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2. Predictors of futile recanalization in nonagenarians treated with mechanical thrombectomy: a multi-center observational study

Author

D’Anna, Lucio, Merlino, Giovanni, Romoli, Michele, Zhang, Liqun, Del Regno, Caterina, Aggour, Mohammed, Levee, Viva, Foschi, Matteo, Sponza, Massimo, Toraldo, Francesco, Algazlan, Razan, Ruggiero, Maria, Longoni, Marco, Lobotesis, Kyriakos, Abu-Rumeileh, Samir, Bagatto, Daniele, Mansoor, Nina, Gigli, Gian Luigi, Valente, Mariarosaria, and Banerjee, Soma

Published
2024
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19. Clinical characteristics of a large cohort of patients with narcolepsy candidate for pitolisant: a cross-sectional study from the Italian PASS Wakix® Cohort

Author

Mutti, Carlotta, Brunetti, Valerio, Figorilli, Michela, Liguori, Claudio, Pizza, Fabio, Proserpio, Paola, Sacco, Tommaso, Pedrazzi, Giuseppe, Lecomte, Isabelle, Blanchard, Nora, Agostoni, Elio Clemente, Bonanni, Enrica, Centonze, Diego, Cicolin, Alessandro, Della Marca, Giacomo, Ferini-Strambi, Luigi, Ferri, Raffaele, Gigli, Gian Luigi, Izzi, Francesca, Liguori, Rocco, Lodi, Raffaele, Nobili, Lino, Parrino, Liborio, Placidi, Fabio, Puligheddu, Monica, Romigi, Andrea, Savarese, Maria Antonietta, Terzaghi, Michele, and Plazzi, Giuseppe

Published
2022
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22. Ketogenic Diet Improves Sleep Quality and Daytime Sleepiness in Chronic Migraine: A Pilot Study.

Author

Tereshko, Yan, Dal Bello, Simone, Belgrado, Enrico, Di Lorenzo, Cherubino, Pittino, Alice, Filippi, Francesca, Valdemarin, Francesca, Lettieri, Christian, Gigli, Gian Luigi, Nilo, Annacarmen, Pellitteri, Gaia, Merlino, Giovanni, and Valente, Mariarosaria

Subjects
SLEEP quality, KETOGENIC diet, EPWORTH Sleepiness Scale, BODY mass index, ADIPOSE tissues
Abstract

Aims: The aim of this study is to assess the sleep quality and daytime sleepiness improvement in chronic migraineurs after 6 months of a 2:1 KD (ketogenic diet) and LGID (low-glycemic-index diet). Methods: Twenty-six patients underwent 2:1 KD (11 patients) and LGID (15 patients). PSQI (Pittsburgh sleep quality index) and ESS (Epworth sleepiness scale) were administered at the baseline and the 3-month and 6-month follow-up. MIDAS (Migraine Disability Assessment), HIT-6 (Headache Impact Test 6), migraine frequency (migraine days per month), migraine intensity, BMI (Body Mass Index), FM (Fat Mass), and FFM (Fat-Free Mass) were also assessed. Results: PSQI (F1.544, 38.606 = 7.250; p = 0.004), ESS (F1.988, 49.708 = 9.938; p < 0.001), HIT-6 (F1.432, 35.805 = 12.693; p < 0.001), migraine frequency (F1.522, 38.041 = 23.070; p < 0.001), migraine intensity (F1.949, 48.721 = 18.798; p < 0.001), BMI (F1.274, 31.857 = 38.191; p < 0.001), and FM (F1.245, 31.134 = 45.487; p < 0.001) improved significantly. The MIDAS (F1.005, 25.121 = 3.037; p = 0.093) and the FMM (F1.311, 32.784 = 1.741; p = 0.197) did not improve significantly. The ESS (p = 0.712) and PSQI (p = 0.776) data at 3-month and 6-month follow-ups did not differ significantly, as well as for migraine frequency, migraine intensity, BMI, FM, and HIT-6. A mild correlation emerged between the mean FM and mean ESS reduction during the 6 months (r = 0.497, p = 0.010). Conclusions: Six months of LGID and 2:1 KD can improve sleep quality and daytime sleepiness in patients with chronic migraine. The effectiveness on migraine, sleep quality, and daytime sleepiness does not differ significantly between the 3-month and 6-month follow-up periods. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Botulinum Toxin Type A for Trigeminal Neuralgia: A Comprehensive Literature Review.

Author

Tereshko, Yan, Dal Bello, Simone, Lettieri, Christian, Belgrado, Enrico, Gigli, Gian Luigi, Merlino, Giovanni, and Valente, Mariarosaria

Subjects
TRIGEMINAL neuralgia, NEURALGIA, BOTULINUM A toxins, BOTULINUM toxin, WESTERN countries, PAIN management
Abstract

Trigeminal neuralgia is a neuropathic pain syndrome responsive to botulinum toxin type A therapy. This review had the goal of analyzing the different studies published from 2002 to January 2024 to better define the techniques and the types of botulinum toxin type A used, the doses, the injection routes, and the different populations of trigeminal neuralgia patients treated. We considered only articles in which the therapy was administered to humans to treat trigeminal neuralgia. Case reports, case series, open-label, retrospective, and RCT studies were considered. The research was conducted on MEDLINE and the keywords included (trigeminal neuralgia) and (botulinum). Thirty-five articles were considered suitable for this review. Botulinum toxin type A was shown to be an effective therapy for TN pain in all the articles analyzed, albeit there is a lack of standardization in methods and outcomes. The techniques, the doses, and the injection approaches were very heterogeneous among the studies. Only two botulinum toxin type A formulations have been used in this setting: onabotulinumtoxinA and lanbotulinumtoxinA. There were 300 patients treated with onabotulinumtoxinA and 760 treated with lanbotulinumtoxinA overall (in 42 patients, the formulation was not specified). The distinction between etiological and clinical types of TN has been made by only a small portion of the studies. The main adverse event was transient facial asymmetry. Botulinum toxin type A is indeed a promising therapy that is clearly effective for trigeminal neuralgia. OnabotulinumtoxinA is the most common formulation used in Western countries; however, the meager sample of TN patients treated, and the lack of standardization are not sufficient for this therapy to be approved by the FDA or EMA. Indeed, more studies with standardized methods and larger samples are needed for this purpose. [ABSTRACT FROM AUTHOR]

Published
2024
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29. The impact of COVID-19 on myocardial infarctions, strokes and out-of-hospital cardiopulmonary arrests: an observational retrospective study on time-sensitive disorders in the Friuli Venezia Giulia region (Italy)

Author

Pegani, Carlo, Buttignon, Giovanni, Tullio, Annarita, Naccarato, Marcello, Manganotti, Paolo, Rakar, Serena, Fabris, Enrico, Nadalin, Federico, Mione, Vincenzo, Gigli, Gian Luigi, Lorenzut, Simone, Spedicato, Leonardo, Passadore, Paolo, Pavan, Daniela, Lutman, Cristina, Andrian, Manila, Borelli, Massimo, Novello, Stefano, Belfiore, Rita, Daneluzzi, Chiara, Sinagra, Gianfranco, and Peratoner, Alberto

Published
2022
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30. Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects

Author

Krohn, Lynne, Heilbron, Karl, Blauwendraat, Cornelis, Reynolds, Regina H., Yu, Eric, Senkevich, Konstantin, Rudakou, Uladzislau, Estiar, Mehrdad A., Gustavsson, Emil K., Brolin, Kajsa, Ruskey, Jennifer A., Freeman, Kathryn, Asayesh, Farnaz, Chia, Ruth, Arnulf, Isabelle, Hu, Michele T. M., Montplaisir, Jacques Y., Gagnon, Jean-François, Desautels, Alex, Dauvilliers, Yves, Gigli, Gian Luigi, Valente, Mariarosaria, Janes, Francesco, Bernardini, Andrea, Högl, Birgit, Stefani, Ambra, Ibrahim, Abubaker, Šonka, Karel, Kemlink, David, Oertel, Wolfgang, Janzen, Annette, Plazzi, Giuseppe, Biscarini, Francesco, Antelmi, Elena, Figorilli, Michela, Puligheddu, Monica, Mollenhauer, Brit, Trenkwalder, Claudia, Sixel-Döring, Friederike, Cochen De Cock, Valérie, Monaca, Christelle Charley, Heidbreder, Anna, Ferini-Strambi, Luigi, Dijkstra, Femke, Viaene, Mineke, Abril, Beatriz, Boeve, Bradley F., Scholz, Sonja W., Ryten, Mina, Bandres-Ciga, Sara, Noyce, Alastair, Cannon, Paul, Pihlstrøm, Lasse, Nalls, Mike A., Singleton, Andrew B., Rouleau, Guy A., Postuma, Ronald B., and Gan-Or, Ziv

Published
2022
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42. Current and emerging pharmaceutical strategies for the treatment and management of restless legs syndrome.

Author

Burini, Alessandra, Pellitteri, Gaia, Merlino, Giovanni, Nilo, Annacarmen, Tereshko, Yan, Dolso, Pierluigi, Gigli, Gian Luigi, and Valente, Mariarosaria

Abstract

Introduction: Restless legs syndrome (RLS) is a sensory-motor sleep disorder that affects up to 13% of adults in the Western world and 2–4% of children. It impairs night sleep with an impact on daily performances and life quality. Thus, moderate-to-severe RLS requires pharmacological treatment. Areas covered: In the present review, which is based on PubMed searches with no time limits, the authors discuss the recommended pharmacotherapy for RLS in addition to other emerging treatment options. The authors provide coverage to the current recommendations for both adults and pediatric patients with RLS. Expert opinion: Current evidence suggests removing all causes of secondary RLS, including iron deficiency, chronic renal failure, drugs, and treating other sleep disorders that may worsen symptoms. Also, intermittent RLS should be addressed with behavioral measures and on-demand therapy. For chronic persistent RLS, α2δ calcium channel ligands are a first-line pharmacological approach, whereas dopamine agonists are associated with increased risk and should be spared. When RLS is refractory to first-line treatment, polytherapy, or opioid monotherapy should be considered. Nonetheless, some patients may not reach sustained symptom relief. Further research is needed to better understand the pathophysiology of RLS and to develop newer more effective drugs. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Safety and Outcomes of Mechanical Thrombectomy in Acute Ischemic Stroke Attributable to Cardiological Diseases: A Scoping Review.

Author

D'Anna, Lucio, Abu Rumeileh, Samir, Merlino, Giovanni, Ornello, Raffaele, Foschi, Matteo, Diana, Francesco, Barba, Lorenzo, Mastrangelo, Vincenzo, Romoli, Michele, Lobotesis, Kyriakos, Bax, Francesco, Kuris, Fedra, Valente, Mariarosaria, Otto, Markus, Korompoki, Eleni, Sacco, Simona, Gigli, Gian Luigi, Nguyen, Thanh N., and Banerjee, Soma

Published
2024
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45. Predictors of futile recanalization in nonagenarians treated with mechanical thrombectomy: a multi-center observational study.

Author

D'Anna, Lucio, Merlino, Giovanni, Romoli, Michele, Zhang, Liqun, Del Regno, Caterina, Aggour, Mohammed, Levee, Viva, Foschi, Matteo, Sponza, Massimo, Toraldo, Francesco, Algazlan, Razan, Ruggiero, Maria, Longoni, Marco, Lobotesis, Kyriakos, Abu-Rumeileh, Samir, Bagatto, Daniele, Mansoor, Nina, Gigli, Gian Luigi, Valente, Mariarosaria, and Banerjee, Soma

Subjects
ISCHEMIC stroke, THROMBECTOMY, NONAGENARIANS, PATIENTS' attitudes, THROMBOLYTIC therapy
Abstract

Background: There is a lack of data regarding patients aged 90 years or older undergoing mechanical thrombectomy and their predictors of futile recanalization. Aims: We sought to evaluate the predictors of futile recanalization in patients ≥ 90 years with large vessel occlusion undergoing mechanical thrombectomy. Methods: This multi-center observational retrospective study included patients ≥ 90 years consecutively treated with mechanical thrombectomy in four thrombectomy capable centers between January 1st, 2016 and 30th March 2023. Futile recanalization was defined as large vessel occlusion patients experiencing a 90-day poor outcome (mRS 3–6) despite successful recanalization (mTICI ≥ 2b) after mechanical thrombectomy. Results: Our cohort included 139 patients ≥ 90 years with acute ischemic stroke due to anterior circulation large vessel occlusion treated with mechanical thrombectomy. One hundred seventeen of one hundred thirty-nine patients ≥ 90 years who achieved successful recanalization were included in the analysis (seventy-six female (64.9%)), of whom thirty-one (26.49%) experienced effective recanalization and eighty-six (73.51%) experienced futile recanalization. Patients with futile recanalization had higher NIHSS on admission (p < 0.001); they were less frequently treated with intravenous thrombolysis (p = 0.048), had more often general anesthesia (p = 0.011), and longer door to groin puncture delay (p = 0.002). Univariable regression analysis showed that use of intravenous thrombolysis (0.29, 95% CI 0.02–0.79, p = 0.034) and site of occlusion distal vs proximal (0.34, 95% CI 0.11–0.97, p = 0.044) were associated with reduced probability of futile recanalization while NIHSS on admission (1.29, 95% CI 1.16–1.45, p < 0.001), NIHSS at 24 h (1.15, 95% CI 1.07–1.25, p = 0.002), type of anesthesia used (4.18, 95% CI 1.57–11.08, p = 0.004), and door to groin puncture time (1.02, 95% CI 1.00–1.05, p = 0.005) were associated with increased probability of futile recanalization. Multivariable regression analysis showed that use of intravenous thrombolysis (0.44, 95% CI 0.09–0.88, p = 0.039) was associated with reduced probability of futile recanalization. Conclusion: Our study seems to suggest that mechanical thrombectomy with intravenous thrombolysis is associated with reduced probability of futile recanalization in a multi-center cohort of patients aged 90 years or older. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Incidence of early poststroke seizures during reperfusion therapies in patients with acute ischemic stroke: An observational prospective study: (TESI study: “Trombolisi/Trombectomia e crisi Epilettiche precoci nello Stroke Ischemico”)

Author

Belcastro, Vincenzo, Brigo, Francesco, Ferlazzo, Edoardo, Gasparini, Sara, Mastroianni, Giovanni, Cianci, Vittoria, Lattanzi, Simona, Silvestrini, Mauro, Versino, Maurizio, Banfi, Paola, Carimati, Federico, Grampa, Giampiero, Lochner, Piergiorgio, Gigli, Gian Luigi, Bax, Francesco, Merlino, Giovanni, Valente, Mariarosaria, Vidale, Simone, and Aguglia, Umberto

Published
2020
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