1. Synthesis and Cytotoxicity of Novel Hexahydrothienocycloheptapyridazinone Derivatives
- Author
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Gabriele Murineddu, Battistina Asproni, Amedeo Pau, Luigi Bagella, Ilaria Marchesi, Gérard Aimé Pinna, M. M. Curzu, Giuseppe Enrico Grella, and Caterina Murruzzu
- Subjects
Programmed cell death ,synthesis ,Stereochemistry ,Pharmaceutical Science ,Antineoplastic Agents ,Thiophenes ,Ring (chemistry) ,Article ,Analytical Chemistry ,lcsh:QD241-441 ,pyridazinones ,lcsh:Organic chemistry ,Cell Line, Tumor ,Drug Discovery ,Cytotoxic T cell ,Humans ,Physical and Theoretical Chemistry ,cytotoxicity ,Cytotoxicity ,Cell Proliferation ,chemistry.chemical_classification ,Cell Death ,Cell growth ,Organic Chemistry ,Biological activity ,Combinatorial chemistry ,Pyridazines ,chemistry ,Chemistry (miscellaneous) ,Cell culture ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Tricyclic - Abstract
Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted-hexahydrothieno-cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.
- Published
- 2009
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