Pallotto, Eugenia K., Brozanski, Beverly, Gien, Jason, Zaniletti, Isabella, Johnson, Yvette R., Seabrook, Ruth B., Porta, Nicolas F. M., Haberman, Beth, DiGeronimo, Robert, Rintoul, Natalie, and on behalf of the Children’s Hospitals Neonatal Consortium’s (CHNC) Congenital Diaphragmatic Hernia Focus Group

Published
2019
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28. Late onset neonatal acute kidney injury: results from the AWAKEN Study

Author

Charlton, Jennifer R., Boohaker, Louis, Askenazi, David, Brophy, Patrick D., Fuloria, Mamta, Gien, Jason, Griffin, Russell, Hingorani, Sangeeta, Ingraham, Susan, Mian, Ayesa, Ohls, Robin K., Rastogi, Shantanu, Rhee, Christopher J., Revenis, Mary, Sarkar, Subrata, Starr, Michelle, Kent, Alison L., and on behalf of the Neonatal Kidney Collaborative (NKC)

Published
2019
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30. Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study

Author

Selewski, David T, Sarkar, Subrata, Kent, Alison, Fletcher, Jeffery, Abitbol, Carolyn L, DeFreitas, Marissa, Duara, Shahnaz, Charlton, Jennifer R, Guillet, Ronnie, D'Angio, Carl, Mian, Ayesa, Rademacher, Erin, Mhanna, Maroun J, Raina, Rupesh, Kumar, Deepak, Ambalavanan, Namasivayam, Arikan, Ayse Akcan, Rhee, Christopher J, Goldstein, Stuart L, Nathan, Amy T, Bhutada, Alok, Rastogi, Shantanu, Bonachea, Elizabeth, Ingraham, Susan, Mahan, John, Nada, Arwa, Brophy, Patrick D, Colaizy, Tarah T, Klein, Jonathan M, Cole, F Sessions, Davis, T Keefe, Dower, Joshua, Milner, Lawrence, Smith, Alexandra, Fuloria, Mamta, Reidy, Kimberly, Kaskel, Frederick J, Gien, Jason, Gist, Katja M, Hanna, Mina H, Hingorani, Sangeeta, Starr, Michelle, Joseph, Catherine, DuPont, Tara, Ohls, Robin, Staples, Amy, Khokhar, Surender, Perazzo, Sofia, Ray, Patricio E, Revenis, Mary, Synnes, Anne, Wintermark, Pia, Jetton, Jennifer G, Boohaker, Louis J, Sethi, Sidharth K, Wazir, Sanjay, Rohatgi, Smriti, Soranno, Danielle E, Chishti, Aftab S, Woroniecki, Robert, Mammen, Cherry, Swanson, Jonathan R, Sridhar, Shanthy, Wong, Craig S, Kupferman, Juan C, Griffin, Russell L, and Askenazi, David J

Published
2017
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31. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia

Author

Abman, Steven H., Collaco, Joseph M., Shepherd, Edward G., Keszler, Martin, Cuevas-Guaman, Milenka, Welty, Stephen E., Truog, William E., McGrath-Morrow, Sharon A., Moore, Paul E., Rhein, Lawrence M., Kirpalani, Haresh, Zhang, Huayan, Gratny, Linda L., Lynch, Susan K., Curtiss, Jennifer, Stonestreet, Barbara S., McKinney, Robin L., Dysart, Kevin C., Gien, Jason, Baker, Christopher D., Donohue, Pamela K., Austin, Eric, Fike, Candice, and Nelin, Leif D.

Published
2017
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35. Fetal lung volumes measured by MRI predict pulmonary morbidity among infants with giant omphaloceles.

Author

Gallagher, Lauren T., Lyttle, Bailey D., Meyers, Mariana L., Gien, Jason, Zaretsky, Michael V., Galan, Henry L., Behrendt, Nicholas, Liechty, Kenneth W., and Derderian, Sarkis Christopher

Abstract

Objective: Giant omphaloceles (GO) have associated pulmonary hypoplasia and respiratory complications. Total lung volumes (TLV) on fetal MRI can prognosticate congenital diaphragmatic hernia outcomes; however, its applicability to GO is unknown. We hypothesize that late gestation TLV and observed‐to‐expected TLV (O/E TLV) on fetal MRI correlate with postnatal pulmonary morbidity in GO. Method: A single‐institution retrospective review of GO evaluated between 2012 and 2022 was performed. Fetal MRI TLV between 32 and 36 weeks' gestation and O/E TLV throughout gestation were calculated and correlated with postnatal outcomes. Results: 86 fetuses with omphaloceles were evaluated; however, only 26 met strict inclusion criteria. MRIs occurred between 18 and 36 weeks' gestation. Those requiring delivery room intubation had significantly lower late gestation TLV and O/E TLV. O/E TLV predicted tracheostomy placement and survival. Neither TLV nor O/E TLV predicted the length of hospitalization or supplemental oxygen after discharge. Three fetuses had a TLV less than 35 mL: one died of respiratory failure, and the other two required tracheostomy. Conclusions: Fetal MRI TLV measured between 32 and 36 weeks' gestation and O/E TLV predict the need for delivery room intubation and tracheostomy. O/E TLV correlated with survival. These data support fetal MRI as a prognostic tool to predict GO associated pulmonary morbidity. Key points: What's already known about this topic? Giant omphaloceles carry a higher risk of pulmonary morbidity, including the need for supplemental oxygen, prolonged mechanical ventilation, requirement for high‐frequency oscillator ventilation, and need for tracheostomy. What does this study add? As pulmonary hypoplasia is a significant contributor to morbidity and mortality associated with GO, our study demonstrates that fetal MRI predicts respiratory requirements at the time of delivery. We demonstrate that O/E TLV measured by prenatal MRI is a useful tool to predict the need for immediate intubation within the delivery room as well as overall survival. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Analgesia, Sedation, and Neuromuscular Blockade in Infants with Congenital Diaphragmatic Hernia.

Author

Weems, Mark F., Grover, Theresa R., Seabrook, Ruth, DiGeronimo, Robert, Gien, Jason, Keene, Sarah, Rintoul, Natalie, Daniel, John M., Johnson, Yvette, Guner, Yigit, Zaniletti, Isabella, and Murthy, Karna

Subjects
MORTALITY risk factors, LENGTH of stay in hospitals, ANALGESIA, ANESTHESIA, NEONATAL intensive care, CHILDREN'S hospitals, TREATMENT duration, GENETIC disorders, DIAPHRAGMATIC hernia, RETROSPECTIVE studies, HEALTH information systems, EXTRACORPOREAL membrane oxygenation, NEONATAL intensive care units, POSTOPERATIVE care, NEUROMUSCULAR blockade, SURVEYS, BENZODIAZEPINES, RISK assessment, RESEARCH funding, DESCRIPTIVE statistics, COMBINED modality therapy, OPIOID analgesics, TRANQUILIZING drugs, CHILDREN
Abstract

Objective The aim of this study was to describe the use, duration, and intercenter variation of analgesia and sedation in infants with congenital diaphragmatic hernia (CDH). Study Design This is a retrospective analysis of analgesia, sedation, and neuromuscular blockade use in neonates with CDH. Patient data from 2010 to 2016 were abstracted from the Children's Hospitals Neonatal Database and linked to the Pediatric Health Information System. Patients were excluded if they also had non-CDH conditions likely to affect the use of the study medications. Results A total of 1,063 patients were identified, 81% survived, and 30% were treated with extracorporeal membrane oxygenation (ECMO). Opioid (99.8%), sedative (93.4%), and neuromuscular blockade (87.9%) use was common. Frequency of use was higher and duration was longer among CDH patients treated with ECMO. Unadjusted duration of use varied 5.6-fold for benzodiazepines (median: 14 days) and 7.4-fold for opioids (median: 16 days). Risk-adjusted duration of use varied among centers, and prolonged use of both opioids and benzodiazepines ≥5 days was associated with increased mortality (p < 0.001) and longer length of stay (p < 0.001). Use of sedation or neuromuscular blockade prior to or after surgery was each associated with increased mortality (p ≤ 0.01). Conclusion Opioids, sedatives, and neuromuscular blockade were used commonly in infants with CDH with variable duration across centers. Prolonged combined use ≥5 days is associated with mortality. Key Points Use of analgesia and sedation varies across children's hospital NICUs. Prolonged opioid and benzodiazepine use is associated with increased mortality. Postsurgery sedation and neuromuscular blockade are associated with mortality. [ABSTRACT FROM AUTHOR]

Published
2023
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